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Weidung, Bodil
Publications (10 of 15) Show all publications
Bergfrid, M., Gustafson, Y., Littbrand, H., Olofsson, B. & Weidung, B. (2024). Having plans for the future in very old people. The International Journal of Aging & Human Development
Open this publication in new window or tab >>Having plans for the future in very old people
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2024 (English)In: The International Journal of Aging & Human Development, ISSN 0091-4150, E-ISSN 1541-3535Article in journal (Refereed) Epub ahead of print
Abstract [en]

This study aimed to investigate the prevalence of having plans for the future among very old people and the factors associated with having such plans. A longitudinal population-based study with home visits for 85-, 90-, and ≥95-year-old participants in Sweden and Finland was used. Multivariate logistic regression and Cox proportional-hazards regression models with a maximum 5-year follow-up period were used. The prevalence of having plans for the future was 18.6% (174/936). More men than women and more people living in Sweden than in Finland had plans for the future. In multivariate models, having plans for the future was associated with speaking Swedish, being dentate, and living in the community in the total sample; speaking Swedish and being dentate among women; and speaking Swedish, having a lower Geriatric Depression Scale score, and urban residence among men. Having plans for the future was associated univariately, but not multivariately, with increased survival.

Place, publisher, year, edition, pages
Sage Publications, 2024
Keywords
aged 80 and over, future perception, gerontology, optimism, plans for the future, survival
National Category
Gerontology, specialising in Medical and Health Sciences Nursing
Identifiers
urn:nbn:se:umu:diva-221560 (URN)10.1177/00914150241231189 (DOI)001159569300001 ()38342991 (PubMedID)2-s2.0-85185275774 (Scopus ID)
Funder
Umeå UniversityThe Dementia Association - The National Association for the Rights of the DementedSwedish Research Council, K2014-99X-22610-01-6Visare NorrRegion VästerbottenKonung Gustaf V:s och Drottning Victorias Frimurarestiftelse
Available from: 2024-03-05 Created: 2024-03-05 Last updated: 2024-03-05
Lopatko Lindman, K., Lockman-Lundgren, J., Weidung, B., Olsson, J., Elgh, F. & Lövheim, H. (2022). Long-term time trends in reactivated herpes simplex infections and treatment in Sweden. BMC Infectious Diseases, 22(1), Article ID 547.
Open this publication in new window or tab >>Long-term time trends in reactivated herpes simplex infections and treatment in Sweden
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2022 (English)In: BMC Infectious Diseases, E-ISSN 1471-2334, Vol. 22, no 1, article id 547Article in journal (Refereed) Published
Abstract [en]

Background: Our aim was to describe the annual prevalence of herpes simplex virus (HSV) reactivation in relation to solar ultraviolet (UV) radiation and antiviral drug use in the Swedish adult population.

Methods: The study comprised 2879 anti-HSV-1 immunoglobulin (Ig) G positive subjects from five different cohorts who had donated serum from 1988 to 2010. The sera were analyzed for anti-HSV IgM using enzyme-linked immunosorbent assay. Associations between the presence of anti-HSV IgM antibodies, the apolipoprotein E ε4 allele and the serum sampling year were assessed by logistic regression. Seasonality of anti-HSV IgM was evaluated in a UV radiation model. Data of antiviral drugs for the entire Swedish population were compiled from two different nationwide databases: the Swedish Prescribed Drug Register and the Swedish Association of the Pharmaceutical Industry.

Results: Cross-sectional and longitudinal analyses indicated that the prevalence of anti-HSV IgM antibodies declined between 1988 and 2010 (odds ratio [OR] = 0.912, p <.001), while the total annual use of antiviral drugs in Sweden gradually increased from 1984 to 2017. Higher UV radiation was associated with higher prevalence of anti-HSV IgM antibodies (OR = 1.071, p =.043).

