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Nordh, Erik
Publications (10 of 30) Show all publications
Böthun, A., Häggman-Henrikson, B., Stålnacke, B.-M., Wänman, A., Nordh, E., Lampa, E. & Hellström, F. (2023). Clinical signs in the jaw and neck region following whiplash trauma: A 2-year follow-up. European Journal of Pain, 27(6), 699-709
Open this publication in new window or tab >>Clinical signs in the jaw and neck region following whiplash trauma: A 2-year follow-up
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2023 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 27, no 6, p. 699-709Article in journal (Refereed) Published
Abstract [en]

Background: Pain in the orofacial region is often reported after whiplash trauma. However, prospective studies evaluating clinical signs related to orofacial pain and disability in whiplash populations are rare. The aim of the present study was to evaluate clinical signs related to pain and dysfunction in orofacial and neck regions after whiplash trauma, in a short- and long-term perspective.

Methods: In total, 84 cases (48 women) diagnosed with neck distortion after a car accident and 116 controls (68 women) were examined within 1 month, and 49 cases (27 women) and 71 controls (41 women) were re-examined 2 years later. Outcome measures were pain on palpation of jaw and neck muscles and maximal jaw opening. Analysis was performed using mixed-models.

Results: Cases and women were at higher risk for pain on palpation of jaw muscles (OR:7.7; p < 0.001 and OR:3.2; p = 0.010 respectively) and neck muscles (OR:12.7; p < 0.001 and OR:2.9; p = 0.020 respectively) but with no significant effect of time. Cases and women also had lower maximal jaw opening (−3.1; p = 0.001 and −3.3; p = 0.001 respectively). There was no significant time effect, but a significant interaction between cases and time (2.2; p = 0.004).

Conclusion: Individuals with a whiplash trauma present a higher risk for pain on palpation in jaw and neck muscles both in a short- and long-term perspective, but show normal jaw movements. No time effect suggests that cases do not spontaneously improve nor get worse. Investigating pain on palpation in the jaw and neck muscles after whiplash trauma can identify individuals at risk for developing long-term orofacial pain and dysfunction.

Significance: Orofacial pain is often reported after whiplash trauma but most previous studies concerning orofacial pain in whiplash populations have been questionnaire studies. Cases with a previous whiplash trauma and women, in general, had higher risk for pain on palpation in the jaw and neck region. Investigating pain on palpation after a whiplash trauma can help to identify individuals at risk of developing long-lasting pain in the orofacial region.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023
National Category
Dentistry
Research subject
Odontology
Identifiers
urn:nbn:se:umu:diva-205666 (URN)10.1002/ejp.2099 (DOI)000945366500001 ()36806817 (PubMedID)2-s2.0-85150413156 (Scopus ID)
Funder
Region Västerbotten, RV-909851Region Västerbotten, VLL-324631
Available from: 2023-03-13 Created: 2023-03-13 Last updated: 2023-06-20Bibliographically approved
Schmidt, H. H., Wixner, J., Planté-Bordeneuve, V., Muñoz-Beamud, F., Lladó, L., Gillmore, J. D., . . . Adams, D. (2022). Patisiran treatment in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy after liver transplantation. American Journal of Transplantation, 22(6), 1646-1657
Open this publication in new window or tab >>Patisiran treatment in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy after liver transplantation
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2022 (English)In: American Journal of Transplantation, ISSN 1600-6135, E-ISSN 1600-6143, Vol. 22, no 6, p. 1646-1657Article in journal (Refereed) Published
Abstract [en]

