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Publications (10 of 135) Show all publications
Byhamre, M. L., Eliasson, M., Söderberg, S., Wennberg, P. & Oskarsson, V. (2023). Association between snus use and lipid status in Swedish men. Scandinavian Journal of Clinical and Laboratory Investigation, 83(4), 241-250
Open this publication in new window or tab >>Association between snus use and lipid status in Swedish men
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2023 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 83, no 4, p. 241-250Article in journal (Refereed) Published
Abstract [en]

Snus is a common tobacco product in Sweden, but the cardiovascular risk profile for snus users is less known than for cigarette smokers. We examined the association of snus use with lipid status, particularly in comparison to non-tobacco use and cigarette smoking, using data from 5930 men in the Northern Sweden MONICA study. Tobacco use was self-reported in 1986 to 2014 (24.4% used snus) and blood samples were collected at the same time. Harmonized analyses on non-high-density lipoprotein (non-HDL) cholesterol, HDL cholesterol, and triglycerides were conducted in 2016 to 2018. Three hundred eighty-one snus users had also been examined more than once, allowing us to study the effect of discontinued use (achieved by 21.0%). In multivariable linear regression models, snus use was associated with higher HDL cholesterol and triglyceride concentrations compared to non-tobacco use (p values ≤ 0.04), and it was associated with higher HDL cholesterol concentrations and lower triglyceride concentrations compared to cigarette smoking (p values ≤ 0.02). Snus use was not associated with non-HDL cholesterol concentrations, irrespective of the comparison group (p values ≥ 0.07). There was no indication that higher intensity of snus use led to a worse lipid profile, given that high-consumers had higher HDL cholesterol concentrations than low-consumers (p value = 0.02), or that discontinuation of snus use led to a better lipid profile, given that continued users had lower triglyceride concentrations than discontinued users (p value = 0.03). Further studies are needed to confirm or refute our findings.

Place, publisher, year, edition, pages
Taylor & Francis, 2023
Keywords
apolipoproteins, cholesterol, cigarettes, lipids, smokeless tobacco, snus, Tobacco, triglycerides
National Category
Public Health, Global Health, Social Medicine and Epidemiology Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-209125 (URN)10.1080/00365513.2023.2209915 (DOI)000986159300001 ()2-s2.0-85159146553 (Scopus ID)
Funder
Norrbotten County CouncilRegion VästerbottenRegion VästernorrlandUmeå University
Available from: 2023-06-07 Created: 2023-06-07 Last updated: 2023-09-28Bibliographically approved
Lieber, I., Ott, M., Lundqvist, R., Eliasson, M. & Werneke, U. (2023). Incidence of hyperthyroidism in patients with bipolar or schizoaffective disorder with or without lithium: 21-year follow-up from the LiSIE retrospective cohort study. Therapeutic Advances in Psychopharmacology, 13, Article ID 20451253231151514.
Open this publication in new window or tab >>Incidence of hyperthyroidism in patients with bipolar or schizoaffective disorder with or without lithium: 21-year follow-up from the LiSIE retrospective cohort study
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2023 (English)In: Therapeutic Advances in Psychopharmacology, ISSN 2045-1253, E-ISSN 2045-1261, Vol. 13, article id 20451253231151514Article in journal (Refereed) Published
Abstract [en]

Background: Lithium-associated hyperthyroidism is much rarer than lithium-associated hypothyroidism. Yet, it may be of substantial clinical significance for affected individuals. For instance, lithium-associated hyperthyroidism could destabilise mood, mimic manic episodes and impact physical health. Only few studies have explored incidence rates of lithium-associated hyperthyroidism. Even fewer studies have compared incidence rates according to lithium exposure history.

Objectives: To determine the impact of lithium treatment on the incidence rate of hyperthyroidism in patients with bipolar or schizoaffective disorder and assess its aetiology.

Design: This study is part of the LiSIE (Lithium - Study into Effects and Side Effects) retrospective cohort study.