Conclusion: The declining time trend of HSV reactivation in a Swedish cohort coincides with a steady increase of antiviral drug use in the Swedish general population.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2022
Keywords
Antiviral agents, Apolipoprotein E4, Cohort study, Epidemiology, Herpes simplex, Seroprevalence, Ultraviolet radiation
National Category
Infectious Medicine
Identifiers
urn:nbn:se:umu:diva-203316 (URN)10.1186/s12879-022-07525-w (DOI)000811753500001 ()35705911 (PubMedID)2-s2.0-85132163265 (Scopus ID)
Funder
Region VästerbottenThe Kempe FoundationsThe Dementia Association - The National Association for the Rights of the DementedHans-Gabriel och Alice Trolle-Wachtmeisters stiftelse för medicinsk forskningAlzheimerfondenGun och Bertil Stohnes Stiftelse
Available from: 2023-01-18 Created: 2023-01-18 Last updated: 2024-01-17Bibliographically approved
Lopatko Lindman, K., Jonsson, C., Weidung, B., Olsson, J., Pandey, J. P., Prokopenko, D., . . . Lövheim, H. (2022). PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk. Scientific Reports, 12(1), Article ID 13264.
Open this publication in new window or tab >>PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 13264Article in journal (Refereed) Published
Abstract [en]

PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer’s disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case–control study of 360 1:1-matched AD subjects. Interactions between the PILRA-A allele, APOE risk variants (ε3/ε4 or ε4/ε4) and GM17 for AD risk were modelled. The associations were cross-validated using two independent whole-genome sequencing datasets. We found negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52–1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32–0.98) in the discovery dataset. In the replication cohort, a joint effect of PILRA and PILRA × GM 17/17 was observed for the risk of developing AD (p.02). Here, we report a negative effect modification by PILRA on APOE and GM17 high-risk variants for future AD risk in two independent datasets. This highlights the complex genetics of AD.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022
National Category
Medical Genetics Public Health, Global Health, Social Medicine and Epidemiology Microbiology
Identifiers
urn:nbn:se:umu:diva-198480 (URN)10.1038/s41598-022-17058-6 (DOI)000836651200031 ()35918447 (PubMedID)2-s2.0-85135234828 (Scopus ID)
Funder
EU, FP7, Seventh Framework ProgrammeRegion VästerbottenThe Kempe FoundationsThe Swedish Medical AssociationThe Dementia Association - The National Association for the Rights of the DementedAlzheimerfondenThe Swedish Brain Foundation
Available from: 2022-08-12 Created: 2022-08-12 Last updated: 2023-09-05Bibliographically approved
Hemmingsson, E.-S., Hjelmare, E., Weidung, B., Olsson, J., Josefsson, M., Adolfsson, R., . . . Lövheim, H. (2021). Antiviral treatment associated with reduced risk of clinical Alzheimer's disease: A nested case-control study. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 7(1), Article ID e12187.
Open this publication in new window or tab >>Antiviral treatment associated with reduced risk of clinical Alzheimer's disease: A nested case-control study
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2021 (English)In: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, E-ISSN 2352-8737, Vol. 7, no 1, article id e12187Article in journal (Refereed) Published
Abstract [en]

Introduction: In this nested case-control study, we investigated if antiviral treatment given prior to onset of Alzheimer's disease (AD) could influence incident AD.

Methods: From a large population-based cohort study in northern Sweden, 262 individuals that later developed AD were compared to a non-AD matched control group with respect to prescriptions of herpes antiviral treatment. All included subjects were herpes simplex virus 1 (HSV1) carriers and the matching criteria were age, sex, apolipoprotein E genotype (ε4 allele carriership), and study sample start year.

Results: Among those who developed AD, 6 prescriptions of antivirals were found, compared to 20 among matched controls. Adjusted for length of follow-up, a conditional logistic regression indicated a difference in the risk for AD development between groups (odds ratio for AD with an antiviral prescription 0.287, P = .018).