Hereditary transthyretin-mediated (hATTR) amyloidosis, or ATTRv amyloidosis, is a progressive disease, for which liver transplantation (LT) has been a long-standing treatment. However, disease progression continues post-LT. This Phase 3b, open-label trial evaluated efficacy and safety of patisiran in patients with ATTRv amyloidosis with polyneuropathy progression post-LT. Primary endpoint was median transthyretin (TTR) reduction from baseline. Twenty-three patients received patisiran for 12 months alongside immunosuppression regimens. Patisiran elicited a rapid, sustained TTR reduction (median reduction [Months 6 and 12 average], 91.0%; 95% CI: 86.1%–92.3%); improved neuropathy, quality of life, and autonomic symptoms from baseline to Month 12 (mean change [SEM], Neuropathy Impairment Score, −3.7 [2.7]; Norfolk Quality of Life-Diabetic Neuropathy questionnaire, −6.5 [4.9]; least-squares mean [SEM], Composite Autonomic Symptom Score-31, −5.0 [2.6]); and stabilized disability (Rasch-built Overall Disability Scale) and nutritional status (modified body mass index). Adverse events were mild or moderate; five patients experienced ≥1 serious adverse event. Most patients had normal liver function tests. One patient experienced transplant rejection consistent with inadequate immunosuppression, remained on patisiran, and completed the study. In conclusion, patisiran reduced serum TTR, was well tolerated, and improved or stabilized key disease impairment measures in patients with ATTRv amyloidosis with polyneuropathy progression post-LT (www.clinicaltrials.gov NCT03862807).

Place, publisher, year, edition, pages
John Wiley & Sons, 2022
Keywords
clinical research/practice, clinical trial, liver allograft function/dysfunction, liver transplantation/hepatology, molecular biology: small interfering RNA, neurology, patient survival, pharmacology
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-193692 (URN)10.1111/ajt.17009 (DOI)000780378600001 ()35213769 (PubMedID)2-s2.0-85127222590 (Scopus ID)
Available from: 2022-05-02 Created: 2022-05-02 Last updated: 2023-05-29Bibliographically approved
Lampa, E., Wänman, A., Nordh, E., Stålnacke, B.-M. & Häggman-Henrikson, B. (2020). The Course of Orofacial Pain and Jaw Disability after Whiplash Trauma: A 2-year Prospective Study. Spine, 45(3), E140-E147
Open this publication in new window or tab >>The Course of Orofacial Pain and Jaw Disability after Whiplash Trauma: A 2-year Prospective Study
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2020 (English)In: Spine, ISSN 0362-2436, E-ISSN 1528-1159, Vol. 45, no 3, p. E140-E147Article in journal (Refereed) Published
Abstract [en]

Study Design: Prospective cohort study.

Objective: To evaluate the course of orofacial pain and jaw disability in relation to neck pain, neck disability and psychosocial factors at the acute stage and the chronic stage after whiplash trauma.

Summary of Background Data: Many individuals report chronic pain in the orofacial region after whiplash trauma. The possible association between whiplash trauma and orofacial pain is debated. Prospective studies are therefore needed to evaluate the development of orofacial pain after whiplash trauma.

Methods: Within one month following a whiplash trauma, 176 cases were examined and compared to 116 controls with questionnaires concerning neck and jaw pain and related disability, non-specific physical symptoms and depression. At the 2-year follow-up, 119 cases (68%) and 104 controls (90%) were re-examined.

Results: Compared to controls, cases reported more jaw and neck pain, both at baseline and follow-up. A majority (68%) of cases with pain in the jaw region in the acute stage also reported jaw pain at the follow-up. The intensity of jaw and neck pain was correlated both at baseline and follow-up. Both neck pain and jaw pain was correlated to non-specific physical symptoms and to depression.

Conclusion: Orofacial pain and jaw disability related to neck pain is often present already at the acute stage after whiplash trauma and persist into the chronic stage for most individuals. Assessment following whiplash trauma should therefore include both the neck and the orofacial regions. More studies are needed to further evaluate risk factors for development of orofacial pain after whiplash trauma.

Level of Evidence: 3

Place, publisher, year, edition, pages
Wolters Kluwer, 2020
Keywords
Jaw pain, Neck Pain, Neck disability, Orofacial pain, Psychosocial factors, Temporomandibular disorders, TMD, Temporomandibular joint, TMJ, Whiplash injury
National Category
Dentistry
Identifiers
urn:nbn:se:umu:diva-153180 (URN)10.1097/BRS.0000000000003212 (DOI)000545584900003 ()31513116 (PubMedID)2-s2.0-85072222876 (Scopus ID)
Funder
The Kempe FoundationsRegion Västerbotten
Note

Originally included in thesis in manuscript form.