Methods: Between 1997 and 2017, patients in the Swedish region of Norrbotten with a diagnosis of bipolar or schizoaffective disorder were screened for all episodes of overt hyperthyroidism in form of thyrotoxicosis or thyroiditis. Incidence rates of episodes of hyperthyroidism per 1000 person-years (PY) were compared in relation to lithium exposure; concurrent, previous, or no exposure ever (lithium-naïve patients).

Results: In 1562 patients, we identified 16 episodes of hyperthyroidism corresponding to an incidence rate of 0.88 episodes per 1000 PY. Ninety-four percent of episodes had occurred in women. Patients who had concurrently been exposed to lithium, had an incidence rate of 1.35 episodes per 1000 PY. Patients who had previously been exposed to lithium had an incidence rate of 0.79 per 1000 PY. Patients who had never been exposed to lithium had an incidence rate of 0.47 per 1000 PY. There were no significant differences in the risk ratios for patients with concurrent or previous exposure compared with lithium-naïve patients, neither for hyperthyroidism overall, thyrotoxicosis, or thyroiditis.

Conclusion: Lithium-associated hyperthyroidism seems uncommon. The risk of hyperthyroidism does not seem significantly higher in patients with current or previous lithium exposure than in lithium-naïve patients.

Place, publisher, year, edition, pages
Sage Publications, 2023
Keywords
bipolar disorder, hyperthyroidism, incidence rate, lithium, schizoaffective disorder, thyroiditis, thyrotoxicosis
National Category
Psychiatry Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-203909 (URN)10.1177/20451253231151514 (DOI)000928749700001 ()36776622 (PubMedID)2-s2.0-85174272670 (Scopus ID)
Funder
Visare Norr, 847881Visare Norr, 939391
Note

Originally included in thesis in manuscript form.

Available from: 2023-01-23 Created: 2023-01-23 Last updated: 2023-10-27Bibliographically approved
Lieber, I., Van Der Feltz-Cornelis, C. M., Razvi, S., Moriarty, A. S., Wilkes, S., Ott, M., . . . Werneke, U. (2023). Treating subclinical hypothyroidism in individuals with or without mental health problems – a Delphi based expert consensus study in two countries. Frontiers in Endocrinology, Article ID 1204842.
Open this publication in new window or tab >>Treating subclinical hypothyroidism in individuals with or without mental health problems – a Delphi based expert consensus study in two countries
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2023 (English)In: Frontiers in Endocrinology, E-ISSN 1664-2392, article id 1204842Article in journal (Refereed) Published
Abstract [en]

Background: Subclinical hypothyroidism (SCH) is a common endocrine problem with prevalence estimates between 4% and 20%. Symptoms are often non-specific but can substantially affect well-being leading to repeated medical consultations. The effect of thyroid hormone replacement therapy (THRT) in patients with SCH remains uncertain. Current guidelines, limited by the lack of high-quality evidence, have been controversial with limited adherence in clinical practice.

Methods: Three-round modified Delphi method to establish consensus regarding diagnosis and treatment of individuals with SCH with and without affective disorder or anxiety, conducted with clinicians from three specialties, general practice, endocrinology and psychiatry, and two countries, Sweden and the United Kingdom.

Results: Sixty clinicians, 20 per specialty, were recruited. Fifty-three (88%) participants completed all three rounds. The participants reached consensus on five of the 26 practice statements that (a) repeated testing was required for the diagnosis of subclinical hypothyroidism, (b) antibody screening should usually occur, and (c and d) antibody screening would strengthen the indication for thyroid hormone replacement therapy in both individuals with or without affective disorder or anxiety. The participants disagreed with (e) a requirement of a TSH threshold ≥ 20 mIU/L for thyroid hormone replacement therapy start. Psychiatrists and GPs but not endocrinologists, agreed that there was a frequent discrepancy between laboratory results and clinical symptoms, and disagreed that testing for thyroid dysfunction was overused in patients presenting with depression or anxiety, or fatigue.

