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Bryndahl, Fredrik
Publikasjoner (8 av 8) Visa alla publikasjoner
Salé, H., Bryndahl, F. & Isberg, A. (2014). A 15-year follow-up of temporomandibular joint symptoms and magnetic resonance imaging findings in whiplash patients: a prospective, controlled study. Oral surgery, oral medicine, oral pathology and oral radiology, 117(4), 522-532
Åpne denne publikasjonen i ny fane eller vindu >>A 15-year follow-up of temporomandibular joint symptoms and magnetic resonance imaging findings in whiplash patients: a prospective, controlled study
2014 (engelsk)Inngår i: Oral surgery, oral medicine, oral pathology and oral radiology, ISSN 2212-4403, Vol. 117, nr 4, s. 522-532Artikkel i tidsskrift (Annet vitenskapelig) Published
Emneord
Whiplash trauma, Temporomandibular joint, Magnetic resonance imaging, follow-up, controlled, prospective
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-48154 (URN)10.1016/j.oooo.2014.01.020 (DOI)000333410000023 ()2-s2.0-84896352344 (Scopus ID)
Merknad

Originally published in thesis in manuscript form.

Tilgjengelig fra: 2011-10-10 Laget: 2011-10-10 Sist oppdatert: 2023-03-23bibliografisk kontrollert
Salé, H., Bryndahl, F. & Isberg, A. (2013). 15-year natural course of temporomandibular joints in asymptomatic and symptomatic non-patient volunteers: a prospective clinical and MR imaging study. Radiology, 267(1), 183-194
Åpne denne publikasjonen i ny fane eller vindu >>15-year natural course of temporomandibular joints in asymptomatic and symptomatic non-patient volunteers: a prospective clinical and MR imaging study
2013 (engelsk)Inngår i: Radiology, ISSN 0033-8419, E-ISSN 1527-1315, Vol. 267, nr 1, s. 183-194Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To determine the incidence, prevalence, and progression of temporomandibular joint (TMJ) magnetic resonance (MR) imaging findings and symptoms during 15 years in adult asymptomatic and symptomatic volunteers (nonpatients).

Materials and Methods: A regional committee for medical research ethics approved the study, and informed volunteer consent was obtained. Fifty-three volunteers were examined at study inception. For clinical assessment, a self-administered questionnaire was given, followed by an interview with each volunteer at study inception, at 1 year later, and at 15 years later. Bilateral TMJ MR imaging and clinical examination were performed at inception and at 15-year follow-up. The MR images were assessed for disk position, bone status, and joint fluid. All 53 volunteers participated at 1-year follow-up, and 50 of 53 volunteers participated at 15-year follow-up; of these 50 volunteers, 47 underwent MR imaging. The Fisher exact test was used to determine differences between groups, and the Wilcoxon signed-rank test was used to determine differences in prevalence of TMJ symptoms among the three examination times.

Results: At study inception, TMJ disk displacement was observed in 31% of asymptomatic volunteers (nine of 29) compared with 89% of symptomatic volunteers (16 of 18, P < .001). Inceptive TMJ status was maintained after 15 years in 91% (43 of 47). Unilateral progression was observed in four volunteers (9%); one was symptomatic and three were asymptomatic. Progression involved development of new disk displacement (n = 1), development of new bone changes (n = 2), and aggravation from reducing to non-reducing disk displacement (n = 1). Prevalence of TMJ symptoms did not change significantly between examination times (P = .77). TMJ clicking was the most common clinical symptom.

Conclusion: Volunteers with mild symptoms had a prevalence of disk displacement of the same magnitude as that reported in patients, although most volunteers, symptomatic as well as asymptomatic, maintained their TMJ status during 15 years.

sted, utgiver, år, opplag, sider
Radiological Society of North America, 2013
Emneord
Temporomandibular joint, Magnetic resonance imaging, natural course, volunteers
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-48153 (URN)10.1148/radiol.12112243 (DOI)2-s2.0-84875419412 (Scopus ID)
Merknad

Originally pulished in thesis in manuscript form.

