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Mickelsson, M., Ekblom, K., Stefansson, K., Liv, P., Nyman, E., Själander, A., . . . Hultdin, J. (2024). ABO blood groups, RhD factor and their association with subclinical atherosclerosis assessed by carotid ultrasonography. Journal of Clinical Medicine, 13(5), Article ID 1333.
Öppna denna publikation i ny flik eller fönster >>ABO blood groups, RhD factor and their association with subclinical atherosclerosis assessed by carotid ultrasonography
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2024 (Engelska)Ingår i: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 13, nr 5, artikel-id 1333Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The ABO blood group system has previously been associated with cardiovascular disease (CVD), where non-O blood group individuals have shown an increased risk. Studies assessing early atherosclerotic disease while also including RhD are few. We aimed to determine whether the ABO and RhD blood groups are associated with subclinical atherosclerosis in a healthy population.

Methods: We included 3532 participants from the VIPVIZA trial with available carotid ultrasonography results to assess subclinical disease. Information about blood groups was obtained from the SCANDAT-3 database, where 85% of VIPVIZA participants were registered.

Results: RhD− individuals aged 40 years showed increased carotid intima–media thickness (B 1.09 CI 95% 1.03; 1.14) compared to RhD+ individuals. For ABO, there were no differences in ultrasonography results when assessing the whole study population. However, 60-year-old individuals with heredity for CVD and a non-O blood group had decreased odds for carotid plaques (OR 0.54 CI 95% 0.33; 0.88).

Conclusions: RhD blood group is associated with subclinical atherosclerosis in younger individuals, indicating a role as a mediator in the atherosclerotic process. In addition, a non-O blood group was associated with decreased subclinical atherosclerosis in individuals aged 60 and with heredity (corresponding to the group with the highest atherosclerotic burden).

Ort, förlag, år, upplaga, sidor
MDPI, 2024
Nyckelord
ABO blood group system, atherosclerosis, cardiovascular prevention, carotid intima–media thickness, carotid plaques, RhD factor
Nationell ämneskategori
Kardiologi Hematologi
Identifikatorer
urn:nbn:se:umu:diva-222584 (URN)10.3390/jcm13051333 (DOI)001182882700001 ()2-s2.0-85187443119 (Scopus ID)
Forskningsfinansiär
Visare Norr, Dnr 981146Region Västerbotten, ALFVLL-298001Region Västerbotten, AALFVLL-643391Vetenskapsrådet, 521-2013-2708Vetenskapsrådet, 2016-01891Hjärt-Lungfonden, 20150369Hjärt-Lungfonden, 20170481
Tillgänglig från: 2024-04-08 Skapad: 2024-04-08 Senast uppdaterad: 2024-04-08Bibliografiskt granskad
Meyer, A., Dong, C., Chan, S. S. M., Touvier, M., Julia, C., Huybrechts, I., . . . Carbonnel, F. (2024). Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis. Alimentary Pharmacology and Therapeutics, 59(4), 558-568
Öppna denna publikation i ny flik eller fönster >>Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis
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2024 (Engelska)Ingår i: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 59, nr 4, s. 558-568Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Nutri-score is now widely available in food packages in Europe.

Aim: To study the overall nutritional quality of the diet in relation to risks of Crohn's disease (CD) and ulcerative colitis (UC), in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Methods: We collected dietary data at baseline from validated food frequency questionnaires. We used a dietary index based on the UK Food Standards Agency modified nutrient profiling system (FSAm-NPS-DI) underlying the Nutri-Score label, to measure the nutritional quality of the diet. We estimated the association between FSAm-NPS-DI score, and CD and UC risks using Cox models stratified by centre, sex and age; and adjusted for smoking status, BMI, physical activity, energy intake, educational level and alcohol intake.

