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Skoglund Larsson, Linn
Publications (3 of 3) Show all publications
Engström, G., Lampa, E., Dekkers, K., Lin, Y.-T., Ahlm, K., Ahlström, H., . . . Sundström, J. (2024). Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications. European Journal of Epidemiology
Open this publication in new window or tab >>Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
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2024 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284Article in journal (Refereed) Epub ahead of print
Abstract [en]

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.

Place, publisher, year, edition, pages
Springer Nature, 2024
Keywords
Atherosclerosis, Coronary heart disease, Emphysema, Spirometry
National Category
Cardiac and Cardiovascular Systems Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-219309 (URN)10.1007/s10654-023-01088-z (DOI)001132630700001 ()38165527 (PubMedID)2-s2.0-85181226926 (Scopus ID)
Funder
EU, European Research Council, ERC-2018-STG-801965Swedish Research Council, 2019-01471Swedish Heart Lung Foundation, 20200173Swedish Heart Lung Foundation, 20190505Göran Gustafsson Foundation for Research in Natural Sciences and MedicineAxel och Signe Lagermans donationsstiftelseKnut and Alice Wallenberg FoundationVinnovaUniversity of GothenburgKarolinska InstituteRegion StockholmLinköpings universitetLund UniversityUmeå UniversityUppsala University
Available from: 2024-01-15 Created: 2024-01-15 Last updated: 2024-04-08
Bergström, G., Rosengren, A., Bacsovics Brolin, E., Brandberg, J., Cederlund, K., Engström, G., . . . Lind, L. (2023). Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS. Atherosclerosis, 373, 46-54
Open this publication in new window or tab >>Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS
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2023 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 373, p. 46-54Article in journal (Refereed) Published
Abstract [en]

Background and aims: Elevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.

Methods: We used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).

Results: The probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p < 0.001 for both sexes). However, weight increase from age 20 until mid-life was only modestly associated with coronary atherosclerosis. The association between weight gain and coronary atherosclerosis was mainly seen in men. However, no significant sex difference could be detected when adjusting for the 10-year delay in disease development in women.

Conclusions: Similar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Coronary artery calcium score, Midlife, Sex, Weight, Weight gain
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-205473 (URN)10.1016/j.atherosclerosis.2023.01.024 (DOI)001010662800001 ()36813601 (PubMedID)2-s2.0-85148722883 (Scopus ID)
Funder
Swedish Heart Lung FoundationKnut and Alice Wallenberg FoundationSwedish Research CouncilVinnovaUniversity of GothenburgKarolinska InstituteLinköpings universitetLund UniversityUmeå UniversityUppsala UniversitySwedish Heart Lung Foundation, 20180324Swedish Research Council, 2019–01140Swedish Research Council, 2018–02527AFA Insurance, 160334
Available from: 2023-03-17 Created: 2023-03-17 Last updated: 2023-09-05Bibliographically approved
Skoglund Larsson, L., Ljungberg, J., Johansson, L., Carlberg, B., Söderberg, S. & Brunström, M. (2022). Survival after surgery of the ascending aorta: a matched cohort study. European Journal of Cardio-Thoracic Surgery, 62(3)
Open this publication in new window or tab >>Survival after surgery of the ascending aorta: a matched cohort study
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2022 (English)In: European Journal of Cardio-Thoracic Surgery, ISSN 1010-7940, E-ISSN 1873-734X, Vol. 62, no 3Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Surgery of ascending aortic aneurysms is performed prophylactically or acute. The expected survival after surgery is uncertain. The goal of this study was to compare mortality in people with aortic surgery with matched controls.

METHODS: All patients undergoing ascending aortic surgery at Umeå University Hospital from 1988 to 2012, who previously participated in 1 of 3 population-based health surveys, were matched to 2 randomly selected controls from the same health survey and followed until death or until censoring on 24 August 2017, whichever came first. Mortality was calculated using the Kaplan-Meier method and the log-rank test. Cox regression analyses were made for all-cause mortality, adjusted for traditional cardiovascular risk factors. Deaths during the first 90 days after surgery and at >90 days postoperatively were studied separately.

RESULTS: The median follow-up time was 9.2 years. A total of 61 of 189 patients and 51 of 370 controls died [hazard ratio (HR) 2.77, 95% confidence interval (CI) 1.91-4.01]. Mortality was increased during the first 90 days post-surgery (HR 43.4, 95% CI 5.83-323), as well as after the first 90 days (HR 1.90, 95% CI 1.25-2.88) and after acute surgery (HR 6.05, 95% CI 2.92-12.56) as well as after elective surgery (HR 2.10, 95% CI 1.35-3.27). Among 57 surgical patients with information about cause of death, 23 (40%) died of aortic disease.

CONCLUSIONS: During follow-up, more patients died than matched controls. Findings were consistent when adjusting for traditional cardiovascular risk factors and across subgroups. Both short-term and long-term postoperative deaths were increased as well.

Place, publisher, year, edition, pages
Oxford University Press, 2022
Keywords
aortic aneurysm, aortic dissection, surgery, survival, Thoracic aorta
National Category
Surgery
Identifiers
urn:nbn:se:umu:diva-200112 (URN)10.1093/ejcts/ezac161 (DOI)000784733900001 ()35394018 (PubMedID)2-s2.0-85138458169 (Scopus ID)
Funder
Region VästerbottenSwedish Heart Lung FoundationKonung Gustaf V:s och Drottning Victorias Frimurarestiftelse
Available from: 2022-10-12 Created: 2022-10-12 Last updated: 2023-05-22Bibliographically approved
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