Conclusions: In many aspects, attitudes toward diagnosing and treating SCH remain diverse. The inability of our Delphi panel to achieve consensus on most items and the disagreement with a TSH ≥ 20 mIU/L threshold for treatment suggest that the concept of SCH may need rethinking with a better understanding of the hypothalamic-pituitary-thyroid physiology. Given that the scientific evidence is currently not conclusive, guidelines in this area should not be taken as definitive.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
subclinical hypothyroidism, TSH, affective disorder, Delphi method, consensus, practice guideline, thyroxine, diagnosis
National Category
Psychiatry
Identifiers
urn:nbn:se:umu:diva-203908 (URN)10.3389/fendo.2023.1204842 (DOI)001035764500001 ()37501790 (PubMedID)2-s2.0-85165991855 (Scopus ID)
Funder
Visare Norr, VISARENORR968201Norrbotten County Council, NLL-969485
Note

Originally included in thesis in manuscript form.

Available from: 2023-01-23 Created: 2023-01-23 Last updated: 2024-01-17Bibliographically approved
Törmä, J., Lundqvist, R., Eliasson, M., Nilsson, L. M., Oskarsson, V. & Wennberg, M. (2022). Comparison of dietary trends between two counties with and without a cardiovascular prevention program: a population-based cross-sectional study in northern Sweden. Public Health Nutrition, 25(7), 1835-1843
Open this publication in new window or tab >>Comparison of dietary trends between two counties with and without a cardiovascular prevention program: a population-based cross-sectional study in northern Sweden
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2022 (English)In: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 25, no 7, p. 1835-1843Article in journal (Refereed) Published
Abstract [en]

Objective: To compare temporal trends, over a 20-year period, in dietary habits between a county (Västerbotten) with a cardiovascular disease (CVD) prevention program and a county (Norrbotten) without such a program.

Design: Cross-sectional data from the Northern Sweden MONICA study (survey period 1994, 1999, 2004, 2009, 2014). Dietary habits were assessed by a semi-quantitative food frequency questionnaire.

Setting: Counties of Norrbotten and Västerbotten, Northern Sweden.

Participants: Five thousand four hundred Swedish adults (mean age 56.9 years; 51.2% women) from Västerbotten (47%) and Norrbotten (53%).

Results: No differences in temporal trend for estimated percentage of energy intake from total carbohydrates, total fat, total protein, and alcohol were observed between the counties (p for interaction ≥0.33). There were no between-county difference in temporal trends for overall diet quality (assessed by the Healthy Diet Score; p for interaction = 0.36). Nor were there any between-county differences for intake of whole grain products, fruits, vegetables, fish, sweetened beverages or fried potatoes (p for interaction ≥ 0.09). Consumption of meat (p for interaction = 0.05) increased to a greater extent in Norrbotten from 2009 and onwards, mainly in men (sex-specific analyses, p for interaction = 0.04). Men in Västerbotten decreased their intake of sweets to a greater extent than men in Norrbotten (p for interaction <0.01).

Conclusions: Over a 20-year period in northern Sweden, only small differences in dietary habits were observed in favor of a county with a CVD prevention program compared to a county without such a program.

Place, publisher, year, edition, pages
Cambridge University Press, 2022
Keywords
alcohol, carbohydrates, cardiovascular disease, dietary patterns, fat, healthy foods, prevention program, protein, unhealthy foods
National Category
Nutrition and Dietetics Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-186577 (URN)10.1017/S1368980021003050 (DOI)000781637200001 ()34296666 (PubMedID)2-s2.0-85111303993 (Scopus ID)
Funder
Region VästerbottenSwedish Research Council
Available from: 2021-08-12 Created: 2021-08-12 Last updated: 2023-03-24Bibliographically approved
Lieber, I., Ott, M., Lundqvist, R., Eliasson, M., Sandlund, M. & Werneke, U. (2022). Elevated Thyroxine Concentration and Lithium Intoxication - An Analysis Based on the LiSIE Retrospective Cohort Study. Journal of Clinical Medicine, 11(11), Article ID 3041.
Open this publication in new window or tab >>Elevated Thyroxine Concentration and Lithium Intoxication - An Analysis Based on the LiSIE Retrospective Cohort Study
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2022 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 11, no 11, article id 3041Article in journal (Refereed) Published
Abstract [en]