Results: We included 394,255 participants (68.1% women; mean age at recruitment 52.1 years). After a mean follow-up of 13.6 years, there were 184 incident cases of CD and 459 incident cases of UC. Risk of CD was higher in those with a lower nutritional quality, that is higher FSAm-NPS-DI Score (fourth vs. first quartile: aHR: 2.04, 95% CI: 1.24–3.36; p-trend: <0.01). Among items of the FSAm-NPS-DI Score, low intakes of dietary fibre and fruits/vegetables/legumes/nuts were associated with higher risk of CD. Nutritional quality was not associated with risk of UC (fourth vs. first quartile of the FSAm-NPS-DI Score: aHR: 0.91, 95% CI: 0.69–1.21; p-trend: 0.76).

Conclusions: A diet with low nutritional quality as measured by the FSAm-NPS-DI Score is associated with a higher risk of CD but not UC.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2024
Nyckelord
dietary, EPIC, FSAm-NPS DI score, inflammatory bowel disease, nutri-score
Nationell ämneskategori
Näringslära
Identifikatorer
urn:nbn:se:umu:diva-218660 (URN)10.1111/apt.17835 (DOI)001125341100001 ()38100159 (PubMedID)2-s2.0-85179951683 (Scopus ID)
Forskningsfinansiär
Cancerfonden
Tillgänglig från: 2023-12-28 Skapad: 2023-12-28 Senast uppdaterad: 2024-04-26Bibliografiskt granskad
Gil-Lespinard, M., Almanza-Aguilera, E., Castañeda, J., Guiñón-Fort, D., Eriksen, A. K., Tjønneland, A., . . . Zamora-Ros, R. (2024). Plasma concentration of 36 (poly)phenols and prospective body weight change in participants from the EPIC cohort. Annals of Nutrition and Metabolism, 80(2), 87-100
Öppna denna publikation i ny flik eller fönster >>Plasma concentration of 36 (poly)phenols and prospective body weight change in participants from the EPIC cohort
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2024 (Engelska)Ingår i: Annals of Nutrition and Metabolism, ISSN 0250-6807, E-ISSN 1421-9697, Vol. 80, nr 2, s. 87-100Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: Dietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Methods: This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons.

Results: Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (−0.53 kg/5 years; 95% confidence interval [CI]: −0.99, −0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction.

Conclusion: Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly) phenol biomarkers are needed to confirm these suggestive protective trends.

Ort, förlag, år, upplaga, sidor
S. Karger, 2024
Nyckelord
Body weight, Cohort, EPIC, Nutritional biomarker, Plasma (poly)phenol
Nationell ämneskategori
Näringslära
Identifikatorer
urn:nbn:se:umu:diva-223490 (URN)10.1159/000535803 (DOI)001198947400003 ()38272006 (PubMedID)2-s2.0-85189860401 (Scopus ID)
Forskningsfinansiär
CancerfondenVetenskapsrådetRegion VästerbottenRegion SkåneEuropeiska kommissionen, 2005328
Tillgänglig från: 2024-04-25 Skapad: 2024-04-25 Senast uppdaterad: 2024-04-29Bibliografiskt granskad
Hansén, N., Ljungberg, J., Bergdahl, I., Hultdin, J., Näslund, U., Johansson, B. & Söderberg, S. (2023). Adipokines are possible risk markers for aortic stenosis requiring surgery. Scandinavian Cardiovascular Journal, 57(1), Article ID 2247193.
Öppna denna publikation i ny flik eller fönster >>Adipokines are possible risk markers for aortic stenosis requiring surgery
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2023 (Engelska)Ingår i: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 57, nr 1, artikel-id 2247193Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: Aortic stenosis (AS) is the most prevalent valvular heart disease among adults. The adipocyte-derived hormones, leptin and adiponectin, have profound metabolic actions. We examined whether these adipokines are independently associated with future aortic valve replacement (AVR).

Design: In this longitudinal case-control study, we identified 336 cases who had undergone AVR due to AS, and who had previously participated in population-based health surveys. Two referents were matched to each case and leptin and adiponectin concentrations were analysed from stored baseline survey samples. Uni- and multivariable logistic regression analyses were used to estimate the risk of future AVR. An additional cohort was identified for validation including 106 cases with AVR and 212 matched referents.