Discussion: Antiviral treatment might possibly reduce the risk for later development of HSV1-associated AD.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021
Keywords
Alzheimer’s disease, antiviral treatment, apolipoprotein E gene, dementia, herpes simplex, major neurocognitive disorder, nested case-control study
National Category
Geriatrics
Identifiers
urn:nbn:se:umu:diva-187310 (URN)10.1002/trc2.12187 (DOI)000750546300053 ()2-s2.0-85114262531 (Scopus ID)
Funder
Region VästerbottenThe Dementia Association - The National Association for the Rights of the DementedAlzheimerfondenKnut and Alice Wallenberg FoundationForte, Swedish Research Council for Health, Working Life and Welfare, 2013-2056
Available from: 2021-09-07 Created: 2021-09-07 Last updated: 2024-04-08Bibliographically approved
Lopatko Lindman, K., Hemmingsson, E.-S., Weidung, B., Brännström, J., Josefsson, M., Olsson, J., . . . Lövheim, H. (2021). Herpesvirus infections, antiviral treatment, and the risk ofdementia: a registry-based cohort study in Sweden. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 7(1), Article ID e12119.
Open this publication in new window or tab >>Herpesvirus infections, antiviral treatment, and the risk ofdementia: a registry-based cohort study in Sweden
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2021 (English)In: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, E-ISSN 2352-8737, Vol. 7, no 1, article id e12119Article in journal (Refereed) Published
Abstract [en]

Introduction: Herpesviruses, including Herpes simplex virus type 1 (HSV1) and varicella zoster‐virus (VZV), have been implicated in Alzheimer's disease (AD) development. Likewise, antiviral treatment has been suggested to protect against dementia development in herpes‐infected individuals.

Methods: The study enrolled 265,172 subjects aged ≥ 50 years, with diagnoses of VZV or HSV, or prescribed antiviral drugs between 31 December 2005 and 31 December 2017. Controls were matched in a 1:1 ratio by sex and birth year.

Results: Antiviral treatment was associated with decreased risk of dementia (adjusted hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.86 to 0.92), while herpes infection without antiviral drugs increased the risk of dementia (adjusted HR 1.50, 95% CI 1.29 to 1.74).

Discussion: Antiviral treatment was associated with a reduced long‐term risk of dementia among individuals with overt signs of herpes infection. This is consistent with earlier findings indicating that herpesviruses are involved in the pathogenesis of AD.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021
Keywords
Alzheimer’s disease, antiviral agents, dementia, herpes simplex, herpes zoster, retrospective cohort study, varicella zoster
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-182629 (URN)10.1002/trc2.12119 (DOI)000750546300096 ()2-s2.0-85103930201 (Scopus ID)
Available from: 2021-04-27 Created: 2021-04-27 Last updated: 2023-09-05Bibliographically approved
Lopatko Lindman, K., Weidung, B., Olsson, J., Josefsson, M., Johansson, A., Eriksson, S., . . . Lövheim, H. (2021). Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and Chlamydophila pneumoniae. Journal of Alzheimer's Disease Reports, 5(1), 229-235
Open this publication in new window or tab >>Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and Chlamydophila pneumoniae
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2021 (English)In: Journal of Alzheimer's Disease Reports, E-ISSN 2542-4823, Vol. 5, no 1, p. 229-235Article in journal (Refereed) Published
Abstract [en]

Background: Amyloid-β (Aβ), the key constituent of Alzheimer’s disease (AD) plaques, has antimicrobial properties.

Objective: To investigate the association between plasma Aβ and antibodies against the AD-related pathogens herpes simplex virus (HSV), cytomegalovirus (CMV), and C. pneumoniae.

Methods: Plasma from 339 AD cases, obtained on average 9.4 years (±4.00) before diagnosis, and their matched controls were analyzed for Aβ40 and Aβ42 concentrations with Luminex xMAP technology and INNOBIA plasma Aβ-form assays. Enzyme-linked immunosorbent assays were utilized for analyses of anti-HSV immunoglobulin (Ig) G, anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG. Follow-up samples were available for 150 of the cases.

Results: Presence and levels of anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG did not correlate with concentrations of Aβ42 or Aβ40 in cases or controls.

Conclusion: Levels of plasma Aβ were not associated with antibodies against different AD-related pathogens.

