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Vu Nu, A., Van Hoang, M., Lindholm, L., Sahlen, K.-G., Nguyen, C. T. & Sun, S. (2024). A systematic review on the direct approach to elicit the demand-side cost-effectiveness threshold: implications for low- and middle-income countries. PLOS ONE, 19(2), Article ID e0297450.
Åpne denne publikasjonen i ny fane eller vindu >>A systematic review on the direct approach to elicit the demand-side cost-effectiveness threshold: implications for low- and middle-income countries
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2024 (engelsk)Inngår i: PLOS ONE, E-ISSN 1932-6203, Vol. 19, nr 2, artikkel-id e0297450Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Several literature review studies have been conducted on cost-effectiveness threshold values. However, only a few are systematic literature reviews, and most did not investigate the different methods, especially in-depth reviews of directly eliciting WTP per QALY. Our study aimed to 1) describe the different direct approach methods to elicit WTP/QALY; 2) investigate factors that contribute the most to the level of WTP/QALY value; and 3) investigate the relation between the value of WTP/QALY and GDP per capita and give some recommendations on feasible methods for eliciting WTP/QALY in low- and middle-income countries (LMICs). A systematic review concerning select studies estimating WTP/QALY from a direct approach was carried out in seven databases, with a cut off date of 03/2022. The conversion of monetary values into 2021 international dollars (i$) was performed via CPI and PPP indexes. The influential factors were evaluated with Bayesian model averaging. Criteria for recommendation for feasible methods in LMICs are made based on empirical evidence from the systematic review and given the resource limitation in LMICs. A total of 12,196 records were identified; 64 articles were included for full-text review. The WTP/QALY method and values varied widely across countries with a median WTP/QALY value of i$16,647.6 and WTP/QALY per GDP per capita of 0.53. A total of 11 factors were most influential, in which the discrete-choice experiment method had a posterior probability of 100%. Methods for deriving WTP/QALY vary largely across studies. Eleven influential factors contribute most to the level of values of WTP/QALY, in which the discrete-choice experiment method was the greatest affected. We also found that in most countries, values for WTP/QALY were below 1 x GDP per capita. Some important principles are addressed related to what LMICs may be concerned with when conducting studies to estimate WTP/QALY.

sted, utgiver, år, opplag, sider
Public Library of Science (PLoS), 2024
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-221104 (URN)10.1371/journal.pone.0297450 (DOI)38329955 (PubMedID)2-s2.0-85184572881 (Scopus ID)
Forskningsfinansiär
Familjen Erling-Perssons Stiftelse
Tilgjengelig fra: 2024-02-29 Laget: 2024-02-29 Sist oppdatert: 2024-02-29bibliografisk kontrollert
Meili, K. W., Mulhern, B., Ssegonja, R., Norström, F., Feldman, I., Månsdotter, A., . . . Lindholm, L. (2024). Eliciting a value set for the Swedish capability-adjusted life years instrument (CALY-SWE). Quality of Life Research, 33(1), 59-72
Åpne denne publikasjonen i ny fane eller vindu >>Eliciting a value set for the Swedish capability-adjusted life years instrument (CALY-SWE)
Vise andre…
2024 (engelsk)Inngår i: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 33, nr 1, s. 59-72Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: Our aim was to elicit a value set for Capability-Adjusted Life Years Sweden (CALY-SWE); a capability-grounded quality of life instrument intended for use in economic evaluations of social interventions with broad consequences beyond health.

Methods: Building on methods commonly used in the quality-adjusted life years EQ-5D context, we collected time-trade off (TTO) and discrete choice experiment (DCE) data through an online survey from a general population sample of 1697 Swedish participants. We assessed data quality using a score based on the severity of inconsistencies. For generating the value set, we compared different model features, including hybrid modeling of DCE and TTO versus TTO data only, censoring of TTO answers, varying intercept, and accommodating for heteroskedasticity. We also assessed the models’ DCE logit fidelity to measure agreement with potentially less-biased DCE data. To anchor the best capability state to 1 on the 0 to 1 scale, we included a multiplicative scaling factor.

