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Bendix, Marie
Publikasjoner (10 av 13) Visa alla publikasjoner
Werneke, U., Maripuu, M., Bendix, M., Öhlund, L. & Widerström, M. (2021). Death associated with coronavirus (COVID-19) infection in individuals with severe mental disorders in sweden during the early months of the outbreak. Paper presented at 29th European Congress of Psychiatry.. European psychiatry, 64(S1), S119-S120, Article ID O145.
Åpne denne publikasjonen i ny fane eller vindu >>Death associated with coronavirus (COVID-19) infection in individuals with severe mental disorders in sweden during the early months of the outbreak
Vise andre…
2021 (engelsk)Inngår i: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 64, nr S1, s. S119-S120, artikkel-id O145Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
Cambridge University Press, 2021
Emneord
COVID-19, mental disorder, Mortality, coronavirus
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-188030 (URN)10.1192/j.eurpsy.2021.339 (DOI)000693665700306 ()
Konferanse
29th European Congress of Psychiatry.
Tilgjengelig fra: 2021-10-11 Laget: 2021-10-11 Sist oppdatert: 2022-11-25bibliografisk kontrollert
Maripuu, M., Bendix, M., Öhlund, L., Widerström, M. & Werneke, U. (2021). Death Associated With Coronavirus (COVID-19) Infection in Individuals With Severe Mental Disorders in Sweden During the Early Months of the Outbreak: An Exploratory Cross-Sectional Analysis of a Population-Based Register Study. Frontiers in Psychiatry, 11, Article ID 609579.
Åpne denne publikasjonen i ny fane eller vindu >>Death Associated With Coronavirus (COVID-19) Infection in Individuals With Severe Mental Disorders in Sweden During the Early Months of the Outbreak: An Exploratory Cross-Sectional Analysis of a Population-Based Register Study
Vise andre…
2021 (engelsk)Inngår i: Frontiers in Psychiatry, E-ISSN 1664-0640, Vol. 11, artikkel-id 609579Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Individuals with severe mental disorder (SMD) have a higher risk of somatic comorbidity and mortality than the rest of the population. We set up a population-based study to assess whether individuals with SMD had a higher risk of death associated with a COVID-19 infection (COVID-19 associated death) than individuals without SMD.

Methods: Exploratory analysis with a cross-sectional design in the framework of a population-based register study covering the entire Swedish population. The Swedish Board for Health and Welfare (Socialstyrelsen) provided anonymized tabulated summary data for further analysis. We compared numbers of COVID-19 associated death in individuals with SMD (cases) and without SMD (controls). We calculated the odds ratio (OR) for the whole sample and by age group and four comorbidities, namely diabetes, cardiovascular disease, hypertension, chronic lung disease.

Results: The sample comprised of 7,923,859 individuals, 103,999 with SMD and 7,819,860 controls. There were 130 (0.1%) COVID-19 associated deaths in the SMD group and 4,945 (0.06%) in the control group, corresponding to an OR of 1.98 (CI 1.66-2.35; p < 0.001). The odds were 4-fold for the age groups between 60 and 79 years and 1.5-fold for cardiovascular diseases. Individuals with SMD without any of the risk factors under study had 3-fold odds of COVID-19 associated death.

Conclusion: Our preliminary results identify individuals with SMD as a further group at increased risk of COVID-19 associated death. In regard to comorbidities, future studies should explore the potential confounding or mediation role in the relationship between SMD and COVID-19 associated deaths.

sted, utgiver, år, opplag, sider
Frontiers Media S.A., 2021
Emneord
coronavirus, COVID-19, severe mental disorder, death, risk factors, mortality, psychotic disorder, bipolar disorder
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-180161 (URN)10.3389/fpsyt.2020.609579 (DOI)000610876800001 ()33488430 (PubMedID)2-s2.0-85099733688 (Scopus ID)
Tilgjengelig fra: 2021-02-22 Laget: 2021-02-22 Sist oppdatert: 2024-01-17bibliografisk kontrollert
Nilsson, N. H., Bendix, M., Öhlund, L., Widerström, M., Werneke, U. & Maripuu, M. (2021). Increased Risks of Death and Hospitalization in Influenza/Pneumonia and Sepsis for Individuals Affected by Psychotic Disorders, Bipolar Disorders, and Single Manic Episodes: A Retrospective Cross-Sectional Study. Journal of Clinical Medicine, 10(19), Article ID 4411.
Åpne denne publikasjonen i ny fane eller vindu >>Increased Risks of Death and Hospitalization in Influenza/Pneumonia and Sepsis for Individuals Affected by Psychotic Disorders, Bipolar Disorders, and Single Manic Episodes: A Retrospective Cross-Sectional Study
Vise andre…
2021 (engelsk)Inngår i: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 10, nr 19, artikkel-id 4411Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

