Umeå University's logo

umu.sePublications
Change search
Link to record
Permanent link

Direct link
Wennberg, Maria
Publications (10 of 78) Show all publications
Berglund, F., Törmä, J., Wennberg, M., Wennberg, P. & Oskarsson, V. (2023). Dietary habits among snus users: a population-based cross-sectional study. Food & Nutrition Research, 67, Article ID 9537.
Open this publication in new window or tab >>Dietary habits among snus users: a population-based cross-sectional study
Show others...
2023 (English)In: Food & Nutrition Research, ISSN 1654-6628, E-ISSN 1654-661X, Vol. 67, article id 9537Article in journal (Refereed) Published
Abstract [en]

Background: The dietary habits among snus users are largely unknown and have not been accounted for in observational studies on the health effects of snus use.

Aim: To examine whether snus users eat unhealthier than never tobacco users.

Methods: A total of 3,397 male participants, examined between 1994 and 2014 in the Northern Sweden Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) study, were included. Snus use and dietary habits were self-reported using questionnaires, from which intakes of different food groups, macronutrients, and a healthy diet score (HDS) were calculated (the latter as a proxy for overall diet quality). The association between snus use and dietary habits was examined by quantile regression models.

Results: In the multivariable-adjusted model, current snus users had a lower HDS (median difference: −0.86 [95% confidence interval: −1.32, −0.40]) than never tobacco users. Snus users also consumed fewer weekly servings of fruits and berries (median difference: −1.03 [−1.65, −0.40]), and their estimated percentage of energy intake con-sisted of less carbohydrates (median difference: −1.43 [−2.12, −0.74]) and of more total fat (median difference: 0.99 [0.30, 1.67]), saturated fat (median difference: 0.67 [0.29, 1.05]), monounsaturated fat (median difference: 0.44 [0.20, 0.68]), trans fat (median difference: 0.03 [0.01, 0.06]), and alcohol (median difference: 0.21 [0.02, 0.40]).

Conclusion: We observed that snus users had an unhealthier diet than never tobacco users. Future studies on the association between snus use and health outcomes should, therefore, consider diet as a potential confounder.

Place, publisher, year, edition, pages
Swedish Nutrition Foundation, 2023
Keywords
beverages, diet, food, smokeless tobacco, snus, tobacco
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-214061 (URN)10.29219/fnr.v67.9537 (DOI)2-s2.0-85168989019 (Scopus ID)
Funder
Norrbotten County Council
Available from: 2023-09-06 Created: 2023-09-06 Last updated: 2023-09-06Bibliographically approved
Fortuin-de Smidt, M., Bergman, F., Grönlund, C., Hult, A., Norberg, M., Wennberg, M. & Wennberg, P. (2023). Early adulthood exercise capacity, but not muscle strength, associates with subclinical atherosclerosis 40 years later in Swedish men. European Journal of Preventive Cardiology, 30(5), 407-415
Open this publication in new window or tab >>Early adulthood exercise capacity, but not muscle strength, associates with subclinical atherosclerosis 40 years later in Swedish men
Show others...
2023 (English)In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 30, no 5, p. 407-415Article in journal (Refereed) Published
Abstract [en]

AIMS: Poor exercise capacity and muscle strength in early adulthood are risk factors for cardiovascular disease (CVD). However, it is unclear how these factors relate to subclinical atherosclerosis due to a lack of longitudinal studies. This study investigated whether early adulthood exercise capacity and muscle strength associated with later adulthood subclinical atherosclerosis.