Available from: 2018-11-08 Created: 2018-11-08 Last updated: 2022-11-29Bibliographically approved
Karlsson, F., Malinova, E., Olofsson, K., Blomstedt, P., Linder, J. & Nordh, E. (2019). Voice Tremor Outcomes of Subthalamic Nucleus and Zona Incerta Deep Brain Stimulation in Patients With Parkinson Disease. Journal of Voice, 33(4), 545-549
Open this publication in new window or tab >>Voice Tremor Outcomes of Subthalamic Nucleus and Zona Incerta Deep Brain Stimulation in Patients With Parkinson Disease
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2019 (English)In: Journal of Voice, ISSN 0892-1997, E-ISSN 1873-4588, Vol. 33, no 4, p. 545-549Article in journal (Refereed) Published
Abstract [en]

Objectives: We aimed to study the effect of deep brain stimulation (DBS) in the subthalamic nucleus (STN) and caudal zona incerta (cZi) on level of perceived voice tremor in patients with Parkinson disease (PD).

Study Design: This is a prospective nonrandomized design with consecutive patients.

Methods: Perceived voice tremor was assessed in patients with PD having received either STN-DBS (8 patients, 5 bilateral and 3 unilateral, aged 43.1-73.6 years; median = 61.2 years) or cZi-DBS (14 bilateral patients, aged 39.0-71.9 years; median = 56.6 years) 12 months before the assessment. Sustained vowels that were produced OFF and ON stimulation (with simultaneous L-DOPA medication) were assessed perceptually in terms of voice tremor by two raters on a four-point rating scale. The assessments were repeated five times per sample and rated in a blinded and randomized procedure.

Results: Three out of the 22 patients (13%) were concluded to have voice tremor OFF stimulation. Patients with PD with STN-DBS showed mild levels of perceived voice tremor OFF stimulation and a group level improvement. Patients with moderate/severe perceived voice tremor and cZi-DBS showed marked improvements, but there was no overall group effect. Six patients with cZi-DBS showed small increases in perceived voice tremor severity.

Conclusions: STN-DBS decreased perceived voice tremor on a group level. cZi-DBS decreased perceived voice tremor in patients with PD with moderate to severe preoperative levels of the symptom.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
DBS; Parkinson disease; STN; Voice tremor; cZi
National Category
Other Clinical Medicine
Research subject
Oto-Rhino-Laryngology; Neurosurgery
Identifiers
urn:nbn:se:umu:diva-144189 (URN)10.1016/j.jvoice.2017.12.012 (DOI)000476489700020 ()29361338 (PubMedID)2-s2.0-85040578940 (Scopus ID)
Funder
Swedish Research Council, 2009-946
Available from: 2018-01-25 Created: 2018-01-25 Last updated: 2023-03-23Bibliographically approved
Heldestad Lilliesköld, V. & Nordh, E. (2018). Method-of-limits: Cold and warm perception thresholds at proximal and distal body regions. Clinical Neurophysiology Practice, 3, 134-140
Open this publication in new window or tab >>Method-of-limits: Cold and warm perception thresholds at proximal and distal body regions
2018 (English)In: Clinical Neurophysiology Practice, E-ISSN 2467-981X, Vol. 3, p. 134-140Article in journal (Refereed) Published
Abstract [en]

Objective: Thermal quantitative sensory testing with the 'Method-of-Limits' is an established rationale for detection of small nerve fiber dysfunction, but adequate reference values are crucial for such evaluations, regardless of the underlying cause. This study assessed reference data for cold- (CPT) and warm- (WPT) perception thresholds at both proximal and distal sites in eight body regions of the lower and upper extremities, all determined within the same test session for each subject.

