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Ekström, M., Sundh, J., Andersson, A., Angerås, O., Blomberg, A., Börjesson, M., . . . Carlhäll, C.-J. (2024). Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women. Respiratory Research, 25(1), Article ID 127.
Öppna denna publikation i ny flik eller fönster >>Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
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2024 (Engelska)Ingår i: Respiratory Research, ISSN 1465-9921, E-ISSN 1465-993X, Vol. 25, nr 1, artikel-id 127Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Breathlessness is common in the population and can be related to a range of medical conditions. We aimed to evaluate the burden of breathlessness related to different medical conditions in a middle-aged population.

Methods: Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study of adults aged 50–64 years. Breathlessness (modified Medical Research Council [mMRC] ≥ 2) was evaluated in relation to self-reported symptoms, stress, depression; physician-diagnosed conditions; measured body mass index (BMI), spirometry, venous haemoglobin concentration, coronary artery calcification and stenosis [computer tomography (CT) angiography], and pulmonary emphysema (high-resolution CT). For each condition, the prevalence and breathlessness population attributable fraction (PAF) were calculated, overall and by sex, smoking history, and presence/absence of self-reported cardiorespiratory disease.

Results: We included 25,948 people aged 57.5 ± [SD] 4.4; 51% women; 37% former and 12% current smokers; 43% overweight (BMI 25.0–29.9), 21% obese (BMI ≥ 30); 25% with respiratory disease, 14% depression, 9% cardiac disease, and 3% anemia. Breathlessness was present in 3.7%. Medical conditions most strongly related to the breathlessness prevalence were (PAF 95%CI): overweight and obesity (59.6–66.0%), stress (31.6–76.8%), respiratory disease (20.1–37.1%), depression (17.1–26.6%), cardiac disease (6.3–12.7%), anemia (0.8–3.3%), and peripheral arterial disease (0.3–0.8%). Stress was the main factor in women and current smokers.

Conclusion: Breathlessness mainly relates to overweight/obesity and stress and to a lesser extent to comorbidities like respiratory, depressive, and cardiac disorders among middle-aged people in a high-income setting—supporting the importance of lifestyle interventions to reduce the burden of breathlessness in the population.

Ort, förlag, år, upplaga, sidor
BioMed Central (BMC), 2024
Nyckelord
Diseases, Dyspnea, Epidemiology, Obesity
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-223242 (URN)10.1186/s12931-024-02766-6 (DOI)001186201900001 ()38493081 (PubMedID)2-s2.0-85187930690 (Scopus ID)
Forskningsfinansiär
Hjärt-LungfondenKnut och Alice Wallenbergs StiftelseVetenskapsrådet, 2019–02081VetenskapsrådetVinnovaGöteborgs universitetKarolinska InstitutetRegion StockholmLinköpings universitetLunds universitetUmeå universitetUppsala universitet
Tillgänglig från: 2024-04-18 Skapad: 2024-04-18 Senast uppdaterad: 2024-04-18Bibliografiskt granskad
Olsson, M., Björkelund, A. J., Sandberg, J., Blomberg, A., Börjesson, M., Currow, D., . . . Ekström, M. (2024). Factors most strongly associated with breathlessness in a population aged 50–64 years. ERJ Open Research, 10(2), Article ID 00582-2023.
Öppna denna publikation i ny flik eller fönster >>Factors most strongly associated with breathlessness in a population aged 50–64 years
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2024 (Engelska)Ingår i: ERJ Open Research, E-ISSN 2312-0541, Vol. 10, nr 2, artikel-id 00582-2023Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Breathlessness is a troublesome and prevalent symptom in the population, but knowledge of related factors is scarce. The aim of this study was to identify the factors most strongly associated with breathlessness in the general population and to describe the shapes of the associations between the main factors and breathlessness.

Methods: A cross-sectional analysis was carried out of the multicentre population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) of adults aged 50 to 64 years. Breathlessness was defined as a modified Medical Research Council breathlessness rating ⩾2. The machine learning algorithm extreme gradient boosting (XGBoost) was used to classify participants as either breathless or nonbreathless using 449 factors, including physiological measurements, blood samples, computed tomography cardiac and lung measurements, lifestyle, health conditions and socioeconomics. The strength of the associations between the factors and breathlessness were measured by SHapley Additive exPlanations (SHAP), with higher scores reflecting stronger associations.

