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  • 1.
    Berglund, Anders
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Tandteknikerprogrammet.
    Hulterström, Anna Karin
    Umeå universitet, Medicinsk fakultet, Odontologi, Tandteknikerprogrammet.
    Gruffman, Ewa
    Umeå universitet, Medicinsk fakultet, Odontologi, Odontologisk materialvetenskap.
    van Dijken, Jan
    Umeå universitet, Medicinsk fakultet, Odontologi, Tandhygienistprogrammet.
    Dimensional change of a calcium aluminate cement for posterior restorations in aqueous and dry media.2006Inngår i: Dental Materials, ISSN 0109-5641, Vol. 22, nr 5, 470-476 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: A calcium aluminate cement has recently been developed, with claims of being an alternative to dental amalgam and resin composites in posterior cavities. However, its' mechanical properties are not well evaluated and the aim of the study was therefore, to evaluate its' dimensional stability over time. METHODS: The dimensional changes of the cement, Doxadent, and two composite resins, Esthet-X and InTen-S, were tested during 360 d. The specimens were stored at 37+/-1 degrees C either in 100% air humidity (dry) or immersed in distilled water (wet), except for the first 24h when all specimens were stored at 100% air humidity and 37+/-1 degrees C. RESULTS: During the first 24h, Doxadent decreased in volume with 0.04%, while InTen-S and Esthet-X decreased with 1.60 and 1.75%, respectively. From d 1-360, the dry Doxadent specimens increased in volume with 2.0% and in weight with 5.5%, while the corresponding increase for the wet specimens were 4.1 and 6.3%, respectively. The volume of both composites increased 0.8% or less in dry and wet conditions, while the increase in weight for InTen-S was 1.2% for the wet specimens and 0.6% for the dry. The corresponding figures for Esthet-X were 0.7 and 0.2%. SIGNIFICANCE: Doxadent was less dimensionally stable than the composites tested. Doxadent increased 2 times more in volume immersed in water than in 100% air humidity, while the increase in weight was almost similar. The clinical implications of the results found in the present study are uncertain. A material that continues to absorb water during prolonged periods and continues to react is questionable for clinical use.

  • 2.
    Hulterström, Anna Karin
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerprogrammet.
    Silicone obturators and the bacterial flora in symptomatic nasal septal perforations2012Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Background A perforation in the nasal septum can cause symptoms such as bleeding, obstruction, crusts and pain, and can be a challenge to treat. Surgery is the treatment of choice, but disease, size of the perforation, or the patient’s wish may contradict surgery. A custom-made silicone obturator is a successful treatment option, but little is known how this treatment affects the microbial flora. The purposes of this thesis were (i) to investigate the microbial flora around symptomatic nasal septal perforations before treatment, (ii) during and after a 12-month treatment period with a custom-made obturator, (iii) to compare the microbial flora around symptomatic perforations with the flora from the same area of the septum in healthy individuals, (iv) to investigate the microbial colonization of the silicone obturator, and (v) also to investigate the water sorption, solubility and if the wettability of silicones are affected by water. The hypotheses were (i) that the bacterial flora around symptomatic perforations would not differ from that found in healthy individuals, apart from a possible presence of Helicobacter pylori; (ii) the bacterial flora would change in composition during the course of treatment and that microorganisms and proteins could be seen on the surface of the silicone obturators; (iii) a material that has adsorbed water would also show an increase in wettability and the surface free energy of the material.

     Methods Twenty-seven patients and 101 healthy individuals volunteered. Swabs were made around the rim of the perforation, or on the septum in the locus Kisselbachi area in the healthy individuals. Bacteria and fungi were isolated and identified with standard laboratory techniques. A biopsy of the granulated tissue at the perforation was taken and cultivated for Helicobacter pylori. Swabs were also taken three, six and twelve months after inserting the obturator. The obturator was analysed after being used twelve months in the nose.  Seven silicones were tested for water sorption and solubility according to ISO standards 1567:1999 and ISO 10477:2004. The change in wettability was examined by measuring the contact angle with a contact goniometer at various stages of the sorption/solubility test.

