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Bjornsdottir, E., Thorarinsdottir, E. H., Lindberg, E., Benediktsdottir, B., Franklin, K. A., Jarvis, D., . . . Janson, C. (2024). Association between physical activity over a 10-year period and current insomnia symptoms, sleep duration and daytime sleepiness: a European population-based study. BMJ Open, 14(3), Article ID e067197.
Öppna denna publikation i ny flik eller fönster >>Association between physical activity over a 10-year period and current insomnia symptoms, sleep duration and daytime sleepiness: a European population-based study
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2024 (Engelska)Ingår i: BMJ Open, E-ISSN 2044-6055, Vol. 14, nr 3, artikel-id e067197Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVES: To explore the relationship between physical activity over a 10-year period and current symptoms of insomnia, daytime sleepiness and estimated sleep duration in adults aged 39-67.

DESIGN: Population-based, multicentre cohort study. SETTING: 21 centres in nine European countries.

METHODS: Included were 4339 participants in the third follow-up to the European Community Respiratory Health Survey (ECRHS III), who answered questions on physical activity at baseline (ECRHS II) and questions on physical activity, insomnia symptoms, sleep duration and daytime sleepiness at 10-year follow-up (ECRHS III). Participants who reported that they exercised with a frequency of at least two or more times a week, for 1 hour/week or more, were classified as being physically active. Changes in activity status were categorised into four groups: persistently non-active; became inactive; became active; and persistently active.

MAIN OUTCOME MEASURES: Insomnia, sleep time and daytime sleepiness in relation to physical activity.

RESULTS: Altogether, 37% of participants were persistently non-active, 25% were persistently active, 20% became inactive and 18% became active from baseline to follow-up. Participants who were persistently active were less likely to report difficulties initiating sleep (OR 0.60, 95% CI 0.45-0.78), a short sleep duration of ≤6 hours/night (OR 0.71, 95% CI 0.59-0.85) and a long sleep of ≥9 hours/night (OR 0.53, 95% CI 0.33-0.84) than persistently non-active subjects after adjusting for age, sex, body mass index, smoking history and study centre. Daytime sleepiness and difficulties maintaining sleep were not related to physical activity status.

CONCLUSION: Physically active people have a lower risk of some insomnia symptoms and extreme sleep durations, both long and short.

Ort, förlag, år, upplaga, sidor
BMJ Publishing Group Ltd, 2024
Nyckelord
epidemiology, primary care, public health, sleep medicine, sports medicine
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-223229 (URN)10.1136/bmjopen-2022-067197 (DOI)001193302200003 ()38531588 (PubMedID)2-s2.0-85189375843 (Scopus ID)
Forskningsfinansiär
Hjärt-LungfondenAstma- och AllergiförbundetForte, Forskningsrådet för hälsa, arbetsliv och välfärdRegion Västerbotten
Tillgänglig från: 2024-04-19 Skapad: 2024-04-19 Senast uppdaterad: 2024-04-19Bibliografiskt granskad
Mir Fakhraei, R., Lindberg, E., Benediktsdóttir, B., Svanes, C., Johannessen, A., Holm, M., . . . Emilsson, Ö. I. (2024). Gastroesophageal reflux and snoring are related to asthma and respiratory symptoms: Results from a Nordic longitudinal population survey. Respiratory Medicine, 221, Article ID 107495.
Öppna denna publikation i ny flik eller fönster >>Gastroesophageal reflux and snoring are related to asthma and respiratory symptoms: Results from a Nordic longitudinal population survey
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2024 (Engelska)Ingår i: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 221, artikel-id 107495Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim: To study if individuals with nocturnal gastroesophageal reflux (nGER) and habitual snoring are more likely to develop asthma and respiratory symptoms (i.e. wheeze, cough, chest tightness, breathlessness) than those without these conditions, and if these associations are additive.

