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Olsson, J., Nourmohammadi, S., Honkala, E., Johansson, A., Hallmans, G., Weidung, B., . . . Elgh, F. (2024). Time trends in herpesvirus seroepidemiology among Swedish adults. BMC Infectious Diseases, 24(1), Article ID 273.
Open this publication in new window or tab >>Time trends in herpesvirus seroepidemiology among Swedish adults
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2024 (English)In: BMC Infectious Diseases, E-ISSN 1471-2334, Vol. 24, no 1, article id 273Article in journal (Refereed) Published
Abstract [en]

Background: Human herpesviruses are widespread among the human population. The infections often occurunnoticed, but severe disease as well as long-term sequelae are part of the symptom spectrum. The prevalence variesamong subpopulations and with time. The aim of this study was to describe the seroprevalence of ImmunoglobulinG against Herpes simplex 1, Herpes simplex 2, Epstein-Barr virus and Cytomegalovirus in the adult Swedish populationover a time period of several decades.

Methods: Serum samples (n = 892) from biobanks, originating from 30-year-old women, 50-year-old menand 50-year-old women sampled between 1975 and 2018, were analyzed for presence of anti-herpesvirus antibod-ies. Linear regression analysis was used to test for a correlation between birth year and seroprevalence. Multiple linearregression analysis was used to differentiate between other factors such as age and gender.

Results: Birth year correlated negatively with the prevalence of immunoglobulin G against Herpes simplex 1and Epstein-Barr virus (p = 0.004 and 0.033), and positively with Immunoglobulin G against Cytomegalovirus(p = 0.039). When participant categories were analyzed separately, birth year correlated negatively with the preva-lence of Immunoglobulin G against Herpes simplex 1 and Herpes simplex 2 (p = 0.032 and 0.028) in 30-year-old women,and with the prevalence of Immunoglobulin G against Cytomegalovirus in 50-year-old men (p = 0.011).

Conclusions: The prevalence of Immunoglobulin G against Herpes simplex 1, Herpes simplex 2 and Epstein-Barr virusdecreases in later birth cohorts. This indicates a trend of declining risk of getting infected with these viruses as a childand adolescen (9) (PDF) Time trends in herpesvirus seroepidemiology among Swedish adults. 

Place, publisher, year, edition, pages
Springer Nature, 2024
Keywords
Herpes, Herpes simplex, Epstein-Barr virus, Cytomegalovirus, Seroprevalence, Epidemiology, Time trends, Immunoglobulin G
National Category
Public Health, Global Health, Social Medicine and Epidemiology Geriatrics Infectious Medicine
Research subject
Infectious Diseases; Geriatrics
Identifiers
urn:nbn:se:umu:diva-221713 (URN)10.1186/s12879-024-09155-w (DOI)38431567 (PubMedID)2-s2.0-85186556771 (Scopus ID)
Funder
Region VästerbottenUmeå UniversityThe Dementia Association - The National Association for the Rights of the DementedAlzheimerfonden
Available from: 2024-03-03 Created: 2024-03-03 Last updated: 2024-03-13Bibliographically approved
Visvanathan, K., Mondul, A. M., Zeleniuch-Jacquotte, A., Wang, M., Gail, M. H., Yaun, S.-S., . . . Ziegler, R. G. (2023). Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts. European Journal of Epidemiology, 38, 11-29
Open this publication in new window or tab >>Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts
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2023 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 38, p. 11-29Article in journal (Refereed) Published
Abstract [en]

Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-hydroxyvitamin D [25(OH)D] to subsequent breast cancer incidence, we harmonized and pooled participant-level data from 10 U.S. and 7 European prospective cohorts. Included were 10,484 invasive breast cancer cases and 12,953 matched controls. Median age (interdecile range) was 57 (42–68) years at blood collection and 63 (49–75) years at breast cancer diagnosis. Prediagnostic circulating 25(OH)D was either newly measured using a widely accepted immunoassay and laboratory or, if previously measured by the cohort, calibrated to this assay to permit using a common metric. Study-specific relative risks (RRs) for season-standardized 25(OH)D concentrations were estimated by conditional logistic regression and combined by random-effects models. Circulating 25(OH)D increased from a median of 22.6 nmol/L in consortium-wide decile 1 to 93.2 nmol/L in decile 10. Breast cancer risk in each decile was not statistically significantly different from risk in decile 5 in models adjusted for breast cancer risk factors, and no trend was apparent (P-trend = 0.64). Compared to women with sufficient 25(OH)D based on Institute of Medicine guidelines (50– < 62.5 nmol/L), RRs were not statistically significantly different at either low concentrations (< 20 nmol/L, 3% of controls) or high concentrations (100– < 125 nmol/L, 3% of controls; ≥ 125 nmol/L, 0.7% of controls). RR per 25 nmol/L increase in 25(OH)D was 0.99 [95% confidence intervaI (CI) 0.95–1.03]. Associations remained null across subgroups, including those defined by body mass index, physical activity, latitude, and season of blood collection. Although none of the associations by tumor characteristics reached statistical significance, suggestive inverse associations were seen for distant and triple negative tumors. Circulating 25(OH)D, comparably measured in 17 international cohorts and season-standardized, was not related to subsequent incidence of invasive breast cancer over a broad range in vitamin D status.

