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2024 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051XArticle in journal (Refereed) Epub ahead of print
Abstract [en]
Background and Aim: The study ‘Periodontitis and Its Relation to Coronary Artery Disease’ (PAROKRANK) reported an association between periodontitis (PD) and the first myocardial infarction (MI). This follow-up study aims to test the hypothesis that those with PD—compared to periodontally healthy individuals—are at increased risk for cardiovascular (CV) events and death.
Methods: A total of 1587 participants (age <75 years; females 19%) had a dental examination including panoramic radiographs between 2010 and 2014. PD was categorized as healthy (≥80% alveolar bone height), mild/moderate (79%–66%) or severe (<66%). A composite CV event (first of all-cause death, non-fatal MI or stroke and hospitalization following to heart failure) was investigated during a mean follow-up period of 9.9 years (range 0.2–12.5 years). Participants were divided into two groups: those with and without PD. The primary event rate, stratified by periodontal status at baseline, was calculated using the Kaplan–Meier method and Cox regression.
Results: The number of events was 187 in the 985 periodontally healthy participants (19%) and 174 in the 602 participants with PD (29%; p < 0.0001). Those with PD had a higher likelihood for a future event (hazard ratio [HR] = 1.26; 95% CI: 1.01–1.57; p = 0.038), following adjustment for age, smoking and diabetes.
Conclusion: The PAROKRANK follow-up revealed that CV events were more common among participants with PD, which supports the assumption that there might be a direct relation between PD and CV disease.
Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
cardiovascular disease, long-term follow-up, myocardial infarction, periodontitis, prognosis
National Category
Dentistry
Identifiers
urn:nbn:se:umu:diva-229918 (URN)10.1111/jcpe.14064 (DOI)001310322600001 ()39261983 (PubMedID)2-s2.0-85203707888 (Scopus ID)
Funder
AFA InsuranceSwedish Heart Lung FoundationSwedish Research CouncilSwedish Society of MedicineRegion Stockholm
2024-09-252024-09-252024-09-25