Results: We excluded 20% of the TTO answers of participants with the largest inconsistencies to improve data quality. A hybrid model with an anchor scale and censoring was chosen to generate the value set; models with heteroskedasticity considerations or individually varying intercepts did not offer substantial improvement. The lowest capability weight was 0.114. Health, social relations, and finance and housing attributes contributed the largest capability gains, followed by occupation, security, and political and civil rights.

Conclusion: We elicited a value set for CALY-SWE for use in economic evaluations of interventions with broad social consequences.

sted, utgiver, år, opplag, sider
Springer Nature, 2024
Emneord
Quality-adjusted life year, Time trade-off, Discrete choice experiment, Capability approach, Hybrid modeling, Economic evaluation
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-214379 (URN)10.1007/s11136-023-03507-w (DOI)001064459600002 ()37695477 (PubMedID)2-s2.0-85170367443 (Scopus ID)
Forskningsfinansiär
Forte, Swedish Research Council for Health, Working Life and Welfare, 2018-00143Forte, Swedish Research Council for Health, Working Life and Welfare, 2018-00143
Tilgjengelig fra: 2023-09-13 Laget: 2023-09-13 Sist oppdatert: 2024-04-29bibliografisk kontrollert
Shimanda, P. P., Shumba, T. W., Brunström, M., Iipinge, S. N., Söderberg, S., Lindholm, L. & Norström, F. (2024). Preventive interventions to reduce the burden of rheumatic heart disease in populations at risk: a systematic review. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 13(5), Article ID e032442.
Åpne denne publikasjonen i ny fane eller vindu >>Preventive interventions to reduce the burden of rheumatic heart disease in populations at risk: a systematic review
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2024 (engelsk)Inngår i: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, E-ISSN 2047-9980, Vol. 13, nr 5, artikkel-id e032442Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Rheumatic heart disease (RHD) is a devastating yet preventable condition that disproportionately affects low-middle-income countries and indigenous populations in some high-income countries. Various preventive interventions have been implemented across the globe, but evidence for the effectiveness of these measures in reducing the incidence or prevalence of acute rheumatic fever and RHD is scattered. This systematic review aims to assess the effectiveness of preventive interventions and identify the strategies used to reduce the burden of RHD.

METHODS AND RESULTS: A comprehensive search was conducted to identify relevant studies on RHD prevention interventions including interventions for primordial, primary, and secondary prevention. Effectiveness measures for the interventions were gathered when available. The findings indicate that school-based primary prevention services targeting the early detection and treatment of Group A Streptococcus pharyngitis infection with penicillin have the potential to reduce the incidence of Group A Streptococcus pharyngitis and acute rheumatic fever. Community-based programs using various prevention strategies also reduced the burden of RHD. However, there is limited evidence from low-middle-income countries and a lack of rigorous evaluations reporting the true impact of the interventions. Narrative synthesis was performed, and the methodological quality appraisal was done using the Joanna Briggs Institute critical appraisal tools.

CONCLUSIONS: This systematic review underscores the importance of various preventive interventions in reducing the incidence and burden of Group A Streptococcus pharyngitis, acute rheumatic fever, and RHD. Rigorous evaluations and comprehensive analyses of interventions are necessary for guiding effective strategies and informing public health policies to prevent and reduce the burden of these diseases in diverse populations.

REGISTRATION: URL: https://www.crd.york.ac.uk/prospero/; Unique identifier: CRD42020170503.

