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Publications (10 of 204) Show all publications
Rolandsson, O., Tornevi, A., Steneberg, P., Edlund, H., Olsson, T., Andreasson, U., . . . Blennow, K. (2024). Acute hyperglycemia induced by hyperglycemic clamp affects plasma Amyloid-β in type 2 diabetes. Journal of Alzheimer's Disease, 99(3), 1033-1046
Open this publication in new window or tab >>Acute hyperglycemia induced by hyperglycemic clamp affects plasma Amyloid-β in type 2 diabetes
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2024 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 99, no 3, p. 1033-1046Article in journal (Refereed) Published
Abstract [en]

Background: Individuals with type 2 diabetes (T2D) have an increased risk of cognitive symptoms and Alzheimer's disease (AD). Mis-metabolism with aggregation of amyloid-β peptides (Aβ) play a key role in AD pathophysiology. Therefore, human studies on Aβ metabolism and T2D are warranted.

Objective: The objective of this study was to examine whether acute hyperglycemia affects plasma Aβ1-40 and Aβ1-42 concentrations in individuals with T2D and matched controls.

Methods: Ten participants with T2D and 11 controls (median age, 69 years; range, 66-72 years) underwent hyperglycemic clamp and placebo clamp (saline infusion) in a randomized order, each lasting 4 hours. Aβ1-40, Aβ1-42, and insulin-degrading enzyme (IDE) plasma concentrations were measured in blood samples taken at 0 and 4 hours of each clamp. Linear mixed-effect regression models were used to evaluate the 4-hour changes in Aβ1-40 and Aβ1-42 concentrations, adjusting for body mass index, estimated glomerular filtration rate, and 4-hour change in insulin concentration.

Results: At baseline, Aβ1-40 and Aβ1-42 concentrations did not differ between the two groups. During the hyperglycemic clamp, Aβ decreased in the control group, compared to the placebo clamp (Aβ1-40: p = 0.034, Aβ1-42: p = 0.020), IDE increased (p = 0.016) during the hyperglycemic clamp, whereas no significant changes in either Aβ or IDE was noted in the T2D group.

Conclusions: Clamp-induced hyperglycemia was associated with increased IDE levels and enhanced Aβ40 and Aβ42 clearance in controls, but not in individuals with T2D. We hypothesize that insulin-degrading enzyme was inhibited during hyperglycemic conditions in people with T2D.

Place, publisher, year, edition, pages
IOS Press, 2024
Keywords
Alzheimer's disease, amyloid-β, cognition, endocrinology and metabolism specialty, hyperglycemia, type 2 diabetes
National Category
Neurosciences
Identifiers
urn:nbn:se:umu:diva-225948 (URN)10.3233/JAD-230628 (DOI)38728183 (PubMedID)2-s2.0-85194944157 (Scopus ID)
Funder
Region VästerbottenSwedish Diabetes AssociationSwedish Research Council, 2023-00356Swedish Research Council, 2022-01018Swedish Research Council, 2019-02397Swedish Research Council, 2017-00915Swedish Research Council, 2022-00732EU, Horizon Europe, 101053962Familjen Erling-Perssons StiftelseStiftelsen Gamla TjänarinnorThe Swedish Brain Foundation, FO2022-0270The Swedish Brain Foundation, FO2017-0243The Swedish Brain Foundation, ALZ2022-0006EU, Horizon 2020, 860197Alzheimerfonden, AF-930351Alzheimerfonden, AF-939721Alzheimerfonden, AF-968270
Available from: 2024-06-12 Created: 2024-06-12 Last updated: 2024-06-12Bibliographically approved
Bäcklund, N., Lundstedt, S., Tornevi, A., Wihlbäck, A.-C., Olsson, T., Dahlqvist, P. & Brattsand, G. (2024). Salivary cortisol and cortisone can circumvent confounding effects of oral contraceptives in the short synacthen test. Journal of Clinical Endocrinology and Metabolism
Open this publication in new window or tab >>Salivary cortisol and cortisone can circumvent confounding effects of oral contraceptives in the short synacthen test
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2024 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197Article in journal (Refereed) Epub ahead of print
Abstract [en]

Context: Adrenal insufficiency (AI) is usually diagnosed by low plasma cortisol levels following a short Synacthen test (SST). Most plasma cortisol is bound to corticosteroid-binding globulin, which is increased by estrogen in combined estrogen-progestin oral contraceptives (COCs). Women with AI using COCs are therefore at risk of having an apparently normal plasma cortisol level during SST, which would not adequately reflect AI.

