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Jonsson, Andreas P.
Alternative names
Publications (10 of 15) Show all publications
de Man Lapidoth, J., Hultdin, J., Jonsson, A. P., Eriksson Svensson, M., Wennberg, M., Zeller, T. & Söderberg, S. (2023). Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study. BMJ Open, 13(8), Article ID e072664.
Open this publication in new window or tab >>Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study
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2023 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 13, no 8, article id e072664Article in journal (Refereed) Published
Abstract [en]

Objective: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.

Design: Repeated cross-sectional population-based studies.

Setting: The two Northern counties (Norr- and Västerbotten) in Sweden.

Participants: Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185).

Interventions: None.

Measures: Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFR crea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFR cysC). Renal function over time was analysed using univariable and multivariable linear regression models.

Results: Renal function, both eGFR crea and eGFR cysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFR crea and eGFR cysC (both p<0.001) after adjustment for classical cardiovascular RF.

Conclusion: Renal function has deteriorated in Northern Sweden between 1986 and 2014.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2023
Keywords
epidemiology, nephrology, public health
National Category
Urology and Nephrology
Identifiers
urn:nbn:se:umu:diva-214628 (URN)10.1136/bmjopen-2023-072664 (DOI)37648389 (PubMedID)2-s2.0-85169231018 (Scopus ID)
Funder
Region VästerbottenEU, FP7, Seventh Framework Programme, HEALTH–F2–2011–278913
Available from: 2023-09-25 Created: 2023-09-25 Last updated: 2023-09-25Bibliographically approved
Fransson, F., Werneke, U., Harju, V., Öhlund, L., de Man Lapidoth, J., Jonsson, A. P., . . . Ott, M. (2022). Kidney function in patients with bipolar disorder with and without lithium treatment compared with the general population in northern Sweden: results from the LiSIE and MONICA cohorts. Lancet psychiatry, 9(10), 804-814
Open this publication in new window or tab >>Kidney function in patients with bipolar disorder with and without lithium treatment compared with the general population in northern Sweden: results from the LiSIE and MONICA cohorts
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2022 (English)In: Lancet psychiatry, ISSN 2215-0374, E-ISSN 2215-0366, Vol. 9, no 10, p. 804-814Article in journal (Refereed) Published
Abstract [en]

Background: The clinical relevance of lithium nephropathy is subject to debate. Kidney function decreases with age and comorbidities, and this decline might lead to attribution bias when erroneously ascribed to lithium. We aimed to investigate whether patients with bipolar or schizoaffective disorder had faster decline in estimated glomerular filtration rate (eGFR) compared with the general population, whether observed differences in the steepness of the decline were attributable to lithium, and whether such changes depended on the length of lithium exposure.

Methods: In this cross-sectional cohort study, we used clinical data from the Lithium–Study into Effects and Side-effects (LiSIE) retrospective cohort study, which included patients with bipolar disorder or schizoaffective disorder whose medical records were reviewed up to Dec 31, 2017, and the WHO Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) study, covering a representative sample of the general population in northern Sweden aged 25–74 years. The primary outcome was the age-associated decline of creatinine-based eGFR, assessed using linear regression. We adjusted for sex and grouped for different lengths of lithium exposure (never or <1 year, 1–5 years, >5–10 years, and >10 years). For patients with moderate-to-severe kidney disease we identified the underlying nephropathy in the case records.

Findings: From LiSIE, we included 785 patients (498 [63%] female and 287 [37%] male), with a mean age of 49·8 years (SD 13·2; range 25–74). From MONICA, we included 1549 individuals (800 [52%] female and 749 [48%] male), with a mean age of 51·9 years (13·8; 25–74). No ethnicity data were collected. Adjusted for duration of lithium exposure, eGFR declined by 0·57 mL/min/1·73 m2/year (95% CI 0·50–0·63) in patients with bipolar disorder or schizoaffective disorder and by 0·57 mL/min/1·73 m2/year (0·53–0·61) in the reference population. Lithium added 0·54 mL/min/1·73 m2 (0·43–0·64) per year of treatment (p<0·0001). After more than 10 years on lithium, decline was significantly steeper than in all other groups including the reference population (p<0·0001). Lithium nephropathy was judged to be the commonest cause of moderate-to-severe chronic kidney disease, but comorbidities played a role. The effect of lithium on eGFR showed a high degree of inter-individual variation.

Interpretation: Steeper eGFR decline in patients with bipolar disorder or schizoaffective disorder can be attributed to lithium, but the trajectory of kidney function decline varies widely. Comorbidities affecting kidneys should be treated assertively as one possible means to affect the trajectory. In patients with a fast trajectory, a trade-off is required between continuing lithium to treat mental health problems and discontinuing lithium for the sake of renal health.

