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Martinez Gamero, CarlosORCID iD iconorcid.org/0000-0001-7652-1695
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Publikasjoner (4 av 4) Visa alla publikasjoner
Malla, S., Bhattarai, D. P., Groza, P., Melguizo-Sanchis, D., Atanasoai, I., Martinez Gamero, C., . . . Aguilo, F. (2022). ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. EMBO Reports, 23(3), Article ID e53191.
Åpne denne publikasjonen i ny fane eller vindu >>ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
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2022 (engelsk)Inngår i: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 23, nr 3, artikkel-id e53191Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The pluripotent state is not solely governed by the action of the core transcription factors OCT4, SOX2, and NANOG, but also by a series of co-transcriptional and post-transcriptional events, including alternative splicing (AS) and the interaction of RNA-binding proteins (RBPs) with defined subpopulations of RNAs. Zinc Finger Protein 207 (ZFP207) is an essential transcription factor for mammalian embryonic development. Here, we employ multiple functional analyses to characterize its role in mouse embryonic stem cells (ESCs). We find that ZFP207 plays a pivotal role in ESC maintenance, and silencing of Zfp207 leads to severe neuroectodermal differentiation defects. In striking contrast to human ESCs, mouse ZFP207 does not transcriptionally regulate neuronal and stem cell-related genes but exerts its effects by controlling AS networks and by acting as an RBP. Our study expands the role of ZFP207 in maintaining ESC identity, and underscores the functional versatility of ZFP207 in regulating neural fate commitment.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2022
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-191672 (URN)10.15252/embr.202153191 (DOI)000743102200001 ()35037361 (PubMedID)2-s2.0-85122763926 (Scopus ID)
Tilgjengelig fra: 2022-01-21 Laget: 2022-01-21 Sist oppdatert: 2024-04-08bibliografisk kontrollert
Martinez-Gamero, C., Malla, S. & Aguilo, F. (2021). LSD1: Expanding functions in stem cells and differentiation. Cells, 10(11), Article ID 3252.
Åpne denne publikasjonen i ny fane eller vindu >>LSD1: Expanding functions in stem cells and differentiation
2021 (engelsk)Inngår i: Cells, E-ISSN 2073-4409, Vol. 10, nr 11, artikkel-id 3252Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific deme-thylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethyl-ates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of nu-merous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory cir-cuitry underlying self-renewal and pluripotency.

sted, utgiver, år, opplag, sider
MDPI, 2021
Emneord
Differentiation, Embryonic stem cells, Epigenetics, Histone methylation, Induced pluripotent stem cells, KDM1A, LSD1, Lysine-specific demethylase, Non-his-tone substrate, Pluripotency, Self-renewal
HSV kategori
Forskningsprogram
molekylärbiologi
Identifikatorer
urn:nbn:se:umu:diva-189925 (URN)10.3390/cells10113252 (DOI)000724414100001 ()34831474 (PubMedID)2-s2.0-85119274398 (Scopus ID)
Tilgjengelig fra: 2021-11-29 Laget: 2021-11-29 Sist oppdatert: 2023-09-05bibliografisk kontrollert
Malla, S., Kumari, K., Martinez Gamero, C., Achour, C., Mermelekas, G., Coege, A., . . . Aguilo, F.LSD1 interacts with CHD7 to regulate the chromatin landscape in mouse embryonic stem cells.
Åpne denne publikasjonen i ny fane eller vindu >>LSD1 interacts with CHD7 to regulate the chromatin landscape in mouse embryonic stem cells
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(engelsk)Manuskript (preprint) (Annet vitenskapelig)
Abstract [en]

 

 

 

HSV kategori
Forskningsprogram
molekylärbiologi
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urn:nbn:se:umu:diva-206717 (URN)
Tilgjengelig fra: 2023-04-14 Laget: 2023-04-14 Sist oppdatert: 2023-04-14
Malla, S., Kumari, K., Martinez Gamero, C., García-Prieto, c. A., Álvarez-Errico3, D., Stransky, S., . . . Aguilo, F.The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells.
Åpne denne publikasjonen i ny fane eller vindu >>The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells
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(engelsk)Manuskript (preprint) (Annet vitenskapelig)
Emneord
LSD1, DNA methylation, DNMT1, UHRF1 and USP7
HSV kategori
Forskningsprogram
molekylärbiologi
Identifikatorer
urn:nbn:se:umu:diva-206715 (URN)
Tilgjengelig fra: 2023-04-14 Laget: 2023-04-14 Sist oppdatert: 2023-04-14
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ORCID-id: ORCID iD iconorcid.org/0000-0001-7652-1695