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Johansson, Lars
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Publications (10 of 29) Show all publications
Lind, P., Nordenström, E., Johansson, L., Wallin, G. & Daskalakis, K. (2024). Impact of fine-needle aspiration cytology in thyroidectomy extent and associated surgical morbidity in thyroid cancer. Langenbeck's archives of surgery (Print), 409(1), Article ID 68.
Open this publication in new window or tab >>Impact of fine-needle aspiration cytology in thyroidectomy extent and associated surgical morbidity in thyroid cancer
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2024 (English)In: Langenbeck's archives of surgery (Print), ISSN 1435-2443, E-ISSN 1435-2451, Vol. 409, no 1, article id 68Article in journal (Refereed) Published
Abstract [en]

Purpose: To assess the impact of fine-needle aspiration cytology (FNAC) in the extent of surgery in patients with thyroid cancer (TC) and the associated surgical morbidity in primary and completion setting.

Methods: A Swedish nationwide cohort of patients having surgery for TC (n = 2519) from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal surgery between 2004 and 2013 was obtained. Data was validated through scrutinizing FNAC and histology reports.

Results: Among the 2519 cases operated for TC, the diagnosis was substantiated and validated through the histology report in 2332 cases (92.6%). Among these, 1679 patients (72%) were female, and the median age at TC diagnosis was 52.3 years (range 18–94.6). Less than total thyroidectomy (LTT) was undertaken in 944 whereas total thyroidectomy (TT) in 1388 cases. The intermediate FNAC categories of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/ FLUS), as well as suspicion for follicular neoplasm (SFN) lesions were more often encountered in LTT (n = 314, 33.3%) than TT (n = 63, 4.6%), whereas FNACs suspicion for malignancy and/or malignancy were overrepresented in TT (n = 963, 69.4%). Completion thyroidectomies were undertaken in 553 patients out of 944 that initially had LTT. In 201 cases with cancer lesions > 1 cm, other than FTC (Follicular TC)/ HTC (Hürthle cell TC) subjected to primary LTT, inadequate procedures were undertaken in 81 due to absent, Bethesda I or II FNAC categories, preoperatively. Complications at completion of surgery in this particular setting were 0.5% for RLN palsy (n = 1) and 1% (n = 2) for hypoparathyroidism 6 months postoperatively. The overall postoperative complication rate was higher in primary TT vs. LTT for RLN palsy (4.8% [n = 67] vs. 2.4% [n = 23]; p = 0.003) and permanent hypoparathyroidism (6.8% [n = 95] vs. 0.8% [n = 8]; p < 0.0001).

Conclusions: FNAC results appear to affect surgical planning in TC as intermediate FNAC categories lead more often to LTT. Overall, inadequate procedures necessitating completion surgery are encountered in up to 15% of TC patients subjected to LTT due to absent, inconclusive, or misleading FNAC, preoperatively. However, completion of thyroidectomy in this setting did not yield significant surgical morbidity. Primary LTT is a safer primary approach compared to TT in respect of RLN palsy and permanent hypoparathyroidism complication rates; therefore, primary TT should probably be reserved for lesions > 1 cm or even larger with suspicion for malignancy or malignant FNAC.

Place, publisher, year, edition, pages
Springer Nature, 2024
Keywords
Fine-needle aspiration cytology, Surgical morbidity, Thyroid cancer
National Category
Surgery
Identifiers
urn:nbn:se:umu:diva-221668 (URN)10.1007/s00423-024-03258-3 (DOI)38374242 (PubMedID)2-s2.0-85185472147 (Scopus ID)
Available from: 2024-03-01 Created: 2024-03-01 Last updated: 2024-03-01Bibliographically approved
Johansson, C., Örtendahl, L., Lind, M. M., Andersson, J., Johansson, L. & Brunström, M. (2023). Diabetes, prediabetes, and atrial fibrillation: a population-based cohort study based on national and regional registers. Journal of Internal Medicine, 294(5), 605-615
Open this publication in new window or tab >>Diabetes, prediabetes, and atrial fibrillation: a population-based cohort study based on national and regional registers
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2023 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 294, no 5, p. 605-615Article in journal (Refereed) Published
Abstract [en]

Background: Previous studies have shown an increased risk for atrial fibrillation and atrial flutter (AF) in people with type 2 diabetes and prediabetes. It is unclear whether this increase in AF risk is independent of other risk factors for AF.