METHODS AND RESULTS: This study included Swedish men (n = 797) who were eligible for military conscription (at ∼18-years of age) and who participated in the baseline assessment of the visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention trial between 2013 and 2016 (at 60 years of age). At conscription, isometric muscle strength (dynamometer) and maximum exercise capacity (maximal load cycle ergometer test) were measured. During later adulthood (at 60 years old), the presence of carotid plaques and intima media thickness were measured by using high-resolution ultrasound. At follow-up, plaques were present in 62% (n = 493) of men. Exercise capacity in early adulthood associated with 19% lower odds of plaques [odds ratio (OR) 0.81, 95% confidence interval (CI) 0.68-0.96], independent of muscle strength. This association was not mediated by any single CVD risk factor. However, the total indirect effect of later, but not early, adulthood CVD risk factors was significant, while the direct effect was non-significant (OR 0.85, 95% CI 0.71-1.02). Associations between muscle strength and subclinical atherosclerosis were non-significant.

CONCLUSION: Higher exercise capacity during early adulthood, but not muscle strength, may protect against carotid plaque development during adulthood mediated by the combination rather than a single later adulthood CVD risk factors.

Place, publisher, year, edition, pages
Oxford University Press, 2023
Keywords
Carotid intima media thickness, Carotid plaques, Exercise capacity, Longitudinal study, Muscle strength
National Category
Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-206445 (URN)10.1093/eurjpc/zwad007 (DOI)000913889800001 ()36631734 (PubMedID)2-s2.0-85151044376 (Scopus ID)
Funder
Region Västerbotten, ALFVLL-298001Region Västerbotten, ALFVLL-643391Swedish Research Council, 521-2013-2708Swedish Research Council, 2016-01891Swedish Heart Lung Foundation, 20150369Swedish Heart Lung Foundation, 20170481Swedish Society of MedicineThe Swedish Stroke AssociationAFA InsuranceVisare Norr
Available from: 2023-04-13 Created: 2023-04-13 Last updated: 2023-04-13Bibliographically approved
Wennberg, M. (2023). Framtagande av enkät för HBM-projekt inom den hälsorelaterade miljöövervakningen. Umeå: Umeå universitet
Open this publication in new window or tab >>Framtagande av enkät för HBM-projekt inom den hälsorelaterade miljöövervakningen
2023 (Swedish)Report (Other academic)
Abstract [sv]

Naturvårdsverkets hälsorelaterade miljöövervakning (HÄMI) har som syfte att övervaka miljöfaktorer som kan påverka människors hälsa. De studier inom HÄMI som genomförs för att mäta exponering av metaller och organiska miljöföroreningar använder ofta enkäter för att beskriva deltagares bakgrund och levnadsvanor och för att öka kunskap om vilka faktorer som har betydelse för människors exponering.

För att öka möjligheter till jämförelser mellan olika studier underlättar det om samma, eller i alla fall jämförbara, frågor och svarsalternativ används.

Ett förslag på basenkätfrågor har tagits fram angående bakgrundsdata. Frågeversioner för studier på barn finns där det kan behövas. Utöver detta har ett förslag på tilläggsfrågor för studier av olika exponeringar påbörjats.

Tidigare använda enkäter i HÄMI-studier har granskats och kommunikation har skett med genomförare av HÄMI-studier för att ta fram förslag på basenkätfrågor och tilläggsfrågor.

Då förändringar i samhället ständigt sker och nya exponeringsvägar för aktuella ämnen kan tillkomma eller upptäckas är det oundvikligt att frågor kommer att behöva uppdateras över tid. Därför föreslås bildande av referensgrupp för enkätfrågor inom HÄMI, bestående av genomförare av HÄMI-studier med intresse för enkätfrågor. Referensgruppen kan dels se över att uppdateringar av frågor görs på ett sätt som möjliggör jämförelser över tid och jämförelser mellan studier, och fungera som stöd när nya studier inom HÄMI ska starta.

