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Feldman, Inna, DocentORCID iD iconorcid.org/0000-0003-3329-6066
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Meili, K. W., Mulhern, B., Ssegonja, R., Norström, F., Feldman, I., Månsdotter, A., . . . Lindholm, L. (2024). Eliciting a value set for the Swedish capability-adjusted life years instrument (CALY-SWE). Quality of Life Research, 33(1), 59-72
Öppna denna publikation i ny flik eller fönster >>Eliciting a value set for the Swedish capability-adjusted life years instrument (CALY-SWE)
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2024 (Engelska)Ingår i: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 33, nr 1, s. 59-72Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: Our aim was to elicit a value set for Capability-Adjusted Life Years Sweden (CALY-SWE); a capability-grounded quality of life instrument intended for use in economic evaluations of social interventions with broad consequences beyond health.

Methods: Building on methods commonly used in the quality-adjusted life years EQ-5D context, we collected time-trade off (TTO) and discrete choice experiment (DCE) data through an online survey from a general population sample of 1697 Swedish participants. We assessed data quality using a score based on the severity of inconsistencies. For generating the value set, we compared different model features, including hybrid modeling of DCE and TTO versus TTO data only, censoring of TTO answers, varying intercept, and accommodating for heteroskedasticity. We also assessed the models’ DCE logit fidelity to measure agreement with potentially less-biased DCE data. To anchor the best capability state to 1 on the 0 to 1 scale, we included a multiplicative scaling factor.

Results: We excluded 20% of the TTO answers of participants with the largest inconsistencies to improve data quality. A hybrid model with an anchor scale and censoring was chosen to generate the value set; models with heteroskedasticity considerations or individually varying intercepts did not offer substantial improvement. The lowest capability weight was 0.114. Health, social relations, and finance and housing attributes contributed the largest capability gains, followed by occupation, security, and political and civil rights.

Conclusion: We elicited a value set for CALY-SWE for use in economic evaluations of interventions with broad social consequences.

Ort, förlag, år, upplaga, sidor
Springer Nature, 2024
Nyckelord
Quality-adjusted life year, Time trade-off, Discrete choice experiment, Capability approach, Hybrid modeling, Economic evaluation
Nationell ämneskategori
Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi
Identifikatorer
urn:nbn:se:umu:diva-214379 (URN)10.1007/s11136-023-03507-w (DOI)001064459600002 ()37695477 (PubMedID)2-s2.0-85170367443 (Scopus ID)
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2018-00143Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2018-00143
Tillgänglig från: 2023-09-13 Skapad: 2023-09-13 Senast uppdaterad: 2024-04-29Bibliografiskt granskad
Sampaio, F., Nystrand, C., Feldman, I. & Mihalopoulos, C. (2024). Evidence for investing in parenting interventions aiming to improve child health: a systematic review of economic evaluations. European Child and Adolescent Psychiatry, 33(2), 323-355
Öppna denna publikation i ny flik eller fönster >>Evidence for investing in parenting interventions aiming to improve child health: a systematic review of economic evaluations
2024 (Engelska)Ingår i: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 33, nr 2, s. 323-355Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

A comprehensive review of the economic evidence on parenting interventions targeting different aspects of child health is lacking to support decision-making. The aim of this review is to provide an up to date synthesis of the available health economic evidence for parenting interventions aiming to improve child health. A systematic review was conducted with articles identified through Econlit, Medline, PsychINFO, and ERIC databases. Only full economic evaluations comparing two or more options, considering both costs and outcomes were included. We assessed the quality of the studies using the Drummond checklist. We identified 44 studies of varying quality that met inclusion criteria; 22 targeting externalizing behaviors, five targeting internalizing problems, and five targeting other mental health problems including autism and alcohol abuse. The remaining studies targeted child abuse (n = 5), obesity (n = 3), and general health (n = 4). Studies varied considerably and many suffered from methodological limitations, such as limited costing perspectives, challenges with outcome measurement and short-time horizons. Parenting interventions showed good value for money in particular for preventing child externalizing and internalizing behaviors. For the prevention of child abuse, some programs had the potential of being cost-saving over the longer-term. Interventions were not cost-effective for the treatment of autism and obesity. Future research should include a broader spectrum of societal costs and quality-of-life impacts on both children and their caregivers.