    Results Staphylococcus aureus was present in 88% of the untreated patients. With treatment a significant reduction of S. aureus occurred to 54.5% (p<0.05). In the healthy group S. aureus was present in 13% of the subjects. No Helicobacter pylori could be cultivated from the biopsies taken of the granulated tissue at the perforation. The flora round the untreated perforation was dominated by S. aureus with few other bacterial species detected. In the healthy group there was a diversified flora with both aerobic and anaerobic bacteria. SEM revealed a rough surface on the silicone obturator and crazing of the silicone surrounding the pigment granules. Both bacteria and proteins could be seen on the obturators in SEM. Candida albicans was detected in one obturator, but not in the mucosal swab at the corresponding time. That patient had, however, been treated for Candida in the nose six months prior to the last visit in the study. Wettability was affected but did not increase with amount of adsorbed water. Some materials showed an increase and some a decrease in the surface-free energy. The tested addition silicones showed little sorption and solubility.

    Conclusions The patients with symptomatic perforations of the nasal septum had a bacterial flora totally dominated by S. aureus. The massive presence of S. aureus around symptomatic perforations may have an impact on the persistence of the granulated and inflamed tissue present in symptomatic perforations, thus forming a vicious circle with bleeding and crustation.

    S. aureus dominance in the mucosa surrounding symptomatic perforations was diminished by using a custom-made obturator. The microbial flora became more diversified with the treatment, although not resembling the flora in healthy individuals. The microbial flora of the obturators was similar, but not the same as the corresponding mucosal flora. The discovery of Candida in the obturator of a patient who had been treated for Candida in the nose six months earlier suggests that obturators need to be exchanged when fungal infections are being treated to prevent the fungus from re-infecting the patient at a later stage.

    The silicone had a rough surface and a poor wettability, both aspects favours colonization of microorganisms. The silicone was negatively affected by the colouring pigments, this should be considered when colouring is not necessary. The slight, but existing solubility of silicones emphasises the importance of using medical grade silicones that are more purified than industrial silicones. 

  • 3.
    Hulterström, Anna Karin
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerprogrammet.
    Berglund, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerprogrammet.
    Ruyter, Ivar Eystein
    Wettability, water sorption and water solubility of seven silicone elastomers used for maxillofacial prostheses2008Inngår i: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 19, nr 1, 225-231 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The wettability, water sorption and solubility of silicone elastomers used for maxillofacial prostheses were studied. The hypothesis was, that a material that has absorbed water would show an increase in the wettability and thus also the surface free energy of the material.

    Seven silicone elastomers, both addition- and condensation type polymers, were included. Five specimens of each material were subjected to treatment according to ISO standards 1567:1999 and 10477: 2004 for water sorption and solubility. The volumes of the specimens were measured according to Archimedes principle. The contact angle was measured with a contact angle goniometer at various stages of the sorption/solubility test.

    Wettability changed over the test period, but not according to theory. The addition type silicones showed little or no sorption and solubility, but two of the condensation type polymers tested had a significant sorption and solubility. This study showed that condensation type polymers may show too large volumetric changes when exposed to fluids, and therefore should no longer be used in prosthetic devices. The results of this study also suggests that it might be of interest to test sorption and solubility of materials that are to be implanted, since most of the materials had some solubility.

  • 4.
    Hulterström, Anna Karin
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerprogrammet.
    Sellin, Mats
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi.
    Berggren, Diana
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Öron- näs- och halssjukdomar.
    High prevalence of S. aureus around symptomatic perforations of the nasal septumManuskript (preprint) (Annet vitenskapelig)
  • 5.
    Hulterström, Anna Karin
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerprogrammet.
    Sellin, Mats
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi.
    Berggren, Diana
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Öron- näs- och halssjukdomar.
    The effect of obturator treatment on the microbial flora surrounding symptomatic nasal septal perforationsManuskript (preprint) (Annet vitenskapelig)
  • 6.
    Hulterström, Anna Karin
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerutbildning.
    Sellin, Mats
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi.
    Berggren, Diana
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Öron- näs- och halssjukdomar.
    The microbial flora in the nasal septum area prone to perforation2012Inngår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 120, nr 3, 210-214 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To explore the colonizing bacterial flora of the nasal septum area, that is mostly afflicted by perforations, 101 healthy police students had swab samples taken from that location. The described culture strategy recovered positive cultures from 95% of the test subjects and from 60% with more than one organism. In total, 191 bacterial isolates were classified according to colony morphology, Gram-stain and a panel of standard laboratory techniques. A part of the bacteria was identified to species-level by biochemical methods and by sequencing of the 16S rRNA gene. The predominant finding was Gram-positive irregular rods - 65 presumptive Corynebacterium isolates, both lipophilic and non-lipophilic, and 37 anaerobic Propionibacterium isolates. The second largest bacterial group was Gram-positive catalase-positive cocci, of which 13 isolates were identified as Staphylococcus aureus and 53 as coagulase-negative staphylococci. The few potential airway pathogens included Streptococcus pneumonia (n = 1) and Moraxella catarrhalis (n = 3) isolates. The bacterial flora colonizing the nasal septum mainly consists of Gram-positive bacteria. Although of low virulence, the microbial flora may impact on occlusion treatment of nasal septum perforations with silicone obturators.

