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Antepohl, U., Butler Forslund, E., Flank, P., Holmlund, L., Antepohl, W., Levi, R., . . . STRIVE-SCI Consortium, . (2026). Psychometric properties of the Swedish versions of Spinal Cord Independence Measure IV (SCIM IV) and Self-report (SCIM-SR) in inpatient and outpatient rehabilitation settings. Spinal Cord
Open this publication in new window or tab >>Psychometric properties of the Swedish versions of Spinal Cord Independence Measure IV (SCIM IV) and Self-report (SCIM-SR) in inpatient and outpatient rehabilitation settings
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2026 (English)In: Spinal Cord, ISSN 1362-4393, E-ISSN 1476-5624Article in journal (Refereed) Epub ahead of print
Abstract [en]

Study design: Psychometric study.

Objectives: To evaluate the data completeness, data distribution and ceiling/floor effects, internal consistency and convergent validity of the Swedish versions of the Spinal Cord Independence Measure IV (s-SCIM IV) and the Spinal Cord Independence Measure Self-report (s-SCIM-SR).

Setting: Swedish inpatient and outpatient spinal cord injury (SCI) rehabilitation.

Methods: The translation process was based on established guidelines with researchers, clinicians and consumers. s-SCIM IV and FIMTM assessments were performed by observation and/or interview, s-SCIM-SR through self-report using paper forms.

Results: In total, 101 participants (82% men) were included. There were no missing data for s-SCIM IV and 92% had answered all items in s-SCIM-SR. No ceiling or floor effects were observed. Cronbach´s alpha for the total s-SCIM IV scale was 0.91 (subscales 0.68–0.93) and for the total s-SCIM-SR scale 0.91 (subscales 0.62–0.93), with the lowest alphas for Respiration and Sphincter Management in both outcome measures. s-SCIM IV and s-SCIM-SR correlated strongly with each other and with FIMTM.

Conclusions: Our results support the data completeness, lack of ceiling/floor effects, internal consistency (except the Respiration and Sphincter Management subscale) and convergent validity of the s-SCIM IV and s-SCIM-SR. Based on this initial psychometric testing, these outcome measures can be considered suitable to assess physical independence in inpatient and outpatient rehabilitation and long-term follow-up after SCI, for both clinical and research purposes. The now available Swedish versions of SCIM will enable a uniform national assessment of SCI-specific physical independence and facilitate research and international collaborations and comparisons.

Place, publisher, year, edition, pages
Springer Nature, 2026
National Category
Physiotherapy
Identifiers
urn:nbn:se:umu:diva-249952 (URN)10.1038/s41393-026-01168-3 (DOI)001667197700001 ()41571760 (PubMedID)2-s2.0-105029517726 (Scopus ID)
Funder
Medical Research Council of Southeast Sweden (FORSS)Promobilia foundationLund University
Available from: 2026-02-18 Created: 2026-02-18 Last updated: 2026-02-18
Mukaino, M., Aguiar Branco, C., Alghwiri, A., Amato, S., Kontaxakis, A., Berteanu, M., . . . Selb, M. (2025). Clinical functioning information tool – coronavirus disease 2019 (ClinFIT COVID): psychometric evaluation and development of an interval-scaled functioning score across the care continuum. Journal of Rehabilitation Medicine, 57, Article ID jrm43227.
Open this publication in new window or tab >>Clinical functioning information tool – coronavirus disease 2019 (ClinFIT COVID): psychometric evaluation and development of an interval-scaled functioning score across the care continuum
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2025 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 57, article id jrm43227Article in journal (Refereed) Published
Abstract [en]

Objective: to report on the development and global testing of the COVID-19 version of the International Classification of Functioning, Disability and Health-based Clinical Functioning Information Tool called “ClinFIT COVID-19” to collect functioning data of rehabilitation patients across the care continuum to establish an interval-scaled functioning score.

Design: Multicentre, cross-sectional observational study.

Subjects/Patients: Rehabilitation patients in acute, post-acute, and long-term settings.

Methods: Three context-specific versions (13–16 ICF categories) of ClinFIT-COVID-19 were administered to collect information on patient functioning. Rasch analysis examined psychometric properties and generated conversion tables from ordinal raw scores to a 0–100 interval metric.

Results: Twenty-six study centres in 17 countries across the globe collected data from 1,747 patients. Problems in exercise tolerance functions were most frequently reported in the acute and post-acute settings (74.2%; 87.6%), while long-term care patients most frequently reported pain as problematic (71.1%). With a testlets approach and item splitting, all 3 ClinFIT COVID-19 versions satisfied Rasch model expectations (item-trait χ² p > 0.05; PSI 0.742–0.812), making it feasible to develop respective transformation tables.

