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Levring Jäghagen, Eva, DDS, PhDORCID iD iconorcid.org/0000-0001-8807-3500
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Publications (10 of 57) Show all publications
Bladh, M., Gustafsson, N., Engström, G., Kennbäck, C., Klinge, B., Nilsson, P. M., . . . Levring Jäghagen, E. (2024). Defined shapes of carotid artery calcifications on panoramic radiographs correlate with specific signs of cardiovascular disease on ultrasound examination. Oral surgery, oral medicine, oral pathology and oral radiology, 137(4), 408-420
Open this publication in new window or tab >>Defined shapes of carotid artery calcifications on panoramic radiographs correlate with specific signs of cardiovascular disease on ultrasound examination
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2024 (English)In: Oral surgery, oral medicine, oral pathology and oral radiology, ISSN 2212-4403, E-ISSN 2212-4411, Vol. 137, no 4, p. 408-420Article in journal (Refereed) Published
Abstract [en]

Objective: The aim was to optimize diagnostics for carotid artery calcifications (CACs) on panoramic radiographs (PRs) to identify cardiovascular disease (CVD) by investigating how 4 defined CAC shapes are associated with ultrasound (US) findings indicating CVD.

Study Design: The study included 414 participants (802 neck sides) from the Malmö Offspring Dental Study, examined with PRs. The PRs were assessed for CAC shapes stratified into 4 categories: single, scattered, vessel-width defining, and vessel-outlining. The carotid arteries were examined with US for signs of CVD: the presence of plaques, largest individual area of a plaque, number of plaques, and percentage reduction of the lumen. Associations between the different CAC categories and US characteristics were analyzed.

Results: All categories of CAC were significantly associated with a higher degree of US findings indicating CVD compared with no CAC (P < .001). The most significant differences were found for vessel-outlining CAC, with the mean of the largest individual plaque area of 17.9 vs 2.3 mm2, mean number of plaques 1.6 vs 0.2, and mean percentage reduction of the lumen 24.1% vs 3.5% (all P < .001).

Conclusions: Independent of shape, CACs detected on PRs were associated with a higher degree of US findings of CVD. This was most pronounced for vessel-outlining CAC. With refined differential diagnostics of CACs in PRs, dentists may contribute to improved identification of patients in need of cardiovascular prevention.

Place, publisher, year, edition, pages
Elsevier, 2024
National Category
Dentistry Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:umu:diva-220848 (URN)10.1016/j.oooo.2023.12.783 (DOI)38320892 (PubMedID)2-s2.0-85183975366 (Scopus ID)
Funder
Region Västerbotten, 7003195Region Västerbotten, 7004491Umeå UniversitySwedish Dental AssociationThe Kempe Foundations
Available from: 2024-02-20 Created: 2024-02-20 Last updated: 2024-04-26Bibliographically approved
Norhammar, A., Näsman, P., Buhlin, K., de Faire, U., Ferrannini, G., Gustafsson, A., . . . Rydén, L. (2024). Does periodontitis increase the risk for future cardiovascular events?: Long-term follow-up of the PAROKRANK study. Journal of Clinical Periodontology
Open this publication in new window or tab >>Does periodontitis increase the risk for future cardiovascular events?: Long-term follow-up of the PAROKRANK study
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2024 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051XArticle in journal (Refereed) Epub ahead of print
Abstract [en]

Background and Aim: The study ‘Periodontitis and Its Relation to Coronary Artery Disease’ (PAROKRANK) reported an association between periodontitis (PD) and the first myocardial infarction (MI). This follow-up study aims to test the hypothesis that those with PD—compared to periodontally healthy individuals—are at increased risk for cardiovascular (CV) events and death.

Methods: A total of 1587 participants (age <75 years; females 19%) had a dental examination including panoramic radiographs between 2010 and 2014. PD was categorized as healthy (≥80% alveolar bone height), mild/moderate (79%–66%) or severe (<66%). A composite CV event (first of all-cause death, non-fatal MI or stroke and hospitalization following to heart failure) was investigated during a mean follow-up period of 9.9 years (range 0.2–12.5 years). Participants were divided into two groups: those with and without PD. The primary event rate, stratified by periodontal status at baseline, was calculated using the Kaplan–Meier method and Cox regression.