Funding: Norrbotten County Research and Learning Fund Sweden, Visare Norr (Northern County Councils Regional Federation Fund), Swedish Kidney Foundation (Njurfonden), Swedish Kidney Association (Njurförbundet), Norrbotten section.

Translation: For the Swedish translation of the Summary see Supplementary Materials section.

Place, publisher, year, edition, pages
Elsevier, 2022
National Category
Psychiatry
Identifiers
urn:nbn:se:umu:diva-199834 (URN)10.1016/S2215-0366(22)00265-6 (DOI)36108668 (PubMedID)2-s2.0-85138080631 (Scopus ID)
Funder
Norrbotten County CouncilVisare Norr
Available from: 2022-10-03 Created: 2022-10-03 Last updated: 2023-05-23Bibliographically approved
Esberg, A., Johansson, L., Berglin, E., Mohammad, A. J., Jonsson, A. P., Dahlqvist, J., . . . Rantapää-Dahlqvist, S. (2022). Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis. Microorganisms, 10(8), Article ID 1572.
Open this publication in new window or tab >>Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis
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2022 (English)In: Microorganisms, E-ISSN 2076-2607, Vol. 10, no 8, article id 1572Article in journal (Refereed) Published
Abstract [en]

Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV). Little is known about the role of oral microbiota in AAV. In this study, levels of IgG antibodies to 53 oral bacterial species/subspecies were screened using immunoblotting in plasma/serum in pre-symptomatic AAV-individuals (n = 85), matched controls, and established AAV-patients (n = 78). Saliva microbiota from acute-AAV and controls was sequenced from 16s rDNA amplicons. Information on dental status was extracted from a national register. IgG levels against oral bacteria were lower in established AAV versus pre-AAV and controls. Specifically, pre-AAV samples had, compared to controls, a higher abundance of periodontitis-associated species paralleling more signs of periodontitis in established AAV-patients than controls. Saliva microbiota in acute-AAV showed higher within-sample diversity but fewer detectable amplicon-sequence variants and taxa in their core microbiota than controls. Acute-AAV was not associated with increased abundance of periodontal bacteria but species in, e.g., Arthrospira, Staphylococcus, Lactobacillus, and Scardovia. In conclusion, the IgG profiles against oral bacteria differed between pre-AAV, established AAV, and controls, and microbiota profiles between acute AAV and controls. The IgG shift from a pre-symptomatic stage to established disease cooccurred with treatment of immunosuppression and/or antibiotics.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
anti-neutrophil cytoplasmatic antibody–associated vasculitis, caries, granulomatosis with polyangiitis (GPA), IgG, microscopic polyangiitis (MPA), myeloperoxidase (MPO)-ANCA, oral microbiota, periodontal disease, proteinase 3 (PR3)-ANCA, vasculitis
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:umu:diva-199365 (URN)10.3390/microorganisms10081572 (DOI)000845508000001 ()36013990 (PubMedID)2-s2.0-85137345895 (Scopus ID)
Funder
Swedish Research Council, 2018-02551
Available from: 2022-11-03 Created: 2022-11-03 Last updated: 2023-05-24Bibliographically approved
Jonsson, A., Viklund, I., Jonsson, A., Valham, F., Bergdahl, E., Lindmark, K. & Norberg, H. (2020). Comparison of creatinine-based methods for estimating glomerular filtration rate in patients with heart failure. ESC Heart Failure, 7(3), 1150-1160
Open this publication in new window or tab >>Comparison of creatinine-based methods for estimating glomerular filtration rate in patients with heart failure
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2020 (English)In: ESC Heart Failure, E-ISSN 2055-5822, Vol. 7, no 3, p. 1150-1160Article in journal (Refereed) Published
Abstract [en]

Aims: Glomerular filtration rate is an important factor in management of heart failure (HF). Our objective was to validate eight creatinine-based equations for estimating glomerular filtration rate (eGFR) in an HF population against measured glomerular filtration rate.

Methods and results: One hundred forty-six HF patients (mean age 68 +/- 13 years, mean left ventricular ejection fraction 45% +/- 15) within a single-centre hospital that underwent Cr-51-EDTA clearance between 2010 and 2018 were included in this retrospective study. eGFR was estimated by means of Cockcroft-Gault ideal and actual weight, the Modification of Diet in Renal Disease Study (MDRD), simplified MDRD with isotope dilution mass spectroscopy traceable calibration, the Chronic Kidney Disease Epidemiology Collaboration, revised Lund-Malmo, full age spectrum, and the Berlin Initiative Study 1. Mean measured glomerular filtration rate was 42 mL/min/1.73 m(2). Pearson's correlation coefficient (r) had the highest precision for MDRD (r = 0.9), followed by revised Lund-Malmo (r = 0.88). All equations except MDRD (mean difference -4.8%) resulted in an overestimation of the renal function. The accuracy was below 75% for all equations except MDRD.