Tilgjengelig fra: 2011-10-10 Laget: 2011-10-10 Sist oppdatert: 2023-03-23bibliografisk kontrollert
Bryndahl, F., Warfvinge, G., Eriksson, L. & Isberg, A. (2011). Cartilage changes link retrognathic mandibular growth to TMJ disc displacement in a rabbit model. International Journal of Oral and Maxillofacial Surgery, 40(6), 621-627
Åpne denne publikasjonen i ny fane eller vindu >>Cartilage changes link retrognathic mandibular growth to TMJ disc displacement in a rabbit model
2011 (engelsk)Inngår i: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 40, nr 6, s. 621-627Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Recent experimental research demonstrated that non-reducing temporomandibular joint (TMJ) disc displacement in growing rabbits impaired mandibular growth. TMJ disc displacement is also shown to induce histological changes of the condylar cartilage. The authors hypothesized that the severity of these changes would correlate to the magnitude of mandibular growth. Bilateral non-reducing TMJ disc displacement was surgically created in 10 growing New Zealand White rabbits. Ten additional rabbits constituted a sham operated control group. Aided by tantalum implants, growth was cephalometrically determined for each mandibular side during a period equivalent to childhood and adolescence in man. At the end of the growth period, histologically classified cartilage features were correlated with the assessed ipsilateral mandibular growth. Non-reducing displacement of the TMJ disc during the growth period induced histological reactions of the condylar cartilage in the rabbit model. The severity of cartilage changes was inversely correlated to the magnitude and the direction of mandibular growth, which resulted in a retrognathic growth pattern.

sted, utgiver, år, opplag, sider
Elsevier, 2011
Emneord
adaptive modelling, adolescence, biomechanical function, mandibular retrognathia, temporomandibular joint
HSV kategori
Forskningsprogram
medicin
Identifikatorer
urn:nbn:se:umu:diva-45669 (URN)10.1016/j.ijom.2011.01.004 (DOI)21334177 (PubMedID)2-s2.0-79956286781 (Scopus ID)
Tilgjengelig fra: 2011-08-09 Laget: 2011-08-09 Sist oppdatert: 2023-03-24bibliografisk kontrollert
Bryndahl, F. (2008). Temporomandibular joint disk displacement and subsequent adverse mandibular growth: a radiographic, histologic and biomolecular experimental study. (Doctoral dissertation). Umeå: Oral diagnostisk radiologi
Åpne denne publikasjonen i ny fane eller vindu >>Temporomandibular joint disk displacement and subsequent adverse mandibular growth: a radiographic, histologic and biomolecular experimental study
2008 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

The mandibular condyles represent important growth sites within the facial skeleton. Condylar growth is not a pacemaker of mandibular development, but it provides regional adaptive growth that is of considerable clinical significance, as the condyle’s upward and backward growth movement regulates the anteriorly and inferiorly directed displacement of the mandible as a whole.

Orthopedic problems of the temporomandibular joint (TMJ), such as displacement of the TMJ disk, are common in the adolescent population. Clinical studies of mandibular asymmetry and mandibular retrognathia in adults as well as in children and adolescents, have reported an association with coexisting non-reducing displacement of the TMJ disk without identifying the cause and effect. Through experimental studies causality has been established, and unilateral affliction during growth has been shown to retard ipsilateral mandibular development with facial asymmetry as the sequel. It was hypothesized that bilateral non-reducing TMJ disk displacement during growth would impair mandibular development bilaterally, resulting in mandibular retrognathia. TMJ disk displacement has repeatedly been demonstrated to induce histological reactions of the condylar cartilage. An additional assumption was therefore that a non-deranged TMJ disk function is crucial for the maintenance of the growing condyle’s biophysical environment, and that a connection ought to exist between the amount of condylar cartilage changes caused by TMJ disk displacement and the amount of subsequent adverse mandibular growth. It was also hypothesized that non-reducing displacement of the TMJ disk in growing individuals would result in qualitative and quantitative changes of the condylar subchondral bone.

An improved experimental cephalometric method was developed in order to optimize the reliability of longitudinal radiographic evaluation of fast growing small animals. Bilateral non-reducing TMJ disk displacement was surgically created in ten growing New Zealand White rabbits, with ten additional rabbits serving as a sham operated control group. The amount and direction of craniofacial growth was followed over time in serial cephalograms, aided by tantalum implants in the jaws. The study period was chosen to correspond to childhood and adolescence in man. The assessed growth of each side of the mandible was correlated to the histological feature of ipsilateral condylar cartilage at the end of the growth period. The amount and composition of subchondral bone from three regions of interest in the condyle, and the expression of local growth factors in the adjacent condylar cartilage was evaluated.