Results :A total of 28 730 participants (52% women) were included in the study. The strongest associated factors for breathlessness were (in order of magnitude): body mass index (SHAP score 0.39), forced expiratory volume in 1 s (0.32), physical activity measured by accelerometery (0.27), sleep apnoea (0.22), diffusing lung capacity for carbon monoxide (0.21), self-reported physical activity (0.17), chest pain when hurrying (0.17), high-sensitivity C-reactive protein (0.17), recent weight change (0.14) and cough (0.13).

Conclusion: This large population-based study of men and women aged 50–64 years identified the main factors related to breathlessness that may be prevented or amenable to public health interventions.

Ort, förlag, år, upplaga, sidor
European Respiratory Society, 2024
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-223074 (URN)10.1183/23120541.00582-2023 (DOI)001193980300005 ()38529345 (PubMedID)2-s2.0-85189107812 (Scopus ID)
Forskningsfinansiär
Hjärt-LungfondenKnut och Alice Wallenbergs StiftelseVetenskapsrådetVinnovaGöteborgs universitetKarolinska InstitutetRegion StockholmLinköpings universitetLunds universitetUmeå universitetUppsala universitetVetenskapsrådet, 2019-02081
Tillgänglig från: 2024-04-18 Skapad: 2024-04-18 Senast uppdaterad: 2024-04-18Bibliografiskt granskad
Uski, O., Rankin, G. D., Wingfors, H., Magnusson, R., Boman, C., Muala, A., . . . Sandström, T. (2024). In vitro toxicity evaluation in A549 cells of diesel particulate matter from two different particle sampling systems and several resuspension media. Journal of Applied Toxicology
Öppna denna publikation i ny flik eller fönster >>In vitro toxicity evaluation in A549 cells of diesel particulate matter from two different particle sampling systems and several resuspension media
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2024 (Engelska)Ingår i: Journal of Applied Toxicology, ISSN 0260-437X, E-ISSN 1099-1263Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

In urban areas, inhalation of fine particles from combustion sources such as diesel engines causes adverse health effects. For toxicity testing, a substantial amount of particulate matter (PM) is needed. Conventional sampling involves collection of PM onto substrates by filtration or inertial impaction. A major drawback to those methodologies is that the extraction process can modify the collected particles and alter their chemical composition. Moreover, prior to toxicity testing, PM samples need to be resuspended, which can alter the PM sample even further. Lastly, the choice of the resuspension medium may also impact the detected toxicological responses. In this study, we compared the toxicity profile of PM obtained from two alternative sampling systems, using in vitro toxicity assays. One system makes use of condensational growth before collection in water in an impinger – BioSampler (CG-BioSampler), and the other, a Dekati® Gravimetric Impactor (DGI), is based on inertial impaction. In addition, various methods for resuspension of DGI collected PM were compared. Tested endpoints included cytotoxicity, formation of cellular reactive oxygen species, and genotoxicity. The alternative collection and suspension methods affected different toxicological endpoints. The water/dimethyl sulfoxide mixture and cell culture medium resuspended particles, along with the CG-BioSampler sample, produced the strongest responses. The water resuspended sample from the DGI appeared least toxic. CG-BioSampler collected PM caused a clear increased response in apoptotic cell death. We conclude that the CG-BioSampler PM sampler is a promising alternative to inertial impaction sampling.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2024
Nyckelord
apoptosis, diesel exhaust, extraction, impinger, particulate matter, reactive oxygen species, sampling, soot, toxicity
Nationell ämneskategori
Farmakologi och toxikologi
Identifikatorer
urn:nbn:se:umu:diva-224261 (URN)10.1002/jat.4616 (DOI)001214370400001 ()38705171 (PubMedID)2-s2.0-85192155238 (Scopus ID)
Tillgänglig från: 2024-05-14 Skapad: 2024-05-14 Senast uppdaterad: 2024-05-14
Lundquist, A., Lindberg, A., Eriksson Ström, J., Blomberg, A. & Backman, H. (2024). Number of follow-up years needed to identify a rapid decline in FEV1 [Letter to the editor]. American Journal of Respiratory and Critical Care Medicine, 209(1), 119-120
Öppna denna publikation i ny flik eller fönster >>Number of follow-up years needed to identify a rapid decline in FEV1
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2024 (Engelska)Ingår i: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 209, nr 1, s. 119-120Artikel i tidskrift, Letter (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
American Thoracic Society, 2024
Nationell ämneskategori
Lungmedicin och allergi
Forskningsämne
lungmedicin; epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-216385 (URN)10.1164/rccm.202309-1664LE (DOI)37879065 (PubMedID)2-s2.0-85181395898 (Scopus ID)
Forskningsfinansiär
Hjärt-LungfondenVisare NorrRegion NorrbottenUmeå universitet
Tillgänglig från: 2023-11-09 Skapad: 2023-11-09 Senast uppdaterad: 2024-01-11Bibliografiskt granskad
Engström, G., Lampa, E., Dekkers, K., Lin, Y.-T., Ahlm, K., Ahlström, H., . . . Sundström, J. (2024). Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications. European Journal of Epidemiology, 39(1), 35-49
Öppna denna publikation i ny flik eller fönster >>Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
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2024 (Engelska)Ingår i: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 39, nr 1, s. 35-49Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.