Objective: To investigate the association between diabetes and different prediabetic states, as independent risk factors for the onset of AF.

Methods: We performed a population-based cohort study in Northern Sweden, including data on fasting plasma glucose, oral glucose tolerance test, major cardiovascular risk factors, medical history, and lifestyle factors. Participants were divided into six groups depending on glycemic status and followed through national registers for AF diagnosis. Cox proportional hazard model was used to assess the association between glycemic status and AF, using normoglycemia as reference.

Results: The cohort consisted of 88,889 participants who underwent a total of 139,661 health examinations. In the model adjusted for age and sex, there was a significant association between glycemic status and development of AF in all groups except the impaired glucose tolerance group, with the strongest association for the group with known diabetes (p-value <0.001). In a model adjusted for sex, age, systolic blood pressure, body mass index, antihypertensive drugs, cholesterol, alcohol, smoking, education level, marital status, and physical activity, there was no significant association between glycemic status and AF.

Conclusions/interpretation: The association between glycemic status and AF disappears upon adjustment for potential confounders. Diabetes and prediabetes do not appear to be independent risk factors for AF.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023
Keywords
atrial fibrillation, diabetes, glucose, oral glucose tolerance test, prediabetes
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-212329 (URN)10.1111/joim.13688 (DOI)37387643 (PubMedID)2-s2.0-85164804333 (Scopus ID)
Funder
Region VästerbottenUmeå University
Available from: 2023-07-25 Created: 2023-07-25 Last updated: 2024-04-08Bibliographically approved
Nylund, O., Johansson, L., Lind, M. & Johansson, M. (2023). The association between self-rated health, health-related quality of life, and risk of venous thromboembolism. Preventive Medicine Reports, 36, Article ID 102434.
Open this publication in new window or tab >>The association between self-rated health, health-related quality of life, and risk of venous thromboembolism
2023 (English)In: Preventive Medicine Reports, E-ISSN 2211-3355, Vol. 36, article id 102434Article in journal (Refereed) Published
Abstract [en]

Poor self-rated health (SRH) is associated with various adverse health outcomes, including cardiovascular disease. Little is known about SRH and health-related quality of life (HRQoL) as predictors of first-time venous thromboembolism (VTE). Our aim was to investigate the association between SRH, HRQoL, and risk of VTE in a whole cohort, as well as in women and men separately. A total of 108,025 middle-aged inhabitants (51 % women) of Västerbotten, Sweden, participated in a health examination between 1985 and 2014. Data on SRH, HRQoL, and potential confounders were collected by questionnaire. Participants were followed as a cohort and validated first-time VTE events were registered. The mean follow-up time was 13.9 years, during which 2054 participants experienced a first-time VTE. Overall, 27 % of participants reported their health as very good, 46 % as good, 20 % as average, 5 % as somewhat bad, and 1 % as bad. In a multivariable analysis, compared with participants who self-rated as having very good SRH, hazard ratios (95 % confidence intervals) for VTE were 1.17 (1.02–1.33) with good SRH, 1.27 (1.09–1.47) with average SRH, and 1.48 (1.00–2.18) with bad SRH. The risk of VTE increased with lower SRH for both men (p for trend 0.02) and women (p for trend 0.04). In a fully adjusted model, we also found significant associations between four aspects of HRQoL (general health, bodily pain, vitality, emotional well-being) and VTE risk. In conclusion, lower perceived health is associated with an increased risk of VTE in both men and women.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Cohort study, Health status, Pulmonary embolism, Quality of Life, Risk factor, Venous thromboembolism
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-214975 (URN)10.1016/j.pmedr.2023.102434 (DOI)2-s2.0-85172304529 (Scopus ID)
Funder
Region VästerbottenSwedish Research CouncilForte, Swedish Research Council for Health, Working Life and Welfare
Available from: 2023-10-16 Created: 2023-10-16 Last updated: 2023-11-07Bibliographically approved
Lind, M., Johansson, M., Själander, A. & Johansson, L. (2022). Incidence and risk factors of venous thromboembolism in men and women. Thrombosis Research, 214, 82-86
Open this publication in new window or tab >>Incidence and risk factors of venous thromboembolism in men and women
2022 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 214, p. 82-86Article in journal (Refereed) Published
Abstract [en]