  • 7.
    Hulterström, Anna Karin
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerutbildning.
    Sellin, Mats
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Monsen, Tor
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Widerström, Micael
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Gurram, Bharath Kumar
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Berggren, Diana
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Öron- näs- och halssjukdomar.
    Bacterial flora and the epidemiology of staphylococcus aureus in the nose among patients with symptomatic nasal septal perforations2016Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, nr 6, 620-625 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conclusions Patients with symptomatic perforations of the nasal septum had a high prevalence of S. aureus in the nasal mucosa. Pulsed field gel electrophoresis (PFGE) analysis revealed a high genetic heterogeneity of S. aureus among both patients and controls. This indicates that presence of different strains of S. aureus can maintain a chronic inflammation in symptomatic nasal septal perforations. Objective The purpose of this study was to investigate the microbial flora around nasal septal perforations in patients having severe symptoms regarding bleeding, obstruction, and crustation associated with their perforation. Methods Twenty-five patients with untreated symptomatic nasal septal perforations were included. For culture, swabs around the perforations were collected. Bacteria were identified with standard laboratory techniques including a MALDI-TOF mass spectrometer. Epidemiological analysis was done using PFGE protocols. Bacteriological data were compared with data from a healthy control group. Results Staphylococcus aureus was present in the mucosa surrounding the nasal perforation significantly more often (p < 0.0001) in the patients (88%) compared to a control group (13%). Corynebacterium spp. and Propionibacterium spp. were significantly more frequently identified in the control group. The PFGE analysis of S. aureus strains revealed a high genetic heterogeneity and no specific S. aureus genotypes were associated with septal perforation.

  • 8. Johansson, Björn
    et al.
    Friberg, Bertil
    Nilson, Hans
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerutbildning. Stockholm Dental Implant Centre, Stockholm, Sweden.
    Digitally planned, immediately loaded dental implants with prefabricated prostheses in the reconstruction of edentulous maxillae: a 1-year prospective, multicenter study2009Inngår i: Clinical Implant Dentistry and Related Research, ISSN 1523-0899, E-ISSN 1708-8208, Vol. 11, nr 3, 194-200 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The introduction of digital planning programs has made it possible to place dental implants in preplanned positions and being immediately functionally loaded by using prefabricated prostheses.

    Purpose: The aim of this multicenter study was to describe the 1-year results of digitally planned, immediately loaded edentulous maxillae.

    Materials and Methods: A total of 312 implants (Branemark System (R), TiUnite RP, Nobel Biocare, Goteborg, Sweden) in 52 patients from eight Scandinavian clinics were digitally planned, surgically as well as prosthetically, by using the NobelGuide (R) (Nobel Biocare AB, Goteborg, Sweden) and received prefabricated, immediately loaded fixed prosthetic constructions in the maxillae. Individual implant stability was manually tested at 1-year follow-up.

    Results: All patients received a Procera Implant Bridge (R) (Nobel Biocare AB); however, in two cases, the bridges were reconstructed due to misfit. In five patients, difficulties in getting the surgical guide completely in position, and in five patients, getting the prostheses completely seated, were noted. All but four patients fulfilled the 1-year follow-up. Two implants were lost during the study period, resulting in a cumulative survival rate of 99.4%. The mean marginal bone resorption from implant placement to the 1-year follow-up was 1.3 mm (SD 1.28). More than 2 mm of marginal resorption was noted in 19% of the implants at this instant. The most frequently reported complications during the first year were gingival hyperplasia and prosthesis-related problems (prosthesis screw loosening, occlusal fractures, and occlusal adjustments).

    Conclusion: The 1-year results in this multicenter are promising regarding implant and bridge stability; however, the study is planned to be running for at least 3 years.