sted, utgiver, år, opplag, sider
American Heart Association, 2024
Emneord
RHD prevention, acute rheumatic fever, rheumatic heart disease, systematic review
HSV kategori
Forskningsprogram
hjärt- och kärlforskning; folkhälsa; epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-221473 (URN)10.1161/JAHA.123.032442 (DOI)38390809 (PubMedID)2-s2.0-85187199895 (Scopus ID)
Forskningsfinansiär
Familjen Erling-Perssons Stiftelse
Tilgjengelig fra: 2024-02-23 Laget: 2024-02-23 Sist oppdatert: 2024-04-02bibliografisk kontrollert
Sun, S., Stenberg, E., Luo, N., Franklin, K. A., Lindholm, L., Sahlen, K.-G. & Cao, Y. (2024). SF-6D normative values among patients undergoing bariatric surgery: results based on real-world evidence from the Scandinavian obesity surgery registry (SOREG). Obesity Surgery, 34, 558-567
Åpne denne publikasjonen i ny fane eller vindu >>SF-6D normative values among patients undergoing bariatric surgery: results based on real-world evidence from the Scandinavian obesity surgery registry (SOREG)
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2024 (engelsk)Inngår i: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 34, s. 558-567Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The SF-6D index can be used to calculate quality-adjusted life years in economic evaluations, which is required by reimbursement agencies and national advisory bodies, including the Swedish ones. However, despite that SF-36 has been largely applied among patients undergoing bariatric surgery, almost no study has accessed the short form six-dimensions (SF-6D) after bariatric surgery.

Aim: To establish normative values for the SF-6D index among patients undergoing bariatric surgery.

Materials and Methods: All patients who received bariatric surgery in Sweden between 2011–01-01 and 2019–03-31 were obtained from the Scandinavian Obesity Surgery Registry (SOReg). Information includes patients’ sociodemographic characteristics, details regarding the procedure, and postsurgical conditions. The SF-36 is applied at baseline and at follow-up years 1, 2, and 5. The multiple sequential imputation method was applied to handle missingness on SF-6D items. Based on the UK tariff, the SF-6D preference scores were calculated. The normative values for the mean (SD) SF-6D index were reported by timepoint and surgical complications for men and women, respectively. Multivariate analyses were applied to investigate how the SF-6D index is associated with timepoint, controlling for age, sex, BMI, and comorbidities in a stepwise manner.

Results: The SF-6D index increased at 1 year relative to baseline and was roughly maintained at the same level at 2 years. The normative value of the SF-6D index can be used in economic evaluations for bariatric surgery. 

sted, utgiver, år, opplag, sider
Springer, 2024
Emneord
Bariatric surgery, Health preference, Normative value, Quality-adjusted life years, Real-world data, SF-6D
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-219487 (URN)10.1007/s11695-023-07024-0 (DOI)001137720100005 ()38189900 (PubMedID)2-s2.0-85181716238 (Scopus ID)
Forskningsfinansiär
Forte, Swedish Research Council for Health, Working Life and Welfare, 2018–00896
Tilgjengelig fra: 2024-01-24 Laget: 2024-01-24 Sist oppdatert: 2024-05-08bibliografisk kontrollert
Tungu, M. M., Mujinja, P. G., Amani, P. J., Mwangu, M. A., Kiwara, A. D. & Lindholm, L. (2023). Health, wealth, and medical expenditures among the elderly in rural Tanzania: experiences from Nzega and Igunga districts. BMC Health Services Research, 23(1), Article ID 1040.
Åpne denne publikasjonen i ny fane eller vindu >>Health, wealth, and medical expenditures among the elderly in rural Tanzania: experiences from Nzega and Igunga districts
Vise andre…
2023 (engelsk)Inngår i: BMC Health Services Research, E-ISSN 1472-6963, Vol. 23, nr 1, artikkel-id 1040Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: The per capita health expenditure (HE) and share of gross domestic product (GDP) spending on elderly healthcare are expected to increase. The gap between health needs and available resources for elderly healthcare is widening in many developing countries, like Tanzania, leaving the elderly in poor health. These conditions lead to catastrophic HEs for the elderly. This study aimed to analyse the association between measures of health, wealth, and medical expenditure in rural residents aged 60 years and above in Tanzania.

METHODS: The data of this study were collected through a cross-sectional household survey to residents aged 60 years and above living in Nzega and Igunga districts using a standardised World Health Organization (WHO) Study on Global Ageing and Adult Health (SAGE) and European Quality of Life Five Dimension (EQ-5D) questionnaires. The quality of life (QoL) was estimated using EQ-5D weights. The wealth index was generated from principal component analysis (PCA). The linear regression analyses (outpatient/inpatient) were performed to analyse the association between measures of health, wealth, medical expenditure, and socio-demographic variables.