Methods: We used data from the population-based prospective questionnaire study Respiratory Health in Northern Europe (RHINE) (11,024 participants), with data from 1999 and 2011. Participants with heartburn or belching after going to bed, at least 1 night/week, were considered to have nGER. Participants reporting loud snoring at least 3 nights/week were considered to have habitual snoring. Participants were grouped into four groups by their nGER and snoring status: “never”; “former”; “incident”; “persistent”. Incident respiratory symptoms were analyzed among participants without respective symptom at baseline.

Results: Snoring and nGER were independently associated with incident asthma and respiratory symptoms. The risk of incident wheeze was increased in subjects with incident or persistent snoring (adjusted odds ratio (95 % CI): 1.44 (1.21–1.72)), nGER (2.18 (1.60–2.98)) and in those with both snoring and nGER (2.59 (1.83–3.65)). The risk of developing asthma was increased in subjects with incident or persistent snoring (1.44 (1.15–1.82)), nGER (1.99 (1.35–2.93)) and in those with both snoring and nGER (1.72 (1.06–2.77)). No significant interaction was found between snoring and nGER. A similar pattern was found for the incidence of all other respiratory symptoms studied, with the highest risk among those with both incident or persistent nGER and snoring.

Conclusion: The risk of developing asthma and respiratory symptoms is increased among subjects with nGER and habitual snoring. These associations are independent of each other and confounding factors. Snoring and nGER together are additive on respiratory symptoms.

Ort, förlag, år, upplaga, sidor
Elsevier, 2024
Nyckelord
Asthma, Epidemiology, Habitual snoring, Nocturnal gastroesophageal reflux, Respiratory symptom
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-218872 (URN)10.1016/j.rmed.2023.107495 (DOI)38101459 (PubMedID)2-s2.0-85180325337 (Scopus ID)
Forskningsfinansiär
Hjärt-LungfondenAstma- och AllergiförbundetForte, Forskningsrådet för hälsa, arbetsliv och välfärdBror Hjerpstedts stiftelse
Tillgänglig från: 2024-01-05 Skapad: 2024-01-05 Senast uppdaterad: 2024-01-05Bibliografiskt granskad
Sun, S., Stenberg, E., Luo, N., Franklin, K. A., Lindholm, L., Sahlen, K.-G. & Cao, Y. (2024). SF-6D normative values among patients undergoing bariatric surgery: results based on real-world evidence from the Scandinavian obesity surgery registry (SOREG). Obesity Surgery, 34, 558-567
Öppna denna publikation i ny flik eller fönster >>SF-6D normative values among patients undergoing bariatric surgery: results based on real-world evidence from the Scandinavian obesity surgery registry (SOREG)
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2024 (Engelska)Ingår i: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 34, s. 558-567Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The SF-6D index can be used to calculate quality-adjusted life years in economic evaluations, which is required by reimbursement agencies and national advisory bodies, including the Swedish ones. However, despite that SF-36 has been largely applied among patients undergoing bariatric surgery, almost no study has accessed the short form six-dimensions (SF-6D) after bariatric surgery.

Aim: To establish normative values for the SF-6D index among patients undergoing bariatric surgery.

Materials and Methods: All patients who received bariatric surgery in Sweden between 2011–01-01 and 2019–03-31 were obtained from the Scandinavian Obesity Surgery Registry (SOReg). Information includes patients’ sociodemographic characteristics, details regarding the procedure, and postsurgical conditions. The SF-36 is applied at baseline and at follow-up years 1, 2, and 5. The multiple sequential imputation method was applied to handle missingness on SF-6D items. Based on the UK tariff, the SF-6D preference scores were calculated. The normative values for the mean (SD) SF-6D index were reported by timepoint and surgical complications for men and women, respectively. Multivariate analyses were applied to investigate how the SF-6D index is associated with timepoint, controlling for age, sex, BMI, and comorbidities in a stepwise manner.

Results: The SF-6D index increased at 1 year relative to baseline and was roughly maintained at the same level at 2 years. The normative value of the SF-6D index can be used in economic evaluations for bariatric surgery. 