  • 9.
    Tillberg, Anders
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Berglund, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerutbildning.
    Mårell, Lena
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Bergdahl, Jan
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Eriksson, Nils
    Umeå universitet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Linden, Gerd
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Stenberg, Berndt
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Dermatologi och venereologi. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Widman, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Changes in health over time in patients with symptoms allegedly caused by dental restorative materials2005Inngår i: Community Dentistry and Oral Epidemiology, ISSN 0301-5661, E-ISSN 1600-0528, Vol. 33, nr 6, 427-437 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Abstract –  Objectives:  In Sweden, many patients with symptoms allegedly caused by their dental materials have exchanged their restorations, but the effects of the exchange have been insufficiently investigated. Therefore, the aim of the study was to describe the change in health over time for these patients and the hypothesis was that the patients could be divided based on their symptoms and that the ability to recover differs between these groups. Furthermore, we also examined if other factors such as replacement of dental restorative materials and follow-up time had any impact on the perceived health status.

    Methods:  A questionnaire was sent to 614 patients who had been referred to the School of Dentistry, Umeå, Sweden, with symptoms allegedly caused by dental restorative materials. The response rate was 55%.

    Results:  The risk of having any further complaints was higher for patients with complex symptoms (P = 0.03) and these patients had exchanged their restorations to a significantly larger extent than the others (P = 0.03). The remaining complaints was more frequent among men (P = 0.02). Exchange of dental restorative materials had no significant impact on the ability to recover completely. However, the patients who had exchanged their restorations completely perceived a significantly larger alleviation of their symptoms than the others (P < 0.01), although the frequency of most of the symptoms had increased.

    Conclusions:  Patients with complex symptoms had a more unfavorable long-term prognosis concerning persistent complaints than those with localized symptoms only. Furthermore, the results indicate that the patients might experience health improvements after removal of their dental restorative materials. The reason for this improvement, however, is unclear. Further analyses regarding other possible explanations than the ‘odontological/medical’ are needed.

  • 10.
    Tillberg, Anders
    et al.
    Umeå universitet, Medicinsk fakultet, Odontologi, Odontologisk materialvetenskap.
    Järvholm, Bengt
    Umeå universitet, Medicinsk fakultet, Folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Berglund, Anders
    Umeå universitet, Medicinsk fakultet, Odontologi, Tandteknikerprogrammet.
    Risks with dental materials2008Inngår i: Dental Materials, ISSN 0109-5641, Vol. 24, nr 7, 940-943 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: Dental materials are among the most used substitutes for biological tissue in the human body. The possible health effects of amalgam have been studied extensively and have sometimes been replaced with other less well-examined materials. The aim was to study the hazards of other dental materials than amalgam. METHODS: Toxicological information was collected from the Swedish Dental Materials Register 2003 (DentMr). The material safety data sheets (MSDS) included in the DentMR was examined regarding the given composition of the products, the occurrence of CAS-numbers and risk and safety phrases of the substances. Furthermore, complementary information about risk and safety phrases for substances with missing information in the MSDS was collected by using two easily available databases. RESULTS: There were 482 products that included 377 substances of which 219 could be identified. Only 26% of 219 substances had risk and safety phrases. However, via the Swedish Chemicals Inspectorate Classification Register and the Sigma-Aldrich product register, risk and safety phrases could be found for 37 substances. A literature search indicated that some of the listed substances had possible hazards, e.g. substances with embryotoxic and neurotoxic potential. SIGNIFICANCE: The information about hazards with dental materials seems insufficiently described in MSDS and there might be materials with side effects unknown to both patients and dental personnel. There is a need for stronger regulation of dental materials, at least substances that the patients will be exposed to for decades.

  • 11.
    Tillberg, Anders
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Mårell, Lena
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Berglund, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerprogrammet.
    Eriksson, Nils
    Umeå universitet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Replacement of restorations in subjects with symptoms associated with dental restorations; a follow-up study2008Inngår i: European Journal of Oral Sciences, ISSN 0909-8836, E-ISSN 1600-0722, Vol. 116, nr 4, 362-368 s.Artikkel i tidsskrift (Fagfellevurdert)
  • 12.
    Tillberg, Anders
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Stenberg, Berndt
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Dermatologi och venereologi.
    Berglund, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandteknikerprogrammet.
    Reactions to resin-based dental materials in patients-type, time to onset, duration, and consequence of the reaction.2009Inngår i: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 61, nr 6, 313-319 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: The aim of the present study was to determine the types of side-effects occurring and for how long they lasted in a group of patients with side-effects assessed to be caused by resin-based materials. METHODS: A total of 618 reports were received by the Swedish National Register of Side-Effects to Dental Materials, among which 36 were on patients with reactions assessed to be caused by resin-based restorative materials. The group examined consisted of 25 women and 11 men, with a mean age of 47.8 +/- 15.6 years. A follow-up was done through a structured telephone interview. RESULTS: The majority of symptoms were intra-oral or a combination of intra-oral and extra-oral symptoms that appeared within the first 24 hr after treatment. The most common adverse effects reported were skin problems, oral ulcers, and burning mouth. Within less than a week, the reactions had disappeared in 50% of the patients. CONCLUSION: Immediate reactions to resin-based materials were more prevalent than delayed allergic reactions, and the mechanism of the immediate reactions is probably non-allergic in most cases. There is a need for developing provocation tests to verify the association between the reaction and the material, and also to identify the offending component.