 Individuals with severe mental disorders (SMDs) such as psychotic disorders, bipolar disorders, and single manic episodes have increased mortality associated with COVID-19 infection. We set up a population-based study to examine whether individuals with SMD also had a higher risk of hospitalization and death from other infectious conditions. Anonymized and summarized data from multiple Swedish patient registers covering the entire Swedish population were supplied by the Swedish National Board of Health and Welfare. The frequencies of hospitalizations and deaths associated with influenza/pneumonia and sepsis in individuals with SMD were compared with the rest of the population during 2018–2019. Possible contributing comorbidities were also examined, of which diabetes, cardiovascular disease, chronic lung disease, and hypertension were chosen. A total of 7,780,727 individuals were included in the study; 97,034 (1.2%) cases with SMD and 7,683,693 (98.8%) controls. Individuals with SMD had increased risk of death associated with influenza/pneumonia (OR = 2.06, 95% CI [1.87–2.27]) and sepsis (OR = 1.61, 95% CI [1.38–1.89]). They also had an increased risk of hospitalization associated with influenza/pneumonia (OR = 2.12, 95% CI [2.03–2.20]) and sepsis (OR = 1.89, 95% CI [1.75–2.03]). Our results identify a need for further evaluation of whether these individuals should be included in prioritized risk groups for vaccination against infectious diseases other than COVID-19.

sted, utgiver, år, opplag, sider
MDPI, 2021
Emneord
bipolar disorder, psychotic disorder, death, mortality, hospitalization, influenza, pneumonia, sepsis, infection, severe mental disorder
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-188177 (URN)10.3390/jcm10194411 (DOI)000777191400016 ()2-s2.0-85115612301 (Scopus ID)
Tilgjengelig fra: 2021-10-04 Laget: 2021-10-04 Sist oppdatert: 2023-09-05bibliografisk kontrollert
Bendix, M., Bixo, M., Wihlbäck, A.-C., Ahokas, A. & Jokinen, J. (2019). Allopregnanolone and progesterone in estradiol treated severe postpartum affective disorder. Paper presented at 49th Annual Conference of the International-Society-of-Psychoneuroendocrinology - 50 Years of Psychoneuroendocrinology - Returning to Where It All Began, AUG 29-31, 2019, Milan, ITALY. Psychoneuroendocrinology, 107, 68-68
Åpne denne publikasjonen i ny fane eller vindu >>Allopregnanolone and progesterone in estradiol treated severe postpartum affective disorder
Vise andre…
2019 (engelsk)Inngår i: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 107, s. 68-68Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
PERGAMON-ELSEVIER SCIENCE LTD, 2019
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-164512 (URN)10.1016/j.psyneuen.2019.07.195 (DOI)000483655400194 ()
Konferanse
49th Annual Conference of the International-Society-of-Psychoneuroendocrinology - 50 Years of Psychoneuroendocrinology - Returning to Where It All Began, AUG 29-31, 2019, Milan, ITALY
Tilgjengelig fra: 2019-11-20 Laget: 2019-11-20 Sist oppdatert: 2024-03-25bibliografisk kontrollert
Bendix, M., Bixo, M., Wihlbäck, A.-C., Ahokas, A. & Jokinen, J. (2019). Allopregnanolone and progesterone in estradiol treated severe postpartum depression and psychosis: Preliminary findings. Neurology, psychiatry and brain research, 34, 50-57
Åpne denne publikasjonen i ny fane eller vindu >>Allopregnanolone and progesterone in estradiol treated severe postpartum depression and psychosis: Preliminary findings
Vise andre…
2019 (engelsk)Inngår i: Neurology, psychiatry and brain research, ISSN 0941-9500, Vol. 34, s. 50-57Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Postpartum affective disorders may be associated with dysregulation of gonadal steroids. We investigated peripheral levels of allopregnanolone and progesterone in a combined group of women with postpartum onset of severe depression and/or psychosis who, as previously reported, responded with rapid symptom remission during sublingual estradiol treatment. The aim was to assess differences in allopregnanolone and progesterone between patients and healthy controls at baseline, and hormonal changes during estradiol treatment and symptom remission in patients.