Methods: Seventy-five healthy subjects (aged 16-72 years) were tested according to the method-of-limit for CPT and WPT at the dorsum of the foot, the medial and lateral lower leg, the ventral thigh, the thenar eminence, the radial and ulnar part of the lower arm, and the anterior deltoid part of the upper arm.

Results: Overall, thermal perception thresholds (TPT) varied with test location, but were higher in the lower than in the upper part of the body, also WPT were generally higher than CPT. TPT at the dorsum foot highly correlated with age, while inconsistent correlations were noted between TPT and age or height at other tested locations.

Conclusion: This study describes for the first time reference values at eight defined body regions, at both proximal and distal sites.

Significance: The report enables refined evaluations of general small nerve fiber function, as assessed by quantitative thermal sensory testing with the Method-of-Limits.

Keywords
Cold perception thresholds, Method-of-Limits, Reference data, Small nerve fiber, Warm perception thresholds
National Category
Neurosciences
Identifiers
urn:nbn:se:umu:diva-151908 (URN)10.1016/j.cnp.2018.06.004 (DOI)000498643800027 ()30215024 (PubMedID)2-s2.0-85050128934 (Scopus ID)
Available from: 2018-09-17 Created: 2018-09-17 Last updated: 2023-09-05Bibliographically approved
Lampa, E., Wänman, A., Nordh, E. & Häggman-Henrikson, B. (2017). Effects on jaw function shortly after whiplash trauma. Journal of Oral Rehabilitation, 44(12), 941-947
Open this publication in new window or tab >>Effects on jaw function shortly after whiplash trauma
2017 (English)In: Journal of Oral Rehabilitation, E-ISSN 1365-2842, Vol. 44, no 12, p. 941-947Article in journal (Refereed) Published
Abstract [en]

Normal jaw function involves muscles and joints of both jaw and neck. A whiplash trauma may disturb the integrated jaw-neck sensory-motor function and thereby impair chewing ability; however, it is not known if such impairment is present shortly after a neck trauma or develops over time. The aim was to evaluate jaw function after a recent whiplash trauma. Eighty cases (47 women) were examined within 1 month after a whiplash trauma and compared to 80 controls (47 women) without neck trauma. Participants completed the Jaw disability checklist (JDC) and Neck Disability Index (NDI) questionnaires and performed a 5-minute chewing test. Elicited fatigue and pain during chewing were noted, and group differences were evaluated with Fisher's exact test and Mann-Whitney U-test. Compared to controls, cases had higher JDC (P<.0001) and NDI scores (15% vs 2%, P<.0001), and reported more fatigue (53% vs 31%, P=.006) and pain (30% vs 10%, P=.003) during the chewing test. Cases also had a shorter onset time for fatigue and pain (both P=.001) Furthermore, cases reporting symptoms during chewing had higher JDC and NDI scores compared to cases not reporting symptoms (both P=.01). Symptoms mainly occurred in the trigeminal area for both groups, but also in spinal areas more often for cases than for controls. Taken together, the results indicate that jaw-neck sensory-motor function is impaired already within 1month after a whiplash trauma. The association between neck disability and jaw impairment underlines the close functional relationship between the regions, and stresses the importance of multidisciplinary assessment.

Place, publisher, year, edition, pages
WILEY, 2017
Keywords
accidents, facial pain, mastication, neck pain, temporomandibular joint dysfunction syndrome, traffic, iplash injuries
National Category
Dentistry
Identifiers
urn:nbn:se:umu:diva-142232 (URN)10.1111/joor.12571 (DOI)000414577300003 ()28891205 (PubMedID)2-s2.0-85032881708 (Scopus ID)
Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2024-01-17Bibliographically approved
Sundstedt, S., Nordh, E., Linder, J., Hedström, J., Finizia, C. & Olofsson, K. (2017). ­­Swallowing quality of life after zona incerta Deep brain stimulation. Annals of Otology, Rhinology and Laryngology, 126(2), 110-116
Open this publication in new window or tab >>­­Swallowing quality of life after zona incerta Deep brain stimulation
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2017 (English)In: Annals of Otology, Rhinology and Laryngology, ISSN 0003-4894, E-ISSN 1943-572X, Vol. 126, no 2, p. 110-116Article in journal (Refereed) Published
Abstract [en]