Results: Median age (interquartile range (IQR)) in years at survey was 59.9 (10.4) and at surgery 68.3 (12.7), and 48% were women. An elevated concentration of leptin was not associated with future AVR (odds ratio [95% confidence interval]) (1.10 [0.92–1.32]), although leptin was associated with a higher risk in patients with coronary artery disease (CAD) having more than 5 years between survey and AVR (1.41 [1.08–1.84]). Adiponectin was not associated with higher risk for future AVR (0.95 [0.82–1.11]), although after stratification for age, higher levels were associated with reduced risk for AVR in persons aged ≥60 years at surgery (0.79 [0.64–0.98]). In the validation study, leptin was associated with future AVR whereas adiponectin was not. None of the associations remained significant after adjustment for body mass index (BMI).

Conclusions: The adipokine leptin may promote the development of AS.

Ort, förlag, år, upplaga, sidor
Taylor & Francis, 2023
Nyckelord
adiponectin, Aortic stenosis, fat mass, leptin, prospective study, risk markers
Nationell ämneskategori
Kardiologi
Identifikatorer
urn:nbn:se:umu:diva-214075 (URN)10.1080/14017431.2023.2247193 (DOI)001050266400001 ()37592808 (PubMedID)2-s2.0-85168287214 (Scopus ID)
Forskningsfinansiär
Hjärt-Lungfonden, 20100635Hjärt-Lungfonden, 20120631Hjärt-Lungfonden, 20140799Hjärt-Lungfonden, 20130630Region Västerbotten, RV-967561Umeå universitet, 964731
Tillgänglig från: 2023-09-04 Skapad: 2023-09-04 Senast uppdaterad: 2023-09-04Bibliografiskt granskad
Bodecker-Zingmark, L., Widbom, L., Hultdin, J., Eriksson, C. & Karling, P. (2023). Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease. Digestive Diseases and Sciences, 68, 608-615
Öppna denna publikation i ny flik eller fönster >>Anti-Saccharomyces Cerevisiae antibodies are only modestly more common in subjects later developing Crohn's disease
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2023 (Engelska)Ingår i: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 68, s. 608-615Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The pathogenic processes in the preclinical phase of inflammatory bowel disease (IBD) are mainly unknown.

Aims: To study typical antibodies for IBD in the preclinical phase in a cohort of Northern Sweden.

Methods: Antibodies typical for IBD (ASCA, pANCA, lactoferrin-ANCA, antibodies to goblet cells, and pancreas antigen) were analyzed in 123 subjects with preclinical ulcerative colitis (UC), 54 subjects with preclinical Crohn's disease (CD) and in 390 sex- and age-matched controls. In addition, in a subset of subjects, inflammatory markers (CRP, albumin, calprotectin and ferritin) were measured in plasma.

Results: The mean years between blood samples and IBD diagnosis were for UC 5.1 (SD 3.5) years and CD 5.6 (SD 3.5) years. There was no difference in the proportion of overall positive antibodies between subjects who later developed IBD compared to controls (16.9% vs. 12.3%; p = 0.137). The subjects who later developed CD had a significantly higher proportion of positive ASCA compared to controls (9.3% vs 2.8%; p = 0.034), but for all other antibodies, there were no differences compared to control subjects. Subjects with preclinical IBD and elevated antibodies showed significantly higher plasma calprotectin levels compared to subjects without antibodies (980 μg/L vs 756 μg/L; p = 0.042), but there was no difference in the levels of CRP, albumin and ferritin.

Conclusions: We found no significant increase in antibodies typical for IBD years before diagnosis except for ASCA, which was slightly more common in subjects who later developed CD. Very few subjects had detectable antibodies to goblet cells and pancreas antigen.