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2023
Keywords
25-Hydroxyvitamin D, Biomarker, Breast cancer, Calibration, Pooled analysis, Prospective cohort study, Vitamin D
National Category
Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-202341 (URN)10.1007/s10654-022-00921-1 (DOI)000908100600003 ()2-s2.0-85145419390 (Scopus ID)
Funder
Swedish Cancer SocietySwedish Research CouncilRegion Västerbotten
Available from: 2023-01-12 Created: 2023-01-12 Last updated: 2024-02-08Bibliographically approved
de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., . . . Fornage, M. (2023). Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci. Frontiers in Genetics, 14, Article ID 1235337.
Open this publication in new window or tab >>Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
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2023 (English)In: Frontiers in Genetics, E-ISSN 1664-8021, Vol. 14, article id 1235337Article in journal (Refereed) Published
Abstract [en]

Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes.

Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals).

Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue.

Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
cholesterol, educational attainment, genome-wide association study, lipids, meta-analysis, triglycerides
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-217379 (URN)10.3389/fgene.2023.1235337 (DOI)38028628 (PubMedID)2-s2.0-85177065494 (Scopus ID)
Available from: 2023-12-01 Created: 2023-12-01 Last updated: 2023-12-04Bibliographically approved
Nordin, E., Steffensen, S. K., Laursen, B. B., Andersson, S.-O., Johansson, J.-E., Åman, P., . . . Landberg, R. (2022). An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method. Scientific Reports, 12(1), Article ID 5260.
Open this publication in new window or tab >>An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 5260Article in journal (Refereed) Published
Abstract [en]

Prostate cancer (PC) is a common cancer among men, and preventive strategies are warranted. Benzoxazinoids (BXs) in rye have shown potential against PC in vitro but human studies are lacking. The aim was to establish a quantitative method for analysis of BXs and investigate their plasma levels after a whole grain/bran rye vs refined wheat intervention, as well as exploring their association with PSA, in men with PC. A quantitative method for analysis of 22 BXs, including novel metabolites identified by mass spectrometry and NMR, was established, and applied to plasma samples from a randomized crossover study where patients with indolent PC (n = 17) consumed 485 g whole grain rye/rye bran or fiber supplemented refined wheat daily for 6 wk. Most BXs were significantly higher in plasma after rye (0.3–19.4 nmol/L in plasma) vs. refined wheat (0.05–2.9 nmol/L) intake. HBOA-glc, 2-HHPAA, HBOA-glcA, 2-HPAA-glcA were inversely correlated to PSA in plasma (p < 0.04). To conclude, BXs in plasma, including metabolites not previously analyzed, were quantified. BX metabolites were significantly higher after rye vs refined wheat consumption. Four BX-related metabolites were inversely associated with PSA, which merits further investigation.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022
National Category
Food Science Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-193683 (URN)10.1038/s41598-022-08856-z (DOI)000774204500041 ()35347164 (PubMedID)2-s2.0-85127262251 (Scopus ID)
Funder
Swedish Research Council, 2017-05840Academy of Finland, 321716EU, Horizon 2020
Available from: 2022-05-03 Created: 2022-05-03 Last updated: 2023-05-24Bibliographically approved
Poveda, A., Pomares-Millan, H., Chen, Y., Kurbasic, A., Patel, C. J., Renström, F., . . . Franks, P. W. (2022). Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits. Scientific Reports, 12(1), Article ID 4088.
Open this publication in new window or tab >>Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 4088Article in journal (Refereed) Published
Abstract [en]