Ort, förlag, år, upplaga, sidor
Springer Nature, 2024
Nyckelord
Atherosclerosis, Coronary heart disease, Emphysema, Spirometry
Nationell ämneskategori
Kardiologi Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-219309 (URN)10.1007/s10654-023-01088-z (DOI)001132630700001 ()38165527 (PubMedID)2-s2.0-85181226926 (Scopus ID)
Forskningsfinansiär
EU, Europeiska forskningsrådet, ERC-2018-STG-801965Vetenskapsrådet, 2019-01471Hjärt-Lungfonden, 20200173Hjärt-Lungfonden, 20190505Göran Gustafssons stiftelse för naturvetenskaplig och medicinsk forskning (KVA)Axel och Signe Lagermans donationsstiftelseKnut och Alice Wallenbergs StiftelseVinnovaGöteborgs universitetKarolinska InstitutetRegion StockholmLinköpings universitetLunds universitetUmeå universitetUppsala universitet
Tillgänglig från: 2024-01-15 Skapad: 2024-01-15 Senast uppdaterad: 2024-05-07Bibliografiskt granskad
Lyytinen, G., Melnikov, G., Brynedal, A., Anesäter, E., Antoniewicz, L., Blomberg, A., . . . Lundbäck, M. (2024). Use of heated tobacco products (IQOS) causes an acute increase in arterial stiffness and platelet thrombus formation. Atherosclerosis, 390, Article ID 117335.
Öppna denna publikation i ny flik eller fönster >>Use of heated tobacco products (IQOS) causes an acute increase in arterial stiffness and platelet thrombus formation
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2024 (Engelska)Ingår i: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 390, artikel-id 117335Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background and aims: Heated tobacco products (HTPs) are novel alternative tobacco products being promoted as an alternative to cigarettes. To evaluate the impact of HTP use on vascular function, we investigated the effects of a brief HTP usage on arterial stiffness and platelet thrombus formation in healthy volunteers.

Methods: In a randomised crossover study, twenty-four healthy young adults with occasional tobacco use smoked the HTP IQOS 3 Multi (Phillip Morris Int.) and “no-exposure” was used as a control, with a wash-out period of at least one week in-between. Arterial stiffness was assessed through pulse wave velocity and pulse wave analysis. Blood samples, collected at baseline and 5 min following exposure, were analysed with the Total-Thrombus-formation analysis system evaluating platelet and fibrin-rich thrombus formation tendency.

Results: HTP exposure caused immediate heightened pulse wave velocity (+0.365 m/s, 95% CI: +0.188 to 0.543; p = 0.004) and enhanced augmentation index corrected to heart rate (+6.22%, 95% CI: +2.33 to 10.11; p = 0.003) compared to the no-exposure occasion. Similarly, blood pressure and heart rate transiently increased immediately following HTP inhalation. Platelet thrombus formation significantly increased following HTP exposure (area under the curve +59.5, 95% CI: +25.6 to 93.4; p < 0.001) compared to no-exposure. No effect was seen on fibrin-rich thrombus formation following HTP-exposure.

Conclusions: Brief HTP use in healthy young adults had immediate adverse effects on vascular function resulting in increased arterial stiffness and platelet thrombus formation, known risk factors for the development of atherosclerosis. Further research is needed to address long term health impacts.