Results: The number of events was 187 in the 985 periodontally healthy participants (19%) and 174 in the 602 participants with PD (29%; p < 0.0001). Those with PD had a higher likelihood for a future event (hazard ratio [HR] = 1.26; 95% CI: 1.01–1.57; p = 0.038), following adjustment for age, smoking and diabetes.

Conclusion: The PAROKRANK follow-up revealed that CV events were more common among participants with PD, which supports the assumption that there might be a direct relation between PD and CV disease.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
cardiovascular disease, long-term follow-up, myocardial infarction, periodontitis, prognosis
National Category
Dentistry
Identifiers
urn:nbn:se:umu:diva-229918 (URN)10.1111/jcpe.14064 (DOI)001310322600001 ()39261983 (PubMedID)2-s2.0-85203707888 (Scopus ID)
Funder
AFA InsuranceSwedish Heart Lung FoundationSwedish Research CouncilSwedish Society of MedicineRegion Stockholm
Available from: 2024-09-25 Created: 2024-09-25 Last updated: 2024-09-25
Lundberg, J., Al-Taai, N., Levring Jäghagen, E., Ransjö, M. & Sjöström, M. (2024). Skeletal stability after maxillary distraction osteogenesis or conventional Le Fort i osteotomy in patients with cleft lip and palate: a superimposition-based cephalometric analysis. Oral and Maxillofacial Surgery, 28(2), 925-934
Open this publication in new window or tab >>Skeletal stability after maxillary distraction osteogenesis or conventional Le Fort i osteotomy in patients with cleft lip and palate: a superimposition-based cephalometric analysis
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2024 (English)In: Oral and Maxillofacial Surgery, ISSN 1865-1550, E-ISSN 1865-1569, Vol. 28, no 2, p. 925-934Article in journal (Refereed) Published
Abstract [en]

Purpose: The aim was to assess skeletal stability after maxillary advancement using either distraction osteogenesis (DO) or conventional Le Fort I osteotomy (CO) in patients with cleft lip and palate (CLP) or cleft palate (CP) utilising a new superimposition-based cephalometric method.

Method: This retrospective study included patients who were treated with DO (N = 12) or CO (N = 9). Sagittal and vertical changes after surgery, and skeletal stability at 18 months post-operatively were assessed with superimposition-based cephalometry, comparing lateral cephalograms performed pre-operatively (T0), post-operatively after CO or immediately after completed distraction in DO (T1), and at 18 months of follow-up (T2).

Results: The mean sagittal movements from T0 to T2 in the DO and CO groups were 5.9 mm and 2.2 mm, respectively, with a skeletal relapse rate of 16% in the DO group and 15% in the CO group between T1 and T2. The vertical mean movement from T0 to T2 in the DO and CO groups was 2.8 mm and 2.0 mm, respectively, and the skeletal relapse rate between T1 and T2 was 36% in the DO group and 32% in the CO group.

Conclusion: Sagittal advancement of the maxilla was stable, in contrast to the vertical downward movement, which showed more-extensive relapse in both groups. Despite more-extensive maxillary advancement in the DO group, the rates of skeletal relapse were similar.

Place, publisher, year, edition, pages
Springer Nature, 2024
Keywords
Distraction osteogenesis, Maxillary repositioning, Orthognathic surgery, Skeletal relapse, Cleft lip and palate
National Category
Dentistry
Identifiers
urn:nbn:se:umu:diva-221090 (URN)10.1007/s10006-024-01227-0 (DOI)001163526500001 ()38363518 (PubMedID)2-s2.0-85185143089 (Scopus ID)
Funder
Umeå University, 396178205
Available from: 2024-02-19 Created: 2024-02-19 Last updated: 2024-06-18Bibliographically approved
de Lange, T., Møystad, A., Torgersen, G., Ahlqvist, J. & Levring Jäghagen, E. (2024). Students' perceptions of post-exam feedback in oral radiology: a comparative study from two dental hygienist educational settings. European journal of dental education, 28(2), 377-387
Open this publication in new window or tab >>Students' perceptions of post-exam feedback in oral radiology: a comparative study from two dental hygienist educational settings
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2024 (English)In: European journal of dental education, ISSN 1396-5883, E-ISSN 1600-0579, Vol. 28, no 2, p. 377-387Article in journal (Refereed) Published
Abstract [en]

Introduction: The aim of this study was to investigate how students perceive the benefit of participating in a teacher-organised session providing feedback on exams, termed post-exam feedback, in two dental hygienist programmes.