Objective: To test whether salivary cortisol or cortisone during SST is more robust against the COC effect and to calculate the lower reference limits (LRLs) for these to be used as tentative diagnostic cutoffs to exclude AI.

Methods: Forty-one healthy women on COCs and 46 healthy women without exogenous estrogens performed an SST with collection of plasma and salivary samples at 0, 30, and 60 min after Synacthen injection. The groups were compared using regression analysis with age as covariate and the LRLs were calculated parametrically.

Results: SST-stimulated plasma cortisol levels were significantly higher in the COC group versus controls, while mean salivary cortisol and cortisone levels were slightly lower in the COC group. Importantly, COC use did not significantly alter LRLs for salivary cortisol or cortisone. The smallest LRL difference between groups was seen for salivary cortisone.

Conclusion: Salivary cortisol and especially salivary cortisone are considerably less affected by COC use than plasma cortisol during SST. Due to similar LRLs, a common cutoff for salivary cortisol and cortisone during SST can be used to exclude AI in premenopausal women irrespective of COC use.

Place, publisher, year, edition, pages
Oxford University Press, 2024
Keywords
short Synacthen test, salivary cortisol, salivary cortisone, oral contraceptives, adrenal insufficiency, reference limits
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-222629 (URN)10.1210/clinem/dgad763 (DOI)001140071500001 ()38173358 (PubMedID)
Funder
Region VästerbottenUmeå University
Available from: 2024-03-22 Created: 2024-03-22 Last updated: 2024-03-25
Imamovic, M., Bäcklund, N., Lundstedt, S., Brattsand, G., Aardal, E., Olsson, T. & Dahlqvist, P. (2023). Confounding effects of liquorice, hydrocortisone, and blood contamination on salivary cortisol but not cortisone. Endocrine Connections, 12(1), Article ID e220324.
Open this publication in new window or tab >>Confounding effects of liquorice, hydrocortisone, and blood contamination on salivary cortisol but not cortisone
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2023 (English)In: Endocrine Connections, E-ISSN 2049-3614, Vol. 12, no 1, article id e220324Article in journal (Refereed) Published
Abstract [en]

Objective: To determine the effects of liquorice consumption, topical hydrocortisone, and blood contamination on salivary cortisol and cortisone concentrations.

Design and methods: Thirty healthy volunteers were randomized to a low, medium, or high dose of liquorice. Late-night saliva samples were collected using a Salivette® collection device at baseline, during 1 week of daily liquorice consumption, and during 4 weeks' washout. Saliva sampling was also performed before and after the application of topical hydrocortisone on the skin. Furthermore, in a subgroup (n  = 16), saliva and venous blood were collected from each individual and mixed to achieve graded blood contamination in saliva. Salivary cortisol and cortisone were analyzed with liquid chromatography-tandem mass spectrometry.

Results: Significant increases in salivary cortisol concentrations were observed during medium- (+49%) and high-dose (+97%) liquorice intake, which returned to baseline 4 days after liquorice withdrawal. Topical hydrocortisone on fingers holding the collection swab increased salivary cortisol concentrations >1000-fold with concomitant pronounced elevation of the cortisol:cortisone ratio. Salivary cortisol increased significantly after contamination with blood ≥0.5%. Visual examination could safely detect these samples. Salivary cortisone concentrations were unaffected by liquorice consumption and blood contamination, and only marginally affected by topical hydrocortisone.

Conclusion: Liquorice, topical hydrocortisone, and blood contamination may all cause elevated salivary cortisol concentrations. Improved sampling instructions and visual examination of the sample may minimize these risks. Salivary cortisone is essentially unaffected by the different preanalytical confounders and may be used as a first-line screening test for Cushing's syndrome.