Samordning av referensgrupp kan ingå under UMUs överenskommelse för HÄMI-arbete.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2023. p. 22
Series
Folkhälsa och klinisk medicin i Umeå rapporterar, ISSN 2003-3281 ; 2023/2
National Category
Environmental Sciences
Research subject
Environmental Objectives, A Non-Toxic Environment; Miljöövervakning, Health
Identifiers
urn:nbn:se:umu:diva-202223 (URN)
Projects
Nationell miljöövervakning på uppdrag av Naturvårdsverket
Funder
Swedish Environmental Protection Agency, NV 03686-21
Available from: 2023-01-05 Created: 2023-01-05 Last updated: 2023-01-18Bibliographically approved
Schmidt, J. A., Huybrechts, I., Overvad, K., Eriksen, A. K., Tjønneland, A., Kaaks, R., . . . Perez-Cornago, A. (2023). Protein and amino acid intakes in relation to prostate cancer risk and mortality: A prospective study in the European Prospective Investigation into Cancer and Nutrition. Cancer Medicine, 12(4), 4725-4738
Open this publication in new window or tab >>Protein and amino acid intakes in relation to prostate cancer risk and mortality: A prospective study in the European Prospective Investigation into Cancer and Nutrition
Show others...
2023 (English)In: Cancer Medicine, E-ISSN 2045-7634, Vol. 12, no 4, p. 4725-4738Article in journal (Refereed) Published
Abstract [en]

Background: The association between protein intake and prostate cancer risk remains unclear.

Aims: To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality.

Methods: In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid intakes were estimated using validated dietary questionnaires. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results: During a mean follow-up of 14.2 years, 6939 men were diagnosed with prostate cancer and 914 died of the disease. Dairy protein was positively associated with overall prostate cancer risk in the three highest fifths compared to the lowest (HRQ3=1.14 (95% CI 1.05–1.23); HRQ4=1.09 (1.01–1.18); HRQ5=1.10 (1.02–1.19)); similar results were observed for yogurt protein (HRQ3=1.14 (1.05–1.24); HRQ4=1.09 (1.01–1.18); HRQ5=1.12 (1.04–1.21)). For egg protein intake and prostate cancer mortality, no association was observed by fifths, but there was suggestive evidence of a positive association in the analysis per standard deviation increment. There was no strong evidence of associations with different tumour subtypes.

Discussion: Considering the weak associations and many tests, the results must be interpreted with caution.

Conclusion: This study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large-scale, pooled analyses of prospective data.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023
Keywords
dietary amino acid intakes, dietary protein intakes, prostate cancer incidence, prostate cancer mortality, tumour subtypes
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-200094 (URN)10.1002/cam4.5289 (DOI)000858927500001 ()36148781 (PubMedID)2-s2.0-85138609288 (Scopus ID)
Available from: 2022-10-13 Created: 2022-10-13 Last updated: 2024-01-17Bibliographically approved
de Man Lapidoth, J., Hultdin, J., Jonsson, A. P., Eriksson Svensson, M., Wennberg, M., Zeller, T. & Söderberg, S. (2023). Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study. BMJ Open, 13(8), Article ID e072664.
Open this publication in new window or tab >>Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study
Show others...
2023 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 13, no 8, article id e072664Article in journal (Refereed) Published
Abstract [en]

Objective: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.

Design: Repeated cross-sectional population-based studies.

Setting: The two Northern counties (Norr- and Västerbotten) in Sweden.

Participants: Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185).

Interventions: None.

Measures: Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFR crea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFR cysC). Renal function over time was analysed using univariable and multivariable linear regression models.

Results: Renal function, both eGFR crea and eGFR cysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFR crea and eGFR cysC (both p<0.001) after adjustment for classical cardiovascular RF.