The results verified that bilateral non-reducing TMJ disk displacement retarded mandibular growth bilaterally; the extent corresponding to mandibular retrognathia in man. Displacement of the TMJ disk during the growth period induced condylar cartilage adaptive reactions that were associated with both an adverse amount and direction of mandibular growth, manifesting in a retrognathic mandibular growth pattern. Growth impairment fluctuated over time, with the most striking retardation occurring during periods of increased general growth, implying a local growth reduction explicitly counteracting general hormonal growth acceleration. A significant decrease of the total amount of subchondral bone, in spite of a general increase of new bone formation in the experimental condyles, pointed to a reparative compensation for an extensive resorption of subchondral bone due to displacement of the TMJ disk, but not to the extent that normal growth would be maintained. These results constitute an explanation for the adverse mandibular development following non-reducing TMJ disk displacement in growing individuals.

This project has shown that non-reducing displacement of the TMJ disk during growth has significant consequences on facial development. The findings strongly advocate early and accurate diagnosis and treatment of TMJ disk displacement in the adolescent population, thereby presumably reducing the need for future orthodontic and surgical craniofacial corrective therapy. The results furthermore enhance the need for full appraisal of TMJ disk function in the adolescent population during orthodontic functional therapy, as the condylar cartilage and subchondral bone reactions to a concomitantly displaced non-reducing TMJ disk must be expected to interfere with the intended growth stimulating treatment. The findings of intact articular layers in spite of gross histological and morphological soft and hard tissue changes as a sequel to TMJ disk displacement in growing individuals, implicate a clinical risk of false positive radiographic diagnosis of degenerative changes of the TMJ in children and adolescents.

sted, utgiver, år, opplag, sider
Umeå: Oral diagnostisk radiologi, 2008. s. 58
Serie
Umeå University odontological dissertations, ISSN 0345-7532 ; 103
Emneord
adolescence, adverse growth, condylar cartilage, subchondral bone, TMJ
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-1624 (URN)978-91-7264-523-3 (ISBN)
Disputas
2008-05-09, Sal B, 1 D, Tandläkarhögskolan, Umeå, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2008-04-28 Laget: 2008-04-28 Sist oppdatert: 2018-06-09bibliografisk kontrollert
Bryndahl, F., Eriksson, L., Legrell, P. E. & Isberg, A. (2006). Bilateral TMJ disk displacement induces mandibular retrognathia. Journal of dental research, 85(12), 1118-1123
Åpne denne publikasjonen i ny fane eller vindu >>Bilateral TMJ disk displacement induces mandibular retrognathia
2006 (engelsk)Inngår i: Journal of dental research, ISSN 0022-0345, Vol. 85, nr 12, s. 1118-1123Artikkel i tidsskrift (Fagfellevurdert) Published
Identifikatorer
urn:nbn:se:umu:diva-3113 (URN)
Tilgjengelig fra: 2008-04-28 Laget: 2008-04-28 Sist oppdatert: 2018-06-09bibliografisk kontrollert
Bryndahl, F., Legrell, P. E., Eriksson, L. & Isberg, A. (2004). Titanium screw implants in optimization of radiographic evaluation of facial growth in longitudinal Animal studies. The angle orthodontist, 74(5), 610-617
Åpne denne publikasjonen i ny fane eller vindu >>Titanium screw implants in optimization of radiographic evaluation of facial growth in longitudinal Animal studies
2004 (engelsk)Inngår i: The angle orthodontist, ISSN 0003-3219, Vol. 74, nr 5, s. 610-617Artikkel i tidsskrift (Fagfellevurdert) Published
Identifikatorer
urn:nbn:se:umu:diva-3112 (URN)
Tilgjengelig fra: 2008-04-28 Laget: 2008-04-28 Sist oppdatert: 2018-06-09bibliografisk kontrollert
Bryndahl, F., Warfvinge, G., Eriksson, L. & Isberg, A. Cartilage changes link retrognathic growth to TMJ disk displacement.
Åpne denne publikasjonen i ny fane eller vindu >>Cartilage changes link retrognathic growth to TMJ disk displacement
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-3114 (URN)
Tilgjengelig fra: 2008-04-28 Laget: 2008-04-28 Sist oppdatert: 2018-06-09bibliografisk kontrollert
Bryndahl, F., Warfvinge, G., Rabie, A. B. & Isberg, A.Subchondral bone loss explains retrognathic mandibular growth at TMJ disk displacement.
Åpne denne publikasjonen i ny fane eller vindu >>Subchondral bone loss explains retrognathic mandibular growth at TMJ disk displacement
(engelsk)Manuskript (Annet (populærvitenskap, debatt, mm))
Identifikatorer
urn:nbn:se:umu:diva-3115 (URN)
Tilgjengelig fra: 2008-04-28 Laget: 2008-04-28 Sist oppdatert: 2018-06-09bibliografisk kontrollert
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