(1) Background: It has been suggested that hyperthyroxinaemia is a risk factor for lithium intoxication by altering tubular renal function. (2) Methods: We determined the relevance of hyperthyroxinaemia as a risk factor for lithium intoxication in patients with bipolar or schizoaffective disorder in the framework of the LiSIE (Lithium-Study into Effects and Side Effects) retrospective cohort study. Of 1562 patients included in the study, 897 patients had been exposed to lithium at any time between 1997 and 2017 with 6684 person-years of observation. (3) Results: There were 65 episodes of unintentional lithium intoxication in 53 patients. There were nine episodes with hyperthyroxinaemia at the time of lithium intoxication, yielding an incidence of 1.3 episodes/1000 person-years. For all nine episodes, we could identify alternative, more plausible, explanations for the observed lithium intoxications. (4) Conclusions: We conclude that hyperthyroxinaemia-associated unintentional lithium intoxication is an uncommon event. A direct causal link between hyperthyroxinaemia and altered tubular renal function remains elusive. Increasing the frequency of routine thyroid function tests seems unlikely to decrease the risk of lithium intoxication.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
hyperthyroxinaemia, hyperthyroidism, thyroxine, lithium, intoxication, bipolar disorder, schizoaffective disorder, thyroid disorder
National Category
Psychiatry Endocrinology and Diabetes Pharmacology and Toxicology
Identifiers
urn:nbn:se:umu:diva-199132 (URN)10.3390/jcm11113041 (DOI)000809003400001 ()35683429 (PubMedID)2-s2.0-85130738317 (Scopus ID)
Funder
Norrbotten County CouncilVisare Norr, 847881Visare Norr, 939391
Available from: 2022-09-05 Created: 2022-09-05 Last updated: 2023-05-23Bibliographically approved
Oskarsson, V., Eliasson, M., Salomaa, V., Reinikainen, J., Männistö, S., Palmieri, L., . . . Söderberg, S. (2022). Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium. British Journal of Nutrition, 128(11), 2208-2218
Open this publication in new window or tab >>Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
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2022 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 128, no 11, p. 2208-2218Article in journal (Refereed) Published
Abstract [en]

Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25[OH]D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in 6 European countries by using harmonized immunoassay data from 81,084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48.9%; median age 50.8 years; examination period 1984 to 2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling, and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65.6 to 63.8 oN), Germany (at 48.4 oN), Finland (at 65.0 to 60.2 oN), Italy (at 45.6 to 41.5 oN), Scotland (at 58.2 to 55.1 oN), and Spain (at 41.5 oN). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as comparator, the median 25(OH)D concentration was 3.03, 3.28, 5.41, 6.54, and 9.28 ng/mL lower in the German, Finnish, Italian, Scottish, and Spanish cohort, respectively (P-value < 0.001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans.

Place, publisher, year, edition, pages
Cambridge University Press, 2022
Keywords
25-hydroxyvitamin D, Epidemiology, Europe, Latitude, Population-based, Vitamin D
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-191009 (URN)10.1017/S0007114521005080 (DOI)000742514400001 ()34933700 (PubMedID)2-s2.0-85121916814 (Scopus ID)
Available from: 2022-01-05 Created: 2022-01-05 Last updated: 2022-12-30Bibliographically approved
Lieber, I., Ott, M., Öhlund, L., Lundqvist, R., Eliasson, M., Sandlund, M. & Werneke, U. (2021). Patterns of thyroid hormone prescription in patients with bipolar or schizoaffective disorder: Findings from the lisie retrospective cohort study. Journal of Clinical Medicine, 10(21), Article ID 5062.
Open this publication in new window or tab >>Patterns of thyroid hormone prescription in patients with bipolar or schizoaffective disorder: Findings from the lisie retrospective cohort study
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2021 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 10, no 21, article id 5062Article in journal (Refereed) Published
Abstract [en]