Place, publisher, year, edition, pages
Bioscientifica, 2023
Keywords
Cushing’s syndrome, salivary cortisol, salivary cortisone, liquorice, sample contamination
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-208130 (URN)10.1530/ec-22-0324 (DOI)000971893300001 ()36383173 (PubMedID)2-s2.0-85151875249 (Scopus ID)
Funder
Region Västerbotten
Available from: 2023-05-10 Created: 2023-05-10 Last updated: 2024-03-26Bibliographically approved
Ragnarsson, O., Carlberg, B. & Olsson, T. (2023). Dietary salt restriction in primary aldosteronism. Journal of Internal Medicine, 294(1), 2-3
Open this publication in new window or tab >>Dietary salt restriction in primary aldosteronism
2023 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 294, no 1, p. 2-3Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2023
National Category
Cardiac and Cardiovascular Systems General Practice
Identifiers
urn:nbn:se:umu:diva-206353 (URN)10.1111/joim.13625 (DOI)000957068400001 ()36945840 (PubMedID)2-s2.0-85150904246 (Scopus ID)
Available from: 2023-04-26 Created: 2023-04-26 Last updated: 2023-07-12Bibliographically approved
Ragnarsson, O., Dahlqvist, P., Muth, A., Calissendorff, J. & Olsson, T. (2023). Mineralocorticoid receptor antagonists for primary aldosteronism - appropriate or not? [Letter to the editor]. European Journal of Endocrinology, 188(3), L1-L2
Open this publication in new window or tab >>Mineralocorticoid receptor antagonists for primary aldosteronism - appropriate or not?
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2023 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 188, no 3, p. L1-L2Article in journal, Letter (Other academic) Published
Place, publisher, year, edition, pages
Oxford University Press, 2023
Keywords
adrenal vein sampling, adrenalectomy, mineralocorticoid receptor antagonist, primary aldosteronism
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-206025 (URN)10.1093/ejendo/lvad020 (DOI)000953971500002 ()36757798 (PubMedID)2-s2.0-85150396850 (Scopus ID)
Available from: 2023-03-28 Created: 2023-03-28 Last updated: 2023-09-05Bibliographically approved
Bäcklund, N., Brattsand, G., Lundstedt, S., Aardal, E., Bartuseviciene, I., Berinder, K., . . . Dahlqvist, P. (2023). Salivary cortisol and cortisone in diagnosis of Cushing's syndrome: a comparison of six different analytical methods. Clinical Chemistry and Laboratory Medicine, 61(10), 1780-1791
Open this publication in new window or tab >>Salivary cortisol and cortisone in diagnosis of Cushing's syndrome: a comparison of six different analytical methods
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2023 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 61, no 10, p. 1780-1791Article in journal (Refereed) Published
Abstract [en]

Objectives: Salivary cortisol and cortisone at late night and after dexamethasone suppression test (DST) are increasingly used for screening of Cushing’s syndrome (CS). We aimed to establish reference intervals for salivary cortisol and cortisone with three liquid chromatography-tandem mass spectrometry (LC-MS/MS) techniques and for salivary cortisol with three immunoassays (IAs), and evaluate their diagnostic accuracy for CS.

Methods: Salivary samples at 08:00 h, 23:00 h and 08:00 h after a 1-mg DST were collected from a reference population (n=155) and patients with CS (n=22). Sample aliquots were analyzed by three LC-MS/MS and three IA methods. After establishing reference intervals, the upper reference limit (URL) for each method was used to calculate sensitivity and specificity for CS. Diagnostic accuracy was evaluated by comparing ROC curves.

Results: URLs for salivary cortisol at 23:00 h were similar for the LC-MS/MS methods (3.4–3.9 nmol/L), but varied between IAs: Roche (5.8 nmol/L), Salimetrics (4.3 nmol/L), Cisbio (21.6 nmol/L). Corresponding URLs after DST were 0.7–1.0, and 2.4, 4.0 and 5.4 nmol/L, respectively. Salivary cortisone URLs were 13.5–16.6 nmol/L at 23:00 h and 3.0–3.5 nmol/L at 08:00 h after DST. All methods had ROC AUCs ≥0.96.