Conclusions: None of the exclusively creatinine-based methods was accurate in predicting eGFR in HF patients. Our findings suggest that more accurate methods are needed for determining eGFR in patients with HF.

Place, publisher, year, edition, pages
John Wiley & Sons, 2020
Keywords
Heart failure, Renal function, Estimated glomerular filtration rate, Creatinine
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-168959 (URN)10.1002/ehf2.12643 (DOI)000513015500001 ()32052932 (PubMedID)2-s2.0-85079448295 (Scopus ID)
Funder
Cancerforskningsfonden i Norrland
Available from: 2020-04-01 Created: 2020-04-01 Last updated: 2023-03-24Bibliographically approved
Wärja, M., Laveborn, E., Ott, M., Jonsson, A. P. & Stegmayr, B. (2020). NT-pro-BNP as marker for cardiac strain that may be caused by high-output arteriovenous shunting in a haemodialysis patient. A case report. BMC Nephrology, 21(1), Article ID 544.
Open this publication in new window or tab >>NT-pro-BNP as marker for cardiac strain that may be caused by high-output arteriovenous shunting in a haemodialysis patient. A case report
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2020 (English)In: BMC Nephrology, ISSN 1471-2369, E-ISSN 1471-2369, Vol. 21, no 1, article id 544Article in journal (Refereed) Published
Abstract [en]

Background: An arteriovenous fistula (AVF) is the first choice when considering access for haemodialysis (HD).When a forearm AVF fails an upper arm AVF is a frequent subsequent dialysis access option. The latter may causecardiac strain. NT-pro-B-type natriuretic peptide (NT-NT-proBNP) is a marker used to estimate volume overload andcardiac strain.This case report shows the benefit of using longitudinal individual follow-up of pre-dialysis NT-proBNP in clinicalpractice to detect changes in cardiac condition that may be due to high-output AVF.

Case presentation: An 18 years old patient performed HD via an upper arm AVF before he was admitted to ourunit. NT-proBNP was above the upper detection level of 70,000 ng/L. Echocardiography revealed a left-ventricularcardiac insufficiency. Interdialytic weight gain (IDWG) was above 5%. He was instructed to lower fluid intake andIDWG towards 2%. Four months later NT-proBNP surpassed 70,000 ng/L again. Flow in the brachial artery was at3034 ml/min. Reconstructive surgery of the AVF did not reduce flow and NT-proBNP in the long run. Clinically, heworsened to NYHA class III-IV. It was decided to close the upper arm AVF and to replace it with a lower arm AVFleading to a reduced artery flow of 1344 mL/min. The clinical condition successively recovered and NT-proBNPdecreased to 7000 ng/L.

Conclusions: Pre-dialysis NT-proBNP should be considered as a suitable routine marker for cardiac strain such ascaused by high-output AVF besides variables such as IDWG. Brachial artery flow besides AVF flow measurement ishelpful.

Place, publisher, year, edition, pages
BioMed Central, 2020
Keywords
Arteriovenous fistula, Congestive heart failure, Haemodialysis, NT-pro-BNP, Case report
National Category
Urology and Nephrology
Identifiers
urn:nbn:se:umu:diva-178541 (URN)10.1186/s12882-020-02195-9 (DOI)000602676600002 ()33349246 (PubMedID)2-s2.0-85097956783 (Scopus ID)
Available from: 2021-01-14 Created: 2021-01-14 Last updated: 2023-03-24Bibliographically approved
Fransson, F., Werneke, U., Jonsson, A. P. & Ott, M. (2020). Renal function after discontinuation of chronic lithium treatment: findings from the LiSIE retrospective cohort study. Paper presented at 57th ERA-EDTA Congress, JUN 06-09, 2020, ELECTR NETWORK. Nephrology, Dialysis and Transplantation, 35, 592-592
Open this publication in new window or tab >>Renal function after discontinuation of chronic lithium treatment: findings from the LiSIE retrospective cohort study
2020 (English)In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 35, p. 592-592Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Oxford University Press, 2020
National Category
Urology and Nephrology
Identifiers
urn:nbn:se:umu:diva-175082 (URN)10.1093/ndt/gfaa142.P0284 (DOI)000562392100861 ()
Conference
57th ERA-EDTA Congress, JUN 06-09, 2020, ELECTR NETWORK
Available from: 2020-09-17 Created: 2020-09-17 Last updated: 2020-09-17Bibliographically approved
Bergh, J., Zetterström, P., Andersen, P. M., Brännström, T., Graffmo, K. S., Jonsson, P. A., . . . Marklund, S. (2015). Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping. Proceedings of the National Academy of Sciences of the United States of America, 112(14), 4489-4494
Open this publication in new window or tab >>Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping
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2015 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 112, no 14, p. 4489-4494Article in journal (Refereed) Published
Abstract [en]