RESULTS: This study found a negative and statistically significant association between QoL and HE, whereby HE increases with the decrease of QoL. We could not find any significant relationship between HE and social gradients. In addition, age influences HE such that as age increases, the HE for both outpatient and inpatient care also increases.

CONCLUSION: The health system in these districts allocate resources mainly according to needs, and social position is not important. We thus conclude that the elderly of lower socio-economic status (SES) was subjected to similar health expenditure as those of higher socio-economic status. Health, not wealth, determines the use of medical expenditures.

sted, utgiver, år, opplag, sider
BioMed Central (BMC), 2023
Emneord
Elderly, EQ-5D, Health expenditure, QoL, Tanzania, Wealth index
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-215073 (URN)10.1186/s12913-023-09943-1 (DOI)37773117 (PubMedID)2-s2.0-85172825682 (Scopus ID)
Tilgjengelig fra: 2023-10-13 Laget: 2023-10-13 Sist oppdatert: 2023-10-13bibliografisk kontrollert
Shimanda, P. P., Söderberg, S., Iipinge, S. N., Lindholm, L., Shidhika, F. F. & Norström, F. (2023). Health-related quality of life and healthcare consultations among adult patients before and after diagnosis with rheumatic heart disease in Namibia. BMC Cardiovascular Disorders, 23(1), Article ID 456.
Åpne denne publikasjonen i ny fane eller vindu >>Health-related quality of life and healthcare consultations among adult patients before and after diagnosis with rheumatic heart disease in Namibia
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2023 (engelsk)Inngår i: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 23, nr 1, artikkel-id 456Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Rheumatic Heart Disease (RHD) causes high morbidity and mortality rates among children and young adults, impacting negatively on their health-related quality of life (HRQoL). This study aimed to evaluate the HRQoL and healthcare consultations of adult patients with RHD in Namibia.

Methods: From June 2019 to March 2020, a questionnaire was administered to 83 RHD patients during routine follow-ups. The EQ-5D-5L instrument was used to assess the health-related quality of life before diagnosis and at the time of the survey. The Ethiopian value set for EQ-5D-5L was used to calculate Quality-Adjusted Life Years (QALY).

Results: Most respondents were women (77%), young adults below the age of 30 years (42%), and individuals who grew up in rural areas (87%). The mean QALY statistically significantly improved from 0.773 pre-diagnosis to 0.942 in the last 12 months (p < 0.001). Sixty-six patients who had surgery reported a better QALY. Healthcare visits statistically significantly increased from on average 1.6 pre-diagnosis to 2.7 days in the last 12 months (p < 0.001). The mean distance to the nearest facility was 55 km, mean cost of transport was N$65, and mean time spent at the clinic was 3.6 h. The median time from diagnosis to the survey was 7 years (quartiles 4 and 14 years).

Conclusion: Treatment and surgery can improve HRQoL substantially among RHD patients. Being diagnosed with RHD affects patients living in socioeconomically disadvantaged rural areas through cost and time for healthcare visits. It would be valuable with further research to understand differences between disease severities.

sted, utgiver, år, opplag, sider
BioMed Central (BMC), 2023
Emneord
Health-related quality of life, RHD, QALY, EQ-5D-5L, Namibia
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-214434 (URN)10.1186/s12872-023-03504-4 (DOI)2-s2.0-85171150062 (Scopus ID)
Forskningsfinansiär
Familjen Erling-Perssons Stiftelse
Tilgjengelig fra: 2023-09-14 Laget: 2023-09-14 Sist oppdatert: 2024-04-02bibliografisk kontrollert
Pham, P. D., Muchadeyi, M. T. & Lindholm, L. (2023). In situ breast cancer surgeries in Sweden: lumpectomy or mastectomy?: a cost-effectiveness analysis over a 30-Year period using Markov model. Cost Effectiveness and Resource Allocation, 21(1), Article ID 86.
Åpne denne publikasjonen i ny fane eller vindu >>In situ breast cancer surgeries in Sweden: lumpectomy or mastectomy?: a cost-effectiveness analysis over a 30-Year period using Markov model
2023 (engelsk)Inngår i: Cost Effectiveness and Resource Allocation, E-ISSN 1478-7547, Vol. 21, nr 1, artikkel-id 86Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Breast cancer represents the most prevalent cancer among Swedish women. Although considerable research has investigated the cost-effectiveness of emerging innovative medical treatments for breast cancer, studies addressing existing surgical procedures remain scant. Therefore, this study aimed to evaluate the cost-effectiveness of three surgical procedures for in situ breast cancer treatment in Sweden: mastectomy, lumpectomy without irradiation, and lumpectomy with irradiation.

