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Andersen, Leon
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Andersen, L., Appelblad, M., Wiklund, U., Sundström, N. & Svenmarker, S. (2023). Our initial experience of monitoring the autoregulation of cerebral blood flow during cardiopulmonary bypass. The journal of extra-corporeal technology, 55(4), 209-217
Open this publication in new window or tab >>Our initial experience of monitoring the autoregulation of cerebral blood flow during cardiopulmonary bypass
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2023 (English)In: The journal of extra-corporeal technology, ISSN 0022-1058, Vol. 55, no 4, p. 209-217Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Cerebral blood flow (CBF) is believed to be relatively constant within an upper and lower blood pressure limit. Different methods are available to monitor CBF autoregulation during surgery. This study aims to critically analyze the application of the cerebral oxygenation index (COx), one of the commonly used techniques, using a reference to data from a series of clinical registrations.

METHOD: CBF was monitored using near-infrared spectroscopy, while cerebral blood pressure was estimated by recordings obtained from either the radial or femoral artery in 10 patients undergoing cardiopulmonary bypass. The association between CBF and blood pressure was calculated as a moving continuous correlation coefficient. A COx index > 0.4 was regarded as a sign of abnormal cerebral autoregulation (CA). Recordings were examined to discuss reliability measures and clinical feasibility of the measurements, followed by interpretation of individual results, identification of possible pitfalls, and suggestions of alternative methods.

RESULTS AND CONCLUSION: Monitoring of CA during cardiopulmonary bypass is intriguing and complex. A series of challenges and limitations should be considered before introducing this method into clinical practice.

Place, publisher, year, edition, pages
EDP Sciences, 2023
Autoregulation, Cardiopulmonary bypass, Cerebral blood flow, Monitoring, Near-infrared spectroscopy
National Category
Cardiac and Cardiovascular Systems
urn:nbn:se:umu:diva-218633 (URN)10.1051/ject/2023032 (DOI)38099638 (PubMedID)2-s2.0-85179772071 (Scopus ID)
Available from: 2023-12-27 Created: 2023-12-27 Last updated: 2023-12-27Bibliographically approved

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