Despite considerable progress in uncovering the molecular details of protein aggregation in vitro, the cause and mechanism of protein-aggregation disease remain poorly understood. One reason is that the amount of pathological aggregates in neural tissue is exceedingly low, precluding examination by conventional approaches. We present here a method for determination of the structure and quantity of aggregates in small tissue samples, circumventing the above problem. The method is based on binary epitope mapping using anti-peptide antibodies. We assessed the usefulness and versatility of the method in mice modeling the neurodegenerative disease amyotrophic lateral sclerosis, which accumulate intracellular aggregates of superoxide dismutase-1. Two strains of aggregates were identified with different structural architectures, molecular properties, and growth kinetics. Both were different from superoxide dismutase-1 aggregates generated in vitro under a variety of conditions. The strains, which seem kinetically under fragmentation control, are associated with different disease progressions, complying with and adding detail to the growing evidence that seeding, infectivity, and strain dependence are unifying principles of neurodegenerative disease.

Place, publisher, year, edition, pages
National Academy of Sciences, 2015
Keywords
protein aggregation, neurodegeneration, strain, amyotrophic lateral sclerosis, transgenic mice
National Category
Pharmacology and Toxicology Medical Bioscience
Identifiers
urn:nbn:se:umu:diva-103147 (URN)10.1073/pnas.1419228112 (DOI)000352287800075 ()25802384 (PubMedID)2-s2.0-84928779088 (Scopus ID)
Available from: 2015-05-28 Created: 2015-05-18 Last updated: 2023-03-23Bibliographically approved
Birve, A., Neuwirth, C., Weber, M., Marklund, S. L., Nilsson, A.-C., Jonsson, P. A. & Andersen, P. M. (2010). A novel SOD1 splice site mutation associated with familial ALS revealed by SOD activity analysis. Human Molecular Genetics, 19(21), 4201-4206
Open this publication in new window or tab >>A novel SOD1 splice site mutation associated with familial ALS revealed by SOD activity analysis
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2010 (English)In: Human Molecular Genetics, ISSN 0964-6906, E-ISSN 1460-2083, Vol. 19, no 21, p. 4201-4206Article in journal (Refereed) Published
Abstract [en]

More than 145 mutations have been found in the gene CuZn-Superoxide dismutase (SOD1) in patients with amyotrophic lateral sclerosis (ALS). The vast majority are easily detected nucleotide mutations in the coding region. In a patient from a Swiss ALS family with half-normal erythrocyte SOD1 activity, exon flanking sequence analysis revealed a novel thymine to guanine mutation 7 bp upstream of exon 4 (c.240-7T>G). The results of splicing algorithm analyses were ambiguous, but five out of seven analysis tools suggested a potential novel splice site that would add six new base pairs to the mRNA. If translated, this mRNA would insert Ser and Ile between Glu78 and Arg79 in the SOD1 protein. In fibroblasts from the patient, the predicted mutant transcript and the mutant protein were both highly expressed, and despite the location of the insertion into the metal ion-binding loop IV, the SOD1 activity appeared high. In erythrocytes, which lack protein synthesis and are old compared with cultured fibroblasts, both SOD1 protein and enzymic activity was 50% of controls. Thus, the usage of the novel splice site is near 100%, and the mutant SOD1 shows the reduced stability typical of ALS-associated mutant SOD1s. The findings suggests that this novel intronic mutation is causing the disease and highlights the importance of wide exon-flanking sequencing and transcript analysis combined with erythrocyte SOD1 activity analysis in comprehensive search for SOD1 mutations in ALS. We find that there are potentially more SOD1 mutations than previously reported.