Methods: Allopregnanolone and progesterone in serum were analyzed with radioimmunoassay before and four weeks after initiation of sublingual estradiol treatment in ten women with postpartum depression and four women with postpartum psychosis (ICD-10). Twenty-eight healthy postpartum controls were included for baseline comparison.

Results: Allopregnanolone declined significantly during estradiol treatment while there was a trend for lower baseline allopregnanolone levels in patients compared with healthy postpartum controls. The ratio between allopregnanolone and progesterone was significantly lower in patients compared with controls and it remained unchanged after clinical recovery.

Limitations: This study is a secondary analysis of two estradiol treatment studies based on availability of samples for the analysis of allopregnanolone. Healthy controls were assessed earlier after delivery. Data on potential confounders (somatic health, breastfeeding, other medication) were not available.

Conclusions: These preliminary findings suggest that clinical recovery of severe postpartum depression and psychosis during estradiol treatment does not seem to depend on increasing levels of allopregnanolone. Differences in progesterone metabolism may constitute a risk factor for severe postnatal affective dysregulation.

sted, utgiver, år, opplag, sider
Elsevier, 2019
Emneord
Postpartum depression, Postpartum psychosis, Allopregnanolone, Progesterone, Estradiol, Estradiol treatment
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-156823 (URN)10.1016/j.npbr.2019.10.003 (DOI)2-s2.0-85074335144 (Scopus ID)
Merknad

Originally included in thesis in manuscript form with title: "Allopregnanolone and progesterone in estradiol treated severe postpartum depression and psychosis".

Tilgjengelig fra: 2019-02-28 Laget: 2019-02-28 Sist oppdatert: 2024-03-25bibliografisk kontrollert
Bendix, M. (2019). Neuroendocrine studies in patients with affective disorders. (Doctoral dissertation). Umeå: Umeå Universitet
Åpne denne publikasjonen i ny fane eller vindu >>Neuroendocrine studies in patients with affective disorders
2019 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Background: Affective disorders are common and a major cause for increased disability and mortality worldwide. Exogenous stressors and biological variables, including neuroendocrine factors, are assumed to contribute to an increased vulnerability to mood dysregulation. Affective disorders are highly heterogeneous and different neuroendocrine systems may play differential roles in the phenotypic expression of affective disorders in men and women.

Aims: The overall aim of this thesis was to study three neuroendocrine systems in relation to underlying behavioral endophenotypes (personality traits, self-directed and interpersonal violence, and psychiatric symptoms) in patients with affective disorders.

Methods: In Study I oxytocin plasma levels were assessed in 101 general psychiatric outpatients and followed-up in 36 patients after one month. Patients underwent diagnostic, symptomatic, and personality trait assessments.

In Study II insulin and glucagon levels in plasma and cerebrospinal fluid (CSF) were assessed in 28 patients hospitalized after a recent suicide attempt and 19 healthy controls. Study persons were assessed regarding lifetime violence expression, psychiatric diagnoses and symptoms.

In Study III serum levels of allopregnanolone, progesterone and estradiol were assessed in 14 women with severe postpartum depression and psychosis who, as previously reported, responded with rapid symptom remission during sublingual estradiol treatment. Hormonal and symptomatic assessment were performed before and after 4 weeks of estradiol treatment. 28 healthy postpartum controls were included for baseline comparison.

Results: I) Plasma oxytocin levels were positively associated with personality traits of impulsiveness (monotony avoidance) and negative emotionality (psychic anxiety) with potential gender differences.

II) Patients after suicide attempt had higher insulin (plasma and CSF) and lower glucagon levels (CSF) than healthy controls. Insulin levels (plasma and CSF) were higher and glucagon levels (plasma) were lower in patients and controls with higher levels of prior violence expression.