Ort, förlag, år, upplaga, sidor
Springer, 2023
Nyckelord
ASCA, Calprotectin, Crohn's disease, Inflammatory bowel disease, Ulcerative colitis
Nationell ämneskategori
Gastroenterologi
Identifikatorer
urn:nbn:se:umu:diva-199100 (URN)10.1007/s10620-022-07630-5 (DOI)000842443300007 ()35989383 (PubMedID)2-s2.0-85136572563 (Scopus ID)
Forskningsfinansiär
Vetenskapsrådet, VR 2017-00650Umeå universitetRegion Västerbotten
Tillgänglig från: 2022-10-14 Skapad: 2022-10-14 Senast uppdaterad: 2023-06-19Bibliografiskt granskad
Castañeda, J., Gil-Lespinard, M., Almanza-Aguilera, E., Llaha, F., Gómez, J.-H., Bondonno, N., . . . Zamora-Ros, R. (2023). Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study. Obesity, 31(4), 1146-1158
Öppna denna publikation i ny flik eller fönster >>Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study
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2023 (Engelska)Ingår i: Obesity, ISSN 1930-7381, E-ISSN 1930-739X, Vol. 31, nr 4, s. 1146-1158Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years.

Methods: A total of 349,165 men and women aged 25 to 70 years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries. Body weight was measured at baseline and at follow-up after a median time of 5 years. Polyphenol intake, including four main polyphenol classes and eighteen subclasses, was estimated using validated dietary questionnaires and Phenol-Explorer. Multilevel mixed linear regression models were used to estimate the associations.

Results: Participants gained, on average, 2.6 kg (±5.0 kg) over 5 years. Total flavonoids intake was inversely associated with body weight change (−0.195 kg/5 years, 95% CI: −0.262 to −0.128). However, the intake of total polyphenols (0.205 kg/5 years, 95% CI: 0.138 to 0.272) and intake of hydroxycinnamic acids (0.324 kg/5 years, 95% CI: 0.267 to 0.381) were positively associated with body weight gain. In analyses stratified by coffee consumption, hydroxycinnamic acid intake was positively associated with body weight gain in coffee consumers (0.379 kg/5 years, 95% CI: 0.319 to 0.440), but not in coffee nonconsumers (−0.179 kg/5 years, 95% CI: −0.490 to 0.133).

Conclusions: Higher intakes of flavonoids and their subclasses are inversely associated with a modest body weight change. Results regarding hydroxycinnamic acids in coffee consumers require further investigation.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2023
Nationell ämneskategori
Näringslära
Identifikatorer
urn:nbn:se:umu:diva-211800 (URN)10.1002/oby.23689 (DOI)000928299300001 ()36693804 (PubMedID)2-s2.0-85144985365 (Scopus ID)
Tillgänglig från: 2023-07-11 Skapad: 2023-07-11 Senast uppdaterad: 2024-03-26Bibliografiskt granskad
Söderström, E., Andersson, J., Söderberg, S., van Guelpen, B., Nilsson, T. K. & Hultdin, J. (2023). CTH G1208T and MTHFR A1298C polymorphisms are associated with a higher risk of a first myocardial infarction with fatal outcome among women. Drug Metabolism and Personalized Therapy, 38(1), 57-63
Öppna denna publikation i ny flik eller fönster >>CTH G1208T and MTHFR A1298C polymorphisms are associated with a higher risk of a first myocardial infarction with fatal outcome among women
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2023 (Engelska)Ingår i: Drug Metabolism and Personalized Therapy, ISSN 2363-8907, Vol. 38, nr 1, s. 57-63Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: Cystathionine-gamma-lyase (CSE) in the transsulfuration pathway generates hydrogen sulfide (H2S), suggested regulating cardiovascular function. The G1208T polymorphism in the CTH gene, rs1021737, has, in addition to MTHFR, been found to increase homocysteine, related to myocardial infarction (MI) risk. This study aimed, for the first time, to investigate the associations of the polymorphisms CTH G1208T, MTHFR C677T, and A1298C with the prospective risk of developing a fatal or non-fatal first MI.