Conclusion: This study found the psychometric properties of ClinFIT COVID-19 acceptable. Future studies are needed to validate the use of the transformation tables to monitor functioning and evaluate intervention impact.

Place, publisher, year, edition, pages
MJS Publishing, 2025
Keywords
COVID-19, functional status, International Classification of Functioning Disability and Health, outcomes, rehabilitation
National Category
Physiotherapy
Identifiers
urn:nbn:se:umu:diva-243970 (URN)10.2340/jrm.v57.43227 (DOI)001560471000001 ()40820498 (PubMedID)2-s2.0-105014731619 (Scopus ID)
Available from: 2025-09-08 Created: 2025-09-08 Last updated: 2025-09-08Bibliographically approved
Sefastsson, A., Andersson, T. C., Littbrand, H., Wester, P., Sörlin, A., Stålnacke, B.-M., . . . Hu, X.-L. (2025). Constraint-induced movement therapy reduced shoulder pain and improved function in subacute and chronic stroke: a cohort study. Frontiers in Neurology, 16, Article ID 1639840.
Open this publication in new window or tab >>Constraint-induced movement therapy reduced shoulder pain and improved function in subacute and chronic stroke: a cohort study
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2025 (English)In: Frontiers in Neurology, E-ISSN 1664-2295, Vol. 16, article id 1639840Article in journal (Refereed) Published
Abstract [en]

Introduction: The objective of this study was to evaluate the effects of Constraint-Induced Movement Therapy (CIMT) on hemiplegic shoulder pain (HSP), shoulder range of motion (ROM) and upper extremity motor function in stroke patients.

Methods: This longitudinal intervention cohort study was performed in an outpatient clinic without a control group. Participants underwent individually tailored CIMT with a patient therapist ratio of 4:1 for 6 h/day, 5 days/week for 2 consecutive weeks, including daily shoulder strength and joint motion training. A total of 221 (101 with and 120 without pre-CIMT HSP) middle-aged (median 54 years) persons at sub-acute or chronic phases after stroke were included in the study. The Fugl-Meyer Assessment (FMA) subscale for pain was used for defining and scoring HSP at passive motion (sum of four directions of movement, maximum 8 points indicating no pain). Passive and active shoulder ROM (sum of flexion and abduction) were assessed. Upper extremity motor function was assessed with B. Lindmark Motor Assessment. Assessments were done pre- and post-CIMT and at 3-month follow-up. Comparisons were stratified by subgroups with- and without HSP.

Results: In the subgroup with pre-CIMT HSP, median HSP score at passive movement was reduced (FMA shoulder pain score increased) from pre- to post-CIMT from 5 points to 7 points post-CIMT, (p < 0.001, Effect size (ES) 0.68). Median active ROM increased from 230° to 308° (p < 0.001, ES 0.72) and median passive ROM increased from 350° to 360° (p < 0.001, ES 0.44). Median motor function improved from 42 to 49 points (p < 0.001, ES 0.92). In the subgroup without pre-CIMT HSP no statistically significant increase of HSP was seen and no clinically significant changes observed for active or passive ROM after CIMT. Median motor function improved from 52 to 56 points (p < 0.001, ES 0.71). All improvements persisted at 3-month follow-up.

Conclusion: CIMT in an outpatient clinical setting may be a feasible treatment to decrease HSP and to improve shoulder ROM and upper extremity motor function among middle-aged persons in the subacute and chronic phases after stroke. Results need to be confirmed in an RCT setting.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2025
Keywords
constraint-induced movement therapy, motor function, range of motion (ROM), shoulder pain, shoulder range of motion, stroke rehabilitation, upper extremity motor function
National Category
Occupational Therapy Physiotherapy
Identifiers
urn:nbn:se:umu:diva-244876 (URN)10.3389/fneur.2025.1639840 (DOI)001575085700001 ()40979203 (PubMedID)2-s2.0-105016569392 (Scopus ID)
Funder
Region VästerbottenUmeå UniversityThe Swedish Stroke Association
Available from: 2025-10-02 Created: 2025-10-02 Last updated: 2025-11-04Bibliographically approved
Mariotti, M., Selb, M., Imamura, M., Alghwiri, A., Amatya, B., Ceravolo, M. G., . . . Perret, C. (2025). From concept to practice: the development of ClinFIT for musculoskeletal disorders. American Journal of Physical Medicine & Rehabilitation
Open this publication in new window or tab >>From concept to practice: the development of ClinFIT for musculoskeletal disorders
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2025 (English)In: American Journal of Physical Medicine & Rehabilitation, ISSN 0894-9115, E-ISSN 1537-7385Article in journal (Refereed) Accepted
Abstract [en]

Objective: This study aimed to develop ClinFIT-MSK, an International Classification of Functioning, Disability and Health (ICF)-based clinical tool for the assessment and reporting of the functioning and rehabilitation potential of patients with a musculoskeletal condition.