Conclusion: Renal function has deteriorated in Northern Sweden between 1986 and 2014.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2023
Keywords
epidemiology, nephrology, public health
National Category
Urology and Nephrology
Identifiers
urn:nbn:se:umu:diva-214628 (URN)10.1136/bmjopen-2023-072664 (DOI)37648389 (PubMedID)2-s2.0-85169231018 (Scopus ID)
Funder
Region VästerbottenEU, FP7, Seventh Framework Programme, HEALTH–F2–2011–278913
Available from: 2023-09-25 Created: 2023-09-25 Last updated: 2023-09-25Bibliographically approved
Törmä, J., Lundqvist, R., Eliasson, M., Nilsson, L. M., Oskarsson, V. & Wennberg, M. (2022). Comparison of dietary trends between two counties with and without a cardiovascular prevention program: a population-based cross-sectional study in northern Sweden. Public Health Nutrition, 25(7), 1835-1843
Open this publication in new window or tab >>Comparison of dietary trends between two counties with and without a cardiovascular prevention program: a population-based cross-sectional study in northern Sweden
Show others...
2022 (English)In: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 25, no 7, p. 1835-1843Article in journal (Refereed) Published
Abstract [en]

Objective: To compare temporal trends, over a 20-year period, in dietary habits between a county (Västerbotten) with a cardiovascular disease (CVD) prevention program and a county (Norrbotten) without such a program.

Design: Cross-sectional data from the Northern Sweden MONICA study (survey period 1994, 1999, 2004, 2009, 2014). Dietary habits were assessed by a semi-quantitative food frequency questionnaire.

Setting: Counties of Norrbotten and Västerbotten, Northern Sweden.

Participants: Five thousand four hundred Swedish adults (mean age 56.9 years; 51.2% women) from Västerbotten (47%) and Norrbotten (53%).

Results: No differences in temporal trend for estimated percentage of energy intake from total carbohydrates, total fat, total protein, and alcohol were observed between the counties (p for interaction ≥0.33). There were no between-county difference in temporal trends for overall diet quality (assessed by the Healthy Diet Score; p for interaction = 0.36). Nor were there any between-county differences for intake of whole grain products, fruits, vegetables, fish, sweetened beverages or fried potatoes (p for interaction ≥ 0.09). Consumption of meat (p for interaction = 0.05) increased to a greater extent in Norrbotten from 2009 and onwards, mainly in men (sex-specific analyses, p for interaction = 0.04). Men in Västerbotten decreased their intake of sweets to a greater extent than men in Norrbotten (p for interaction <0.01).

Conclusions: Over a 20-year period in northern Sweden, only small differences in dietary habits were observed in favor of a county with a CVD prevention program compared to a county without such a program.

Place, publisher, year, edition, pages
Cambridge University Press, 2022
Keywords
alcohol, carbohydrates, cardiovascular disease, dietary patterns, fat, healthy foods, prevention program, protein, unhealthy foods
National Category
Nutrition and Dietetics Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-186577 (URN)10.1017/S1368980021003050 (DOI)000781637200001 ()34296666 (PubMedID)2-s2.0-85111303993 (Scopus ID)
Funder
Region VästerbottenSwedish Research Council
Available from: 2021-08-12 Created: 2021-08-12 Last updated: 2023-03-24Bibliographically approved
Fiolet, T., Casagrande, C., Nicolas, G., Horvath, Z., Frenoy, P., Weiderpass, E., . . . Romana Mancini, F. (2022). Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries. Environment International, 163, Article ID 107213.
Open this publication in new window or tab >>Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries
Show others...
2022 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 163, article id 107213Article in journal (Refereed) Published
Abstract [en]

Background: Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure.

Methods: Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5–16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority.

Results: Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors.

Conclusions: This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.

Place, publisher, year, edition, pages
Elsevier, 2022
Keywords
Breast cancer, Diet, Dioxins, PCBs, Persistent pollutants, Polychlorobiphenyls
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-193690 (URN)10.1016/j.envint.2022.107213 (DOI)000793759600003 ()35364416 (PubMedID)2-s2.0-85127167792 (Scopus ID)
Funder
Swedish Cancer SocietySwedish Research Council
Available from: 2022-05-02 Created: 2022-05-02 Last updated: 2023-09-05Bibliographically approved
Meltzer, H. M., Jensen, T. K., Májek, O., Moshammer, H., Wennberg, M., Åkesson, A. & Tolonen, H. (2022). Enhancing Human Biomonitoring Studies through Linkage to Administrative Registers–Status in Europe. International Journal of Environmental Research and Public Health, 19(9), Article ID 5678.
Open this publication in new window or tab >>Enhancing Human Biomonitoring Studies through Linkage to Administrative Registers–Status in Europe
Show others...
2022 (English)In: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 19, no 9, article id 5678Article in journal (Refereed) Published
Abstract [en]

