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Razooqi, Z., Tjellström, I., Höglund-Åberg, C., Kwamin, F., Claesson, R., Haubek, D., . . . Oscarsson, J. (2024). Association of Filifactor alocis and its RTX toxin gene ftxA with periodontal attachment loss, and in synergy with Aggregatibacter actinomycetemcomitans. Frontiers in Cellular and Infection Microbiology, 14, Article ID 1376358.
Open this publication in new window or tab >>Association of Filifactor alocis and its RTX toxin gene ftxA with periodontal attachment loss, and in synergy with Aggregatibacter actinomycetemcomitans
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2024 (English)In: Frontiers in Cellular and Infection Microbiology, E-ISSN 2235-2988, Vol. 14, article id 1376358Article in journal (Refereed) Published
Abstract [en]

The Gram-positive bacterium, Filifactor alocis is an oral pathogen, and approximately 50% of known strains encode a recently identified repeat-in-toxin (RTX) protein, FtxA. By assessing a longitudinal Ghanaian study population of adolescents (10-19 years of age; mean age 13.2 years), we recently discovered a possible correlation between deep periodontal pockets measured at the two-year follow-up, presence of the ftxA gene, and a high quantity of F. alocis. To further understand the contribution of F. alocis and FtxA in periodontal disease, we used qPCR in the present study to assess the carriage loads of F. alocis and the prevalence of its ftxA gene in subgingival plaque specimens, sampled at baseline from the Ghanaian cohort (n=500). Comparing these results with the recorded clinical attachment loss (CAL) longitudinal progression data from the two-year follow up, we concluded that carriers of ftxA-positive F. alocis typically exhibited higher loads of the bacterium. Moreover, high carriage loads of F. alocis and concomitant presence of the ftxA gene were two factors that were both associated with an enhanced prevalence of CAL progression. Interestingly, CAL progression appeared to be further promoted upon the simultaneous presence of F. alocis and the non-JP2 genotype of Aggregatibacter actinomycetemcomitans. Taken together, our present findings are consistent with the notion that F. alocis and its ftxA gene promotes CAL during periodontal disease.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024
Keywords
Filifactor alocis, FtxA, RTX toxin, Aggregatibacter actinomycetemcomitans, JP2, periodontitis, clinical attachment loss (CAL)
National Category
Clinical Medicine Infectious Medicine
Research subject
Infectious Diseases; Odontology
Identifiers
urn:nbn:se:umu:diva-222780 (URN)10.3389/fcimb.2024.1376358 (DOI)001198452500001 ()38596650 (PubMedID)2-s2.0-85189802243 (Scopus ID)
Funder
Region Västerbotten, 7003766Region Västerbotten, 7003193
Available from: 2024-03-27 Created: 2024-03-27 Last updated: 2024-04-16Bibliographically approved
Oscarsson, J., Bao, K., Shiratsuchi, A., Grossmann, J., Wolski, W., Aung, K. M., . . . Bostanci, N. (2024). Bacterial symbionts in oral niche use type VI secretion nanomachinery for fitness increase against pathobionts. iScience, Article ID 109650.
Open this publication in new window or tab >>Bacterial symbionts in oral niche use type VI secretion nanomachinery for fitness increase against pathobionts
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2024 (English)In: iScience, ISSN 2589-0042, article id 109650Article in journal (Refereed) Published
Abstract [en]