Place, publisher, year, edition, pages
IOS Press, 2021
Keywords
Alzheimer’s disease, amyloid-β peptides, Chlamydophila pneumoniae, cytomegalovirus, dementia, Herpes simplex, nested case-control study
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-182612 (URN)10.3233/ADR-210008 (DOI)000651079100025 ()2-s2.0-85103991159 (Scopus ID)
Available from: 2021-04-27 Created: 2021-04-27 Last updated: 2023-09-05Bibliographically approved
Lopatko Lindman, K., Weidung, B., Olsson, J., Josefsson, M., Kok, E., Johansson, A., . . . Lövheim, H. (2019). A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex-associated Alzheimer's disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 5, 697-704
Open this publication in new window or tab >>A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex-associated Alzheimer's disease
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2019 (English)In: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, E-ISSN 2352-8737, Vol. 5, p. 697-704Article in journal (Refereed) Published
Abstract [en]

Introduction: Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis.

Methods: Plasma from 360 AD cases, obtained on average 9.6 years before diagnosis, and their age- and sex-matched controls, were analyzed for anti-HSV1 immunoglobulin (Ig) G with enzyme-linked immunosorbent assays (ELISAs). APOE genotype and nine other selected risk genes for AD were extracted from a genome-wide association study analysis by deCODE genetics, Reykjavik, Iceland.

Results: The interaction between APOEε4 heterozygosity (APOEε24 or ε3/ε4) and anti-HSV1 IgG carriage increased the risk of AD (OR 4.55, P = .02). A genetic risk score based on the nine AD risk genes also interacted with anti-HSV1 IgG for the risk of developing AD (OR 2.35, P = .01).

Discussion: The present findings suggest that the APOEε4 allele and other AD genetic risk factors might potentiate the risk of HSV1-associated AD.

Keywords
APOEε4, Alzheimer's disease, Apolipoprotein E4, Dementia, HSV, Herpes simplex, Nested case-control study
National Category
Clinical Medicine
Research subject
Medical Virology
Identifiers
urn:nbn:se:umu:diva-167226 (URN)10.1016/j.trci.2019.09.014 (DOI)000737692800074 ()31921962 (PubMedID)2-s2.0-85074268423 (Scopus ID)
Available from: 2020-01-13 Created: 2020-01-13 Last updated: 2023-09-05Bibliographically approved
Lövheim, H., Norman, T., Weidung, B., Olsson, J., Josefsson, M., Adolfsson, R., . . . Elgh, F. (2019). Herpes Simplex Virus, APOE ɛ4, and Cognitive Decline in Old Age: Results from the Betula Cohort Study. Journal of Alzheimer's Disease, 67(1), 211-220
Open this publication in new window or tab >>Herpes Simplex Virus, APOE ɛ4, and Cognitive Decline in Old Age: Results from the Betula Cohort Study
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2019 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 67, no 1, p. 211-220Article in journal (Refereed) Published
Abstract [en]

Background: Herpes simplex virus (HSV) has been suggested to play a role in Alzheimer’s disease (AD) development.

Objective: The aim of the present study was to investigate the early AD-related symptom episodic memory decline in relation to HSV and carriage of allele 4 of the apolipoprotein E gene (APOE ɛ4) in a large population-based cohort with a long follow-up time.

Methods: The study included 3,413 persons, with longitudinal data available for 1,293 persons with a mean follow-up time of 11.6 years. The associations between HSV carriage, APOE ɛ4 carriage, and episodic memory was investigated at baseline, as well as in longitudinal analyses where individuals with and without HSV antibodies (HSV1/2 non-specific) were matched and episodic memory decline compared.

Results: Cross-sectional analyses revealed an age-dependent association of HSV carriage with lower episodic memory function, particularly among APOE ɛ4 carriers (p = 0.008). Longitudinal analyses showed an increased risk of episodic memory decline in HSV carriers (≥65 years: p < 0.001, all ages: non-significant), and a significant interaction between HSV and APOE ɛ4 for episodic memory decline (p < 0.001).