Methods: A six-state Markov model with a 30-year time horizon was used to compare the cost-effectiveness of the three alternatives. Transition probabilities were based on a targeted literature review focusing on available evidence in Sweden and comparable contexts. Costs were estimated from both healthcare and societal perspectives, using patient data from the Swedish National Cancer Registry in 2020 (Cancerregistret). Health outcomes were quantified in terms of quality-adjusted life years (QALYs). Cost and health outcomes were then summarised into an incremental cost-effectiveness ratio (ICER) between competing strategies. A probabilistic sensitivity analysis (PSA) was conducted to address the uncertainties in the input parameters.

Results: The results showed that compared to lumpectomy without irradiation, lumpectomy with irradiation yielded a “moderate” ICER per QALY gained of 402,994 Swedish Krona (SEK) from a healthcare perspective and a “high” ICER of 575,833 SEK from a societal perspective. Mastectomy proved to be the costliest and least effective of the three alternatives over a 30-year period. The PSA results further substantiated these findings.

Conclusions: Our study demonstrated that lumpectomy with irradiation is “moderately” cost-effective compared with lumpectomy without irradiation. Nevertheless, extending this study by conducting a comprehensive budget impact analysis to account for the prevalence of in situ breast cancer in Sweden is prudent. These results imply that a costlier and less effective mastectomy should only be considered when lumpectomy options are infeasible. Further studies are needed to obtain more reliable parameters relevant to Sweden and to increase the consistency of the findings.

sted, utgiver, år, opplag, sider
BioMed Central (BMC), 2023
Emneord
Breast cancer surgeries, Breast conserving Surgery, Cost-effectiveness, Cost-effectiveness analysis, Follow-up irradiation, Iumpectomy, Mastectomy
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-217024 (URN)10.1186/s12962-023-00495-z (DOI)2-s2.0-85176603812 (Scopus ID)
Tilgjengelig fra: 2023-11-24 Laget: 2023-11-24 Sist oppdatert: 2023-11-24bibliografisk kontrollert
Sun, S., Stenberg, E., Cao, Y., Lindholm, L., Sahlen, K.-G., Franklin, K. A. & Luo, N. (2023). Mapping the obesity problems scale to the SF-6D: results based on the Scandinavian Obesity Surgery Registry (SOReg). European Journal of Health Economics, 24, 279-292
Åpne denne publikasjonen i ny fane eller vindu >>Mapping the obesity problems scale to the SF-6D: results based on the Scandinavian Obesity Surgery Registry (SOReg)
Vise andre…
2023 (engelsk)Inngår i: European Journal of Health Economics, ISSN 1618-7598, E-ISSN 1618-7601, Vol. 24, s. 279-292Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Obesity Problem Scale (OP) is a widely applied instrument for obesity, however currently calculation of health utility based on OP is not feasible as it is not a preference-based measure. Using data from the Scandinavian Obesity Surgery Registry (SOReg), we sought to develop a mapping algorithm to estimate SF-6D utility from OP. Furthermore, to test whether the mapping algorithm is robust to the effect of surgery.

METHOD: The source data SOReg (n = 36 706) contains both OP and SF-36, collected at pre-surgery and at 1, 2 and 5 years post-surgery. The Ordinary Least Square (OLS), beta-regression and Tobit regression were used to predict the SF-6D utility for different time points respectively. Besides the main effect model, different combinations of patient characteristics (age, sex, Body Mass Index, obesity-related comorbidities) were tested. Both internal validation (split-sample validation) and validation with testing the mapping algorithm on a dataset from other time points were carried out. A multi-stage model selection process was used, accessing model consistency, parsimony, goodness-of-fit and predictive accuracy. Models with the best performance were selected as the final mapping algorithms.