Ort, förlag, år, upplaga, sidor
Elsevier, 2024
Nyckelord
Arterial stiffness, Heated tobacco products, Nicotine, Platelets, Thrombosis, Tobacco
Nationell ämneskategori
Kardiologi
Identifikatorer
urn:nbn:se:umu:diva-215940 (URN)10.1016/j.atherosclerosis.2023.117335 (DOI)001203215800001 ()37872010 (PubMedID)2-s2.0-85174705819 (Scopus ID)
Tillgänglig från: 2023-11-01 Skapad: 2023-11-01 Senast uppdaterad: 2024-05-14Bibliografiskt granskad
Rahman, M., Upadhyay, S., Ganguly, K., Introna, M., Ji, J., Boman, C., . . . Palmberg, L. (2023). Comparable response following exposure to biodiesel and diesel exhaust particles in advanced multicellular human lung models. Toxics, 11(6), Article ID 532.
Öppna denna publikation i ny flik eller fönster >>Comparable response following exposure to biodiesel and diesel exhaust particles in advanced multicellular human lung models
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2023 (Engelska)Ingår i: Toxics, E-ISSN 2305-6304, Vol. 11, nr 6, artikel-id 532Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Biodiesel is considered to be a sustainable alternative for fossil fuels such as petroleum-based diesel. However, we still lack knowledge about the impact of biodiesel emissions on humans, as airways and lungs are the primary target organs of inhaled toxicants. This study investigated the effect of exhaust particles from well-characterized rapeseed methyl ester (RME) biodiesel exhaust particles (BDEP) and petro-diesel exhaust particles (DEP) on primary bronchial epithelial cells (PBEC) and macrophages (MQ). The advanced multicellular physiologically relevant bronchial mucosa models were developed using human primary bronchial epithelial cells (PBEC) cultured at air–liquid interface (ALI) in the presence or absence of THP-1 cell-derived macrophages (MQ). The experimental set-up used for BDEP and DEP exposures (18 µg/cm2 and 36 µg/cm2) as well as the corresponding control exposures were PBEC-ALI, MQ-ALI, and PBEC co-cultured with MQ (PBEC-ALI/MQ). Following exposure to both BDEP and DEP, reactive oxygen species as well as the stress protein heat shock protein 60 were upregulated in PBEC-ALI and MQ-ALI. Expression of both pro-inflammatory (M1: CD86) and repair (M2: CD206) macrophage polarization markers was increased in MQ-ALI after both BDEP and DEP exposures. Phagocytosis activity of MQ and the phagocytosis receptors CD35 and CD64 were downregulated, whereas CD36 was upregulated in MQ-ALI. Increased transcript and secreted protein levels of CXCL8, as well as IL-6 and TNF-α, were detected following both BDEP and DEP exposure at both doses in PBEC-ALI. Furthermore, the cyclooxygenase-2 (COX-2) pathway, COX-2-mediated histone phosphorylation and DNA damage were all increased in PBEC-ALI following exposure to both doses of BDEP and DEP. Valdecoxib, a COX-2 inhibitor, reduced the level of prostaglandin E2, histone phosphorylation, and DNA damage in PBEC-ALI following exposure to both concentrations of BDEP and DEP. Using physiologically relevant multicellular human lung mucosa models with human primary bronchial epithelial cells and macrophages, we found BDEP and DEP to induce comparable levels of oxidative stress, inflammatory response, and impairment of phagocytosis. The use of a renewable carbon-neutral biodiesel fuel does not appear to be more favorable than conventional petroleum-based alternative, as regards of its potential for adverse health effects.

Ort, förlag, år, upplaga, sidor
MDPI, 2023
Nyckelord
biodiesel, COX-2, DNA damage, lung, MQ-ALI, oxidative stress, particles, PBEC-ALI, petro-diesel, PGE2, phagocytosis
Nationell ämneskategori
Farmakologi och toxikologi
Identifikatorer
urn:nbn:se:umu:diva-212077 (URN)10.3390/toxics11060532 (DOI)001017713500001 ()37368632 (PubMedID)2-s2.0-85163637334 (Scopus ID)
Forskningsfinansiär
Vetenskapsrådet, 2018-03233Stiftelsen Forska utan djurförsökHjärt-Lungfonden
Tillgänglig från: 2023-07-17 Skapad: 2023-07-17 Senast uppdaterad: 2023-07-17Bibliografiskt granskad
Malinovschi, A., Zhou, X., Andersson, A., Backman, H., Bake, B., Blomberg, A., . . . Engvall, J. E. (2023). Consequences of using post- or prebronchodilator reference values in interpreting spirometry. American Journal of Respiratory and Critical Care Medicine, 208(4), 461-471
Öppna denna publikation i ny flik eller fönster >>Consequences of using post- or prebronchodilator reference values in interpreting spirometry
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2023 (Engelska)Ingår i: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 208, nr 4, s. 461-471Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Rationale: Postbronchodilator spirometry is used for the diagnosis of chronic obstructive pulmonary disease. However, prebronchodilator reference values are used for spirometry interpretation.