Ort, förlag, år, upplaga, sidor
Springer, 2024
Nyckelord
Bariatric surgery, Health preference, Normative value, Quality-adjusted life years, Real-world data, SF-6D
Nationell ämneskategori
Kirurgi
Identifikatorer
urn:nbn:se:umu:diva-219487 (URN)10.1007/s11695-023-07024-0 (DOI)001137720100005 ()38189900 (PubMedID)2-s2.0-85181716238 (Scopus ID)
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2018–00896
Tillgänglig från: 2024-01-24 Skapad: 2024-01-24 Senast uppdaterad: 2024-05-08Bibliografiskt granskad
Ljunggren, M., Zhou, X., Theorell-Haglöw, J., Janson, C., Franklin, K. A., Emilsson, Ö. & Lindberg, E. (2024). Sleep apnea indices associated with markers of inflammation and cardiovascular disease: a proteomic study in the MUSTACHE cohort [Letter to the editor]. Annals of the American Thoracic Society, 21(1), 165-169
Öppna denna publikation i ny flik eller fönster >>Sleep apnea indices associated with markers of inflammation and cardiovascular disease: a proteomic study in the MUSTACHE cohort
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2024 (Engelska)Ingår i: Annals of the American Thoracic Society, ISSN 2329-6933, E-ISSN 2325-6621, Vol. 21, nr 1, s. 165-169Artikel i tidskrift, Letter (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
American Thoracic Society, 2024
Nationell ämneskategori
Kardiologi Annan hälsovetenskap
Identifikatorer
urn:nbn:se:umu:diva-219319 (URN)10.1513/AnnalsATS.202305-472RL (DOI)37788298 (PubMedID)2-s2.0-85181396439 (Scopus ID)
Forskningsfinansiär
Hjärt-Lungfonden, 20190218Vetenskapsrådet, 2020-02192Bror Hjerpstedts stiftelse
Anmärkning

Letter to the editor.

Tillgänglig från: 2024-01-12 Skapad: 2024-01-12 Senast uppdaterad: 2024-01-12Bibliografiskt granskad
Kisiel, M. A., Arnfelt, O., Lindberg, E., Jogi, O., Malinovschi, A., Johannessen, A., . . . Janson, C. (2023). Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study. Respiratory Medicine, 211, Article ID 107213.
Öppna denna publikation i ny flik eller fönster >>Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study
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2023 (Engelska)Ingår i: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 211, artikel-id 107213Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. Aims and objectives: We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic obstructive pulmonary disease independently from general obesity in women and men.

Methods: This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010–2012. Abdominal obesity was self-measured waist circumference using a sex-specific standard cut-off point: ≥102 cm in males and ≥88 cm in females. General obesity was defined as self-reported BMI ≥30.0 kg/m2.

Results: There were 4261 subjects (63% women) with abdominal obesity and 1837 subjects (50% women) with general obesity. Both abdominal and general obesity was independent of each other and associated with respiratory symptoms (odds ratio (OR) from 1.25 to 2.00)). Asthma was significantly associated with abdominal and general obesity in women, OR (95% CI) 1.56 (1.30–1.87) and 1.95 (1.56–2.43), respectively, but not in men, OR 1.22 (0.97–3.17) and 1.28 (0.97–1.68) respectively. A similar sex difference was found for self-reported chronic obstructive pulmonary disease.

Conclusions: General and abdominal obesity were independent factors associated with respiratory symptoms in adults. Asthma and chronic obstructive pulmonary disease were independently linked to abdominal and general obesity in women but not men.