Methods: This case-referent study included 545 cases later developing a first-ever MI and 1,054 referents from the Northern Sweden Health and Disease Study. Fatal MI was defined as death within 28 days after MI symptoms.

Results: Women, but not men, had a positive association between fatal MI and the CTH G1208T, odds ratio [95% confidence interval] 3.14 [1.16-8.54] for heterozygotes, and the dominant model 3.22 [1.22-8.51], and for the MTHFR A1298C heterozygotes 3.24 [1.26-8.34] and the dominant model 2.63 [1.06-6.50]. The MTHFR C677T polymorphism was not related to MI.

Conclusions: This study indicates that the minor alleles of CTH G1208T and MTHFR A1298C polymorphisms are associated with a higher risk for a fatal MI among women but not for non-fatal MI. No association was found in men.

Ort, förlag, år, upplaga, sidor
De Gruyter Open, 2023
Nationell ämneskategori
Kardiologi Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-193051 (URN)10.1515/dmpt-2022-0119 (DOI)36279151 (PubMedID)2-s2.0-85141312253 (Scopus ID)
Forskningsfinansiär
Region NorrbottenRegion VästerbottenVetenskapsrådet, 2017-00650
Anmärkning

Originally included in thesis in manuscript form. 

Tillgänglig från: 2022-03-14 Skapad: 2022-03-14 Senast uppdaterad: 2023-11-21Bibliografiskt granskad
de Man Lapidoth, J., Hultdin, J., Jonsson, A. P., Eriksson Svensson, M., Wennberg, M., Zeller, T. & Söderberg, S. (2023). Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study. BMJ Open, 13(8), Article ID e072664.
Öppna denna publikation i ny flik eller fönster >>Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study
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2023 (Engelska)Ingår i: BMJ Open, E-ISSN 2044-6055, Vol. 13, nr 8, artikel-id e072664Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.

Design: Repeated cross-sectional population-based studies.

Setting: The two Northern counties (Norr- and Västerbotten) in Sweden.

Participants: Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185).

Interventions: None.

Measures: Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFR crea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFR cysC). Renal function over time was analysed using univariable and multivariable linear regression models.

Results: Renal function, both eGFR crea and eGFR cysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFR crea and eGFR cysC (both p<0.001) after adjustment for classical cardiovascular RF.

Conclusion: Renal function has deteriorated in Northern Sweden between 1986 and 2014.

Ort, förlag, år, upplaga, sidor
BMJ Publishing Group Ltd, 2023
Nyckelord
epidemiology, nephrology, public health
Nationell ämneskategori
Urologi och njurmedicin
Identifikatorer
urn:nbn:se:umu:diva-214628 (URN)10.1136/bmjopen-2023-072664 (DOI)37648389 (PubMedID)2-s2.0-85169231018 (Scopus ID)
Forskningsfinansiär
Region VästerbottenEU, FP7, Sjunde ramprogrammet, HEALTH–F2–2011–278913
Tillgänglig från: 2023-09-25 Skapad: 2023-09-25 Senast uppdaterad: 2023-09-25Bibliografiskt granskad
Rehm, M., Rothenbacher, D., Iacoviello, L., Costanzo, S., Tunstall-Pedoe, H., Fitton, C. A., . . . Koenig, W. (2022). Chronic kidney disease and risk of atrial fibrillation and heart failure in general population-based cohorts: the BiomarCaRE project. ESC Heart Failure, 9(1), 57-65
Öppna denna publikation i ny flik eller fönster >>Chronic kidney disease and risk of atrial fibrillation and heart failure in general population-based cohorts: the BiomarCaRE project
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2022 (Engelska)Ingår i: ESC Heart Failure, E-ISSN 2055-5822, Vol. 9, nr 1, s. 57-65Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aims: Chronic kidney disease (CKD) has a complicated relationship with the heart, leading to many adverse outcomes. The aim of this study was to evaluate the relationship between CKD and the incidence of atrial fibrillation (AF) and heart failure (HF) along with mortality as a competing risk in general population cohorts. We also included an assessment of baseline biomarkers of inflammation, myocardial injury, and left ventricular dysfunction with risk of AF and HF, respectively, to shed light on the potential underlying pathophysiology.