Microbial ecosystems experience spatial and nutrient restrictions, leading to the coevolution of cooperation and competition among cohabiting species. To increase their fitness for survival, bacteria exploit machinery to antagonizing rival species upon close contact. As such, the bacterial type VI secretion system (T6SS) nanomachinery, typically expressed by pathobionts, can transport proteins directly into eukaryotic or prokaryotic cells, consequently killing cohabiting competitors. Here we demonstrate first time that oral symbiont Aggregatibacter aphrophilus possesses a T6SS and can eliminate its close relative oral pathobiont Aggregatibacter actinomycetemcomitans using its T6SS. These findings bring newer the anti-bacterial prospects of symbionts against cohabiting pathobionts while introducing presence of an active T6SS in the oral cavity.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Pathobiont, aggregatibacter species, Type VI secretion system
National Category
Infectious Medicine Dentistry
Research subject
Microbiology
Identifiers
urn:nbn:se:umu:diva-223048 (URN)10.1016/j.isci.2024.109650 (DOI)2-s2.0-85190136052 (Scopus ID)
Funder
Swedish Research Council, 2022-010
Available from: 2024-04-09 Created: 2024-04-09 Last updated: 2024-04-22Bibliographically approved
Johansson, A. & Hedberg, M. E. (2024). Fermented rye bran as biocide replacement in paper production. In: Marzena Smol (Ed.), 4th international conference strategies toward green deal implementation water, raw materials & energy: Abstract book. Paper presented at 4th International Conference Strategies toward Green Deal Implementation Water, Raw Materials & Energy, Online conference, 14-15 December, 2023. (pp. 78-78). Cracow: Publishing House, Mineral and Energy Economy Research Institute, Polish Academy of Sciences
Open this publication in new window or tab >>Fermented rye bran as biocide replacement in paper production
2024 (English)In: 4th international conference strategies toward green deal implementation water, raw materials & energy: Abstract book / [ed] Marzena Smol, Cracow: Publishing House, Mineral and Energy Economy Research Institute, Polish Academy of Sciences , 2024, p. 78-78Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Microbial contamination causes environmental and costly problems in paper production. Today, chemical-based biocides are used to control these problems. We have developed a biocide substitute that consists of fermented rest products from the cereal industry. Rye bran is a suitable nutrient for growth of a selected strain of Lactiplantibacillus plantarum. Previous studies have shown that fermented rye bran contains bioactive metabolites that powerfully limit virtually all bacterial growth. The cereals also contain fibres with potential to be a supplement in the raw material (pulp) of paper production. Our intention with this study was to investigate the potential of fermented rye bran as an antibacterial raw material in paper production. We will specifically determine the antibacterial effect of fermented rye bran on bacterial strains isolated from pulp and process water at a paper mill. In addition, to analyse the effect of the single metabolites discovered in the fermented rye bran. The results showed that fermented rye bran inhibited growth of the majority of the bacterial strains isolated from the paper mill. The pure metabolites showed also antibacterial properties, but less potent in comparison to the crude fermented rye bran product. The Lactobacillus strain used in the present study was resistant to all the tested metabolites. In conclusion, fermented rye bran shows properties indicating potential to be used as a bioactive raw material, limiting the need to add antimicrobial chemicals in paper production

Place, publisher, year, edition, pages
Cracow: Publishing House, Mineral and Energy Economy Research Institute, Polish Academy of Sciences, 2024
Keywords
Paper production, Lactoplantibacillus plantarum, fermentation, rye bran, antimicrobials
National Category
Biological Sciences Food Science Environmental Sciences
Research subject
environmental change
Identifiers
urn:nbn:se:umu:diva-221714 (URN)978-83-67606-27-1 (ISBN)
Conference
4th International Conference Strategies toward Green Deal Implementation Water, Raw Materials & Energy, Online conference, 14-15 December, 2023.
Available from: 2024-03-03 Created: 2024-03-03 Last updated: 2024-03-04Bibliographically approved
Johansson, A. & Hedberg, M. E. (2024). Industrial rest materials as biocide replacement in paper production. In: Research workshop on bacillus in clinical and agricultural environments: . Paper presented at Research Workshop on Bacillus in Clinical and Agricultural Environments, Umeå, Sweden, February 29 February - March 1, 2024 (pp. 15-15). German Multidisciplinary Publishing Center
Open this publication in new window or tab >>Industrial rest materials as biocide replacement in paper production
2024 (English)In: Research workshop on bacillus in clinical and agricultural environments, German Multidisciplinary Publishing Center , 2024, p. 15-15Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Microbial contamination causes environmental and costly problems in paper production (gas formation in stored pulp, and biofilm/slime) and waste water systems (biofilm formation causing corrosion of the pipes). Today, chemical-based biocides are used to control these problems. We have developed a biocide substitute consisting of industrial rest products; rye bran or spruce bark. Rye bran is a suitable nutrient for growth of a selected strain of Lactiplantibacillus plantarum. Previous studies have shown that fermented rye bran, as well as spruce bark extracts, contains bioactive metabolites with the power to limit virtually all bacterial growth. These products also contain fibres with potential to be a supplement as raw material in the pulp.