III) Serum allopregnanolone decreased in women with postpartum depression and psychosis during estradiol treatment. The ratio between allopregnanolone and progesterone was significantly lower in patients than in healthy controls at baseline and it remained unchanged after symptom remission.

Conclusion: Behavioral endophenotypes, rather than categorical diagnoses, of affective disorders were associated with neuroendocrine variation in three different cohorts of patients with affective disorder. Hormonal variation pointed towards an association with trait, rather than state like facets of affective behavior, constituting potential vulnerability markers for affective dysregulation.

Abstract [sv]

Världen över drabbas 350 miljoner människor av unipolära depressioner och bipolära sjukdomar (affektiva sjukdomar). Patienter med affektiva sjukdomar dör cirka femton år tidigare på grund av kroppsliga sjukdomar och suicid. Upp till varannan patient försöker ta sitt liv och lika många svarar inte på behandling eller får återfall trots behandling. Det är mycket vanligt med sociala svårigheter som påverkar familj- och arbetsliv. Medan män har större risk att ta sina liv löper kvinnor ökad risk att göra suicidförsök och att utveckla depression. Efter en förlossning är risken att drabbas av svåra affektiva sjukdomar förhöjd som kan uttrycka sig i form av svåra depressioner, manier eller psykoser. Dessa tillstånd ökar risken för att modern tar sitt liv och i sällsynta fall även barnets liv.

Vissa människor är särskilt sårbara att utveckla affektiva sjukdomar. Sårbarheten påverkas av genetiska faktorer och livshändelser. Det är dock oklart hur patienternas emotionella, kognitiva och kroppsliga symtom uppstår och hur dessa hänger ihop med förändringar i hjärnan och generna. Ökad kunskap om dessa processer skulle sannolikt förbättra möjligheten att behandla och förebygga affektiva sjukdomar.

Patienter i gruppen affektiva sjukdomar är väldigt olika; de skiljer sig avseende emotionella, kognitiva och kroppsliga symtom, avseende risker för sjukdomsutveckling samt återfallsrisk och behandlingssvar. Ett sätt att försöka koppla sjukdomstecken och förändringar i hjärnan är att undersöka mer enhetliga grupper av patienter som till exempel patienter som gjort suicidförsök eller kvinnor efter förlossningen. Ett annat sätt är att undersöka särskilda underliggande aspekter som till exempel personlighet.

Hos många patienter med psykisk sjukdom har man hittat förändringar i stressystemet. Vid stress påverkas bland annat hormonella system. Hormoner påverkar inte enbart kroppens men även hjärnans funktion. Genom att undersöka kopplingen av hormonella faktorer med kroppsliga, mentala och beteendeuttryck kan man indirekt dra slutsatser om hjärnans funktion vid affektiva sjukdomar.

I den här avhandlingen har vi undersökt hur tre olika hormonella system är kopplade till särskilda underliggande aspekter av affektiva sjukdomar. Avhandlingen består av tre olika studier.

I den första frågade vi oss om oxytocin är kopplad till personlighetsdrag som har relevans för patienternas sociala svårigheter. Detta undersökte vi i en stor grupp av öppenvårdspatienter med olika psykiska sjukdomar.

I den andra ville vi veta om patienter som hade gjort självmordsförsök hade förändrade nivåer av insulin och glukagon och om detta var kopplad till våldsamt beteende.

I den tredje studien undersökte vi om kvinnor med svår depression och psykos efter förlossningen uppvisade förändringar av allopregnanolon och progesteron. Dessutom kunde vi undersöka förändringar av dessa hormon under behandling med estradiol när kvinnorna hade tillfrisknat.

I den första studien visade vi att patienter med psykiska sjukdomar som hade mer impulsiva och negativ emotionella personlighetsdrag hade högre oxytocin nivåer. Dessa patienter hade särskilda drag av ångest och var mer extroverta. Möjligen var dessa samband särskild tydliga hos män.

I den andra studien visade vi att patienter som hade gjort självmordsförsök hade högre nivåer av insulin i blodet och i ryggmärgsvätskan än friska kontroll-personer. Dessutom hade de lägre nivåer av glukagon i blodet. Högre nivåer av insulin och lägre nivåer av glukagon var kopplade till självrapporterat interpersonellt våld sedan femton års ålder hos patienter och friska kontroller.