  • 13. Uo, Motohiro
    et al.
    Berglund, Anders
    Umeå universitet, Medicinsk fakultet, Odontologi, Tandteknikerprogrammet.
    Cardenas, Juan
    Umeå universitet, Teknisk-naturvetenskaplig fakultet, Kemi.
    Pohl, Lars
    Umeå universitet, Medicinsk fakultet, Odontologi.
    Watari, Fumio
    Bergman, Maud
    Umeå universitet, Medicinsk fakultet, Odontologi.
    Sjöberg, Staffan
    Umeå universitet, Teknisk-naturvetenskaplig fakultet, Kemi.
    Surface analysis of dental amalgams by X-ray photoelectron spectroscopy and X-ray diffraction.2003Inngår i: Dental materials : official publication of the Academy of Dental Materials, Vol. 19, nr 7, 639-644 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: It is important to characterize the surface of dental amalgam in order to understand the process of mercury release from amalgam restorations in the oral cavity. The mercury evaporation occurs not only from the newly made restoration but also from the set material. METHODS: The surfaces of four different types of amalgams, which had been well set, were analyzed with X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD) and the relationship between surface compositions and mercury release was studied. Fresh amalgam surfaces as well as aged surfaces, which were stored for 30 days in air, were investigated using XPS and the chemical states of amalgam components and oxygen were studied. The aged surfaces were also characterized with XRD and grazing angle XRD. RESULTS: With increased oxidation, the surface contents of tin and oxygen were increased in all amalgams. In contrast, the surface contents of copper and mercury were decreased. An increase of zinc or indium content were observed in zinc or indium containing amalgams, respectively. A surface layer enriched with indium and oxygen was clearly detected by XPS but not with grazing angle XRD. SIGNIFICANCE: The thickness of the enriched surface layer is estimated to be in the order of few nanometer, which is approximately equal to the analysis depth of XPS. In addition, the presence of metallic elements, like tin and zinc, that readily form a stable oxide layer at the surface suppress the release of mercury.

  • 14. van Noort, R
    et al.
    Gjerdet, NR
    Schedle, A
    Björkman, L
    Berglund, Anders
    Umeå universitet, Medicinsk fakultet, Odontologi, Tandteknikerprogrammet.
    An overview of the current status of national reporting systems for adverse reactions to dental materials.2004Inngår i: Journal of Dentistry, ISSN 0300-5712, Vol. 32, nr 5, 351-358 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: Since all dental materials pose a potential risk to patients and members of the dental team, the post-market monitoring of adverse reactions caused by dental materials should be considered essential. This article reviews the current status of post-market monitoring of adverse reactions to dental materials and highlights some of the issues that arise in trying to establish an evidence base on the characteristics of adverse reactions to dental materials. METHODS: Norway, Sweden and more recently the UK have sought to monitor adverse reactions to dental materials systematically and proactively in an effort to add to the evidence base on the safety of dental materials. Their experiences in undertaking post-market surveillance have been combined in preparing this article. RESULTS: To date the Norwegian, Swedish and the UK projects has received 1268 reports over 11 years, 848 reports over 5.5 years and 1117 reports over 3 years, respectively, relating to adverse reactions seen or experienced by dental personnel and patients. Presently, there are no harmonized criteria for what can be classified as an adverse reaction related to dental materials. Under reporting is a recognised problem and lack of awareness and lack of clarity as to what constitutes an adverse reaction may be contributory factors. A pro-active reporting system takes a considerable time to become established, but can generate a lot of potentially useful information. CONCLUSIONS: There is a need to raise the awareness among dental professionals of the potential for adverse reactions due to dental materials and to develop an internationally accepted system of data gathering that can produce the evidence that reflect the extent, severity and incidence of adverse reactions to dental materials.

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