Ort, förlag, år, upplaga, sidor
Elsevier, 2023
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-206011 (URN)10.1016/j.rmed.2023.107213 (DOI)000972687200001 ()2-s2.0-85150384769 (Scopus ID)
Tillgänglig från: 2023-03-28 Skapad: 2023-03-28 Senast uppdaterad: 2024-02-08Bibliografiskt granskad
Johansson, P. J., Crowley, P., Axelsson, J., Franklin, K., Garde, A. H., Hettiarachchi, P., . . . Svartengren, M. (2023). Development and performance of a sleep estimation algorithm using a single accelerometer placed on the thigh: an evaluation against polysomnography. Journal of Sleep Research, 32(2), Article ID e13725.
Öppna denna publikation i ny flik eller fönster >>Development and performance of a sleep estimation algorithm using a single accelerometer placed on the thigh: an evaluation against polysomnography
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2023 (Engelska)Ingår i: Journal of Sleep Research, ISSN 0962-1105, E-ISSN 1365-2869, Vol. 32, nr 2, artikel-id e13725Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Accelerometers placed on the thigh provide accurate measures of daily physical activity types, postures and sedentary behaviours, over 24 h and across consecutive days. However, the ability to estimate sleep duration or quality from thigh-worn accelerometers is uncertain and has not been evaluated in comparison with the ‘gold-standard’ measurement of sleep polysomnography. This study aimed to develop an algorithm for sleep estimation using the raw data from a thigh-worn accelerometer and to evaluate it in comparison with polysomnography. The algorithm was developed and optimised on a dataset consisting of 23 single-night polysomnography recordings, collected in a laboratory, from 15 asymptomatic adults. This optimised algorithm was then applied to a separate evaluation dataset, in which, 71 adult males (mean [SD] age 57 [11] years, height 181 [6] cm, weight 82 [13] kg) wore ambulatory polysomnography equipment and a thigh-worn accelerometer, simultaneously, whilst sleeping at home. Compared with polysomnography, the algorithm had a sensitivity of 0.84 and a specificity of 0.55 when estimating sleep periods. Sleep intervals were underestimated by 21 min (130 min, Limits of Agreement Range [LoAR]). Total sleep time was underestimated by 32 min (233 min LoAR). Our results evaluate the performance of a new algorithm for estimating sleep and outline the limitations. Based on these results, we conclude that a single device can provide estimates of the sleep interval and total sleep time with sufficient accuracy for the measurement of daily physical activity, sedentary behaviour, and sleep, on a group level in free-living settings.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2023
Nyckelord
actigraphy, activity tracker, wearables, physical activity, sedentary behaviour
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-200237 (URN)10.1111/jsr.13725 (DOI)000860314300001 ()36167935 (PubMedID)2-s2.0-85139070466 (Scopus ID)
Forskningsfinansiär
AFA Försäkring, 150159Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2021-01561Hjärt-Lungfonden, 20160343
Tillgänglig från: 2022-10-13 Skapad: 2022-10-13 Senast uppdaterad: 2024-02-08Bibliografiskt granskad
Kirkeleit, J., Riise, T., Wielscher, M., Accordini, S., Carsin, A.-E., Dratva, J., . . . Svanes, C. (2023). Early life exposures contributing to accelerated lung function decline in adulthood: a follow-up study of 11,000 adults from the general population. eClinicalMedicine, 66, Article ID 102339.
Öppna denna publikation i ny flik eller fönster >>Early life exposures contributing to accelerated lung function decline in adulthood: a follow-up study of 11,000 adults from the general population
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2023 (Engelska)Ingår i: eClinicalMedicine, E-ISSN 2589-5370, Vol. 66, artikel-id 102339Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements.

Methods: Participants (20–68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991–2013 and 1997–2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking.

Findings: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found.

Interpretation: Mothers’ smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years. 

Ort, förlag, år, upplaga, sidor
Elsevier, 2023
Nyckelord
Accelerated decline, Early life risk factors, FEV1, FEV1/FVC ratio, FVC, Lung function, Maternal asthma, Maternal smoking, Paternal asthma
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-218319 (URN)10.1016/j.eclinm.2023.102339 (DOI)2-s2.0-85179447237 (Scopus ID)
Forskningsfinansiär
EU, Horisont 2020, 633212EU, Horisont 2020, 874703Norges forskningsråd, 274767Finlands Akademi, 285547Europeiska regionala utvecklingsfonden (ERUF), 539/2010 A31592EU, Horisont 2020, 633212EU, Horisont 2020, 824989
Tillgänglig från: 2023-12-21 Skapad: 2023-12-21 Senast uppdaterad: 2024-02-08Bibliografiskt granskad
Kisiel, M. A., Sedvall, M., Malinovschi, A., Franklin, K. A., Gislason, T., Shlunssen, V., . . . Janson, C. (2023). Inflammatory bowel disease and asthma: results from the RHINE study. Respiratory Medicine, 216, Article ID 107307.
Öppna denna publikation i ny flik eller fönster >>Inflammatory bowel disease and asthma: results from the RHINE study
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2023 (Engelska)Ingår i: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 216, artikel-id 107307Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Asthma and inflammatory bowel disease (IBD) are common inflammatory diseases. The aim of this study was to investigate the associations of IBD with asthma and respiratory symptoms.