RESULTS: The final mapping algorithms were based on OP summary score using OLS models, for pre- and post-surgery respectively. Mapping algorithms with different combinations of patients' characteristics were presented, to satisfy the user with a different need.

CONCLUSION: This study makes available algorithms enabling crosswalk from the Obesity Problem Scale to the SF-6D utility. Different mapping algorithms are recommended for the mapping of pre- and post-operative data.

sted, utgiver, år, opplag, sider
Springer-Verlag New York, 2023
Emneord
Cross-walk, Health utility, Mapping, Obesity, Obesity-problem scale (OP), Quality of life (QOL), SF-6D
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-202669 (URN)10.1007/s10198-022-01473-7 (DOI)000798119000001 ()35596099 (PubMedID)2-s2.0-85130222208 (Scopus ID)
Forskningsfinansiär
Forte, Swedish Research Council for Health, Working Life and Welfare, 2018–00896
Tilgjengelig fra: 2023-01-12 Laget: 2023-01-12 Sist oppdatert: 2024-02-08bibliografisk kontrollert
Sun, S., Stenberg, E., Lindholm, L., Sahlen, K.-G., Franklin, K. A., Luo, N. & Cao, Y. (2023). Prediction of quality-adjusted life years (QALYs) after bariatric surgery using regularized linear regression models: results from a Swedish nationwide quality register. Obesity Surgery, 33(8), 2452-2462
Åpne denne publikasjonen i ny fane eller vindu >>Prediction of quality-adjusted life years (QALYs) after bariatric surgery using regularized linear regression models: results from a Swedish nationwide quality register
Vise andre…
2023 (engelsk)Inngår i: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 33, nr 8, s. 2452-2462Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To investigate whether the quality-adjusted life years (QALYs) of the patients who underwent bariatric surgery could be predicted using their baseline information.

Materials and Methods: All patients who received bariatric surgery in Sweden between January 1, 2011 and March 31, 2019 were obtained from the Scandinavian Obesity Surgery Registry (SOReg). Baseline information included patients' sociodemographic characteristics, details regarding the procedure, and postsurgical conditions. QALYs were assessed by the SF-6D at follow-up years 1 and 2. The general and regularized linear regression models were used to predict postoperative QALYs.

Results: All regression models demonstrated satisfactory and comparable performance in predicting QALYs at follow-up year 1, with R2 and relative root mean squared error (RRMSE) values of about 0.57 and 9.6%, respectively. The performance of the general linear regression model increased with the number of variables; however, the improvement was ignorable when the number of variables was more than 30 and 50 for follow-up years 1 and 2, respectively. Although minor L1 and L2 regularization provided better prediction ability, the improvement was negligible when the number of variables was more than 20. All the models showed poorer performance for predicting QALYs at follow-up year 2.

Conclusions: Patient characteristics before bariatric surgery including health related quality of life, age, sex, BMI, postoperative complications within six weeks, and smoking status, may be adequate in predicting their postoperative QALYs after one year. Understanding these factors can help identify individuals who require more personalized and intensive support before, during, and after surgery. 

sted, utgiver, år, opplag, sider
Springer, 2023
Emneord
Bariatric surgery, Prediction, Quality-adjusted life years, Real-world data, SF-6D
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-210892 (URN)10.1007/s11695-023-06685-1 (DOI)001013018400001 ()37322243 (PubMedID)2-s2.0-85161825147 (Scopus ID)
Forskningsfinansiär
Forte, Swedish Research Council for Health, Working Life and Welfare, 2018–00896
Tilgjengelig fra: 2023-06-28 Laget: 2023-06-28 Sist oppdatert: 2024-02-08bibliografisk kontrollert
Philipson, A., Duberg, A., Hagberg, L., Högström, S., Lindholm, L., Möller, M. & Ryen, L. (2023). The cost-effectiveness of a dance and yoga intervention for girls with functional abdominal pain disorders. PharmacoEconomics - Open, 7, 321-335
Åpne denne publikasjonen i ny fane eller vindu >>The cost-effectiveness of a dance and yoga intervention for girls with functional abdominal pain disorders
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2023 (engelsk)Inngår i: PharmacoEconomics - Open, ISSN 2509-4262, Vol. 7, s. 321-335Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Functional abdominal pain disorders (FAPDs) affect children worldwide, being more prevalent among girls. The individual and societal burdens of the disease are substantial, and evidence-based interventions are needed. Non-pharmacological treatments have generally produced promising results, with dance and yoga specifically having potential as an effective treatment option. Beside efficacy, the cost-effectiveness of interventions is important when prioritizing and allocating public resources.