Conclusions: We present robust reference intervals for salivary cortisol and cortisone at 08:00 h, 23:00 h and 08:00 h after DST for several clinically used methods. The similarities between LC-MS/MS methods allows for direct comparison of absolute values. Diagnostic accuracy for CS was high for all salivary cortisol and cortisone LC-MS/MS methods and salivary cortisol IAs evaluated.

Place, publisher, year, edition, pages
Walter de Gruyter, 2023
Keywords
Cushing's syndrome, immunoassay, LC-MS/MS, method comparison, salivary cortisol, salivary cortisone
National Category
Analytical Chemistry Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-206793 (URN)10.1515/cclm-2023-0141 (DOI)000964106600001 ()37013440 (PubMedID)2-s2.0-85151863068 (Scopus ID)
Funder
Region Västerbotten
Available from: 2023-04-24 Created: 2023-04-24 Last updated: 2024-03-26Bibliographically approved
Mendham, A. E., Micklesfield, L. K., Karpe, F., Kengne, A. P., Chikowore, T., Kufe, C. N., . . . Goedecke, J. H. (2023). Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women. Diabetologia, 66, 174-189
Open this publication in new window or tab >>Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women
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2023 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 66, p. 174-189Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis: Using a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose metabolism (IGM) and type 2 diabetes in a Black South African cohort. In addition, we assessed sex-specific associations between the validated proteins and pathophysiological pathways of type 2 diabetes.

Methods: This cross-sectional study included Black South African men (n=380) and women (n=375) who were part of the Middle-Aged Soweto Cohort (MASC). Dual-energy x-ray absorptiometry was used to determine fat mass and visceral adipose tissue, and fasting venous blood samples were collected for analysis of glucose, insulin and C-peptide and for targeted proteomics, measuring a total of 184 pre-selected protein biomarkers. An OGTT was performed on participants without diabetes, and peripheral insulin sensitivity (Matsuda index), HOMA-IR, basal insulin clearance, insulin secretion (C-peptide index) and beta cell function (disposition index) were estimated. Participants were classified as having normal glucose tolerance (NGT; n=546), IGM (n=116) or type 2 diabetes (n=93). Proteins associated with dysglycaemia (IGM or type 2 diabetes) in the MASC were validated in the Swedish EpiHealth cohort (NGT, n=1706; impaired fasting glucose, n=550; type 2 diabetes, n=210).

Results: We identified 73 proteins associated with dysglycaemia in the MASC, of which 34 were validated in the EpiHealth cohort. Among these validated proteins, 11 were associated with various measures of insulin dynamics, with the largest number of proteins being associated with HOMA-IR. In sex-specific analyses, IGF-binding protein 2 (IGFBP2) was associated with lower HOMA-IR in women (coefficient –0.35; 95% CI –0.44, –0.25) and men (coefficient –0.09; 95% CI –0.15, –0.03). Metalloproteinase inhibitor 4 (TIMP4) was associated with higher insulin secretion (coefficient 0.05; 95% CI 0.001, 0.11; p for interaction=0.025) and beta cell function (coefficient 0.06; 95% CI 0.02, 0.09; p for interaction=0.013) in women only. In contrast, a stronger positive association between IGFBP2 and insulin sensitivity determined using an OGTT (coefficient 0.38; 95% CI 0.27, 0.49) was observed in men (p for interaction=0.004). A posteriori analysis showed that the associations between TIMP4 and insulin dynamics were not mediated by adiposity. In contrast, most of the associations between IGFBP2 and insulin dynamics, except for insulin secretion, were mediated by either fat mass index or visceral adipose tissue in men and women. Fat mass index was the strongest mediator between IGFBP2 and insulin sensitivity (total effect mediated 40.7%; 95% CI 37.0, 43.6) and IGFBP2 and HOMA-IR (total effect mediated 39.1%; 95% CI 31.1, 43.5) in men.