Our intention with this study was to investigate the potential of these rest materials as an antibacterial raw material in paper production. We will specifically determine the antibacterial effect on strains isolated from pulp, process water from the paper mill, and waste water pipes. In addition, likewise analyse the antimicrobial activity of single metabolites discovered in the crude extracts. The results so far, show that the products efficiently inhibit growth of the bacterial strains isolated from waste water and the paper mill. The pure metabolites showed also antibacterial properties, but were less potent as compared to the crude products. The Lactiplantiobacillus strain, used to ferment the rye bran in the present study, was resistant to all the tested products.

In conclusion, fermented rye bran and spruce bark extracts show properties indicating a potential to be used as a bioactive raw material, limiting the need of adding synthetic biocides in paper production and waste water systems.

Place, publisher, year, edition, pages
German Multidisciplinary Publishing Center, 2024
Series
GMPC thesis & opinions platform, E-ISSN 2747-5735 ; 2024:4(1)
Keywords
Paper production, Lactiplantibacillus plantarum, fermentation, rye bran, spruce bark extracts, biocide replacement
National Category
Agricultural Biotechnology
Research subject
biological chemistry
Identifiers
urn:nbn:se:umu:diva-221715 (URN)10.51585/gtop.2024.1.0036 (DOI)
Conference
Research Workshop on Bacillus in Clinical and Agricultural Environments, Umeå, Sweden, February 29 February - March 1, 2024
Available from: 2024-03-03 Created: 2024-03-03 Last updated: 2024-03-26Bibliographically approved
Widerström, M., Mörtberg, S., Magnusson, M., Fjällström, P. & Johansson, A. (2024). Treatment outcome of severe respiratory type B tularemia using fluoroquinolones. Clinical Infectious Diseases, 78, S38-S46
Open this publication in new window or tab >>Treatment outcome of severe respiratory type B tularemia using fluoroquinolones
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2024 (English)In: Clinical Infectious Diseases, ISSN 1058-4838, E-ISSN 1537-6591, Vol. 78, p. S38-S46Article in journal (Refereed) Published
Abstract [en]

Background: Fluoroquinolones lack approval for treatment of tularemia but have been used extensively for milder illness. Here, we evaluated fluoroquinolones for severe illness.

Methods: In an observational study, we identified case-patients with respiratory tularemia from July to November 2010 in Jämtland County, Sweden. We defined severe tularemia by hospitalization for >24 hours and severe bacteremic tularemia by Francisella tularensis subsp. holarctica growth in blood or pleural fluid. Clinical data and drug dosing were retrieved from electronic medical records. Chest images were reexamined. We used Kaplan-Meier curves to evaluate time to defervescence and hospital discharge.

Results: Among 67 case-patients (median age, 66 years; 81% males) 30-day mortality was 1.5% (1 of 67). Among 33 hospitalized persons (median age, 71 years; 82% males), 23 had nonbacteremic and 10 had bacteremic severe tularemia. Subpleural round consolidations, mediastinal lymphadenopathy, and unilateral pleural fluid were common on chest computed tomography. Among 29 hospitalized persons with complete outcome data, ciprofloxacin/levofloxacin (n = 12), ciprofloxacin/levofloxacin combinations with doxycycline and/or gentamicin (n = 11), or doxycycline as the single drug (n = 6) was used for treatment. One disease relapse occurred with doxycycline treatment. Treatment responses were rapid, with median fever duration 41.0 hours in nonbacteremic and 115.0 hours in bacteremic tularemia. Increased age-adjusted Charlson comorbidity index predicted severe bacteremic tularemia (odds ratio, 2.7 per score-point; 95% confidence interval, 1.35-5.41). A 78-year-old male with comorbidities and delayed ciprofloxacin/gentamicin treatment died.

Conclusions: Fluoroquinolone treatment is effective for severe tularemia. Subpleural round consolidations and mediastinal lymphadenopathy were typical findings on computed tomography among case-patients in this study.