Ort, förlag, år, upplaga, sidor
Springer, 2024
Nyckelord
Child health, Cost-effectiveness analysis, Economic evaluation, Parenting, Prevention, treatment
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Psykiatri
Identifikatorer
urn:nbn:se:umu:diva-193354 (URN)10.1007/s00787-022-01969-w (DOI)000770503100001 ()35304645 (PubMedID)2-s2.0-85126538651 (Scopus ID)
Tillgänglig från: 2022-04-01 Skapad: 2022-04-01 Senast uppdaterad: 2024-04-30Bibliografiskt granskad
Sampaio, F., Feldman, I., Lavelle, T. A. & Skokauskas, N. (2022). The cost-effectiveness of treatments for attention deficit-hyperactivity disorder and autism spectrum disorder in children and adolescents: a systematic review. European Child and Adolescent Psychiatry, 31, 1655-1670
Öppna denna publikation i ny flik eller fönster >>The cost-effectiveness of treatments for attention deficit-hyperactivity disorder and autism spectrum disorder in children and adolescents: a systematic review
2022 (Engelska)Ingår i: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 31, s. 1655-1670Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Economic evaluations can help decision makers identify what services for children with neurodevelopmental disorders provide best value-for-money. The aim of this paper is to review the best available economic evidence to support decision making for attention deficit-hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in children and adolescents. We conducted a systematic review of economic evaluations of ADHD and ASD interventions including studies published 2010–2020, identified through Econlit, Medline, PsychINFO, and ERIC databases. Only full economic evaluations comparing two or more options, considering both costs and consequences were included. The quality of the studies was assessed using the Drummond checklist. We identified ten studies of moderate-to-good quality on the cost-effectiveness of treatments for ADHD and two studies of good quality of interventions for ASD. The majority of ADHD studies evaluated pharmacotherapy (n = 8), and two investigated the economic value of psychosocial/behavioral interventions. Both economic evaluations for ASD investigated early and communication interventions. Included studies support the cost-effectiveness of behavioral parenting interventions for younger children with ADHD. Among pharmacotherapies for ADHD, different combinations of stimulant/non-stimulant medications for children were cost-effective at willingness-to-pay thresholds reported in the original papers. Early intervention for children with suspected ASD was cost-effective, but communication-focused therapy for preschool children with ASD was not. Prioritizing more studies in this area would allow decision makers to promote cost-effective and clinically effective interventions for this target group.

Ort, förlag, år, upplaga, sidor
Springer, 2022
Nyckelord
Attention deficit-hyperactivity disorder, Autism spectrum disorder, Cost-effectiveness analysis, Intervention, Neurodevelopmental disorders, Treatment
Nationell ämneskategori
Psykiatri Pediatrik
Identifikatorer
urn:nbn:se:umu:diva-181648 (URN)10.1007/s00787-021-01748-z (DOI)000626857700002 ()33751229 (PubMedID)2-s2.0-85102335990 (Scopus ID)
Tillgänglig från: 2021-06-11 Skapad: 2021-06-11 Senast uppdaterad: 2022-12-30Bibliografiskt granskad
Wijana, M. B., Feldman, I., Ssegonja, R., Enebrink, P. & Ghaderi, A. (2021). A pilot study of the impact of an integrated individual- and family therapy model for self-harming adolescents on overall healthcare consumption. BMC Psychiatry, 21(1), Article ID 374.
Öppna denna publikation i ny flik eller fönster >>A pilot study of the impact of an integrated individual- and family therapy model for self-harming adolescents on overall healthcare consumption
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2021 (Engelska)Ingår i: BMC Psychiatry, E-ISSN 1471-244X, Vol. 21, nr 1, artikel-id 374Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Self-harming behaviors in adolescents cause great suffering and can lead to considerable costs to the healthcare system. The aim of the current study was to investigate the cost of an integrated individual and family therapy (Intensive Contextual Treatment: ICT) and to compare the adolescent’s healthcare consumption 1 year before and 1 year after treatment.

Method: The study had a within group design with repeated measures. The clinical outcomes and the cost of ICT treatment are based on a sample of 49 participants who were previously enrolled in an intervention trial. Participants with significantly improved clinical outcomes (self-harm behavior, or general mental health symptoms) were defined as treatment responders. Calculation of changes in healthcare consumption is based on 25 participants who gave their consent to participate in a retrospective collection of healthcare data from medical records, including inpatient and outpatient care, and prescribed medication.

Results: The average estimated cost of ICT per person was €5293. There were no significant differences between the cost of healthcare consumption 1 year before and after ICT, but the results suggested that the adolescents consumed less inpatient and specialized care after treatment. There was a significantly higher cost of psychotropic medication after treatment explained by a higher consumption of central stimulants. Treatment responders (general mental health problems) reduced their consumption of healthcare resources significantly more than non-responders, especially regarding hospital visits and total health care costs.