The prescription of thyroid hormone replacement therapy (THRT) has increased in the general population; the thyroid stimulating hormone (TSH) threshold to initiate THRT has decreased. It remains unclear whether a similar trend has occurred in patients with bipolar disorder (BD). In this work we explore patterns and trends of prescribing THRT in patients with BD or schizoaffective disorder (SZD) with an observational study and time‐trend analysis in the framework of the LiSIE (Lithium—Study into Effects and Side Effects) retrospective cohort study. In most patients, THRT was initiated for subclinical hypothyroidism. The median TSH at which THRT was started was 6.0 (IQR 4.0) mIU/L and the median free serum thyroxine (fT4) at which THRT was started was 11.8 (IQR 3.9) pmol/L. The median TSH concentration at the start of THRT decreased annually with 0.10 mIU/L (p = 0.047) and was higher in patients treated with lithium than in patients treated with other mood stabilisers (p = 0.02). In conclusion, THRT was typically initiated in the context of mild or absent alterations of thyroid function tests with a decreasing TSH threshold. As THRT is rarely reversed once initiated, clinicians need to weigh up potential benefits and risks when prescribing THRT for subclinical hypothyroidism in patients with BD or SZD.

Place, publisher, year, edition, pages
MDPI, 2021
Keywords
Bipolar disorder, Hypothyroidism, Lithium, Mood stabilizer, Schizoaffective disorder, Thyroid dysfunction, TSH
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-189214 (URN)10.3390/jcm10215062 (DOI)000718656200001 ()2-s2.0-85118180676 (Scopus ID)
Available from: 2021-11-12 Created: 2021-11-12 Last updated: 2023-09-05Bibliographically approved
Özgümüş, T., Sulaieva, O., Jessen, L. E., Jain, R., Falhammar, H., Nyström, T., . . . Lyssenko, V. (2021). Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study. Scientific Reports, 11(1), Article ID 20735.
Open this publication in new window or tab >>Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes: the PROLONG study
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2021 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 11, no 1, article id 20735Article in journal (Refereed) Published
Abstract [en]

Type 1 diabetes is a chronic autoimmune disease requiring insulin treatment for survival. Prolonged duration of type 1 diabetes is associated with increased risk of microvascular complications. Although chronic hyperglycemia and diabetes duration have been considered as the major risk factors for vascular complications, this is not universally seen among all patients. Persons with long-term type 1 diabetes who have remained largely free from vascular complications constitute an ideal group for investigation of natural defense mechanisms against prolonged exposure of diabetes. Transcriptomic signatures obtained from RNA sequencing of the peripheral blood cells were analyzed in non-progressors with more than 30 years of diabetes duration and compared to the patients who progressed to microvascular complications within a shorter duration of diabetes. Analyses revealed that non-progressors demonstrated a reduction in expression of the oxidative phosphorylation (OXPHOS) genes, which were positively correlated with the expression of DNA repair enzymes, namely genes involved in base excision repair (BER) machinery. Reduced expression of OXPHOS and BER genes was linked to decrease in expression of inflammation-related genes, higher glucose disposal rate and reduced measures of hepatic fatty liver. Results from the present study indicate that at transcriptomic level reduction in OXPHOS, DNA repair and inflammation-related genes is linked to better insulin sensitivity and protection against microvascular complications in persons with long-term type 1 diabetes.

Place, publisher, year, edition, pages
Springer Nature, 2021
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-189033 (URN)10.1038/s41598-021-00183-z (DOI)000709427000007 ()34671071 (PubMedID)2-s2.0-85117709553 (Scopus ID)
Funder
Swedish Foundation for Strategic Research , BFS811294, IRC15-0067Swedish Research Council, 349-2006-237Novo Nordisk, NNF12OC1016467EXODIAB - Excellence of Diabetes Research in Sweden, 2009-1039
Available from: 2021-11-01 Created: 2021-11-01 Last updated: 2023-09-05Bibliographically approved
Brunström, M., Andersson, J., Eliasson, M., Fu, M., Hansson, P.-O. & Söderberg, S. (2021). SCORE2 – ett uppdaterat verktyg för att skatta kardiovaskulär risk: [SCORE2 - an updated model for cardiovascular risk prediction]. Läkartidningen, 118, Article ID 21164.
Open this publication in new window or tab >>SCORE2 – ett uppdaterat verktyg för att skatta kardiovaskulär risk: [SCORE2 - an updated model for cardiovascular risk prediction]
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2021 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 118, article id 21164Article in journal (Refereed) Published
Abstract [en]