Objectives: The management of Parkinson’s disease (PD) has been improved, but management of features like swallowing problems is still challenging. Deep Brain Stimulation (DBS) alleviates the cardinal motor symptoms and improves quality of life, but its effect on swallowing is not fully explored. The purpose of this study was to examine self-reported swallowing specific quality of life, before and after caudal zona incerta DBS (cZI DBS), in comparison with a control group.

Methods: Nine PD patients (2 women and 7 men) completed the self-report Swallowing Quality of Life questionnaire (SWAL-QOL) before and 12 months after cZI DBS surgery. The postoperative data were compared to nine controls. Median ages were 53 years (range 40-70) for patients and 54 years (range 42-72) for controls.

Results: No significant differences were found between the pre-, or postoperative scores. The SWAL-QOL total scores did not differ significantly between PD patients and controls. PD patients reported significantly lower scores in the 'burden' subscale and in the 'symptom' scale.

Conclusions: PD patients selected for cZI DBS showed a good self-reported swallowing specific quality of life, in many aspects equal to controls. CZI DBS did not negatively affect swallowing specific quality of life in this study.

Keywords
caudal zona incerta, Deep Brain Stimulation, Dysphagia, Parkinson’s disease, Swallowing quality of life
National Category
Otorhinolaryngology
Research subject
Oto-Rhino-Laryngology
Identifiers
urn:nbn:se:umu:diva-127115 (URN)10.1177/0003489416675874 (DOI)000397728500004 ()27831516 (PubMedID)2-s2.0-85009799652 (Scopus ID)
Available from: 2016-11-21 Created: 2016-10-31 Last updated: 2023-03-23Bibliographically approved
Sundstedt, S., Holmén, L., Rova, E., Linder, J., Nordh, E. & Olofsson, K. (2017). Swallowing safety in Parkinson's disease after zona incerta Deep Brain Stimulation. Brain and Behavior, 7(6), Article ID e00709.
Open this publication in new window or tab >>Swallowing safety in Parkinson's disease after zona incerta Deep Brain Stimulation
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2017 (English)In: Brain and Behavior, ISSN 2162-3279, E-ISSN 2162-3279, Vol. 7, no 6, article id e00709Article in journal (Refereed) Published
Abstract [en]

Objectives: The objective of this study was to examine swallowing function in patients with Parkinson's disease before and after caudal zona incerta deep brain (cZI DBS) surgery. The aims were to examine the effect of cZI DBS on swallowing safety regarding liquid and solid food, as well as to identify the effect of cZI DBS on body mass index (BMI) and specific items from part II of the Unified Parkinson's Disease Rating Scale (UPDRS).

Materials and Methods: The median age of the 14 patients was 57 years (range 46–71), with a median disease duration of 6 years (range 2–13). The present sample is an extension of a previous report, into which six additional patients have been added. Fiber endoscopic examinations of swallowing function, measures of BMI, and evaluation of UPDRS part II items were made before and 12 months after surgery, with and without activated DBS.

Results: There were no significant changes due to cZI DBS regarding penetration/aspiration, pharyngeal residue or premature spillage (> .05). Median BMI increased by +1.1 kg/m2 12 months after surgery (= .01, = .50). All reported specific symptoms from the UPDRS part II were slight or mild. A significant improvement regarding handling of utensils was seen 12 months postoperatively (= .03, = −.42).

Conclusions: Caudal zona incerta DBS was found not to have a negative impact on swallowing safety. A significant increase in postoperative weight was observed, and speech seemed to be slightly negatively affected, whereas handling of utensils was improved with cZI DBS.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
body mass index, caudal zona incerta, deep brain stimulation, Parkinson's disease, swallowing function
National Category
Otorhinolaryngology Neurosciences
Research subject
Oto-Rhino-Laryngology
Identifiers
urn:nbn:se:umu:diva-129785 (URN)10.1002/brb3.709 (DOI)000403784700017 ()28638714 (PubMedID)2-s2.0-85018629501 (Scopus ID)
Note

Originally published in thesis in manuscript form.