Conclusions: Good response to the ICT in terms of improved general mental health symptoms seems to be associated with reduced healthcare consumption during the post-treatment period. However, controlled studies with larger sample sizes are needed to draw causal conclusions. The results of this study should be interpreted with caution as it is based on a small sample and attrition rate was high. Trial registration: This study has been registered with the ISRCTN: 15885573.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2021
Nyckelord
Adolescents, Cost of treatment, Healthcare consumption, Self-harm
Nationell ämneskategori
Psykiatri Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi
Identifikatorer
urn:nbn:se:umu:diva-186572 (URN)10.1186/s12888-021-03375-z (DOI)000678571100004 ()34311711 (PubMedID)2-s2.0-85111297885 (Scopus ID)
Forskningsfinansiär
Jerringfonden
Tillgänglig från: 2021-08-12 Skapad: 2021-08-12 Senast uppdaterad: 2024-01-17Bibliografiskt granskad
Lindvall, K., Vaezghasemi, M., Feldman, I., Ivarsson, A., Stevens, K. J. & Petersen, S. (2021). Feasibility, reliability and validity of the health-related quality of life instrument Child Health Utility 9D (CHU9D) among school-aged children and adolescents in Sweden. Health and Quality of Life Outcomes, 19(1), Article ID 193.
Öppna denna publikation i ny flik eller fönster >>Feasibility, reliability and validity of the health-related quality of life instrument Child Health Utility 9D (CHU9D) among school-aged children and adolescents in Sweden
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2021 (Engelska)Ingår i: Health and Quality of Life Outcomes, ISSN 1477-7525, E-ISSN 1477-7525, Vol. 19, nr 1, artikel-id 193Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: This study was conducted in a general population of schoolchildren in Sweden, with the aim to assess the psychometric properties of a generic preference-based health related quality of life (HRQoL) instrument, the Swedish Child Health Utility 9D (CHU9D), among schoolchildren aged 7–15 years, and in subgroups aged 7–9, 10–12 and 13–15 years.

Methods: In total, 486 school aged children, aged 7–15 years, completed a questionnaire including the CHU9D, the Pediatric quality of life inventory 4.0 (PedsQL), KIDSCREEN-10, questions on general health, long-term illness, and sociodemographic characteristics. Psychometric testing was undertaken of feasibility, internal consistency reliability, test–retest reliability, construct validity, factorial validity, concurrent validity, convergent validity and divergent validity.

Results: The CHU9D evidenced very few missing values, minimal ceiling, and no floor effects. The instrument achieved satisfactory internal consistency (Cronbach’s Alfa > 0.7) and strong test–retest reliability (r > 0.6). Confirmatory factor analyses supported the proposed one-factor structure of the CHU9D. For child algorithm, RMSEA = 0.05, CFI = 0.95, TLI = 0.94, and SRMR = 0.04. For adult algorithm RMSEA = 0.04, CFI = 0.96, TLI = 0.95, and SRMR = 0.04. The CHU9D utility value correlated moderately or strongly with KIDSCREEN-10 and PedsQL total scores (r > 0.5–0.7). The CHU9D discriminated as anticipated on health and on three of five sociodemographic characteristics (sex, age, and custody arrangement, but not socioeconomic status and ethnic origin).

Conclusions: This study provides evidence that the Swedish CHU9D is a feasible, reliable and valid measure of preference-based HRQoL in children. The study furthermore suggests that the CHU9D is appropriate for use among children 7–15 years of age in the general population, as well as among subgroups aged 7– 9, 10–12 and 13–15 years.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2021
Nyckelord
Adolescent, Child, CHU9D, Health related quality of life, HRQoL, Psychometrics, Sweden
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-186637 (URN)10.1186/s12955-021-01830-9 (DOI)000683730500003 ()34344386 (PubMedID)2-s2.0-85112016482 (Scopus ID)
Tillgänglig från: 2021-08-30 Skapad: 2021-08-30 Senast uppdaterad: 2023-03-24Bibliografiskt granskad
Nystrand, C., Sampaio, F., Hoch, J. S., Osman, F. & Feldman, I. (2021). The cost-effectiveness of a culturally tailored parenting program: estimating the value of multiple outcomes. Cost Effectiveness and Resource Allocation, 19(1), Article ID 23.
Öppna denna publikation i ny flik eller fönster >>The cost-effectiveness of a culturally tailored parenting program: estimating the value of multiple outcomes
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2021 (Engelska)Ingår i: Cost Effectiveness and Resource Allocation, E-ISSN 1478-7547, Vol. 19, nr 1, artikel-id 23Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Parenting programs can be economically attractive interventions for improving the mental health of both parents and their children. Few attempts have been made to analyse the value of children's and parent's outcomes simultaneously, to provide a qualified support for decision making.