Methods: This study is based on 13,499 participants from seven northern European countries that filled in a postal questionnaire on asthma, respiratory symptoms, IBD including ulcerative colitis and Crohn's disease and various lifestyle variables.

Results: There were 195 participants with IBD. The prevalence of asthma (14.5 vs 8.1%, p = 0.001), different respiratory symptoms (range 11.9–36.8% vs range 6.0–18.6%, p < 0.005), non-infectious rhinitis (52.1 vs. 41.6%, p = 0.004) and chronic rhinosinusitis (11.6 vs 6.0%, p = 0.001) were higher in subjects with IBD than in those without IBD. In multivariable regression analysis, the association between IBD and asthma was statistically significant (OR 1.95 (95% CI 1.28–2.96)) after adjusting for confounders such as sex, BMI, smoking history, educational level and physical activity. There was a significant association between asthma and ulcerative colitis (adjusted OR 2.02 (95% CI 1.27–2.19)), and asthma but not Crohn's disease (adjusted OR 1.66 (95% CI 0.69–3.95)). A significant gender interaction was found with a significant association between IBD and asthma in women but not in men ((OR 2.72 (95% CI 1.67–4.46) vs OR 0.87 (95% CI 0.35–2.19), p = 0.038).

Conclusions: Patients with IBD, particularly those with ulcerative colitis and female, have a higher prevalence of asthma and respiratory symptoms. Our findings indicate that it is important to consider respiratory symptoms and disorders when examining patients with manifest or suspected IBD.

Ort, förlag, år, upplaga, sidor
Elsevier, 2023
Nyckelord
Asthma, Inflammatory bowel disease, Respiratory symptoms, Ulcerative colitis and Crohn's disease
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-212015 (URN)10.1016/j.rmed.2023.107307 (DOI)37271300 (PubMedID)2-s2.0-85161725846 (Scopus ID)
Tillgänglig från: 2023-07-13 Skapad: 2023-07-13 Senast uppdaterad: 2024-02-08Bibliografiskt granskad
Sun, S., Stenberg, E., Cao, Y., Lindholm, L., Sahlen, K.-G., Franklin, K. A. & Luo, N. (2023). Mapping the obesity problems scale to the SF-6D: results based on the Scandinavian Obesity Surgery Registry (SOReg). European Journal of Health Economics, 24, 279-292
Öppna denna publikation i ny flik eller fönster >>Mapping the obesity problems scale to the SF-6D: results based on the Scandinavian Obesity Surgery Registry (SOReg)
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2023 (Engelska)Ingår i: European Journal of Health Economics, ISSN 1618-7598, E-ISSN 1618-7601, Vol. 24, s. 279-292Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Obesity Problem Scale (OP) is a widely applied instrument for obesity, however currently calculation of health utility based on OP is not feasible as it is not a preference-based measure. Using data from the Scandinavian Obesity Surgery Registry (SOReg), we sought to develop a mapping algorithm to estimate SF-6D utility from OP. Furthermore, to test whether the mapping algorithm is robust to the effect of surgery.

METHOD: The source data SOReg (n = 36 706) contains both OP and SF-36, collected at pre-surgery and at 1, 2 and 5 years post-surgery. The Ordinary Least Square (OLS), beta-regression and Tobit regression were used to predict the SF-6D utility for different time points respectively. Besides the main effect model, different combinations of patient characteristics (age, sex, Body Mass Index, obesity-related comorbidities) were tested. Both internal validation (split-sample validation) and validation with testing the mapping algorithm on a dataset from other time points were carried out. A multi-stage model selection process was used, accessing model consistency, parsimony, goodness-of-fit and predictive accuracy. Models with the best performance were selected as the final mapping algorithms.