Methods: The study was based on interviews with 22 participants, including 18 students and 4 faculty teachers. The data were approached on the basis of thematic analysis, allowing us to generate insights on how the participants reflected on their participation in the post-exam feedback sessions and how they perceived this arrangement as learners.

Results: The findings from the study suggest that motivated students consider post-exam feedback to be beneficial in clearing up uncertainties and deepening their understanding of issues not fully understood during the exam, as well as supporting their further learning. Less motivated students mainly consider post-exam feedback to be relevant for students who do not pass the exams.

Conclusions: Organised in a student-centred way and with attentiveness to student learning preferences, the results suggest that post-exam feedback can be valuable for enhancing assessment and supporting student learning related to exams.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
Assessment, oral radiology, post-exam feedback, student learning
National Category
Dentistry
Identifiers
urn:nbn:se:umu:diva-216218 (URN)10.1111/eje.12959 (DOI)001089702100001 ()37885281 (PubMedID)2-s2.0-85175033873 (Scopus ID)
Funder
Umeå University
Available from: 2023-11-06 Created: 2023-11-06 Last updated: 2024-07-03Bibliographically approved
Selg, J., Holmlund, T., Levring Jäghagen, E., McGreevy, J., Svanberg, S., Wester, P. & Hägglund, P. (2024). Validity and reliability of the Swedish version of the gugging swallowing screen for use in acute stroke care. Dysphagia (New York. Print)
Open this publication in new window or tab >>Validity and reliability of the Swedish version of the gugging swallowing screen for use in acute stroke care
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2024 (English)In: Dysphagia (New York. Print), ISSN 0179-051X, E-ISSN 1432-0460Article in journal (Refereed) Epub ahead of print
Abstract [en]

The purpose of this study was to cross-culturally validate the Swedish version of the Gugging Swallowing Screen (GUSS-S) for use in the acute phase of stroke. Further, to evaluate the inter-rater reliability between different healthcare professionals. GUSS was translated into Swedish using a forward-backward method followed by expert rating to obtain content validity. For criterion validity, the GUSS-S score was compared with Flexible Endoscopic Evaluation of Swallowing (FEES) assessed with the Penetration-Aspiration Scale (PAS) in acute stroke patients (≤ 96 h after stroke onset). Convergent validity was calculated by comparison with the Functional Oral Intake Scale (FOIS) as per the comprehensive FEES assessment, the Standardized Swallowing Assessment (SSA), and the National Institutes of Health Stroke Scale (NIHSS). To evaluate inter-rater reliability, a nurse and a speech-language pathologist (SLP) independently assessed 30 patients. In total, 80 patients (32 women, median age 77 years (range 29–93) were included, mean 1.7 ± 0.9 days after admission. With a cut-off value of 14 points, the GUSS-S identified aspiration with a sensitivity of 100% and a specificity of 73% (area under the curve: 0.87, 95% CI 0.78–0.95). Spearman rank correlation showed very strong correlation between the GUSS-S and PAS (rs=-0.718, P = < 0.001) and FOIS (rs=0.720, P = 0.001) and strong correlation between the GUSS-S and SSA (rs=0.545, P = < 0.001) and NIHSS (rs=-0.447, P = 0.001). The inter-rater agreement for GUSS-S was substantial (Kw=0.67, P = < 0.001). The results indicate that the GUSS-S is a valid and reliable tool for the assessment of dysphagia in acute stroke patients by different healthcare professionals.

