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Mendham, A. E., Goedecke, J. H., Zeng, Y., Larsen, S., George, C., Hauksson, J., . . . Chorell, E. (2021). Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia, 64(7), 1642-1659
Åpne denne publikasjonen i ny fane eller vindu >>Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity
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2021 (engelsk)Inngår i: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 64, nr 7, s. 1642-1659Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aims/hypothesis: We sought to determine putative relationships among improved mitochondrial respiration, insulin sensitivity and altered skeletal muscle lipids and metabolite signature in response to combined aerobic and resistance training in women with obesity.

Methods: This study reports a secondary analysis of a randomised controlled trial including additional measures of mitochondrial respiration, skeletal muscle lipidomics, metabolomics and protein content. Women with obesity were randomised into 12 weeks of combined aerobic and resistance exercise training (n = 20) or control (n = 15) groups. Pre- and post-intervention testing included peak oxygen consumption, whole-body insulin sensitivity (intravenous glucose tolerance test), skeletal muscle mitochondrial respiration (high-resolution respirometry), lipidomics and metabolomics (mass spectrometry) and lipid content (magnetic resonance imaging and spectroscopy). Proteins involved in glucose transport (i.e. GLUT4) and lipid turnover (i.e. sphingomyelin synthase 1 and 2) were assessed by western blotting.

Results: The original randomised controlled trial showed that exercise training increased insulin sensitivity (median [IQR]; 3.4 [2.0–4.6] to 3.6 [2.4–6.2] x10−5 pmol l−1 min−1), peak oxygen consumption (mean ± SD; 24.9 ± 2.4 to 27.6 ± 3.4 ml kg−1 min−1), and decreased body weight (84.1 ± 8.7 to 83.3 ± 9.7 kg), with an increase in weight (pre intervention, 87.8± 10.9 to post intervention 88.8 ± 11.0 kg) in the control group (interaction p < 0.05). The current study shows an increase in mitochondrial respiration and content in response to exercise training (interaction p < 0.05). The metabolite and lipid signature at baseline were significantly associated with mitochondrial respiratory capacity (p < 0.05) but were not associated with whole-body insulin sensitivity or GLUT4 protein content. Exercise training significantly altered the skeletal muscle lipid profile, increasing specific diacylglycerol(32:2) and ceramide(d18:1/24:0) levels, without changes in other intermediates or total content of diacylglycerol and ceramide. The total content of cardiolipin, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) increased with exercise training with a decrease in the PC:PE ratios containing 22:5 and 20:4 fatty acids. These changes were associated with content-driven increases in mitochondrial respiration (p < 0.05), but not with the increase in whole-body insulin sensitivity or GLUT4 protein content. Exercise training increased sphingomyelin synthase 1 (p < 0.05), with no change in plasma-membrane-located sphingomyelin synthase 2.

Conclusions/interpretation: The major findings of our study were that exercise training altered specific intramuscular lipid intermediates, associated with content-driven increases in mitochondrial respiration but not whole-body insulin sensitivity. This highlights the benefits of exercise training and presents putative target pathways for preventing lipotoxicity in skeletal muscle, which is typically associated with the development of type 2 diabetes.

