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Martinez Gamero, CarlosORCID iD iconorcid.org/0000-0001-7652-1695
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Publikationer (4 of 4) Visa alla publikationer
Malla, S., Bhattarai, D. P., Groza, P., Melguizo-Sanchis, D., Atanasoai, I., Martinez Gamero, C., . . . Aguilo, F. (2022). ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. EMBO Reports, 23(3), Article ID e53191.
Öppna denna publikation i ny flik eller fönster >>ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
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2022 (Engelska)Ingår i: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 23, nr 3, artikel-id e53191Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The pluripotent state is not solely governed by the action of the core transcription factors OCT4, SOX2, and NANOG, but also by a series of co-transcriptional and post-transcriptional events, including alternative splicing (AS) and the interaction of RNA-binding proteins (RBPs) with defined subpopulations of RNAs. Zinc Finger Protein 207 (ZFP207) is an essential transcription factor for mammalian embryonic development. Here, we employ multiple functional analyses to characterize its role in mouse embryonic stem cells (ESCs). We find that ZFP207 plays a pivotal role in ESC maintenance, and silencing of Zfp207 leads to severe neuroectodermal differentiation defects. In striking contrast to human ESCs, mouse ZFP207 does not transcriptionally regulate neuronal and stem cell-related genes but exerts its effects by controlling AS networks and by acting as an RBP. Our study expands the role of ZFP207 in maintaining ESC identity, and underscores the functional versatility of ZFP207 in regulating neural fate commitment.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2022
Nationell ämneskategori
Cell- och molekylärbiologi
Identifikatorer
urn:nbn:se:umu:diva-191672 (URN)10.15252/embr.202153191 (DOI)000743102200001 ()35037361 (PubMedID)2-s2.0-85122763926 (Scopus ID)
Tillgänglig från: 2022-01-21 Skapad: 2022-01-21 Senast uppdaterad: 2024-04-08Bibliografiskt granskad
Martinez-Gamero, C., Malla, S. & Aguilo, F. (2021). LSD1: Expanding functions in stem cells and differentiation. Cells, 10(11), Article ID 3252.
Öppna denna publikation i ny flik eller fönster >>LSD1: Expanding functions in stem cells and differentiation
2021 (Engelska)Ingår i: Cells, E-ISSN 2073-4409, Vol. 10, nr 11, artikel-id 3252Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific deme-thylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethyl-ates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of nu-merous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory cir-cuitry underlying self-renewal and pluripotency.

Ort, förlag, år, upplaga, sidor
MDPI, 2021
Nyckelord
Differentiation, Embryonic stem cells, Epigenetics, Histone methylation, Induced pluripotent stem cells, KDM1A, LSD1, Lysine-specific demethylase, Non-his-tone substrate, Pluripotency, Self-renewal
Nationell ämneskategori
Cell- och molekylärbiologi
Forskningsämne
molekylärbiologi
Identifikatorer
urn:nbn:se:umu:diva-189925 (URN)10.3390/cells10113252 (DOI)000724414100001 ()34831474 (PubMedID)2-s2.0-85119274398 (Scopus ID)
Tillgänglig från: 2021-11-29 Skapad: 2021-11-29 Senast uppdaterad: 2023-09-05Bibliografiskt granskad
Malla, S., Kumari, K., Martinez Gamero, C., Achour, C., Mermelekas, G., Coege, A., . . . Aguilo, F.LSD1 interacts with CHD7 to regulate the chromatin landscape in mouse embryonic stem cells.
Öppna denna publikation i ny flik eller fönster >>LSD1 interacts with CHD7 to regulate the chromatin landscape in mouse embryonic stem cells
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(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Abstract [en]

 

 

 

Nationell ämneskategori
Cell- och molekylärbiologi
Forskningsämne
molekylärbiologi
Identifikatorer
urn:nbn:se:umu:diva-206717 (URN)
Tillgänglig från: 2023-04-14 Skapad: 2023-04-14 Senast uppdaterad: 2023-04-14
Malla, S., Kumari, K., Martinez Gamero, C., García-Prieto, c. A., Álvarez-Errico3, D., Stransky, S., . . . Aguilo, F.The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells.
Öppna denna publikation i ny flik eller fönster >>The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells
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(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nyckelord
LSD1, DNA methylation, DNMT1, UHRF1 and USP7
Nationell ämneskategori
Cell- och molekylärbiologi
Forskningsämne
molekylärbiologi
Identifikatorer
urn:nbn:se:umu:diva-206715 (URN)
Tillgänglig från: 2023-04-14 Skapad: 2023-04-14 Senast uppdaterad: 2023-04-14
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Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0001-7652-1695

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