Introduction: Studies have indicated that men have a higher overall risk of VTE than women. In previous studies, we have noted that risk factors for VTE, such as alcohol consumption and physical activity, can differ between sexes.

The aim of the present study was to estimate the incidence of first-ever VTE and the association of traditional cardiovascular risk factors with VTE risk in men and women separately.

Materials and methods: Inhabitants of Västerbotten County in northern Sweden, who had participated in a health examination between 1985 and 2014 were included. The mean age at inclusion was 46.3 years (range 26–65 years). All first-ever VTE events experienced by the participants from the health examination to September 5, 2014 were identified and validated.

Results: A total of 1110 men and 944 women had an objectively verified first-ever VTE event. The incidence of VTE was 1.54 (95% CI 1.45–1.63) per 1000 years of follow-up for men and 1.22 (95% CI 1.14–1.30) for women. Higher age, weight and body mass index were associated with increased risk of VTE in both sexes. Men with hypertension had a lower risk of VTE, HR 0.75 (95% CI 0.65–0.87) and men with more than secondary school education had a higher risk of VTE. Taller women had an increased risk of VTE.

Conclusions: In the studied age group, we found that men had a higher incidence of first-ever VTE than women. Notably, we also found that hypertension was associated with lower risk of VTE in men but not in women.

Keywords
Arterial, Hypertension, Risk factors, Venous thromboembolism
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-195061 (URN)10.1016/j.thromres.2022.04.014 (DOI)000800176100006 ()35523076 (PubMedID)2-s2.0-85129943754 (Scopus ID)
Funder
Region Västerbotten
Available from: 2022-05-23 Created: 2022-05-23 Last updated: 2023-09-05Bibliographically approved
Skoglund Larsson, L., Ljungberg, J., Johansson, L., Carlberg, B., Söderberg, S. & Brunström, M. (2022). Survival after surgery of the ascending aorta: a matched cohort study. European Journal of Cardio-Thoracic Surgery, 62(3)
Open this publication in new window or tab >>Survival after surgery of the ascending aorta: a matched cohort study
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2022 (English)In: European Journal of Cardio-Thoracic Surgery, ISSN 1010-7940, E-ISSN 1873-734X, Vol. 62, no 3Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Surgery of ascending aortic aneurysms is performed prophylactically or acute. The expected survival after surgery is uncertain. The goal of this study was to compare mortality in people with aortic surgery with matched controls.

METHODS: All patients undergoing ascending aortic surgery at Umeå University Hospital from 1988 to 2012, who previously participated in 1 of 3 population-based health surveys, were matched to 2 randomly selected controls from the same health survey and followed until death or until censoring on 24 August 2017, whichever came first. Mortality was calculated using the Kaplan-Meier method and the log-rank test. Cox regression analyses were made for all-cause mortality, adjusted for traditional cardiovascular risk factors. Deaths during the first 90 days after surgery and at >90 days postoperatively were studied separately.