Place, publisher, year, edition, pages
Oxford University Press, 2024
Keywords
computed tomography, fluoroquinolone/therapeutic use, treatment outcome, tularemia/drug therapy, X ray
National Category
Infectious Medicine
Identifiers
urn:nbn:se:umu:diva-220852 (URN)10.1093/cid/ciad690 (DOI)001154832000010 ()38294118 (PubMedID)2-s2.0-85183755279 (Scopus ID)
Funder
Region Jämtland HärjedalenRegion Västerbotten
Note

Special issue, supplement_1

Available from: 2024-02-20 Created: 2024-02-20 Last updated: 2024-02-20Bibliographically approved
Claesson, R., Johansson, A. & Belibasakis, G. N. (2023). Age-related subgingival colonization of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and parvimonas micra: a pragmatic microbiological retrospective report. Microorganisms, 11(6), Article ID 1434.
Open this publication in new window or tab >>Age-related subgingival colonization of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and parvimonas micra: a pragmatic microbiological retrospective report
2023 (English)In: Microorganisms, E-ISSN 2076-2607, Vol. 11, no 6, article id 1434Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to compare data about the prevalence and proportions of the bacterial species Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Parvimonas micra in periodontitis pocket samples collected from young, <35 years, and old, >35-year-old patients, YP and OP, respectively. The results from the analyses of a total of 3447 subgingival plaque samples analyzed for clinical diagnosis purposes by cultivation regarding the proportions of these species were collected from a database and elucidated. The prevalence of A. actinomycetemcomitans was found to be more than twice as high (OR = 2.96, 95% CI; 2.50–3.50) in samples from the younger (42.2%) than the older group (20.4%) (p < 0.001). The prevalence of P. micra was significantly lower in samples from the younger age group (OR = 0.43, 95%) (p < 0.001), whereas P. gingivalis was similarly distributed (OR = 0.78, 95%) in the two age groups (p = 0.006). A similar pattern was noticed for A. actinomycetemcomitans and P. gingivalis when high proportions (>50%) of the samples of these bacterial species were elucidated. In contrast, the proportion of samples containing >50% with P. micra was lower compared with the two other bacterial species. Furthermore, it was noted that the proportion of samples from old patients containing A. actinomycetemcomitans in combination with P. micra was almost three times higher than in samples when P. micra was replaced by P. gingivalis. In conclusion, A. actinomycetemcomitans showed an increased presence and proportion in samples from young patients compared with the old patients, while P. gingivalis was similarly distributed in the two age groups. P. micra showed an increased presence and proportion in samples from old patients compared with the young patients.

Place, publisher, year, edition, pages
Basel: MDPI, 2023
Keywords
periodontitis, age-related, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Parvimonas micra
National Category
Dentistry
Research subject
Odontology; Microbiology
Identifiers
urn:nbn:se:umu:diva-209102 (URN)10.3390/microorganisms11061434 (DOI)001014582300001 ()37374936 (PubMedID)2-s2.0-85163798066 (Scopus ID)
Funder
Region Västerbotten, 7003193
Available from: 2023-06-06 Created: 2023-06-06 Last updated: 2023-07-18Bibliographically approved
Martinsson, K., Di Matteo, A., Öhman, C., Johansson, A., Anna, S., Kluuver, M., . . . Kastbom, A. (2023). Antibodies to leukotoxin A from the periodontal pathogen Aggregatibacter actinomycetemcomitans in patients at an increased risk of rheumatoid arthritis. Frontiers in Medicine, 10, Article ID 1176165.
Open this publication in new window or tab >>Antibodies to leukotoxin A from the periodontal pathogen Aggregatibacter actinomycetemcomitans in patients at an increased risk of rheumatoid arthritis
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2023 (English)In: Frontiers in Medicine, E-ISSN 2296-858X, Vol. 10, article id 1176165Article in journal (Refereed) Published
Abstract [en]

Objectives: Periodontitis and underlying bacteria have been linked to the development of rheumatoid arthritis (RA). One suggested pathogen is Aggregatibacter actinomycetemcomitans (A.a.), which expresses leukotoxin A (LtxA) that can citrullinate human proteins, providing a possible trigger for the production of anti-citrullinated protein antibodies (ACPA). In this study, we seek to determine the presence of antibodies toward LtxA in patients at risk of developing RA.