Place, publisher, year, edition, pages
Springer, 2024
Keywords
Stroke, Dysphagia screening, Validation, Sensitivity, Specificity, The Gugging swallowing screen
National Category
Otorhinolaryngology Neurology
Identifiers
urn:nbn:se:umu:diva-225527 (URN)10.1007/s00455-024-10717-y (DOI)001226594800001 ()38753206 (PubMedID)2-s2.0-85193223225 (Scopus ID)
Available from: 2024-06-03 Created: 2024-06-03 Last updated: 2024-07-02
Jonsson, A., Holmer, J., Kullman, L., Eriksdotter, M., Ahlqvist, J., Levring Jäghagen, E. & Buhlin, K. (2023). Calcified carotid artery atheromas in individuals with cognitive dysfunction. Acta Odontologica Scandinavica, 81(4), 325-331
Open this publication in new window or tab >>Calcified carotid artery atheromas in individuals with cognitive dysfunction
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2023 (English)In: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 81, no 4, p. 325-331Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of this case-control study was to investigate whether cognitively impaired individuals have a higher burden of calcified carotid artery atheroma (CCAA) than controls without cognitive impairment.

Material and methods: The study included 154 cases with Alzheimer’s disease (n = 52), mild cognitive impairment (n = 51), or subjective cognitive decline (n = 51) diagnosed at a university memory clinic. Seventy-six cognitively healthy controls were sampled through the Swedish population register. All participants underwent clinical oral and panoramic radiographic examinations. Two oral and maxillofacial radiologists performed blinded analyses of the panoramic radiographs for signs of CCAA, which was registered as absent or present and, if present, unilateral or bilateral. Consensus assessment was used for all statistical analyses.

Results: CCAA was common (40%) in this middle-aged and older Swedish population. We found no differences in the prevalence of CCAA between cases and controls (40% vs. 42%).

Conclusion: Cognitively impaired patients do not have a higher burden of CCAA than matched controls without cognitive impairment.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2023
Keywords
Alzheimer’s disease, cardiovascular disease, cognitive disorders, dentistry, panoramic radiography
National Category
Dentistry Radiology, Nuclear Medicine and Medical Imaging Geriatrics
Research subject
Odontology
Identifiers
urn:nbn:se:umu:diva-201842 (URN)10.1080/00016357.2022.2152863 (DOI)000900707600001 ()36538364 (PubMedID)2-s2.0-85144537909 (Scopus ID)
Funder
Stockholm County Council
Available from: 2022-12-21 Created: 2022-12-21 Last updated: 2023-06-19Bibliographically approved
Al-Taai, N., Persson, M., Ransjö, M., Levring Jäghagen, E. & Westerlund, A. (2023). Dentoskeletal and soft tissue changes after treatment of crowding with premolar extractions: a 50-year follow-up. European Journal of Orthodontics, 41(1), 79-87
Open this publication in new window or tab >>Dentoskeletal and soft tissue changes after treatment of crowding with premolar extractions: a 50-year follow-up
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2023 (English)In: European Journal of Orthodontics, ISSN 0141-5387, E-ISSN 1460-2210, Vol. 41, no 1, p. 79-87Article in journal (Refereed) Published
Abstract [en]

Background: The long-term effects on dentofacial morphology of interceptive treatment with premolar extractions, in the absence of subsequent orthodontic treatment, have not been fully explored.

Objective: The aim was to investigate the effects of premolar extractions (without subsequent orthodontic treatment) on the dentoskeletal and soft tissue profile of patients aged between 12 and 62 years with Class I malocclusion with severe crowding, as compared to untreated controls.

Materials and methods: The Extraction group (N = 30 with Class I crowding malocclusion) had their first premolars removed in early adolescence without subsequent orthodontic treatment. The Control group included 30 untreated subjects with Class I normal occlusion. Cephalograms were taken at 12 (T1), 15 (T2), 30 (T3), and 62 (T4) years of age. A superimposition-based cephalometric method was used to assess the dentoskeletal and soft tissue changes.