sted, utgiver, år, opplag, sider
Springer, 2021
Emneord
Acylcarnitines, Aerobic and resistance training, Cardiolipins, Cardiorespiratory fitness, Ectopic fat, Mitochondrial biogenesis, Obesity, Phospholipid hydrolysis, Sphingomyelin, Triacylglycerol
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-182159 (URN)10.1007/s00125-021-05430-6 (DOI)000633274200001 ()33770195 (PubMedID)2-s2.0-85103352083 (Scopus ID)
Tilgjengelig fra: 2021-04-21 Laget: 2021-04-21 Sist oppdatert: 2023-03-24bibliografisk kontrollert
Chorell, E., Otten, J., Stomby, A., Ryberg, M., Waling, M., Hauksson, J., . . . Olsson, T. (2021). Improved peripheral and hepatic insulin sensitivity after lifestyle interventions in type 2 diabetes is associated with specific metabolomic and lipidomic signatures in skeletal muscle and plasma. Metabolites, 11(12), Article ID 834.
Åpne denne publikasjonen i ny fane eller vindu >>Improved peripheral and hepatic insulin sensitivity after lifestyle interventions in type 2 diabetes is associated with specific metabolomic and lipidomic signatures in skeletal muscle and plasma
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2021 (engelsk)Inngår i: Metabolites, ISSN 2218-1989, E-ISSN 2218-1989, Vol. 11, nr 12, artikkel-id 834Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Lifestyle interventions with weight loss can improve insulin sensitivity in type 2 diabetes (T2D), but mechanisms are unclear. We explored circulating and skeletal muscle metabolite signatures of altered peripheral (pIS) and hepatic insulin sensitivity (hIS) in overweight and obese T2D individuals that were randomly assigned a 12-week Paleolithic-type diet with (diet-ex, n = 13) or without (diet, n = 13) supervised exercise. Baseline and post-intervention measures included: mass spectrometry-based metabolomics and lipidomics of skeletal muscle and plasma; pIS and hIS; ectopic lipid deposits in the liver and skeletal muscle; and skeletal muscle fat oxidation rate. Both groups lowered BMI and total % fat mass and increased their pIS. Only the diet-group improved hIS and reduced ectopic lipids in the liver and muscle. The combined improvement in pIS and hIS in the diet-group were associated with decreases in muscle and circulating branched-chain amino acid (BCAA) metabolites, specifically valine. Improved pIS with diet-ex was instead linked to increased diacylglycerol (34:2) and triacylglycerol (56:0) and decreased phosphatidylcholine (34:3) in muscle coupled with improved muscle fat oxidation rate. This suggests a tissue crosstalk involving BCAA-metabolites after diet intervention with improved pIS and hIS, reflecting reduced lipid influx. Increased skeletal muscle lipid utilization with exercise may prevent specific lipid accumulation at sites that perturb insulin signaling.

sted, utgiver, år, opplag, sider
MDPI, 2021
Emneord
Branched-chain amino acids (BCAA), Diacylglycerol (DAG), Diet, Ectopic fat, Exercise training, Hepatic insulin sensitivity (hIS), Peripheral insulin sensitivity (pIS), Skeletal muscle, Type 2 diabetes
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-190949 (URN)10.3390/metabo11120834 (DOI)000735530300001 ()34940592 (PubMedID)2-s2.0-85121572914 (Scopus ID)
Forskningsfinansiär
The Kempe Foundations, JCK-1725Swedish Heart Lung Foundation, 20150553
Tilgjengelig fra: 2022-01-05 Laget: 2022-01-05 Sist oppdatert: 2023-09-05bibliografisk kontrollert
Fortuin-De Smidt, M. C., Mendham, A. E., Hauksson, J., Alhamud, A., Stefanovski, D., Hakim, O., . . . Goedecke, J. H. (2021). β-cell function in black South African women: Exploratory associations with insulin clearance, visceral and ectopic fat. Endocrine Connections, 10(5), 550-560
Åpne denne publikasjonen i ny fane eller vindu >>β-cell function in black South African women: Exploratory associations with insulin clearance, visceral and ectopic fat
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2021 (engelsk)Inngår i: Endocrine Connections, E-ISSN 2049-3614, Vol. 10, nr 5, s. 550-560Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The role of ectopic fat, insulin secretion and clearance in the preservation of β-cell function in black African women with obesity who typically present with hyperinsulinaemia is not clear. We aim to examine the associations between disposition index (DI, an estimate of β-cell function), insulin secretion and clearance and ectopic fat deposition. This is a cross-sectional study of 43 black South African women (age 20–35 years) with obesity (BMI 30–40 kg/m2) and without type 2 diabetes that measured the following: DI, insulin sensitivity (SI), acute insulin response (AIRg), insulin secretion rate (ISR), hepatic insulin extraction and peripheral insulin clearance (frequently sampled i.v. glucose tolerance test); pancreatic and hepatic fat, visceral adipose tissue (VAT) and abdominal s.c. adipose tissue (aSAT) volume (MRI), intra-myocellular (IMCL) and extra-myocellular fat content (EMCL) (magnetic resonance spectroscopy). DI correlated positively with peripheral insulin clearance (β 55.80, P = 0.002). Higher DI was associated with lower VAT, pancreatic fat and soleus fat, but VAT explained most of the variance in DI (32%). Additionally, higher first phase ISR (P = 0.033) and lower hepatic insulin extraction (P = 0.022) were associated with lower VAT, independent from SI, rather than with ectopic fat. In conclusion, peripheral insulin clearance emerged as an important correlate of DI. However, VAT was the main determinant of a lower DI above ectopic fat depots. Importantly, VAT, but not ectopic fat, is associated with both lower insulin secretion and higher hepatic insulin extraction. Prevention of VAT accumulation in young black African women should, therefore, be an important target for beta cell preservation.