Methods: Two prospective observational patient cohorts (one Swedish and one British) with symptomatic at-risk patients were studied. Anti-LtxA antibodies were analyzed by a cell-based neutralization assay in baseline serum and compared to 100 Swedish blood donors that served as controls.

Results: Serum anti-LtxA levels or positivity did not differ between patients and blood donors. In the British cohort, anti-LtxA was more prevalent among ACPA-positive arthralgia patients compared with ACPA-negative arthralgia cases (24% vs. 13%, p < 0.0001). In the Swedish at-risk cohort, anti-LtxA positive patients were at increased risk of progression to arthritis (hazard ratio (HR) 2.10, 95% CI 1.04–4.20), but this was not confirmed in the UK at-risk cohort (HR 0.99, CI 0.60–1.65).

Conclusion: Serum anti-LtxA is not elevated before RA diagnosis, and associations with disease progression and ACPA levels differ between populations. Other features of the oral microbiome should be explored in upcoming periodontitis-related RA research.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
ACPA, Aggregatibacter actinomycetemcomitans, rheumatoid arthritis, progression, periodontitis
National Category
Rheumatology and Autoimmunity Dentistry
Research subject
rheumatology; Odontology
Identifiers
urn:nbn:se:umu:diva-212538 (URN)10.3389/fmed.2023.1176165 (DOI)001049460600001 ()37601773 (PubMedID)2-s2.0-85168358474 (Scopus ID)
Funder
Swedish Society of MedicineSwedish Research CouncilSwedish Rheumatism AssociationStiftelsen Konung Gustaf V:s 80-årsfond
Available from: 2023-08-03 Created: 2023-08-03 Last updated: 2023-08-29Bibliographically approved
Belibasakis, G. N., Belstrøm, D., Eick, S., Gursoy, U. K., Johansson, A. & Könönen, E. (2023). Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives. Periodontology 2000
Open this publication in new window or tab >>Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives
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2023 (English)In: Periodontology 2000, ISSN 0906-6713, E-ISSN 1600-0757Article in journal (Refereed) Epub ahead of print
Abstract [en]

This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis-centered interpretation. Reference is made to anerobic microbiology and to the discovery of select periodontal pathogens and their virulence factors, as well as to biofilms. The evolution of contemporary molecular methods and high-throughput platforms is highlighted in appreciating the breadth and depth of the periodontal microbiome. Finally clinical microbiology is brought into perspective with the contribution of different microbial species in periodontal diagnosis, the combination of microbial and host biomarkers for this purpose, and the use of antimicrobials in the treatment of the disease.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2023
Keywords
Infectious Diseases, Microbiology (medical), Immunology, Microbiology, Periodontitis
National Category
Dentistry Infectious Medicine
Research subject
Odontology
Identifiers
urn:nbn:se:umu:diva-203841 (URN)10.1111/prd.12473 (DOI)000916606400001 ()36661184 (PubMedID)2-s2.0-85147022674 (Scopus ID)
Available from: 2023-01-20 Created: 2023-01-20 Last updated: 2023-02-17Bibliographically approved
Lindholm, M., Claesson, R., Löf, H., Chiang, H.-M., Oscarsson, J., Johansson, A. & Höglund-Åberg, C. (2023). Radiographic and clinical signs of periodontitis and associated bacterial species in a Swedish adolescent population. Journal of Periodontology, 94(5), 630-640
Open this publication in new window or tab >>Radiographic and clinical signs of periodontitis and associated bacterial species in a Swedish adolescent population
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2023 (English)In: Journal of Periodontology, ISSN 0022-3492, E-ISSN 1943-3670, Vol. 94, no 5, p. 630-640Article in journal (Refereed) Published
Abstract [en]

Background: Periodontitis in adolescents has historically been rare in the Nordic countries but could be expected to increase due to changes in demographics. The primary aim was to cross-sectionally examine the presence of radiographic bone loss in adolescents in Västerbotten County, Sweden. The secondary aim was to compare periodontal and microbial parameters, as well as demographic patterns, in controls without bone loss with cases with bone loss.