Results: There were no significant differences between the Extraction and Control groups in terms of skeletal sagittal relation, incisor inclination, and protrusion, or most of the soft tissue parameters throughout the observation period. However, significant differences were observed between the groups with respect to the vertical relations in T2-T3, such that the Extraction group showed more-pronounced decreases in the ML/NSL, ML/NL, and Gonial angles and more-pronounced increases in facial heights.

Conclusions and implications: Treatment for subjects with Class I malocclusion with severe crowding by the extraction of four premolars, without subsequent orthodontic treatment, does not affect the long-term dentoskeletal and soft tissue profile, as compared to an untreated Control group. The degree of crowding, rather than changes in dentofacial morphology, is crucial in deciding on extraction therapy.

Place, publisher, year, edition, pages
Oxford University Press, 2023
National Category
Dentistry Surgery
Research subject
Odontology
Identifiers
urn:nbn:se:umu:diva-199060 (URN)10.1093/ejo/cjac035 (DOI)000820957600001 ()35791441 (PubMedID)2-s2.0-85147834504 (Scopus ID)
Funder
Umeå University
Available from: 2022-09-02 Created: 2022-09-02 Last updated: 2023-03-06Bibliographically approved
Levring Jäghagen, E., de Lange, T., Torgersen, G., Møystad, A. & Ahlqvist, J. (2023). The use of post-exam feedback in oral radiology: a survey study of dental and dental hygienist schools in Europe. European journal of dental education, 27(4), 1048-1052
Open this publication in new window or tab >>The use of post-exam feedback in oral radiology: a survey study of dental and dental hygienist schools in Europe
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2023 (English)In: European journal of dental education, ISSN 1396-5883, E-ISSN 1600-0579, Vol. 27, no 4, p. 1048-1052Article in journal (Refereed) Published
Abstract [en]

Introduction: A combination of summative assessments and post-exam feedback can create a formative environment to support student learning. It remains unknown to what extent feedback sessions are conducted after exams in oral radiology courses for dental and dental hygienist students in Europe. This survey study aimed to explore whether post-exam feedback sessions were conducted, and if so, in what format.

Materials and Methods: A questionnaire was distributed to 76 dental schools in 26 countries and 34 dental hygienist schools in 14 countries in Europe. The questions addressed whether feedback was provided after exams in oral radiology, the feedback format, and whether feedback sessions were formalised or performed for other reasons.

Results: Questionnaire responses were received from 33 dental schools in 18 countries, and 20 dental hygienist schools in 11 countries. Information about grades was provided in 23–30% of the schools. Post-exam feedback sessions including opportunities for discussion was provided at 39% of the schools, all with guidelines stating that these sessions should be carried out. The remaining schools provided feedback either on request by individual students or as written examples of correct answers.

Conclusion: Almost one third of the dental schools announced grades without providing any post-exam feedback that could support learning. Two fifth utilised feedback sessions to assist students in gaining knowledge and sorting out misconceptions, all according to guidelines. Given the possible learning potential in post-exam feedback with opportunity to discuss, further studies of this format would be valuable, including the role and use of feedback guidelines.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023
Keywords
examination, feedback, learning outcomes, oral radiology, survey
National Category
Dentistry
Identifiers
urn:nbn:se:umu:diva-204769 (URN)10.1111/eje.12897 (DOI)000921604900001 ()36690585 (PubMedID)2-s2.0-85147263153 (Scopus ID)
Funder
Umeå University
Available from: 2023-02-20 Created: 2023-02-20 Last updated: 2024-01-08Bibliographically approved
Gustafsson, N., Ahlqvist, J., Norhammar, A., Näslund, U., Rydén, L., Wester, P. & Levring Jäghagen, E. (2022). Association of high cardiovascular risk and diabetes with calcified carotid artery atheromas depicted on panoramic radiographs. Oral surgery, oral medicine, oral pathology and oral radiology, 133(1), 88-99
Open this publication in new window or tab >>Association of high cardiovascular risk and diabetes with calcified carotid artery atheromas depicted on panoramic radiographs
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2022 (English)In: Oral surgery, oral medicine, oral pathology and oral radiology, ISSN 2212-4403, E-ISSN 2212-4411, Vol. 133, no 1, p. 88-99Article in journal (Refereed) Published
Abstract [en]