Conclusions/interpretation: We validated 34 proteins that were associated with type 2 diabetes, of which 11 were associated with measures of type 2 diabetes pathophysiology such as peripheral insulin sensitivity and beta cell function. This study highlights biomarkers that are similar between cohorts of different ancestry, with different lifestyles and sociodemographic profiles. The African-specific biomarkers identified require validation in African cohorts to identify risk markers and increase our understanding of the pathophysiology of type 2 diabetes in African populations.

Place, publisher, year, edition, pages
Springer, 2023
Keywords
Adiposity, Beta cell function, Ethnicity, IGFBP2, Impaired glucose metabolism, Insulin clearance, Insulin secretion, Insulin sensitivity, Obesity, TIMP4, Type 2 diabetes
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-199906 (URN)10.1007/s00125-022-05788-1 (DOI)000854821000001 ()36114877 (PubMedID)2-s2.0-85138286209 (Scopus ID)
Funder
Region Västerbotten
Available from: 2022-10-04 Created: 2022-10-04 Last updated: 2022-12-30Bibliographically approved
Pillon, N. J., Smith, J. A., Alm, P. S., Chibalin, A. V., Alhusen, J., Arner, E., . . . Zierath, J. R. (2022). Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes. Science Advances, 8(36), Article ID eabo3192.
Open this publication in new window or tab >>Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes
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2022 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 8, no 36, article id eabo3192Article in journal (Refereed) Published
Abstract [en]

Mechanistic insights into the molecular events by which exercise enhances the skeletal muscle phenotype are lacking, particularly in the context of type 2 diabetes. Here, we unravel a fundamental role for exercise-responsive cytokines (exerkines) on skeletal muscle development and growth in individuals with normal glucose tolerance or type 2 diabetes. Acute exercise triggered an inflammatory response in skeletal muscle, concomitant with an infiltration of immune cells. These exercise effects were potentiated in type 2 diabetes. In response to contraction or hypoxia, cytokines were mainly produced by endothelial cells and macrophages. The chemokine CXCL12 was induced by hypoxia in endothelial cells, as well as by conditioned medium from contracted myotubes in macrophages. We found that CXCL12 was associated with skeletal muscle remodeling after exercise and differentiation of cultured muscle. Collectively, acute aerobic exercise mounts a noncanonical inflammatory response, with an atypical production of exerkines, which is potentiated in type 2 diabetes.

Place, publisher, year, edition, pages
NLM (Medline), 2022
National Category
Physiology
Identifiers
urn:nbn:se:umu:diva-199460 (URN)10.1126/sciadv.abo3192 (DOI)000911968500015 ()36070371 (PubMedID)2-s2.0-85137461286 (Scopus ID)
Funder
Novo Nordisk, 17OC0030088Knut and Alice Wallenberg Foundation, 2018.0094Diabetesfonden, 2018-357Swedish Research Council, 2015-00165Swedish National Centre for Research in Sports, P2019-0140Swedish National Centre for Research in Sports, P2020-0064AstraZeneca, 2014-2019Novo Nordisk, 21SA0072747Swedish Heart Lung Foundation, 2017-0669Swedish Heart Lung Foundation, 2020-0627Diabetesfonden, 2018-336Novo Nordisk, 20SA0064144
Available from: 2022-09-26 Created: 2022-09-26 Last updated: 2023-09-05Bibliographically approved
Franklin, K. A., Lindberg, E., Svensson, J., Larsson, C., Lindahl, B., Mellberg, C., . . . Ryberg, M. (2022). Effects of a palaeolithic diet on obstructive sleep apnoea occurring in females who are overweight after menopause: a randomised controlled trial. International Journal of Obesity, 46(10), 1833-1839
Open this publication in new window or tab >>Effects of a palaeolithic diet on obstructive sleep apnoea occurring in females who are overweight after menopause: a randomised controlled trial
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2022 (English)In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 46, no 10, p. 1833-1839Article in journal (Refereed) Published
Abstract [en]

Background/Objectives: Obesity is the main risk factor for obstructive sleep apnoea, commonly occurring in females who are overweight after menopause. We aimed to study the effect of a palaeolithic diet on sleep apnoea in females with overweight after menopause from the population.