sted, utgiver, år, opplag, sider
Bioscientifica, 2021
Emneord
ectopic fat, hepatic insulin extraction, insulin secretion, peripheral insulin clearance, β-cell function
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-184207 (URN)10.1530/EC-21-0153 (DOI)000661111700011 ()2-s2.0-85106929941 (Scopus ID)
Tilgjengelig fra: 2021-06-14 Laget: 2021-06-14 Sist oppdatert: 2023-09-05bibliografisk kontrollert
Fortuin-de Smidt, M. C., Mendham, A. E., Hauksson, J., Hakim, O., Stefanovski, D., Clamp, L., . . . Goedecke, J. H. (2020). Effect of exercise training on insulin sensitivity, hyperinsulinemia and ectopic fat in black South African women: a randomized controlled trial. European Journal of Endocrinology, 183(1), 51-61
Åpne denne publikasjonen i ny fane eller vindu >>Effect of exercise training on insulin sensitivity, hyperinsulinemia and ectopic fat in black South African women: a randomized controlled trial
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2020 (engelsk)Inngår i: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 183, nr 1, s. 51-61Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: We investigated the effects of a 12-week exercise intervention on insulin sensitivity (SI) and hyperinsulinemia and associated changes in regional and ectopic fat.

Research design and methods: Healthy, black South African women with obesity (mean age 23 ± 3.5 years) and of isiXhosa ancestry were randomised into a 12-week aerobic and resistance exercise training group (n = 23) and a no exercise group (control, n = 22). Pre and post-intervention testing included assessment of SI, insulin response to glucose (AIRg), insulin secretion rate (ISR), hepatic insulin extraction (FEL) and disposition index (DI) (AIRg × SI) (frequently sampled i.v. glucose tolerance test); fat mass and regional adiposity (dual-energy X-ray absorptiometry); hepatic, pancreatic and skeletal muscle fat content and abdominal s.c. and visceral adipose tissue volumes (MRI).

Results: Exercise training increased VO2peak (mean ± s.d.: 24.9 ± 2.42 to 27.6 ± 3.39 mL/kg/min, P < 0.001), SI (2.0 (1.2–2.8) to 2.2 (1.5–3.7) (mU/l)−1 min−1, P = 0.005) and DI (median (interquartile range): 6.1 (3.6–7.1) to 6.5 (5.6–9.2) × 103 arbitrary units, P = 0.028), and decreased gynoid fat mass (18.5 ± 1.7 to 18.2 ± 1.6%, P < 0.001) and body weight (84.1 ± 8.7 to 83.3 ± .9.7 kg, P = 0.038). None of these changes were observed in the control group, but body weight increased (P = 0.030). AIRg, ISR and FEL, VAT, SAT and ectopic fat were unaltered after exercise training. The increase in SI and DI were not associated with changes in regional or ectopic fat.