Objective: This study evaluated the cost-effectiveness of an 8-month dance and yoga intervention for girls with functional abdominal pain or irritable bowel syndrome, based on a randomized control trial called ‘Just in TIME’.

Methods: The intervention, performed in Sweden, was studied using a decision analysis tool, i.e., a decision tree within the trial followed by a Markov model with a time horizon of 10 years. The base case considered healthcare costs as well as productivity losses, measuring the effects in gained quality-adjusted life-years (QALYs) and presenting an incremental cost-effectiveness ratio (ICER).

Results: The base case results show that the intervention, compared with current practice, was the dominant strategy from both the 12-month and long-term perspectives. The sensitivity analyses indicated that the long-term, but not the short-term, findings were robust for different assumptions and changes in parameter estimates, resulting in ICERs similar to those of the base case scenario.

Conclusions: Offering dance and yoga to young girls with FAPDs generates small QALY gains and monetary savings compared with standard healthcare and is likely cost-effective. These findings make a valuable contribution to an area where evidence-based and cost-effective treatment interventions are needed.

Clinical Trials Registration Number: ClinicalTrials.gov identifier: NCT02920268; Name: Just in TIME—Intervention With Dance and Yoga for Girls With Recurrent Abdominal Pain

sted, utgiver, år, opplag, sider
Springer Nature, 2023
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-204066 (URN)10.1007/s41669-022-00384-w (DOI)000913116600001 ()36646863 (PubMedID)2-s2.0-85146283913 (Scopus ID)
Forskningsfinansiär
Nyckelfonden, OLL-689081Fredrik och Ingrid Thurings Stiftelse, 2016-00243
Tilgjengelig fra: 2023-01-31 Laget: 2023-01-31 Sist oppdatert: 2023-07-14bibliografisk kontrollert
Prosjekter
Nätverk: Svenskt Forskarnätverk för Ekonomisk Analys av Folkhälsa (F-EKAFH) [2012-01452_Forte]; Umeå universitetGoda år - ett nytt mått för utvärdering av välfärdsinsatser [2018-01550_Forte]; Umeå universitet; Publikasjoner
Meili, K. W., Månsdotter, A., Richter Sundberg, L., Hjelte, J. & Lindholm, L. (2022). An initiative to develop capability-adjusted life years in Sweden (CALY-SWE): Selecting capabilities with a Delphi panel and developing the questionnaire. PLOS ONE, 17(2), Article ID e0263231.
Goda år - ett nytt mått för utvärdering av välfärdsinsatser [2018-00143_Forte]; Umeå universitet; Publikasjoner
Meili, K. W. (2024). Capability for broader cost-effectiveness in public health and social welfare: developing, valuing, and applyingcapability-adjusted life years Sweden (CALY-SWE). (Doctoral dissertation). Umeå: Umeå UniversityMeili, K. W., Jonsson, H., Lindholm, L. & Månsdotter, A. (2022). Perceived changes in capability during the COVID-19 pandemic: A Swedish cross-sectional study from June 2020. Scandinavian Journal of Public Health, 50(1), 102-110Meili, K. W., Hjelte, J., Lindholm, L. & Månsdotter, A.Capability inequality: Does disadvantage or plurality matter more for policy?: A Swedish cross-sectional study on the population distribution and group differences of capability using CALY-SWE. Meili, K. W., Hjelte, J., Jonsson, F., Löfgren, C., Månsdotter, A. & Lindholm, L.NEET prevention through Sweden’s youth payroll tax cut: Evaluating cost-effectiveness using CALY-SWE.
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Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-1633-2179