I den tredje studien visade vi att allopregnanolon minskade under estradiol behandling för postpartum depression och postpartum psykos. Patienterna uppvisade både före och under behandlingen förändringar i relationen mellan allopregnanolon och progesteron jämfört med friska kvinnor.

Sammanfattningsvis tyder resultaten på att särskilda underliggande aspekter av affektiva sjukdomar är kopplade med förändringar i hormonella system. Dessa förändringar ter sig vara kopplade med långvariga drag hellre än akuta sjukdomsuttryck och kan på så sätt tyda på sårbarhetsfaktorer för affektiva sjukdomar. Resultaten bidrar till ökad förståelse om särskilda hormonella aspekter hos specifika grupper av personer med affektiva sjukdomar.

sted, utgiver, år, opplag, sider
Umeå: Umeå Universitet, 2019. s. 74
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2010
Emneord
Affective disorder, Suicide attempt, Postpartum depression, Postpartum psychosis, Personality traits, Violence, Oxytocin, Insulin, Glucagon, Allopregnanolone, Progesterone, Estradiol
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-156829 (URN)978-91-7855-015-9 (ISBN)
Disputas
2019-03-28, Föreläsningssal A, Psykiatriska kliniken, Målpunkt F, Plan 0, Norrlands universitetssjukhus, Umeå, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2019-03-07 Laget: 2019-02-28 Sist oppdatert: 2024-03-25bibliografisk kontrollert
Blomdahl Wetterholm, M., Bendix, M., Pettersson, K. & Lindefors, N. (2018). Bättre perinatalpsykiatrisk vård genom integrerat samarbete: Obstetrik och psykiatri i samverkan kan leda till minskade risker för mor och barn. Läkartidningen, 115, Article ID E9ES.
Åpne denne publikasjonen i ny fane eller vindu >>Bättre perinatalpsykiatrisk vård genom integrerat samarbete: Obstetrik och psykiatri i samverkan kan leda till minskade risker för mor och barn
2018 (svensk)Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, artikkel-id E9ESArtikkel i tidsskrift (Annet vitenskapelig) Published
Abstract [en]

A Swedish example of integrated perinatal mental health care

Mental disorders are common during the perinatal period and expose mother and child to major risks. Almost all women in Sweden attend maternal and child health care centers regularly before and after birth. This constitutes a unique opportunity to detect women with early signs of mental disorder or at risk of recurrence of prior illness. Identified women need fast access to diagnostic and treatment providers with specialized knowledge on perinatal mental disorders. As perinatal mental disorders can have severe consequences for mothers and their children a tight cooperation between caregivers is often needed.

sted, utgiver, år, opplag, sider
Läkartidningen Förlag AB, 2018
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-169653 (URN)30226630 (PubMedID)2-s2.0-85055733199 (Scopus ID)
Tilgjengelig fra: 2020-04-15 Laget: 2020-04-15 Sist oppdatert: 2020-04-16bibliografisk kontrollert
Bendix, M. & Lindbom, U. (2018). Multiprofessionella epilepsiteam med psykiatrisk kompetens: Samarbete ger förutsättningar för kvalitet och effektivitet i vården. Läkartidningen, 115, Article ID E9ET.
Åpne denne publikasjonen i ny fane eller vindu >>Multiprofessionella epilepsiteam med psykiatrisk kompetens: Samarbete ger förutsättningar för kvalitet och effektivitet i vården
2018 (svensk)Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, artikkel-id E9ETArtikkel i tidsskrift (Annet vitenskapelig) Published
Abstract [en]

Multi-professional epilepsy teams including psychiatric expertise

Epilepsy has a diverse spectrum of consequences that can necessitate multi-professional cooperation in order to guarantee a high level of care. Psychiatric comorbidity is common, which influences quality of life, seizure control and mortality. Multi-professional teams, with participation from neurology, psychiatry, psychology, occupational therapy and social work, can together tailor the individual care for patients with complex needs. Close cooperation among team members increases quality and efficiency of care and reassurance for patients and their relatives while decreasing the work load for individual team members.