Cardiovascular disease is the most important cause of death and life-years lost in Sweden today. Cardiovascular risk prediction is a cornerstone in primary prevention; the use of antihypertensive and lipid-lowering therapy is guided by absolute cardiovascular risk. The Systematic COronary Risk Evaluation (SCORE) model has been the most widely applied model in Sweden for almost two decades. Recently, an updated model called SCORE2 was published. The new risk prediction model is based on contemporary data, predicts the risk of incident cardiovascular disease in addition to cardiovascular mortality, and accounts for competing risks, thus overcoming some major limitations with SCORE. Sweden is classified as a moderate-risk country according to the new model; here we report the risk chart for moderate-risk countries translated into Swedish.

National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-192277 (URN)34590704 (PubMedID)
Note

Publicerad på Lakartidningen.se 2021-09-29

Available from: 2022-02-07 Created: 2022-02-07 Last updated: 2024-04-08Bibliographically approved
Ostgren, C. J., Söderberg, S., Festin, K., Angeras, O., Bergstrom, G., Blomberg, A., . . . Jernberg, T. (2021). Systematic Coronary Risk Evaluation estimated risk and prevalent subclinical atherosclerosis in coronary and carotid arteries: A population-based cohort analysis from the Swedish Cardiopulmonary Bioimage Study. European Journal of Preventive Cardiology, 28(3), 250-259
Open this publication in new window or tab >>Systematic Coronary Risk Evaluation estimated risk and prevalent subclinical atherosclerosis in coronary and carotid arteries: A population-based cohort analysis from the Swedish Cardiopulmonary Bioimage Study
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2021 (English)In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 28, no 3, p. 250-259Article in journal (Refereed) Published
Abstract [en]

Background: It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and prevalent subclinical atherosclerosis.

Design: The design of this study was as a cross-sectional analysis from a population-based study cohort.

Methods: From the general population, the Swedish Cardiopulmonary Bioimage Study randomly invited individuals aged 50–64 years and enrolled 13,411 participants mean age 57 (standard deviation 4.3) years; 46% males between November 2013–December 2016. Associations between Systematic Coronary Risk Evaluation risk estimates and coronary artery calcification and plaques in the carotid arteries by using imaging data from a computed tomography of the heart and ultrasonography of the carotid arteries were examined.

Results: Coronary calcification was present in 39.5% and carotid plaque in 56.0%. In men, coronary artery calcium score >0 ranged from 40.7–65.9% and presence of carotid plaques from 54.5% to 72.8% in the age group 50–54 and 60–65 years, respectively. In women, the corresponding difference was from 17.1–38.9% and from 41.0–58.4%. A doubling of Systematic Coronary Risk Evaluation was associated with an increased probability to have coronary artery calcium score >0 (odds ratio: 2.18 (95% confidence interval 2.07–2.30)) and to have >1 carotid plaques (1.67 (1.61–1.74)).

Conclusion: Systematic Coronary Risk Evaluation estimated risk is associated with prevalent subclinical atherosclerosis in two major vascular beds in a general population sample without established cardiovascular disease or diabetes mellitus. Thus, the Systematic Coronary Risk Evaluation risk chart may be of use for estimating the risk of subclinical atherosclerosis.

Place, publisher, year, edition, pages
Oxford University Press, 2021
Keywords
Systematic Coronary Risk Evaluation, estimated risk, subclinical, atherosclerosis, population
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-169120 (URN)10.1177/2047487320909300 (DOI)000517878800001 ()32126830 (PubMedID)2-s2.0-85081674459 (Scopus ID)
Funder
Swedish Heart Lung Foundation, 2019-0012Knut and Alice Wallenberg Foundation, 2014-0047Swedish Research Council, 822-2013-2000Vinnova, 2012-04476
Available from: 2020-03-23 Created: 2020-03-23 Last updated: 2024-07-02Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-2866-8972

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