RESULTS: The final mapping algorithms were based on OP summary score using OLS models, for pre- and post-surgery respectively. Mapping algorithms with different combinations of patients' characteristics were presented, to satisfy the user with a different need.

CONCLUSION: This study makes available algorithms enabling crosswalk from the Obesity Problem Scale to the SF-6D utility. Different mapping algorithms are recommended for the mapping of pre- and post-operative data.

Ort, förlag, år, upplaga, sidor
Springer-Verlag New York, 2023
Nyckelord
Cross-walk, Health utility, Mapping, Obesity, Obesity-problem scale (OP), Quality of life (QOL), SF-6D
Nationell ämneskategori
Kirurgi
Identifikatorer
urn:nbn:se:umu:diva-202669 (URN)10.1007/s10198-022-01473-7 (DOI)000798119000001 ()35596099 (PubMedID)2-s2.0-85130222208 (Scopus ID)
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2018–00896
Tillgänglig från: 2023-01-12 Skapad: 2023-01-12 Senast uppdaterad: 2024-02-08Bibliografiskt granskad
Sun, S., Stenberg, E., Lindholm, L., Sahlen, K.-G., Franklin, K. A., Luo, N. & Cao, Y. (2023). Prediction of quality-adjusted life years (QALYs) after bariatric surgery using regularized linear regression models: results from a Swedish nationwide quality register. Obesity Surgery, 33(8), 2452-2462
Öppna denna publikation i ny flik eller fönster >>Prediction of quality-adjusted life years (QALYs) after bariatric surgery using regularized linear regression models: results from a Swedish nationwide quality register
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2023 (Engelska)Ingår i: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 33, nr 8, s. 2452-2462Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: To investigate whether the quality-adjusted life years (QALYs) of the patients who underwent bariatric surgery could be predicted using their baseline information.

Materials and Methods: All patients who received bariatric surgery in Sweden between January 1, 2011 and March 31, 2019 were obtained from the Scandinavian Obesity Surgery Registry (SOReg). Baseline information included patients' sociodemographic characteristics, details regarding the procedure, and postsurgical conditions. QALYs were assessed by the SF-6D at follow-up years 1 and 2. The general and regularized linear regression models were used to predict postoperative QALYs.

Results: All regression models demonstrated satisfactory and comparable performance in predicting QALYs at follow-up year 1, with R2 and relative root mean squared error (RRMSE) values of about 0.57 and 9.6%, respectively. The performance of the general linear regression model increased with the number of variables; however, the improvement was ignorable when the number of variables was more than 30 and 50 for follow-up years 1 and 2, respectively. Although minor L1 and L2 regularization provided better prediction ability, the improvement was negligible when the number of variables was more than 20. All the models showed poorer performance for predicting QALYs at follow-up year 2.

Conclusions: Patient characteristics before bariatric surgery including health related quality of life, age, sex, BMI, postoperative complications within six weeks, and smoking status, may be adequate in predicting their postoperative QALYs after one year. Understanding these factors can help identify individuals who require more personalized and intensive support before, during, and after surgery. 

Ort, förlag, år, upplaga, sidor
Springer, 2023
Nyckelord
Bariatric surgery, Prediction, Quality-adjusted life years, Real-world data, SF-6D
Nationell ämneskategori
Kirurgi
Identifikatorer
urn:nbn:se:umu:diva-210892 (URN)10.1007/s11695-023-06685-1 (DOI)001013018400001 ()37322243 (PubMedID)2-s2.0-85161825147 (Scopus ID)
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2018–00896
Tillgänglig från: 2023-06-28 Skapad: 2023-06-28 Senast uppdaterad: 2024-02-08Bibliografiskt granskad
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-5306-1697

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