Objective: To evaluate whether estimates of risk of future cardiovascular events and death and established or unknown diabetes are significantly associated with calcified carotid artery atheromas (CCAAs) on panoramic radiographs (PRs). The main focus was on men and women without previous myocardial infarction (MI). Methods: The PAROKRANK (Periodontitis and its Relation to Coronary Artery Disease) study included patients with a first MI and matched control subjects. In this substudy, 738 patients (138 women) and 744 control subjects (144 women) with available PRs were assessed for CCAA. Cardiovascular risk estimates were determined according to the Framingham Risk Score (FRS) and Systematic COronary Risk Evaluation (SCORE). Established and previously unknown diabetes was also determined. Results: CCAA was detected on PRs in 206 control subjects (28%) and 251 patients (34%). FRS was significantly associated with CCAA among control subjects (P = .04) and patients (P = .001). SCORE was associated with CCAA among control subjects (P < .01) but not patients (P = .07). Among men, FRS and SCORE were associated with CCAA in both control subjects and patients. Diabetes was not significantly associated with CCAA after adjustments. Conclusions: Elevated cardiovascular risk scores were associated with CCAA on PRs among control subjects. Diabetes was not independently associated with CCAA, possibly owing to selection bias.

Place, publisher, year, edition, pages
Elsevier, 2022
National Category
Dentistry
Research subject
Odontology
Identifiers
urn:nbn:se:umu:diva-191345 (URN)10.1016/j.oooo.2021.06.006 (DOI)000883453900018 ()34305040 (PubMedID)2-s2.0-85111060233 (Scopus ID)
Available from: 2022-01-14 Created: 2022-01-14 Last updated: 2024-07-02Bibliographically approved
Al-Taai, N., Persson, M., Ransjö, M., Levring Jäghagen, E., Fors, R. & Westerlund, A. (2022). Craniofacial changes from 13 to 62 years of age. European Journal of Orthodontics, 44(5), 556-565
Open this publication in new window or tab >>Craniofacial changes from 13 to 62 years of age
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2022 (English)In: European Journal of Orthodontics, ISSN 0141-5387, E-ISSN 1460-2210, Vol. 44, no 5, p. 556-565Article in journal (Refereed) Published
Abstract [en]

Background: In long-term studies of orthodontic, orthognathic, and prosthodontic treatments, control subjects are needed for comparison.

Objectives: To study the craniofacial (skeletal, soft tissue, and dental) changes that occur in untreated subjects with normal occlusion between13 and 62 years of age.

Materials/Methods: Thirty subjects with a Class I normal occlusion and harmonious facial profle were studied. X-ray examinations were performed at 13 (T1), 16 (T2), 31 (T3), and 62 (T4) years of age, and data were obtained from cephalograms. In total, 53 angular and linear parameters were measured using superimposition-based and conventional cephalometric methods to describe the craniofacial changes.

Results: The jaws showed signifcant anterior growth from T1 to T2, and signifcant retrognathism from T3 to T4. The anterior face height andjaw dimensions increased signifcantly until T3. Signifcant posterior rotation of the mandible and opening of the vertical jaw relation, in additionto signifcant retroclination of the incisors and straightening of the facial profle, were found from T3 to T4.Limitations: Given the small sample size at T4, it was not possible to analyse the gender dimension.

Conclusions/Implications: Craniofacial changes continue up to the sixth decade of life. These changes are consistent, albeit to a lesser extent,with the adolescent growth patterns for most of the studied parameters, with the exceptions of incisor inclination, sagittal jaw position, verticaljaw relation and inclination, and posterior face height.

Place, publisher, year, edition, pages
Oxford University Press, 2022
National Category
Dentistry
Research subject
Odontology
Identifiers
urn:nbn:se:umu:diva-194661 (URN)10.1093/ejo/cjac011 (DOI)000786746700001 ()35348638 (PubMedID)2-s2.0-85133267986 (Scopus ID)
Available from: 2022-05-12 Created: 2022-05-12 Last updated: 2023-03-24Bibliographically approved
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