Methods: Adolescents born 2001 and who had a dental examination 2016 (n = 1656) were screened for proximal bone loss using bitewing radiographs taken during dental examinations (2014-2016). Individuals that exhibited proximal bone loss (> 2 mm) were invited to participate in a complete periodontal examination. Subgingival plaque and saliva were also sampled. For each adolescent with bone loss, two healthy individuals as controls were examined. Selected bacterial species in saliva and subgingival plaque were quantitatively examined by quantitative PCR. The subgingival plaque samples were also analysed with cultivation technique.

Results: Proximal bone loss was identified in 24 individuals (1.45%) based on all the radiographs. Thirteen of these cases were periodontally examined and matched with 26 controls. Most cases were diagnosed with periodontitis (12/13 [92%]), whereas none of the controls had periodontitis. Higher concentrations and higher prevalence of the bacteria Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Filifactor alocis were generally found in the cases.

Conclusion:The results suggest that periodontitis among adolescents, because of demographic differences (an increasingly heterogenous population), in Sweden is increasing and emphasizes the importance of radiographs for early detection of this disease.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023
National Category
Dentistry
Identifiers
urn:nbn:se:umu:diva-200254 (URN)10.1002/JPER.22-0453 (DOI)000900264200001 ()36413341 (PubMedID)2-s2.0-85144377232 (Scopus ID)
Funder
Region Västerbotten, 7002667Region Västerbotten, 7003193
Note

Originally included in thesis in manuscript form. 

Available from: 2022-10-13 Created: 2022-10-13 Last updated: 2023-07-14Bibliographically approved
Razooqi, Z., Höglund-Åberg, C., Kwamin, F., Claesson, R., Haubek, D., Oscarsson, J. & Johansson, A. (2022). Aggregatibacter actinomycetemcomitans and Filifactor alocis as associated with periodontal attachment loss in a cohort of ghanaian adolescents. Microorganisms, 10(12), Article ID 2511.
Open this publication in new window or tab >>Aggregatibacter actinomycetemcomitans and Filifactor alocis as associated with periodontal attachment loss in a cohort of ghanaian adolescents
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2022 (English)In: Microorganisms, E-ISSN 2076-2607, Vol. 10, no 12, article id 2511Article in journal (Refereed) Published
Abstract [en]

The aims of the present study were to document the presence of Aggregatibacter actinomyctemcomitans and the emerging oral pathogen Filifactor alocis, as well as to identify genotypes of these bacterial species with enhanced virulence. In addition, these data were analyzed in relation to periodontal pocket depth (PPD) and the progression of PPD from the sampled periodontal sites during a two-year period. Subgingival plaque samples were collected from 172 periodontal pockets of 68 Ghanaian adolescents. PPD at sampling varied from 3–14 mm and the progression from baseline, i.e., two years earlier up to 8 mm. The levels of A. actinomycetemcomitans and F. alocis were determined with quantitative PCR. The highly leukotoxic JP2-genotype of A. actinomycetemcomitans and the ftxA a gene of F. alocis, encoding a putative Repeats-in-Toxin (RTX) protein, were detected with conventional PCR. The prevalence of A. actinomycetemcomitans was 57%, and 14% of the samples contained the JP2 genotype. F. alocis was detected in 92% of the samples and the ftxA gene in 52%. The levels of these bacterial species were significantly associated with enhanced PPD and progression, with a more pronounced impact in sites positive for the JP2 genotype or the ftxA gene. Taken together, the results indicate that the presence of both A. actinomycetemcomitans and F. alocis with their RTX proteins are linked to increased PPD and progression of disease.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
periodontitis; adolescents; Aggregatibacter actinomycetemcomitans; Filifactor alocis; RTX proteins
National Category
Dentistry Microbiology
Research subject
Microbiology; Odontology
Identifiers
urn:nbn:se:umu:diva-201839 (URN)10.3390/microorganisms10122511 (DOI)000902757700001 ()36557764 (PubMedID)2-s2.0-85144648921 (Scopus ID)
Funder
Region Västerbotten, 7003193Region Västerbotten, 7003766
Available from: 2022-12-20 Created: 2022-12-20 Last updated: 2023-09-05Bibliographically approved
Projects
Microbial interference as biocide in paper production ans waste water system [P44220-1_Energi]; Umeå University
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-8069-8263

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