Available from: 2017-01-09 Created: 2017-01-09 Last updated: 2023-03-24Bibliographically approved
Dyck, P. J., Wang, A. K., Kincaid, J. C., Wiesman, J. F., Chaudhry, V., Robinson-Papp, J., . . . Dyck, P. J. (2015). Evaluation of modifications of nis+7 score in oligonucleotide trials in ttr fap. Paper presented at Biennial Meeting of the Peripheral-Nerve-Society, JUN 27-JUL 02, 2015, Quebec, CANADA. Journal of the peripheral nervous system, 20(2), 132-133
Open this publication in new window or tab >>Evaluation of modifications of nis+7 score in oligonucleotide trials in ttr fap
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2015 (English)In: Journal of the peripheral nervous system, ISSN 1085-9489, E-ISSN 1529-8027, Vol. 20, no 2, p. 132-133Article in journal, Meeting abstract (Other academic) Published
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-109468 (URN)000360214600120 ()
Conference
Biennial Meeting of the Peripheral-Nerve-Society, JUN 27-JUL 02, 2015, Quebec, CANADA
Available from: 2015-10-05 Created: 2015-09-28 Last updated: 2018-06-07Bibliographically approved
Bergenheim, T. A., Nordh, E., Larsson, E. & Hariz, M. (2015). Selective peripheral denervation for cervical dystonia: long-term follow-up. Journal of Neurology, Neurosurgery and Psychiatry, 86(12), 1307-1313
Open this publication in new window or tab >>Selective peripheral denervation for cervical dystonia: long-term follow-up
2015 (English)In: Journal of Neurology, Neurosurgery and Psychiatry, ISSN 0022-3050, E-ISSN 1468-330X, Vol. 86, no 12, p. 1307-1313Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: 61 procedures with selective peripheral denervation for cervical dystonia were retrospectively analysed concerning surgical results, pain, quality of life (QoL) and recurrences.

METHODS: The patients were assessed with the Tsui torticollis scale, Visual Analogue Scale (VAS) for pain and Fugl-Meyer scale for QoL. Evaluations were performed preoperatively, early postoperatively, at 6 months, then at a mean of 42 (13-165) months. All patients underwent electromyogram at baseline, which was repeated in cases who presented with recurrence of symptoms after surgery.

RESULTS: Six months of follow-up was available for 55 (90%) of the procedures and late follow-up for 34 (56%). The mean score of the Tsui scale was 10 preoperatively. It improved to 4.5 (p<0.001) at 6 months, and 5.3 (p<0.001) at late follow-up. VAS for pain improved from 6.5 preoperatively to 4.2 (p<0.001) at 6 months and 4 (p<0.01) at late follow-up. The Fugl-Meyer score for QoL improved from 43.3 to 46.6 (p<0.05) at 6 months, and to 51.1 (p<0.05) at late follow-up. Major reinnervation and/or change in the dystonic pattern occurred following 29% of the procedures, and led in 26% of patients to reoperation with either additional denervation or pallidal stimulation.

CONCLUSIONS: Selective peripheral denervation remains a surgical option in the treatment of cervical dystonia when conservative measures fail. Although the majority of patients experience a significant relief of symptoms, there is a substantial risk of reinnervation and/or change in the pattern of the cervical dystonia.

National Category
Neurology Psychiatry Surgery
Identifiers
urn:nbn:se:umu:diva-98391 (URN)10.1136/jnnp-2014-307959 (DOI)000365859500006 ()25362089 (PubMedID)2-s2.0-84956589610 (Scopus ID)
Available from: 2015-01-21 Created: 2015-01-21 Last updated: 2023-03-23Bibliographically approved
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