[{"_id":"project:949","_type":"project","abstract":{"sv":"Metabolites of stress and sex hormones (GABA-steroids) agonistically modulate the GABA-A receptor and cause mental symptoms and disorders but the mechanisms are poorly known. Only a few individuals react negatively on GABA-steroids but all individuals have variations in GABA-steroids especially women during the menstrual cycle. The reason for individual responses to GABA-steroids is unknown. Previous research indicates that tolerance development with decreased function in the GABA-A system may be one reason. Another is that GABA-steroids have a biphasic action with low levels provoking symptoms while absence or higher levels give less severe symptoms. Personality factors and chronic stress seem to be of importance. Aims are: In humans investigate if tolerance against GABA-steroids occurs in conditions with increased endogenous or exogenous GABA-steroid exposure by using sensitivity tests of the GABA-A system? With brain imaging studies, in humans, investigate if activity in neural structures responsible for emotions, change in response to stimuli under GABA-steroid influence? In animals studies investigate if psychological trait factors, or chronic social stress, are important for the sensitivity towards GABA-steroids? In HEK-cells, expressing single recombinant human GABA-A receptor, with patch-clamp methods, investigate if 3alpha-hydroxy metabolites of endogenous or therapeutic progestagens, androgens and glucocorticoids are active on the GABA-A receptor?"},"project_id":"2009-02637_VR","identifier_short":"2009-02637","dates":{"start_date":"2010-01-01","end_date":"2012-12-31"},"organizations":[{"funding":[{"_id":2,"id":"202100-5208","sv":"Vetenskapsrådet","en":"Swedish Research Council"}]},{"coordinating":[{"_id":715,"id":"202100-2874","sv":"Umeå universitet","en":"Umeå University"}]}],"people":[{"project_leaders":[{"orcid":"0000-0002-0907-3535","name":"Bäckström, Torbjörn","role":"principal_investigator","affiliation":[{"_id":715,"id":"202100-2874","sv":"Umeå universitet","en":"Umeå University"}]}]},{"other_personnel":[]}],"tags":[],"titles":{"sv":"Basen för stress och könshormon orsakade mentala symtom och sjukdomar.","en":"Basis for sex and stress hormone induced mood symptoms and diseases"},"total_funding":"2250000","type_of_awards":{"sv":"Projektbidrag","en":"Project grant"},"publications":[],"links":[{"type":"pid","link":"https://umu.diva-portal.org/smash/api/project/swecris/project:949"}]}]