Objectives: To compare the resulting prevalence rates of abnormal spirometry and study the consequences of using preor postbronchodilator reference values generated within SCAPIS (Swedish CArdioPulmonary bioImage Study) when interpreting postbronchodilator spirometry in a general population.

Methods: SCAPIS reference values for postbronchodilator and prebronchodilator spirometry were based on 10,156 and 1,498 never-smoking, healthy participants, respectively. We studied the associations of abnormal spirometry, defined by using pre- or postbronchodilator reference values, with respiratory burden in the SCAPIS general population (28,851 individuals).

Measurements and Main Results: Bronchodilation resulted in higher predicted medians and lower limits of normal (LLNs) for FEV1/FVC ratios. The prevalence of postbronchodilator FEV1/FVC ratio lower than the prebronchodilator LLN was 4.8%, and that of postbronchodilator FEV1/FVC lower than the postbronchodilator LLN was 9.9%, for the general population. An additional 5.1% were identified as having an abnormal postbronchodilator FEV1/FVC ratio, and this group hadmore respiratory symptoms, emphysema (13.5% vs. 4.1%; P < 0.001), and self-reported physician-diagnosed chronic obstructive pulmonary disease (2.8% vs. 0.5%, P < 0.001) than subjects with a postbronchodilator FEV1/FVC ratio greater than the LLN for both pre- and postbronchodilation.

Conclusions: Pre- and postbronchodilator spirometry reference values differ with regard to FEV1/FVC ratio. Use of postbronchodilator reference values doubled the population prevalence of airflow obstruction; this was related to a higher respiratory burden. Using postbronchodilator reference values when interpreting postbronchodilator spirometry might enable the identification of individuals with mild disease and be clinically relevant.

Ort, förlag, år, upplaga, sidor
American Thoracic Society, 2023
Nyckelord
spirometry, pre-bronchodilator, post-bronchodilator, reference values, respiratory burden
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-217871 (URN)10.1164/rccm.202212-2341OC (DOI)001055487600023 ()37339507 (PubMedID)
Forskningsfinansiär
Hjärt-LungfondenKnut och Alice Wallenbergs StiftelseVetenskapsrådetVinnovaGöteborgs universitetKarolinska InstitutetLinköpings universitetLunds universitetUmeå universitetUppsala universitetSveriges Kommuner och Regioner, SKR
Tillgänglig från: 2023-12-13 Skapad: 2023-12-13 Senast uppdaterad: 2023-12-13Bibliografiskt granskad
Lyytinen, G., Brynedal, A., Anesäter, E., Antoniewicz, L., Blomberg, A., Wallén, H., . . . Lundbäck, M. (2023). Electronic cigarette vaping with nicotine causes increased thrombogenicity and impaired microvascular function in healthy volunteers: a randomised clinical trial. Cardiovascular Toxicology, 23(7-8), 255-264
Öppna denna publikation i ny flik eller fönster >>Electronic cigarette vaping with nicotine causes increased thrombogenicity and impaired microvascular function in healthy volunteers: a randomised clinical trial
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2023 (Engelska)Ingår i: Cardiovascular Toxicology, ISSN 1530-7905, E-ISSN 1559-0259, Vol. 23, nr 7-8, s. 255-264Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Electronic cigarette (EC) vaping is increasingly popular, despite growing evidence of adverse health effects. To further evaluate the impact of EC use on vascular health, we investigated the effects of brief EC inhalation on flow-dependent thrombus formation and microcirculation in healthy volunteers. The study was performed with a randomised double-blind crossover design. Twenty-two healthy subjects aged between 18 and 45 years with occasional tobacco use were recruited. Subjects inhaled 30 puffs of EC aerosol with and without nicotine on two occasions separated by a wash-out period of at least 1 week. Blood samples were collected at baseline and at 15 and 60 min following exposure and analysed with the Total-Thrombus-formation analysis system evaluating fibrin-rich thrombus formation and platelet thrombus formation in whole blood under flow. Microvascular function was assessed at baseline and 30 min after exposure by laser speckle contrast imaging and iontophoresis of acetylcholine and sodium nitroprusside (SNP) to evaluate the endothelium-dependent and independent pathways of vasodilation. Compared with nicotine free EC aerosol, exposure to EC aerosol with nicotine significantly increased platelet thrombus formation and fibrin-rich thrombus formation at 15 min (p = 0.017 and p = 0.037, respectively) with normalisation after 60 min. Peak SNP-mediated microvascular perfusion, i.e. endothelium-independent vasodilation, was reduced following EC vaping with nicotine compared with baseline (p = 0.006). Thirty puffs of EC aerosol with nicotine increased platelet and fibrin-dependent thrombus formation and reduced microvascular dilatation capacity. No compelling effects of EC vaping without nicotine were observed, indicating nicotine as the main effector.