sted, utgiver, år, opplag, sider
Läkartidningen Förlag AB, 2018
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-169654 (URN)30226631 (PubMedID)2-s2.0-85055733723 (Scopus ID)
Tilgjengelig fra: 2020-04-15 Laget: 2020-04-15 Sist oppdatert: 2020-04-16bibliografisk kontrollert
Bendix, M., Wahlström, L., John, M., Lexne, E., König, M., Östryd, P., . . . Strindhall, P. (2018). Towards a Swedish identity in consultation-liaison (CL) psychiatry and psychosomatics: Re-foundation of the Swedish Association of CL Psychiatry [Letter to the editor]. Journal of Psychosomatic Research, 108, 20-21
Åpne denne publikasjonen i ny fane eller vindu >>Towards a Swedish identity in consultation-liaison (CL) psychiatry and psychosomatics: Re-foundation of the Swedish Association of CL Psychiatry
Vise andre…
2018 (engelsk)Inngår i: Journal of Psychosomatic Research, ISSN 0022-3999, E-ISSN 1879-1360, Vol. 108, s. 20-21Artikkel i tidsskrift, Letter (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Elsevier, 2018
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-169655 (URN)10.1016/j.jpsychores.2018.02.006 (DOI)000429632600003 ()29602321 (PubMedID)
Tilgjengelig fra: 2020-04-15 Laget: 2020-04-15 Sist oppdatert: 2020-04-16bibliografisk kontrollert
Bendix, M., Uvnäs-Moberg, K., Petersson, M., Kaldo, V., Åsberg, M. & Jokinen, J. (2017). Insulin and glucagon in plasma and cerebrospinal fluid in suicide attempters and healthy controls. Psychoneuroendocrinology, 81, 1-7
Åpne denne publikasjonen i ny fane eller vindu >>Insulin and glucagon in plasma and cerebrospinal fluid in suicide attempters and healthy controls
Vise andre…
2017 (engelsk)Inngår i: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 81, s. 1-7Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Mental disorders and related behaviors such as suicidality and violence have been associated to dysregulation of e g carbohydrate metabolism. We hypothesized that patients after suicide attempt, compared to healthy controls, would have higher insulin and lower glucagon levels in plasma and cerebrospinal fluid and that these changes would be associated to violent behavior. Twenty-eight medication-free patients (10 women, 18 men), hospitalized after suicide attempt, and 19 healthy controls (7 women, 12 men) were recruited with the aim to study risk factors for suicidal behavior. Psychological/psychiatric assessment was performed with SCID I and II or the SCID interview for healthy volunteers respectively, the Karolinska Interpersonal Violence Scale (KIVS) for assessment of lifetime violence expression behavior, the Montgomery-Asberg-Depression-Scale (MADRS) and the Comprehensive Psychological Rating Scale (CPRS) for symptomatic assessment of depression and appetite. Fasting levels of insulin and glucagon were measured in plasma (P) and cerebrospinal fluid (CSF). Suicide attempters had higher insulin- and lower glucagon-levels in plasma- and CSF compared to controls. Except for P-glucagon these associations remained significant after adjusting for age and/or BMI. Patients reported significantly more expressed interpersonal violence compared to healthy volunteers. Expressed violence was significantly positively correlated with P- and CSF-insulin and showed a significant negative correlation with P-glucagon in study participants. These findings confirm and extend prior reports that higher insulin and lower glucagon levels in plasma and cerebrospinal fluid are associated with suicidal behavior pointing towards a potential autonomic dysregulation in the control of insulin and glucagon secretion in suicidal patients. 

sted, utgiver, år, opplag, sider
Elsevier, 2017
Emneord
Suicide attempt, Insulin, Glucagon, Aggression, Violence, Depression
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-137977 (URN)10.1016/j.psyneuen.2017.03.019 (DOI)000404815200001 ()28391069 (PubMedID)2-s2.0-85017147746 (Scopus ID)
Merknad

Errata: Bendix M, Uvnäs-Moberg K, Petersson M, Kaldo V, Åsberg M, Jokinen J. Corrigendum to “Insulin and glucagon in plasma and cerebrospinal fluid in suicide attempters and healthy controls” [Psychoneuroendocrinology 81 (2017) 1–7]. Psychoneuroendocrinology (2018) 94, 168. DOI: 10.1016/j.psyneuen.2018.04.014

Tilgjengelig fra: 2017-08-02 Laget: 2017-08-02 Sist oppdatert: 2023-03-24bibliografisk kontrollert
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