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Renman, E., Ekici, R., Sundström, M. & Lejon, K. (2022). HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse. Autoimmunity, 55(8), 520-528
Open this publication in new window or tab >>HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse
2022 (English)In: Autoimmunity, ISSN 0891-6934, E-ISSN 1607-842X, Vol. 55, no 8, p. 520-528Article in journal (Refereed) Published
Abstract [en]

B cells have been shown to be essential for Type 1 diabetes development in the non-obese diabetic mouse, where their contribution as antigen presenting cells has been emphasised. Other important functions for B cells include surface capture of immunoglobulins and transportation of immune complexes, with subsequent endocytosis, antigen processing and antigen presentation. We have previously demonstrated that NOD B cells capture IgM and IgG immune complexes through an unknown surface molecule. In this study, we revealed the presumptive immunoglobulin-binding molecule to be HSC70. Moreover, we detected increased levels of HSC70 on NOD B cells. HSC70 has been shown to play a role in antigen processing and presentation as well as being important in several autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Due to its protein stabilising properties, increased HSC70 could contribute to enhanced self-antigen collection and presentation and thereby contribute to the development of Type 1 diabetes.

Place, publisher, year, edition, pages
Taylor & Francis, 2022
Keywords
B lymphocyte, HSC70, immune complex, NOD mouse, Type 1 diabetes
National Category
Immunology in the medical area
Research subject
Immunology
Identifiers
urn:nbn:se:umu:diva-199900 (URN)10.1080/08916934.2022.2117307 (DOI)000855330200001 ()36120986 (PubMedID)2-s2.0-85138421853 (Scopus ID)
Funder
DiabetesfondenSwedish Child Diabetes Foundation
Available from: 2022-10-03 Created: 2022-10-03 Last updated: 2022-11-29Bibliographically approved
Ekici, R. (2010). B cells in Type 1 diabetes: studies on cell surface antibody binding. (Licentiate dissertation). Umeå: Umeå universitet
Open this publication in new window or tab >>B cells in Type 1 diabetes: studies on cell surface antibody binding
2010 (English)Licentiate thesis, monograph (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2010. p. 34
Keywords
typ 1 diabetes, insulin, NOD, B cell
National Category
Immunology in the medical area
Research subject
Immunology
Identifiers
urn:nbn:se:umu:diva-37376 (URN)978-91-7459-075-3 (ISBN)
Supervisors
Available from: 2010-11-08 Created: 2010-10-30 Last updated: 2022-10-03Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-0273-8485

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