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Renman, E., Ekici, R., Sundström, M. & Lejon, K. (2022). HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse. Autoimmunity, 55(8), 520-528
Öppna denna publikation i ny flik eller fönster >>HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse
2022 (Engelska)Ingår i: Autoimmunity, ISSN 0891-6934, E-ISSN 1607-842X, Vol. 55, nr 8, s. 520-528Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

B cells have been shown to be essential for Type 1 diabetes development in the non-obese diabetic mouse, where their contribution as antigen presenting cells has been emphasised. Other important functions for B cells include surface capture of immunoglobulins and transportation of immune complexes, with subsequent endocytosis, antigen processing and antigen presentation. We have previously demonstrated that NOD B cells capture IgM and IgG immune complexes through an unknown surface molecule. In this study, we revealed the presumptive immunoglobulin-binding molecule to be HSC70. Moreover, we detected increased levels of HSC70 on NOD B cells. HSC70 has been shown to play a role in antigen processing and presentation as well as being important in several autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Due to its protein stabilising properties, increased HSC70 could contribute to enhanced self-antigen collection and presentation and thereby contribute to the development of Type 1 diabetes.

Ort, förlag, år, upplaga, sidor
Taylor & Francis, 2022
Nyckelord
B lymphocyte, HSC70, immune complex, NOD mouse, Type 1 diabetes
Nationell ämneskategori
Immunologi inom det medicinska området
Forskningsämne
immunologi
Identifikatorer
urn:nbn:se:umu:diva-199900 (URN)10.1080/08916934.2022.2117307 (DOI)000855330200001 ()36120986 (PubMedID)2-s2.0-85138421853 (Scopus ID)
Forskningsfinansiär
DiabetesfondenBarndiabetesfonden
Tillgänglig från: 2022-10-03 Skapad: 2022-10-03 Senast uppdaterad: 2022-11-29Bibliografiskt granskad
Ekici, R. (2010). B cells in Type 1 diabetes: studies on cell surface antibody binding. (Licentiate dissertation). Umeå: Umeå universitet
Öppna denna publikation i ny flik eller fönster >>B cells in Type 1 diabetes: studies on cell surface antibody binding
2010 (Engelska)Licentiatavhandling, monografi (Övrigt vetenskapligt)
Ort, förlag, år, upplaga, sidor
Umeå: Umeå universitet, 2010. s. 34
Nyckelord
typ 1 diabetes, insulin, NOD, B cell
Nationell ämneskategori
Immunologi inom det medicinska området
Forskningsämne
immunologi
Identifikatorer
urn:nbn:se:umu:diva-37376 (URN)978-91-7459-075-3 (ISBN)
Handledare
Tillgänglig från: 2010-11-08 Skapad: 2010-10-30 Senast uppdaterad: 2022-10-03Bibliografiskt granskad
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-0273-8485

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