Methods: Seventy healthy, non-smoking females with a mean age of 60 years and a mean BMI of 33 kg/m2 were randomised to a palaeolithic diet or to a control low-fat diet according to Nordic Nutritional Recommendations, for 2 years. The apnoea-hypopnoea index was measured and daytime sleepiness was estimated during the intervention.

Results: The mean apnoea-hypopnoea index at baseline was 11.6 (95% CI 8.6–14.5). The mean weight loss was 7.2 kg (95% CI 5.3–9.2 kg) in the palaeolithic diet group and 3.9 kg in the control group (95% CI 1.9–5.9 kg); p < 0.021 for the group difference. The reduction in weight corresponded to a reduction in the apnoea-hypopnoea index in the palaeolithic diet group (r = 0.38, p = 0.034) but not in the control group (r = 0.08, p = 0.69). The apnoea-hypopnoea index was reduced in the palaeolithic diet group when the weight was reduced by more than 8 kg. Daytime sleepiness according to the Epworth Sleepiness Scale score and the Karolinska Sleepiness Scale score was unaffected by dietary group allocation.

Conclusions: A substantial decrease in body weight of 8 kg was needed to achieve a reduction in sleep apnoea in this small trial of women who are overweight after menopause. The palaeolithic diet was more effective for weight reduction than a control low-fat diet and the reduction in sleep apnoea was related to the degree of weight decrement within this diet group.

Trial registration: Clinicaltrials.gov: NCT00692536.

Place, publisher, year, edition, pages
Springer Nature, 2022
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-198343 (URN)10.1038/s41366-022-01182-4 (DOI)000829692700001 ()35879528 (PubMedID)2-s2.0-85134643819 (Scopus ID)
Funder
Swedish Heart Lung FoundationSwedish Research CouncilForte, Swedish Research Council for Health, Working Life and WelfareRegion Västerbotten
Available from: 2022-08-01 Created: 2022-08-01 Last updated: 2023-09-26Bibliographically approved
Kufe, C. N., Micklesfield, L. K., Masemola, M., Chikowore, T., Kengne, A. P., Karpe, F., . . . Goedecke, J. H. (2022). Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women. European Journal of Endocrinology, 186(5), 523-533
Open this publication in new window or tab >>Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women
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2022 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 186, no 5, p. 523-533Article in journal (Refereed) Published
Abstract [en]

Aims: Despite a higher prevalence of overweight/obesity in Black South African women compared to men, the prevalence of type 2 diabetes (T2D) does not differ. We explored if this could be due to sex differences in insulin sensitivity, clearance and/or beta-cell function and also sex-specific associations with total and regional adiposity.

Methods: This cross-sectional study included 804 Black South African men (n = 388) and women (n = 416). Dual-energy X-ray absorptiometry was used to measure total and regional adiposity. Insulin sensitivity (Matsuda index), secretion (C-peptide index) and clearance (C-peptide/insulin ratio) were estimated from an oral glucose tolerance test.

Results: After adjusting for sex differences in the fat mass index, men were less insulin sensitive and had lower beta-cell function than women (P < 0.001), with the strength of the associations with measures of total and central adiposity being greater in men than women (P < 0.001 for interactions). Further, the association between total adiposity and T2D risk was also greater in men than women (relative risk ratio (95% CI): 2.05 (1.42-2.96), P < 0.001 vs 1.38 (1.03-1.85), P = 0.031).

Conclusion: With increasing adiposity, particularly increased centralisation of body fat linked to decreased insulin sensitivity and beta-cell function, Black African men are at greater risk for T2D than their female counterparts.

Place, publisher, year, edition, pages
Bioscientifica, 2022
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-193965 (URN)10.1530/EJE-21-0527 (DOI)000802046600010 ()35225824 (PubMedID)2-s2.0-85128000417 (Scopus ID)
Available from: 2022-05-04 Created: 2022-05-04 Last updated: 2023-09-05Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0001-7768-1076

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