Methods: A within trial cost-effectiveness evaluation was conducted, comparing Ladnaan, a culturally tailored parenting program for Somali-born parents, with a waitlist control. Quality-adjusted life years (QALY) for parents were estimated by mapping the General Health Questionnaire-12 to Euroqol's EQ-5D-3L to retrieve utilities. Behavioural problems in children were measured using the Child Behaviour Checklist (CBCL). Intervention costs were estimated for the trial. A net benefit regression framework was employed to study the cost-effectiveness of the intervention, dealing with multiple effects in the same analysis to estimate different combinations of willingness-to pay (WTP) thresholds.

Results: For a WTP of roughly euro300 for a one point improvement in total problems on the CBCL scale (children), Ladnaan is cost-effective. In contrast, the WTP would have to be roughly euro580,000 per QALY (parents) for it to be cost-effective. Various combinations of WTP values for the two outcomes (i.e., CBCL and QALY) may be used to describe other scenarios where Ladnaan is cost-effective.

Conclusions: Decision-makers interested in multiple effects must take into account combinations of effects in relation to budget, in order to obtain cost-effective results. A culturally adapted parenting program may be cost-effective, depending on the primary outcome, or multiple outcomes of interest.

Ort, förlag, år, upplaga, sidor
BioMed Central (BMC), 2021
Nyckelord
Child health, Cost-effectiveness, Parenting program
Nationell ämneskategori
Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi
Identifikatorer
urn:nbn:se:umu:diva-187349 (URN)10.1186/s12962-021-00278-4 (DOI)000642907400001 ()33892740 (PubMedID)2-s2.0-85139919656 (Scopus ID)
Forskningsfinansiär
Folkhälsomyndigheten, 802/2014-6.2
Tillgänglig från: 2021-09-09 Skapad: 2021-09-09 Senast uppdaterad: 2023-03-23Bibliografiskt granskad
Månsdotter, A., Ekman, B., Meili, K. W., Feldman, I., Hagberg, L., Hurtig, A.-K. & Lindholm, L. (2020). Towards capability-adjusted life years in public health and social welfare: results from a Swedish survey on ranking capabilities. PLOS ONE, 15(12), Article ID e0242699.
Öppna denna publikation i ny flik eller fönster >>Towards capability-adjusted life years in public health and social welfare: results from a Swedish survey on ranking capabilities
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2020 (Engelska)Ingår i: PLOS ONE, E-ISSN 1932-6203, Vol. 15, nr 12, artikel-id e0242699Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

INTRODUCTION: The aim of this study was to rank capabilities and suggest a relevant set of capabilities for the Swedish context to inform the development of capability-adjusted life years (CALYs). CALYs is a quality of life measure for policy making based on the capability approach by Amartya Sen.

MATERIALS AND METHODS: A Swedish governmental review proposed the following 10 relevant capabilities: time, financial situation, mental/physical health, political resources, knowledge, living environment, occupation, social relations, security, and housing. Researchers in health-related disciplines from 5 universities ranked these capabilities from 1 to 10 (most to least important) in a web-based cross-sectional survey; 115 of 171 responses were eligible.

RESULTS: Health, social relations, and financial situation were deemed most important. Stratification by gender, research field, and age group revealed few differences. We found that it was possible to rank capabilities and that health, social relations, and financial situation were ranked highest by a non-representative sample of researchers and doctoral students from health-related disciplines at five Swedish universities.

CONCLUSIONS: The revealed ranking is dependent on the metric and must be further explored. The findings support continued development of CALYs for monitoring and evaluating outcomes in public health and social-welfare interventions.

Ort, förlag, år, upplaga, sidor
San Francisco: Public Library of Science, 2020
Nationell ämneskategori
Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-177334 (URN)10.1371/journal.pone.0242699 (DOI)000596503200010 ()33259528 (PubMedID)2-s2.0-85097035100 (Scopus ID)
Tillgänglig från: 2020-12-07 Skapad: 2020-12-07 Senast uppdaterad: 2021-11-25Bibliografiskt granskad
Projekt
Hälso- och ekonomiska effekter av ett generellt hälsofrämjande program för barn och föräldrar [2014-01399_Forte]; Uppsala universitetKan en förstärkt hälsofrämjande strategi för barn och föräldrar bidra till folkhälsan? [2017-00912_Forte]; Uppsala universitetMetodologiska aspekter av hälsoekonomisk utvärdering inom folkhälsa: Ett besök av Jeffrey Hoch, professor och enhetschef, Division of Health Policy and Management, University of California, Davis. [2018-01601_Forte]; Uppsala universitet
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0003-3329-6066

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