Conclusion: In this large population-based cohort study, both cross-sectional and longitudinal results support an association between HSV carriage and declining episodic memory function, especially among APOE ɛ4 carriers. The results strengthen the hypothesis that HSV is associated with AD development.

Place, publisher, year, edition, pages
IOS Press, 2019
Keywords
Alzheimer’s disease, APOE ɛ4, apolipoprotein E4, cognitive impairment, cohort study, dementia, epidemiological study, episodic memory, herpes simplex virus
National Category
Neurosciences
Identifiers
urn:nbn:se:umu:diva-162728 (URN)10.3233/JAD-171162 (DOI)000457778000017 ()30636735 (PubMedID)2-s2.0-85059836237 (Scopus ID)
Available from: 2019-08-27 Created: 2019-08-27 Last updated: 2024-04-08Bibliographically approved
Lövheim, H., Olsson, J., Weidung, B., Johansson, A., Eriksson, S., Hallmans, G. & Elgh, F. (2018). Interaction between Cytomegalovirus and Herpes Simplex Virus Type 1 Associated with the Risk of Alzheimer’s Disease Development. Journal of Alzheimer's Disease, 61, 939-945
Open this publication in new window or tab >>Interaction between Cytomegalovirus and Herpes Simplex Virus Type 1 Associated with the Risk of Alzheimer’s Disease Development
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2018 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 61, p. 939-945Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Several environmental factors, including infectious agents, have been suggested to cause Alzheimer's disease (AD). Cytomegalovirus (CMV) has been associated with AD in several recent studies.

OBJECTIVE: To investigate whether carriage of CMV, alone or in combination with Herpes simplex virus (HSV), increased the risk of developing AD.

METHODS: Plasma samples from 360 AD cases (75.3% women, mean age 61.2 years), taken an average of 9.6 years before AD diagnosis, and 360 age-, sex-, cohort-, and sampling date matched dementia-free controls were analyzed to detect anti-CMV (immunoglobulin [Ig] G and IgM), group-specific anti-HSV (IgG and IgM), and specific anti-HSV1 and HSV2 IgG antibodies by enzyme-linked immunosorbent assays. AD cases and dementia-free controls were compared using conditional logistic regression analyses.

RESULTS: The presence of anti-CMV IgG antibodies did not increase the risk of AD (odds ratio [OR], 0.857; p = 0.497). Among AD cases, an association between CMV and HSV1 carriage was detected (OR 7.145, p < 0.001); in a conditional logistic regression model, the interaction between CMV and HSV1 was associated with AD development (OR 5.662; p = 0.007).

CONCLUSION: The present findings do not support a direct relationship between CMV infection and the development of AD; however, an interaction between CMV and HSV1 was found to be associated significantly with AD development. These findings suggest that CMV infection facilitates the development of HSV1-associated AD, possibly via its effects on the immune system.

Keywords
Alzheimer’s disease, Herpes simplex virus, cytomegalovirus, dementia, nested case-control study
National Category
Medical and Health Sciences
Research subject
Epidemiology
Identifiers
urn:nbn:se:umu:diva-143394 (URN)10.3233/JAD-161305 (DOI)000422845200010 ()29254081 (PubMedID)2-s2.0-85040335462 (Scopus ID)
Available from: 2018-01-26 Created: 2018-01-26 Last updated: 2023-03-24Bibliographically approved
Weidung, B. (2017). Samband mellan gånghastighet och risker vid högt blodtryck hos äldre. Läkartidningen, 114(11), Article ID EHCI.
Open this publication in new window or tab >>Samband mellan gånghastighet och risker vid högt blodtryck hos äldre
2017 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 114, no 11, article id EHCIArticle in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
Sveriges läkarförbund, 2017
National Category
Geriatrics
Identifiers
urn:nbn:se:umu:diva-216315 (URN)2-s2.0-85015312833 (Scopus ID)
Available from: 2023-11-08 Created: 2023-11-08 Last updated: 2023-11-08Bibliographically approved
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