Trial registration: ClinicalTrials.gov Identifier: NCT04175457 URL: https://clinicaltrials.gov/ct2/show/NCT04175457.

Ort, förlag, år, upplaga, sidor
Springer Nature, 2023
Nyckelord
Coagulation, E-cigarette, Electronic cigarette, Microcirculation, Nicotine, Platelets, Thrombosis
Nationell ämneskategori
Kardiologi
Identifikatorer
urn:nbn:se:umu:diva-212844 (URN)10.1007/s12012-023-09802-9 (DOI)37548804 (PubMedID)2-s2.0-85166954236 (Scopus ID)
Forskningsfinansiär
Hjärt-LungfondenRiksförbundet HjärtLungSvenska läkaresällskapetRegion StockholmRegion VästerbottenKarolinska Institutet
Tillgänglig från: 2023-08-15 Skapad: 2023-08-15 Senast uppdaterad: 2023-10-13Bibliografiskt granskad
Olsson, M., Björkelund, A. J., Sandberg, J., Blomberg, A., Börjesson, M., Currow, D., . . . Ekström, M. (2023). Factors important for health-related quality of life in men and women: the population based SCAPIS study. PLOS ONE, 18(11), Article ID e0294030.
Öppna denna publikation i ny flik eller fönster >>Factors important for health-related quality of life in men and women: the population based SCAPIS study
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2023 (Engelska)Ingår i: PLOS ONE, E-ISSN 1932-6203, Vol. 18, nr 11, artikel-id e0294030Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: Health-related quality of life (HRQoL) is essential for human wellbeing, influenced by a complex interplay of factors, and is reported lower in women than men. We aimed to evaluate which factors were the most important for HRQoL in a middle-aged general population.

Methods: This was a cross-sectional, multi-centre study of 29,212 men (48%) and women (52%) aged 50-64 in the general population in Sweden. Physical and mental HRQoL (0-100) was assessed using the Short Form 12 questionnaire, and association was evaluated for 356 variables including demographics, lifestyle, symptoms, physiological measurements, and health conditions. Using machine learning, each variable´s importance for HRQoL was measured by an importance score, comparable to effect size, and summarised in 54 factors, in men and women separately.

Results: Men and women had similar mean and standard deviation (SD) scores for physical HRQoL (53.4 [SD 8.1] vs 51.4 [9.7]) and mental HRQoL (37.1 [5.0] vs 37.3 [5.4]). The most important factors for physical HRQoL were (importance score) physical activity (40), employment (36), pain (33), sleep (33), and sense of control (26). The most important factors for mental HRQoL were sense of control (18), physical activity (12), depression (12), pain (6), and employment (5).

Conclusions: The factors important for HRQoL identified by this study are likely to be amenable to interventions, and our findings can support prioritising interventions. The identified factors need to be a target even before middle-age to lay the foundation for long and happy lives.

Ort, förlag, år, upplaga, sidor
Public Library of Science (PLoS), 2023
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-216793 (URN)10.1371/journal.pone.0294030 (DOI)37922283 (PubMedID)2-s2.0-85176006546 (Scopus ID)
Forskningsfinansiär
Vetenskapsrådet, 2019-02081
Tillgänglig från: 2023-11-20 Skapad: 2023-11-20 Senast uppdaterad: 2023-11-20Bibliografiskt granskad
Organisationer
Identifikatorer
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