Record linkage of human biomonitoring (HBM) survey data with administrative register data can be used to enhance available datasets and complement the possible shortcomings of both data sources. Through record linkage, valuable information on medical history (diagnosed diseases, medication use, etc.) and follow-up information on health and vital status for established cohorts can be obtained. In this study, we investigated the availability of health registers in different EU Member States and EEA countries and assessed whether they could be linked to HBM studies. We found that the availability of administrative health registers varied substantially between European countries as well as the availability of unique personal identifiers that would facilitate record linkage. General protocols for record linkage were similar in all countries with ethical and data protections approval, informed consent, approval by administrative register owner, and linkage conducted by the register owner. Record linkage enabled cross-sectional survey data to be used as cohort study data with available follow-up and health endpoints. This can be used for extensive exposure-health effect association analysis. Our study showed that this is possible for many, but not all European countries.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
administrative registers, biomonitoring, chemicals, HBM4EU, health, health registers
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-194888 (URN)10.3390/ijerph19095678 (DOI)000795231200001 ()2-s2.0-85129380730 (Scopus ID)
Funder
EU, Horizon 2020, 733032
Available from: 2022-06-07 Created: 2022-06-07 Last updated: 2022-06-07Bibliographically approved
Steur, M., Johnson, L., Sharp, S. J., Imamura, F., Sluijs, I., Key, T. J., . . . Forouhi, N. G. (2021). Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 10(23), Article ID e019814.
Open this publication in new window or tab >>Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries
Show others...
2021 (English)In: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 10, no 23, article id e019814Article in journal (Refereed) Published
Abstract [en]

Background: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain.

Methods and Results: We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88-0.99]), cheese (HR, 0.98 [95% CI, 0.96-1.00]), and fish (HR, 0.87 [95% CI, 0.75-1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02-1.12]) and butter (HR, 1.02 [95% CI, 1.00-1.04]).

Conclusions: This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite directions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.

Place, publisher, year, edition, pages
American Heart Association, 2021
Keywords
coronary heart disease, dietary guidelines, nutritional epidemiology, primary prevention, saturated fat
National Category
Nutrition and Dietetics Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-190618 (URN)10.1161/JAHA.120.019814 (DOI)000727412400024 ()34796724 (PubMedID)2-s2.0-85121028397 (Scopus ID)
Available from: 2021-12-20 Created: 2021-12-20 Last updated: 2023-09-05Bibliographically approved
Aglago, E. K., Murphy, N., Huybrechts, I., Nicolas, G., Casagrande, C., Fedirko, V., . . . Gunter, M. J. (2021). Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. International Journal of Cancer, 149(4), 865-882
Open this publication in new window or tab >>Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
Show others...
2021 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 149, no 4, p. 865-882Article in journal (Refereed) Published
Abstract [en]

Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HRQ5vsQ1 = 0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vsQ1 = 0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vsQ1 = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, ORQ4vsQ1 = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vsQ1 = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR1-SD = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD = 1.04, 95%CI:0.95-1.15, Pheterogeneity = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021
Keywords
biomarker, colorectal cancer, dietary intake, fatty acids
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-186329 (URN)10.1002/ijc.33615 (DOI)000650333600001 ()33913149 (PubMedID)2-s2.0-85105928331 (Scopus ID)
Funder
Region SkåneSwedish Cancer SocietySwedish Research Council
Available from: 2021-07-22 Created: 2021-07-22 Last updated: 2023-03-24Bibliographically approved
Organisations

Search in DiVA

Show all publications