RESULTS: The median follow-up time was 9.2 years. A total of 61 of 189 patients and 51 of 370 controls died [hazard ratio (HR) 2.77, 95% confidence interval (CI) 1.91-4.01]. Mortality was increased during the first 90 days post-surgery (HR 43.4, 95% CI 5.83-323), as well as after the first 90 days (HR 1.90, 95% CI 1.25-2.88) and after acute surgery (HR 6.05, 95% CI 2.92-12.56) as well as after elective surgery (HR 2.10, 95% CI 1.35-3.27). Among 57 surgical patients with information about cause of death, 23 (40%) died of aortic disease.

CONCLUSIONS: During follow-up, more patients died than matched controls. Findings were consistent when adjusting for traditional cardiovascular risk factors and across subgroups. Both short-term and long-term postoperative deaths were increased as well.

Place, publisher, year, edition, pages
Oxford University Press, 2022
Keywords
aortic aneurysm, aortic dissection, surgery, survival, Thoracic aorta
National Category
Surgery
Identifiers
urn:nbn:se:umu:diva-200112 (URN)10.1093/ejcts/ezac161 (DOI)000784733900001 ()35394018 (PubMedID)2-s2.0-85138458169 (Scopus ID)
Funder
Region VästerbottenSwedish Heart Lung FoundationKonung Gustaf V:s och Drottning Victorias Frimurarestiftelse
Available from: 2022-10-12 Created: 2022-10-12 Last updated: 2023-05-22Bibliographically approved
Morseth, B., Geelhoed, B., Linneberg, A., Johansson, L., Kuulasmaa, K., Salomaa, V., . . . Schnabel, R. B. (2021). Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: Results from the MORGAM Consortium. Open heart, 8(2), Article ID e001624.
Open this publication in new window or tab >>Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: Results from the MORGAM Consortium
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2021 (English)In: Open heart, E-ISSN 2053-3624, Vol. 8, no 2, article id e001624Article in journal (Refereed) Published
Abstract [en]

Background The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age.

Methods We used individual-level data (n=66 951, 49.1% men, age range 40-98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF.

Results AF incidence increased from 0.9 per 1000 person-years at baseline age 40-49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001).

Conclusion In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2021
Keywords
atrial fibrillation, epidemiology, risk factors, stroke
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-186639 (URN)10.1136/openhrt-2021-001624 (DOI)000692284700003 ()34341095 (PubMedID)2-s2.0-85112007774 (Scopus ID)
Available from: 2021-08-25 Created: 2021-08-25 Last updated: 2023-09-05Bibliographically approved
Johansson, K., Johansson, L., Nilsson, T. K. & Lind, M. (2021). Factor XII Concentrations and Risk of Intracerebral Haemorrhage: A Prospective Case-Referent Study. Journal of Stroke & Cerebrovascular Diseases, 30(3), Article ID 105565.
Open this publication in new window or tab >>Factor XII Concentrations and Risk of Intracerebral Haemorrhage: A Prospective Case-Referent Study
2021 (English)In: Journal of Stroke & Cerebrovascular Diseases, ISSN 1052-3057, E-ISSN 1532-8511, Vol. 30, no 3, article id 105565Article in journal (Refereed) Published
Abstract [en]

Objectives: In a previous pilot study, we found an association between high factorXII levels and risk of haemorrhagic stroke suggesting that factor XII is a risk markerfor intracerebral haemorrhage (ICH). The aim of this study was to further investigate the association between factor XII and risk of ICH in a larger population.

Materials and Methods:This study was conducted as a prospective nested case-referent study. All participants underwent a health examination and blood sampling for factor XII analysis at baseline. Cases were defined as participants who were diagnosed with a first-ever ICH between 1985 and 2000. Two referents were matched to eachcase.

Results:We identified 70 individuals withfirst-ever ICH and 137 matchedreferents who had undergone a health examination and donated blood samples Factor XII Concentrations and Risk of Intracerebral Haemorrhage. A Prospective Case-Referent Studybefore the ICH event. The mean age was 54 years, and 33% were women. The median time-to-event was 3.5 years (range 0.04 to 10.2 years). Conditional logistic regression showed no association between factor XII and risk of ICH, (odds ratio1.06 per SD; [95% confidence interval: 0.57–1.97] in a multivariable model).