Design: This multistep, mixed-methods tool development process encompassed developing an initial shortlist of ICF categories (comprising the aggregation of the ICF Core Sets for musculoskeletal conditions and a literature search), identifying the ClinFIT-MSK items feasible for clinical use via a two-round Delphi survey, developing a simple description for each item and deciding on the rating scale through development working group consultations. These consultations were also instrumental at each step of tool development.

Results: Based on a shortlist of 33 categories, the Delphi survey generated 17 items (7 body function and 10 activity and participation categories) which can be rated with a 0-4 scale (0 = no problem to 4 = complete problem) accompanied with rating specifications or with a 0-10 numeric rating scale without specification.

Conclusions: ClinFIT-MSK can be used by rehabilitation professionals to support individualized care and track functional outcomes. It can also be employed in research and public health. Psychometric testing and cross-cultural validation will be pursued to ensure ClinFIT-MSK's scientific robustness and applicability across diverse settings.

Place, publisher, year, edition, pages
Wolters Kluwer, 2025
National Category
Nursing
Identifiers
urn:nbn:se:umu:diva-250978 (URN)10.1097/phm.0000000000002875 (DOI)
Available from: 2026-03-13 Created: 2026-03-13 Last updated: 2026-03-13
Marklund, I., Fure, B., Klässbo, M., Liv, P., Stålnacke, B.-M. & Hu, X.-L. (2025). Post-stroke health-related quality of life following lower-extremity constraint-induced movement therapy: an observational survey study. PLOS ONE, 20(5), Article ID e0323290.
Open this publication in new window or tab >>Post-stroke health-related quality of life following lower-extremity constraint-induced movement therapy: an observational survey study
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2025 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 20, no 5, article id e0323290Article in journal (Refereed) Published
Abstract [en]

Lower- extremity constraint-induced movement therapy (LE-CIMT) has proven effective in overcoming physical disabilities. Participating in the LE-CIMT requires some independent walking ability without aids that indicates a higher level of motor function than for the entire stroke population. However, only few studies evaluated health-related quality of life (HRQoL) after LE-CIMT. This study aimed to compare HRQoL of people who had participated in LE-CIMT post-stroke to the general population and evaluate whether descriptive characteristics and clinical result were associated with their HRQoL. An observational survey study with a questionnaire including the Swedish RAND-36 and Saltin–Grimby Physical Activity Level Scale was sent to 162 people. Reference data from the Mid-Health Survey in Sweden was used for norm-based comparisons of RAND-36. Respondents’ result from six-minute walk test post-LE-CIMT were used in the univariate analyse. The response rate was 65% (n=106; 69 males and 37 females with a mean age of 62±12 years). Ninety percent of the respondents could move around indoors and outdoors independently, despite this, 21% considered themselves physically inactive. The respondents had significantly reduced HRQoL compared to the general population in four of eight domains in the RAND-36: physical functioning (p=0.001), role-functioning (physical; p<0.001), general health (p=0.010), and social functioning (p<0.001). Regression analysis showed that longer walking distance significantly was associated with the RAND-36 physical functioning domain (β=6.45, 95% confidence interval=2.03–10.87, p=0.005). People in the chronic phase post-stroke who had previously participated in LE- CIMT had reduced HRQoL compared to the general population regarding physical functioning, role-functioning physical, general health, and social functioning. A longer walking distance was associated with higher HRQoL in physical functioning domain, emphasising the importance of mobility training in post-stroke rehabilitation.