Conclusion: Exercise training increased SI independent from changes in hyperinsulinemia and ectopic fat, suggesting that ectopic fat might not be a principal determinant of insulin resistance in this cohort.

sted, utgiver, år, opplag, sider
Bioscientifica, 2020
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-173706 (URN)10.1530/EJE-19-0957 (DOI)000546300200016 ()32503004 (PubMedID)2-s2.0-85085954370 (Scopus ID)
Tilgjengelig fra: 2020-07-24 Laget: 2020-07-24 Sist oppdatert: 2023-03-24bibliografisk kontrollert
Mendham, A. E., Larsen, S., George, C., Adams, K., Hauksson, J., Olsson, T., . . . Goedecke, J. H. (2020). Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Scientific Reports, 10(1), Article ID 3785.
Åpne denne publikasjonen i ny fane eller vindu >>Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
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2020 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 10, nr 1, artikkel-id 3785Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (S-I). Obese, black South African women (n = 45) were randomized into exercise (n = 23) or control (n = 22) groups. Exercise group completed 12-weeks of aerobic and resistance training (n = 20), while the control group (n = 15) continued usual behaviours. Mitochondrial function (high-resolution respirometry and fluorometry) in gSAT and aSAT, SI (frequently sampled intravenous glucose tolerance test), body composition (dual-energy X-ray absorptiometry), and ectopic fat (MRI) were assessed pre- and post-intervention. At baseline, gSAT had higher mitochondrial respiratory capacity and hydrogen peroxide (H2O2) production than aSAT (p < 0.05). Higher gSAT respiration was associated with higher gynoid fat (p < 0.05). Higher gSAT H2O2 production and lower aSAT mitochondrial respiration were independently associated with lower SI (p < 0.05). In response to training, S-I improved and gynoid fat decreased (p < 0.05), while H2O2 production reduced in both depots, and mtDNA decreased in gSAT (p < 0.05). Mitochondrial respiration increased in aSAT and correlated with a decrease in body fat and an increase in soleus and hepatic fat content (p < 0.05). This study highlights the importance of understanding the differences in mitochondrial function in multiple SAT depots when investigating the pathophysiology of insulin resistance and associated risk factors such as body fat distribution and ectopic lipid deposition. Furthermore, we highlight the benefits of exercise training in stimulating positive adaptations in mitochondrial function in gluteal and abdominal SAT depots.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2020
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-174882 (URN)10.1038/s41598-020-60286-x (DOI)000562886200010 ()32123205 (PubMedID)2-s2.0-85081043315 (Scopus ID)
Tilgjengelig fra: 2020-09-16 Laget: 2020-09-16 Sist oppdatert: 2023-03-23bibliografisk kontrollert
Otten, J., Andersson, J., Ståhl, J., Stomby, A., Saleh, A., Waling, M., . . . Olsson, T. (2019). Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 8(2), Article ID e010634.
Åpne denne publikasjonen i ny fane eller vindu >>Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus
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2019 (engelsk)Inngår i: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 8, nr 2, artikkel-id e010634Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The accumulation of myocardial triglycerides and remodeling of the left ventricle are common features in type 2 diabetes mellitus and represent potential risk factors for the development of diastolic and systolic dysfunction. A few studies have investigated the separate effects of diet and exercise training on cardiac function, but none have investigated myocardial changes in response to a combined diet and exercise intervention. This 12-week randomized study assessed the effects of a Paleolithic diet, with and without additional supervised exercise training, on cardiac fat, structure, and function.

Methods and Results: Twenty-two overweight and obese subjects with type 2 diabetes mellitus were randomized to either a Paleolithic diet and standard-care exercise recommendations ( PD ) or to a Paleolithic diet plus supervised exercise training 3 hours per week ( PD - EX ). This study includes secondary end points related to cardiac structure and function, ie, myocardial triglycerides levels, cardiac morphology, and strain were measured using cardiovascular magnetic resonance, including proton spectroscopy, at baseline and after 12 weeks. Both groups showed major favorable metabolic changes. The PD - EX group showed significant decreases in myocardial triglycerides levels (-45%, P=0.038) and left ventricle mass to end-diastolic volume ratio (-13%, P=0.008) while the left ventricle end-diastolic volume and stroke volume increased significantly (+14%, P=0.004 and +17%, P=0.008, respectively). These variables were unchanged in the PD group.

Conclusions: Exercise training plus a Paleolithic diet reduced myocardial triglycerides levels and improved left ventricle remodeling in overweight/obese subjects with type 2 diabetes mellitus.

Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 01513798.

sted, utgiver, år, opplag, sider
Wiley-Blackwell, 2019
Emneord
cardiovascular magnetic resonance imaging, diet, exercise, myocardial metabolism, type 2 diabetes mellitus
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-157046 (URN)10.1161/JAHA.118.010634 (DOI)000460105800010 ()30652528 (PubMedID)2-s2.0-85060171480 (Scopus ID)
Tilgjengelig fra: 2019-03-07 Laget: 2019-03-07 Sist oppdatert: 2023-03-24bibliografisk kontrollert
Otten, J., Stomby, A., Waling, M., Isaksson, A., Söderström, I., Ryberg, M., . . . Olsson, T. (2018). A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial. Diabetologia, 61(7), 1548-1559
Åpne denne publikasjonen i ny fane eller vindu >>A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial
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2018 (engelsk)Inngår i: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 61, nr 7, s. 1548-1559Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aims/hypothesis: The aim of the study was to investigate ectopic fat deposition and insulin sensitivity, in a parallel single-blinded randomised controlled trial, comparing Paleolithic diet alone with the combination of Paleolithic diet and exercise in individuals with type 2 diabetes. Methods: Thirty-two individuals with type 2 diabetes with BMI 25-40 kg/m(2) and 30-70 years of age followed a Paleolithic diet ad libitum for 12 weeks. In addition, study participants were randomised by computer program to either supervised combined exercise training (PD-EX group) or standard care exercise recommendations (PD group). Staff performing examinations and assessing outcomes were blinded to group assignment. Thirteen participants were analysed in each group: hepatic and peripheral insulin sensitivity were measured using the hyperinsulinaemic-euglycaemic clamp technique combined with [6,6-H-2(2)]glucose infusion, and liver fat was assessed by proton magnetic resonance spectroscopy; both analyses were secondary endpoints. Intramyocellular lipid (IMCL) content was measured by magnetic resonance spectroscopy as a secondary analysis. All examinations were performed at Umca University Hospital, Umca, Sweden. Results: Both study groups showed a median body weight loss of 7 kg. Fat mass decreased by 5.7 kg in the PD group and by 6.5 kg in the PD-EX group. Maximum oxygen uptake increased in the PD-EX group only. Liver fat showed a consistent reduction (74% decrease) in the PD group, while the response in the PD-EX group was heterogeneous (p < 0.05 for the difference between groups). IMCL content of the soleus muscle decreased by 40% in the PD group and by 22% in the PD-EX group (p < 0.05 for the difference between groups). Both groups improved their peripheral and adipose tissue insulin sensitivity, but not their hepatic insulin sensitivity. Plasma fetuin-A decreased by 11% in the PD group (p < 0.05) and remained unchanged in the PD-EX group. Liver fat changes during the intervention were correlated with changes in fetuin-A (r(S) = 0.63, p < 0.01). Participants did not report any important adverse events caused by the intervention. Conclusions/interpretation: A Paleolithic diet reduced liver fat and IMCL content, while there was a tissue-specific heterogeneous response to added exercise training.

sted, utgiver, år, opplag, sider
Springer, 2018
Emneord
Exercise, Hyperinsulinaemic-euglycaemic clamp, Insulin sensitivity, Intramyocellular fat, Liver fat, Nutrition, Obesity, Paleolithic diet, Proton magnetic resonance spectroscopy, Weight loss
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-150764 (URN)10.1007/s00125-018-4618-y (DOI)000434250500007 ()29696296 (PubMedID)2-s2.0-85046029986 (Scopus ID)
Tilgjengelig fra: 2018-08-27 Laget: 2018-08-27 Sist oppdatert: 2023-03-24bibliografisk kontrollert
Goedecke, J. H., Mendham, A. E., Clamp, L., Nankam, P. A. N., Fortuin-de Smidt, M. C., Phiri, L., . . . Olsson, T. (2018). An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants. JMIR Research Protocols, 7(4), Article ID e75.
Åpne denne publikasjonen i ny fane eller vindu >>An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants
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2018 (engelsk)Inngår i: JMIR Research Protocols, E-ISSN 1929-0748, Vol. 7, nr 4, artikkel-id e75Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The pathogenesis of type 2 diabetes (T2D) in black African women is complex and differs from that in their white counterparts. However, earlier studies have been cross-sectional and provide little insight into the causal pathways. Exercise training is consistently used as a model to examine the mechanisms underlying insulin resistance and risk for T2D.