The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test associations with 10-year change in the cardiometabolic traits. ‘Physical activity’ and ‘General Health’ were the exposure categories containing the highest number of ‘tentative signals’ in analyses assessing the average association of lifestyle variables, while ‘Tobacco use’ was the top category for the 10-year change association analyses. Eleven modifiable variables showed a consistent average association among the majority of cardiometabolic traits. These variables belonged to the domains: (i) Smoking, (ii) Beverage (filtered coffee), (iii) physical activity, (iv) alcohol intake, and (v) specific variables related to Nordic lifestyle (hunting/fishing during leisure time and boiled coffee consumption). We used an agnostic, data-driven approach to assess a wide range of established and novel risk factors for cardiometabolic disease. Our findings highlight key variables, along with their respective effect estimates, that might be prioritised for subsequent prediction models and lifestyle interventions.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-193212 (URN)10.1038/s41598-022-08050-1 (DOI)000826474600156 ()35260745 (PubMedID)2-s2.0-85126079444 (Scopus ID)
Funder
Swedish Research Council
Available from: 2022-03-23 Created: 2022-03-23 Last updated: 2023-09-05Bibliographically approved
Clay-Gilmour, A., Chattopadhyay, S., Hildebrandt, M. A. T., Thomsen, H., Weinhold, N., Vodicka, P., . . . Hemminki, K. (2022). Genome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6 [Letter to the editor]. Blood Cancer Journal, 12(4), Article ID 60.
Open this publication in new window or tab >>Genome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6
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2022 (English)In: Blood Cancer Journal, E-ISSN 2044-5385, Vol. 12, no 4, article id 60Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Springer Nature, 2022
National Category
Hematology
Identifiers
urn:nbn:se:umu:diva-194331 (URN)10.1038/s41408-022-00658-w (DOI)000783707700002 ()35418122 (PubMedID)2-s2.0-85128121039 (Scopus ID)
Available from: 2022-05-04 Created: 2022-05-04 Last updated: 2023-11-15Bibliographically approved
Östman, J. R., Pinto, R. C., Ebbels, T. M. D., Thysell, E., Hallmans, G. & Moazzami, A. A. (2022). Identification of prediagnostic metabolites associated with prostate cancer risk by untargeted mass spectrometry-based metabolomics: a case-control study nested in the Northern Sweden Health and Disease Study. International Journal of Cancer, 151(12), 2115-2127
Open this publication in new window or tab >>Identification of prediagnostic metabolites associated with prostate cancer risk by untargeted mass spectrometry-based metabolomics: a case-control study nested in the Northern Sweden Health and Disease Study
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2022 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 151, no 12, p. 2115-2127Article in journal (Refereed) Published
Abstract [en]

Prostate cancer (PCa) is the most common cancer form in males in many European and American countries, but there are still open questions regarding its etiology. Untargeted metabolomics can produce an unbiased global metabolic profile, with the opportunity for uncovering new plasma metabolites prospectively associated with risk of PCa, providing insights into disease etiology. We conducted a prospective untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics analysis using prediagnostic fasting plasma samples from 752 PCa case-control pairs nested within the Northern Sweden Health and Disease Study (NSHDS). The pairs were matched by age, BMI, and sample storage time. Discriminating features were identified by a combination of orthogonal projection to latent structures-effect projections (OPLS-EP) and Wilcoxon signed-rank tests. Their prospective associations with PCa risk were investigated by conditional logistic regression. Subgroup analyses based on stratification by disease aggressiveness and baseline age were also conducted. Various free fatty acids and phospholipids were positively associated with overall risk of PCa and in various stratification subgroups. Aromatic amino acids were positively associated with overall risk of PCa. Uric acid was positively, and glucose negatively, associated with risk of PCa in the older subgroup. This is the largest untargeted LC-MS based metabolomics study to date on plasma metabolites prospectively associated with risk of developing PCa. Different subgroups of disease aggressiveness and baseline age showed different associations with metabolites. The findings suggest that shifts in plasma concentrations of metabolites in lipid, aromatic amino acid, and glucose metabolism are associated with risk of developing PCa during the following two decades.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022
Keywords
liquid chromatography-mass spectrometry, nested case-control study, prostate cancer, risk biomarkers, untargeted metabolomics
National Category
Cancer and Oncology Nutrition and Dietetics
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-198934 (URN)10.1002/ijc.34223 (DOI)000839504600001 ()35866293 (PubMedID)2-s2.0-85135769811 (Scopus ID)
Funder
Science for Life Laboratory, SciLifeLabSwedish Research Council, 2017-00650Swedish Research Council, 222-2014-1341
Available from: 2022-09-16 Created: 2022-09-16 Last updated: 2023-05-23Bibliographically approved
Lopatko Lindman, K., Jonsson, C., Weidung, B., Olsson, J., Pandey, J. P., Prokopenko, D., . . . Lövheim, H. (2022). PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk. Scientific Reports, 12(1), Article ID 13264.
Open this publication in new window or tab >>PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 13264Article in journal (Refereed) Published
Abstract [en]

PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer’s disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case–control study of 360 1:1-matched AD subjects. Interactions between the PILRA-A allele, APOE risk variants (ε3/ε4 or ε4/ε4) and GM17 for AD risk were modelled. The associations were cross-validated using two independent whole-genome sequencing datasets. We found negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52–1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32–0.98) in the discovery dataset. In the replication cohort, a joint effect of PILRA and PILRA × GM 17/17 was observed for the risk of developing AD (p.02). Here, we report a negative effect modification by PILRA on APOE and GM17 high-risk variants for future AD risk in two independent datasets. This highlights the complex genetics of AD.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022
National Category
Medical Genetics Public Health, Global Health, Social Medicine and Epidemiology Microbiology
Identifiers
urn:nbn:se:umu:diva-198480 (URN)10.1038/s41598-022-17058-6 (DOI)000836651200031 ()35918447 (PubMedID)2-s2.0-85135234828 (Scopus ID)
Funder
EU, FP7, Seventh Framework ProgrammeRegion VästerbottenThe Kempe FoundationsThe Swedish Medical AssociationThe Dementia Association - The National Association for the Rights of the DementedAlzheimerfondenThe Swedish Brain Foundation
Available from: 2022-08-12 Created: 2022-08-12 Last updated: 2023-09-05Bibliographically approved
Klein, R. J., Vertosick, E., Sjoberg, D., Ulmert, D., Rönn, A.-C., Häggström, C., . . . Lilja, H. (2022). Prostate cancer polygenic risk score and prediction of lethal prostate cancer. npj Precision Oncology, 6(1), Article ID 25.
Open this publication in new window or tab >>Prostate cancer polygenic risk score and prediction of lethal prostate cancer
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2022 (English)In: npj Precision Oncology, E-ISSN 2397-768X, Vol. 6, no 1, article id 25Article in journal (Refereed) Published
Abstract [en]

Polygenic risk scores (PRS) for prostate cancer incidence have been proposed to optimize prostate cancer screening. Prediction of lethal prostate cancer is key to any stratified screening program to avoid excessive overdiagnosis. Herein, PRS for incident prostate cancer was evaluated in two population-based cohorts of unscreened middle-aged men linked to cancer and death registries: the Västerbotten Intervention Project (VIP) and the Malmö Diet and Cancer study (MDC). SNP genotypes were measured by genome-wide SNP genotyping by array followed by imputation or genotyping of selected SNPs using mass spectrometry. The ability of PRS to predict lethal prostate cancer was compared to PSA and a commercialized pre-specified model based on four kallikrein markers. The PRS was associated with incident prostate cancer, replicating previously reported relative risks, and was also associated with prostate cancer death. However, unlike PSA, the PRS did not show stronger association with lethal disease: the hazard ratio for prostate cancer incidence vs. prostate cancer metastasis and death was 1.69 vs. 1.65 in VIP and 1.25 vs. 1.25 in MDC. PSA was a much stronger predictor of prostate cancer metastasis or death with an area-under-the-curve of 0.78 versus 0.63 for the PRS. Importantly, addition of PRS to PSA did not contribute additional risk stratification for lethal prostate cancer. We have shown that a PRS that predicts prostate cancer incidence does not have utility above and beyond that of PSA measured at baseline when applied to the clinically relevant endpoint of prostate cancer death. These findings have implications for public health policies for delivery of prostate cancer screening. Focusing polygenic risk scores on clinically significant endpoints such as prostate cancer metastasis or death would likely improve clinical utility.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-194353 (URN)10.1038/s41698-022-00266-8 (DOI)000781349700001 ()35396534 (PubMedID)2-s2.0-85128179283 (Scopus ID)
Funder
Swedish Cancer Society, 2017/559Swedish Research Council, 2016-02974
Available from: 2022-05-03 Created: 2022-05-03 Last updated: 2023-05-24Bibliographically approved
Clendenen, T. V., Ge, W., Koenig, K. L., Afanasyeva, Y., Agnoli, C., Bertone-Johnson, E., . . . Zeleniuch-Jacquotte, A. (2021). Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women. Journal of Clinical Endocrinology and Metabolism, 106(11), E4542-E4553
Open this publication in new window or tab >>Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women
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2021 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 106, no 11, p. E4542-E4553Article in journal (Refereed) Published
Abstract [en]

Context: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.

Objective: This study assessed whether risk factors for breast cancer are correlates of AMH concentration.

Methods: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population.

Results: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05).

Conclusion: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.

Place, publisher, year, edition, pages
Oxford University Press, 2021
Keywords
AMH correlates, anti-Müllerian hormone, breast cancer risk factors
National Category
Cancer and Oncology Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:umu:diva-189995 (URN)10.1210/clinem/dgab461 (DOI)000715561700042 ()34157104 (PubMedID)2-s2.0-85119505940 (Scopus ID)
Funder
NIH (National Institute of Health), R01 CA178949
Available from: 2021-11-30 Created: 2021-11-30 Last updated: 2023-03-24Bibliographically approved
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Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-9581-3845

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