Methods and results: This study was conducted within the BiomarCaRE project using harmonized data from 12 European population-based cohorts (n = 48 518 participants). Renal function was assessed by glomerular filtration rate estimated using the combined Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation with standardized serum creatinine (Cr) and non-standardized serum cystatin C (CysC). Incidence of AF and HF respectively, during a median follow-up of 8 years was recorded. Cox proportional hazards models were used to determine hazard ratios (HRs) for the incidence of AF and HF in CKD and the competing risk of mortality after adjustment for covariates. The mean age at baseline was 51.4 (standard deviation 12.1) years, 49% were men. Overall, 4.3% of subjects had CKD at baseline. The rate for AF was 3.8 per 1000 person-years during follow-up. The HR for AF in patients with CKD compared with patients without CKD was 1.28 (95% confidence interval 1.07–1.54) after adjustment for covariates. The rate for incident HF was 4.1 per 1000 person-years and the HR of CKD for HF was 1.71 (95% confidence interval 1.45–2.01. In subjects with CKD, N-terminal-pro-brain natriuretic peptide (NT-proBNP) showed an association with AF, whereas NT-proBNP and C-reactive protein were associated with HF.

Conclusions: Chronic kidney disease is an independent risk factor for subsequent AF and is even more closely associated with HF. In these relatively young participants with CKD, NT-proBNP was strongly associated with subsequent risk of AF. For HF, in addition, elevated levels of hs-C-reactive protein at baseline were related to incident events.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2022
Nyckelord
Atrial fibrillation, Biomarkers, Chronic kidney disease, Cohort study, General population, Heart failure
Nationell ämneskategori
Kardiologi Urologi och njurmedicin
Identifikatorer
urn:nbn:se:umu:diva-191297 (URN)10.1002/ehf2.13699 (DOI)000722619600001 ()34825788 (PubMedID)2-s2.0-85119878102 (Scopus ID)
Tillgänglig från: 2022-01-13 Skapad: 2022-01-13 Senast uppdaterad: 2023-03-24Bibliografiskt granskad
Wedekind, R., Rothwell, J. A., Viallon, V., Keski-Rahkonen, P., Schmidt, J. A., Chajes, V., . . . Scalbert, A. (2022). Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition. Clinical Nutrition, 41(8), 1735-1745
Öppna denna publikation i ny flik eller fönster >>Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
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2022 (Engelska)Ingår i: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 41, nr 8, s. 1735-1745Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed.

Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in plasma phospholipid fraction and amino acids in blood were assessed.

Results: Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were associated with the corresponding fatty acids in plasma (partial-r = 0.24) or with intake of specific foods such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain amino acids (partial-r = 0.5). Intake of most other foods and of carnitine showed little association with AC levels.

Conclusions: Our results show that determinants of ACs in blood vary according to their fatty acid moiety, and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential determinants may help interpret associations of ACs with disease risk and inform on potential dietary and lifestyle factors that might be modified for disease prevention.

Ort, förlag, år, upplaga, sidor
Elsevier, 2022
Nyckelord
Acylcarnitines, Branched-chain amino acids, Diet, Fatty acids, Metabolomics
Nationell ämneskategori
Näringslära
Identifikatorer
urn:nbn:se:umu:diva-198033 (URN)10.1016/j.clnu.2022.05.020 (DOI)000822382600013 ()2-s2.0-85133224937 (Scopus ID)
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CancerfondenVetenskapsrådet
Tillgänglig från: 2022-07-15 Skapad: 2022-07-15 Senast uppdaterad: 2023-09-05Bibliografiskt granskad
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ORCID-id: ORCID iD iconorcid.org/0000-0002-9599-0961

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