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Renman, E., Ekici, R., Sundström, M. & Lejon, K. (2022). HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse. Autoimmunity, 55(8), 520-528
Åpne denne publikasjonen i ny fane eller vindu >>HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse
2022 (engelsk)Inngår i: Autoimmunity, ISSN 0891-6934, E-ISSN 1607-842X, Vol. 55, nr 8, s. 520-528Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

B cells have been shown to be essential for Type 1 diabetes development in the non-obese diabetic mouse, where their contribution as antigen presenting cells has been emphasised. Other important functions for B cells include surface capture of immunoglobulins and transportation of immune complexes, with subsequent endocytosis, antigen processing and antigen presentation. We have previously demonstrated that NOD B cells capture IgM and IgG immune complexes through an unknown surface molecule. In this study, we revealed the presumptive immunoglobulin-binding molecule to be HSC70. Moreover, we detected increased levels of HSC70 on NOD B cells. HSC70 has been shown to play a role in antigen processing and presentation as well as being important in several autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Due to its protein stabilising properties, increased HSC70 could contribute to enhanced self-antigen collection and presentation and thereby contribute to the development of Type 1 diabetes.

sted, utgiver, år, opplag, sider
Taylor & Francis, 2022
Emneord
B lymphocyte, HSC70, immune complex, NOD mouse, Type 1 diabetes
HSV kategori
Forskningsprogram
immunologi
Identifikatorer
urn:nbn:se:umu:diva-199900 (URN)10.1080/08916934.2022.2117307 (DOI)000855330200001 ()36120986 (PubMedID)2-s2.0-85138421853 (Scopus ID)
Forskningsfinansiär
DiabetesfondenSwedish Child Diabetes Foundation
Tilgjengelig fra: 2022-10-03 Laget: 2022-10-03 Sist oppdatert: 2022-11-29bibliografisk kontrollert
Ekici, R. (2010). B cells in Type 1 diabetes: studies on cell surface antibody binding. (Licentiate dissertation). Umeå: Umeå universitet
Åpne denne publikasjonen i ny fane eller vindu >>B cells in Type 1 diabetes: studies on cell surface antibody binding
2010 (engelsk)Licentiatavhandling, monografi (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Umeå: Umeå universitet, 2010. s. 34
Emneord
typ 1 diabetes, insulin, NOD, B cell
HSV kategori
Forskningsprogram
immunologi
Identifikatorer
urn:nbn:se:umu:diva-37376 (URN)978-91-7459-075-3 (ISBN)
Veileder
Tilgjengelig fra: 2010-11-08 Laget: 2010-10-30 Sist oppdatert: 2022-10-03bibliografisk kontrollert
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-0273-8485