Conclusions: A previous finding of an association between high concentration of factor XII and risk of ICH could not be replicated in this larger study

Place, publisher, year, edition, pages
Elsevier, 2021
Keywords
Intracerebral haemorrhage, Factor XII, Haemostasis, Biomarkers, Intracranial bleeding
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-180311 (URN)10.1016/j.jstrokecerebrovasdis.2020.105565 (DOI)000620676300033 ()2-s2.0-85098886681 (Scopus ID)
Funder
Region Västerbotten
Available from: 2021-02-16 Created: 2021-02-16 Last updated: 2023-09-05Bibliographically approved
Johansson, C., Lind, M., Eriksson, M., Wennberg, M., Andersson, J. & Johansson, L. (2020). Alcohol consumption and risk of incident atrial fibrillation: a population-based cohort study. European journal of internal medicine, 76, 50-57
Open this publication in new window or tab >>Alcohol consumption and risk of incident atrial fibrillation: a population-based cohort study
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2020 (English)In: European journal of internal medicine, ISSN 0953-6205, E-ISSN 1879-0828, Vol. 76, p. 50-57Article in journal (Refereed) Published
Abstract [en]

AIMS: Atrial fibrillation (AF) is a common tachyarrhythmia. High alcohol consumption is associated with increased AF risk. It remains unclear whether lower levels of alcohol consumption are also associated with AF risk, and whether the association differs between men and women. In this study, we investigated the association between low to moderate levels of alcohol consumption and AF risk in men and women.

METHODS: We performed a population-based cohort study of 109,230 health examination participants in northern Sweden. Data regarding alcohol intake were obtained using a questionnaire administered at the health examination. Incident AF cases were identified from the Swedish National Patient Registry.

RESULTS: AF was diagnosed in 5,230 individuals during a total follow-up of 1,484,547 person-years. Among men, AF risk increased over quartiles of weekly alcohol consumption (P for trend 0.001). Men with alcohol consumption in the highest quartile (≥4.83 standard drinks [each drink containing 12 gs of ethanol] per week; SDW) had a HR of 1.21 (95% CI 1.09-1.34) for AF compared to men in the lowest quartile (<0.90 SDW). In men, problem drinking was also associated with an increased AF risk (HR: 1.24; 95% CI: 1.10-1.39). Among women, AF risk was not significantly associated with alcohol consumption (P for trend 0.09 for decreasing risk of AF over quartiles of weekly alcohol consumption) or problem drinking (HR: 1.00; 95% CI 0.70-1.42).

CONCLUSION: Self-reported alcohol consumption and problem drinking were associated with an increased risk of AF among men, but not in women.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
Alcohol drinking, Atrial fibrillation, Atrial flutter, Sex
National Category
Substance Abuse
Identifiers
urn:nbn:se:umu:diva-170167 (URN)10.1016/j.ejim.2020.02.022 (DOI)000539254000012 ()32147331 (PubMedID)2-s2.0-85081015477 (Scopus ID)
Available from: 2020-04-28 Created: 2020-04-28 Last updated: 2024-04-08Bibliographically approved
Johansson, M., Johansson, L., Wennberg, M. & Lind, M. (2019). Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women. Thrombosis and Haemostasis, 119(6), 962-970
Open this publication in new window or tab >>Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women
2019 (English)In: Thrombosis and Haemostasis, ISSN 0340-6245, E-ISSN 2567-689X, Vol. 119, no 6, p. 962-970Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The relationship between alcohol intake and risk of venous thromboembolism (VTE) is unclear. Men and women differ in their drinking habits, which may affect a possible association.

OBJECTIVE: This article investigates the association between alcohol consumption, alcohol dependence and VTE in the total population as well as in men and women separately.