Objective: The objective of the study was to examine the mechanisms underlying the changes in insulin sensitivity and secretion in response to a 12-week exercise intervention in obese black South African (SA) women.

Methods: A total of 45 obese (body mass index, BMI: 30-40 kg/m2) black SA women were randomized into a control (n=22) or experimental (exercise; n=23) group. The exercise group completed 12 weeks of supervised combined aerobic and resistance training (40-60 min, 4 days/week), while the control group maintained their typical physical activity patterns, and both groups were requested not to change their dietary patterns. Before and following the 12-week intervention period, insulin sensitivity and secretion (frequently sampled intravenous glucose tolerance test) and its primary and secondary determinants were measured. Dietary intake, sleep quality and quantity, physical activity, and sedentary behaviors were measured every 4 weeks.

Results: The final sample included 20 exercise and 15 control participants. Baseline sociodemographics, cardiorespiratory fitness, anthropometry, cardiometabolic risk factors, physical activity, and diet did not differ between the groups (P>.05).

Conclusions: The study describes a research protocol for an exercise intervention to understand the mechanisms underlying insulin sensitivity and secretion in obese black SA women and aims to identify causal pathways underlying the high prevalence of insulin resistance and risk for T2D in black SA women, targeting specific areas for therapeutic intervention.

sted, utgiver, år, opplag, sider
JMIR PUBLICATIONS, INC, 2018
Emneord
diabetes mellitus type 2, insulin resistance, body fat distribution, adipose tissue, skeletal muscle, gastrointestinal microbiome, exercise, fatty liver, inflammation, energy metabolism, cardiorespiratory fitness, lipids, metabolomics, fatty acids, diet records, mitochondria, ectopic fat
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-151181 (URN)10.2196/resprot.9098 (DOI)000433882700008 ()29669711 (PubMedID)2-s2.0-85103336318 (Scopus ID)
Tilgjengelig fra: 2018-09-04 Laget: 2018-09-04 Sist oppdatert: 2024-01-17bibliografisk kontrollert
Otten, J., Stomby, A., Waling, M., Isaksson, A., Söderström, I., Ryberg, M., . . . Olsson, T. (2017). Exercise training reverses the effect of a Paleolithic diet on liver fat and intramyocellular lipid content in patients with type 2 diabetes. In: : . Paper presented at Cell Symposia Exercise Metabolism, 21-23 May, 2017, Gothenburg, Sweden.
Åpne denne publikasjonen i ny fane eller vindu >>Exercise training reverses the effect of a Paleolithic diet on liver fat and intramyocellular lipid content in patients with type 2 diabetes
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2017 (engelsk)Konferansepaper, Poster (with or without abstract) (Fagfellevurdert)
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-135408 (URN)
Konferanse
Cell Symposia Exercise Metabolism, 21-23 May, 2017, Gothenburg, Sweden
Tilgjengelig fra: 2017-05-26 Laget: 2017-05-26 Sist oppdatert: 2018-08-27bibliografisk kontrollert
Otten, J., Stomby, A., Waling, M., Isaksson, A., Söderström, I., Ryberg, M., . . . Olsson, T. (2017). Exercise training reverses the effect of a Paleolithic diet on liver fat and intramyocellular lipid content in patients with type 2 diabetes. In: : . Paper presented at Endokrindagarna, 1-3 februari 2017, Uppsala, Sweden.
Åpne denne publikasjonen i ny fane eller vindu >>Exercise training reverses the effect of a Paleolithic diet on liver fat and intramyocellular lipid content in patients with type 2 diabetes
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2017 (engelsk)Konferansepaper, Poster (with or without abstract) (Fagfellevurdert)
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-135409 (URN)
Konferanse
Endokrindagarna, 1-3 februari 2017, Uppsala, Sweden
Tilgjengelig fra: 2017-05-26 Laget: 2017-05-26 Sist oppdatert: 2018-08-27bibliografisk kontrollert
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0001-8597-0468