Keywords
ALS
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
urn:nbn:se:umu:diva-40729 (URN)10.1093/hmg/ddq338 (DOI)000282751500007 ()20709807 (PubMedID)2-s2.0-77957882718 (Scopus ID)
Available from: 2011-03-08 Created: 2011-03-08 Last updated: 2023-03-24Bibliographically approved
Forsberg, K., Jonsson, P. A., Andersen, P. M., Bergemalm, D., Graffmo, K. S., Hultdin, M., . . . Brännström, T. (2010). Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients. PLOS ONE, 5(7), e11552
Open this publication in new window or tab >>Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients
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2010 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 5, no 7, p. e11552-Article in journal (Refereed) Published
Abstract [en]

Mutations in CuZn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) and are found in 6% of ALS patients. Non-native and aggregation-prone forms of mutant SOD1s are thought to trigger the disease. Two sets of novel antibodies, raised in rabbits and chicken, against peptides spaced along the human SOD1 sequence, were by enzyme-linked immunosorbent assay and an immunocapture method shown to be specific for denatured SOD1. These were used to examine SOD1 in spinal cords of ALS patients lacking mutations in the enzyme. Small granular SOD1-immunoreactive inclusions were found in spinal motoneurons of all 37 sporadic and familial ALS patients studied, but only sparsely in 3 of 28 neurodegenerative and 2 of 19 non-neurological control patients. The granular inclusions were by confocal microscopy found to partly colocalize with markers for lysosomes but not with inclusions containing TAR DNA binding protein-43, ubiquitin or markers for endoplasmic reticulum, autophagosomes or mitochondria. Granular inclusions were also found in carriers of SOD1 mutations and in spinobulbar muscular atrophy (SBMA) patients and they were the major type of inclusion detected in ALS patients homozygous for the wild type-like D90A mutation. The findings suggest that SOD1 may be involved in ALS pathogenesis in patients lacking mutations in the enzyme.

Place, publisher, year, edition, pages
Public library of science, 2010
Keywords
amyotrophic-lateral-sclerosis; cu/zn superoxide-dismutase; motor-neuron degeneration; molecular pathology; gene mutation; linked SOD1; mutant SOD1; mice; disease; immunoreactivity
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Research subject
Medicine
Identifiers
urn:nbn:se:umu:diva-40739 (URN)10.1371/journal.pone.0011552 (DOI)000279884900009 ()20644736 (PubMedID)2-s2.0-77955352066 (Scopus ID)
Available from: 2011-03-08 Created: 2011-03-08 Last updated: 2023-03-24Bibliographically approved
Bergemalm, D., Forsberg, K., Jonsson, P. A., Graffmo, K. S., Brännström, T., Andersen, P. M., . . . Marklund, S. L. (2009). Changes in the spinal cord proteome of an amyotrophic lateral sclerosis murine model determined by differential in-gel electrophoresis. Molecular and cellular proteomics, 8(6), 1306-1317
Open this publication in new window or tab >>Changes in the spinal cord proteome of an amyotrophic lateral sclerosis murine model determined by differential in-gel electrophoresis
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2009 (English)In: Molecular and cellular proteomics, ISSN 1535-9484, Vol. 8, no 6, p. 1306-1317Article in journal (Refereed) Published
Abstract [en]

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by loss of motor neurons resulting in progressive paralysis. To date, more than 140 different mutations in the gene encoding CuZn-superoxide dismutase (SOD1) have been associated with ALS. Several transgenic murine models exist in which various mutant SOD1s are expressed. We have used differential in-gel electrophoresis (DIGE) to analyze the changes in the spinal cord proteome induced by expression of the unstable SOD1 truncation mutant G127insTGGG (G127X) in mice. Unlike mutants used in most other models, G127X lacks SOD activity and is present at low levels, thus reducing the risk of overexpression artifacts. The mice were analyzed at their peak body weights, just before onset of symptoms. Variable importance plot (VIP) analysis showed that 420 of 1,800 detected protein spots contributed significantly to the differences between the groups. By MALDI-TOF MS analysis, 54 proteins were identified. One spot was found to be a covalently linked mutant SOD1 dimer, apparently analogous to SOD1 immunoreactive bands migrating at double the molecular weight of SOD1 monomers previously detected in humans and mice carrying mutant SOD1s and in sporadic ALS cases. Analyses of affected functional pathways, and the subcellular representation of alterations suggest that the toxicity exerted by mutant SODs induces oxidative stress and affects mitochondria, cellular assembly/organization, and protein degradation.

Place, publisher, year, edition, pages
The American Society for Biochemistry and Molecular Biology,Inc, 2009
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-22132 (URN)10.1074/mcp.M900046-MCP200 (DOI)19357085 (PubMedID)2-s2.0-67650526816 (Scopus ID)
Available from: 2009-04-24 Created: 2009-04-24 Last updated: 2023-03-24Bibliographically approved
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