METHODS: We performed a prospective, population-based cohort study in northern Sweden. Study participants were 108,025 (51% women) persons aged 30 to 60 years who underwent a health examination between 1985 and 2014. We assessed alcohol consumption and defined alcohol dependence using a questionnaire. The outcome was a validated first-time VTE.

RESULTS: The mean follow-up time was 13.9 years, and 2,054 participants had a first-time VTE. The mean alcohol consumption was 3.5 standard drinks weekly in men and 1.5 in women. Alcohol dependence was found in 10% of men and 3% of women. There was an association between alcohol consumption (hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.00-1.03 per standard drink weekly) as well as alcohol dependence (HR, 1.27; 95% CI, 1.06-1.52) and VTE after adjustments. In men, the risk of VTE increased over quartiles of weekly alcohol consumption (p for trend 0.02), with a HR of 1.22 (95% CI, 1.01-1.47) for the highest quartile. Alcohol dependence was associated with VTE in men (HR, 1.30; 95% CI, 1.07-1.59). In women, there were no significant associations.

CONCLUSION: High alcohol consumption and alcohol dependence were associated with increased risk of first-time VTE in men, but not in women.

Place, publisher, year, edition, pages
Georg Thieme Verlag KG, 2019
Keywords
venous thromboembolism, venous thrombosis, alcohol consumption, alcohol intake, alcohol drinking, alcohol dependence, risk marker, prospective studies, cohort studies
National Category
Other Clinical Medicine
Research subject
Medicine
Identifiers
urn:nbn:se:umu:diva-157495 (URN)10.1055/s-0039-1681100 (DOI)000474924300013 ()30900224 (PubMedID)2-s2.0-85066132287 (Scopus ID)
Projects
Venous thromboEmbolism In Northern Sweden
Funder
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and WelfareVästerbotten County Council
Available from: 2019-03-24 Created: 2019-03-24 Last updated: 2023-08-28Bibliographically approved
Johansson, M., Johansson, L., Wennberg, P. & Lind, M. (2019). Physical activity and risk of first-time venous thromboembolism. European Journal of Preventive Cardiology, 26(11), 1181-1187
Open this publication in new window or tab >>Physical activity and risk of first-time venous thromboembolism
2019 (English)In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 26, no 11, p. 1181-1187Article in journal (Refereed) Published
Abstract [en]

Background: Physical activity may have a protective effect against venous thromboembolism (VTE). The aim of this study was to investigate the association between leisure time physical activity, occupational physical activity, and the risk of VTE in men and women separately.

Methods: The population-based, prospective Venous thromboEmbolism In Northern Sweden (VEINS) cohort study included 108,025 participants of health examinations between 1985 and 2014. Physical activity data were collected by questionnaire. Participants were followed from health examination to first-time VTE event, death, emigration or the end of the study. All VTE events were validated by reviewing medical records and radiology reports.

Results: During 1,496,669 person-years, 2054 participants experienced VTE. Women who performed leisure time physical activity at least once a week had a lower risk of first-time VTE (hazard ratio (HR) 0.83; 95% confidence interval (CI) 0.71–0.98 after adjustments) compared with women with less or no physical activity. Furthermore, women with high occupational physical activity also had a lower risk of VTE (HR 0.85; 95% CI 0.74–0.98). In men, there was no consistent association between either measure of physical activity and the risk of VTE.

Conclusion: We found an association between increased physical activity and a lower risk of first-time VTE in women.

Place, publisher, year, edition, pages
Sage Publications, 2019
Keywords
Venous thromboembolism, exercise, physical activity, venous thrombosis
National Category
Other Clinical Medicine
Research subject
Medicine
Identifiers
urn:nbn:se:umu:diva-156241 (URN)10.1177/2047487319829310 (DOI)000472573700010 ()30727768 (PubMedID)2-s2.0-85061651499 (Scopus ID)
Funder
Västerbotten County Council
Available from: 2019-03-01 Created: 2019-03-01 Last updated: 2020-05-14Bibliographically approved
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