Place, publisher, year, edition, pages
Public Library of Science (PLoS), 2025
National Category
Physiotherapy
Identifiers
urn:nbn:se:umu:diva-239111 (URN)10.1371/journal.pone.0323290 (DOI)001488714900002 ()40341838 (PubMedID)2-s2.0-105004837822 (Scopus ID)
Funder
Region VärmlandRegion VästerbottenUmeå UniversityThe Swedish Stroke Association
Available from: 2025-05-27 Created: 2025-05-27 Last updated: 2025-05-27Bibliographically approved
Zampolini, M., Oral, A., Barotsis, N., Aguiar Branco, C., Burger, H., Capodaglio, P., . . . Kiekens, C. (2024). Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice on telerehabilitation: the European PRM position (UEMS PRM Section). European Journal of Physical and Rehabilitation Medicine, 60(2), 165-181
Open this publication in new window or tab >>Evidence-based position paper on Physical and Rehabilitation Medicine (PRM) professional practice on telerehabilitation: the European PRM position (UEMS PRM Section)
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2024 (English)In: European Journal of Physical and Rehabilitation Medicine, ISSN 1973-9087, E-ISSN 1973-9095, Vol. 60, no 2, p. 165-181Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: The evidence on the utility and effectiveness of rehabilitation interventions delivered via telerehabilitation is growing rapidly. Telerehabilitation is expected to have a key role in rehabilitation in the future.

AIM: The aim of this evidence-based position paper (EBPP) is to improve PRM physicians' professional practice in telerehabilitation to be delivered to improve functioning and to reduce activity limitations and/or participation restrictions in individuals with a variety of disabling health conditions.

METHODS: To produce recommendations for PRM physicians on telerehabilitation, a systematic review of the literature and a consensus procedure by means of a Delphi process have been performed involving the delegates of all European countries represented in the UEMS PRM Section. RESULTS: The systematic literature review is reported together with the 32 recommendations resulting from the Delphi procedure.

CONCLUSIONS: It is recommended that PRM physicians deliver rehabilitation services remotely, via digital means or using communication technologies to eligible individuals, whenever required and feasible in a variety of health conditions in favor of the patient and his/her family, based on evidence of effectiveness and in compliance with relevant regulations. This EBPP represents the official position of the European Union through the UEMS PRM Section and designates the professional role of PRM physicians in telerehabilitation.

Place, publisher, year, edition, pages
Edizioni Minerva Medica, 2024
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:umu:diva-223618 (URN)10.23736/S1973-9087.24.08396-5 (DOI)001184975700001 ()38477069 (PubMedID)2-s2.0-85190562389 (Scopus ID)
Available from: 2024-04-30 Created: 2024-04-30 Last updated: 2024-04-30Bibliographically approved
Sefastsson, A., Marklund, I., Littbrand, H., Wester, P., Stålnacke, B.-M., Sörlin, A., . . . Hu, X.-L. (2024). Positive effects of lower extremity constraint-induced movement therapy on balance, leg strength and dual-task ability in stroke patients: a longitudinal cohort study. Journal of Rehabilitation Medicine, 56, Article ID jrm24168.
Open this publication in new window or tab >>Positive effects of lower extremity constraint-induced movement therapy on balance, leg strength and dual-task ability in stroke patients: a longitudinal cohort study
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2024 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 56, article id jrm24168Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate whether high-intensity lower extremity constraint-induced movement therapy can improve balance, leg strength, and dual-task ability.

Design: A longitudinal cohort study in a real-world outpatient clinic.

Patients: 147 community-dwelling participants in the subacute and chronic poststroke phases.

Methods: Participants received lower extremity constraint-induced movement therapy for 6 hours/day during 2 consecutive weeks, including balance, strength, and functional training. The Berg Balance Scale (BBS), Single-Leg-Stance (SLS) bilaterally, one Repetition Maximum (1RM) in a leg press, symmetry of leg strength (Diff-1RM), Timed Up and Go (TUG), and the TUG Manual test were assessed before, after, and 3 months after lower extremity constraint-induced movement therapy.

Results: Compared with preintervention data, statistically significant improvements after lower extremity constraint-induced movement therapy (p < 0.001) were demonstrated for balance with an absolute value in BBS at 1.9 points (effect size 0.38) and SLS at 2.4 s (effect size 0.24), and for leg strength at 10.2 kg (effect size 0.54) for the affected leg. Diff 1RM decreased significantly at 5.8 kg (effect size 0.39) and improvements on dual-task ability at 2.7 s were significant (effect size 0.14). The effects persisted at the 3-month follow-up.

Conclusions: High-intensity lower extremity constraint-induced movement therapy may be a feasible treatment option for middle-aged stroke patients to affect balance, leg strength, and dual-task ability positively in an out-patient clinical setting.

Place, publisher, year, edition, pages
MJS Publishing, 2024
Keywords
balance, constraint-induced movement therapy, dual-task, high-intensity training, lower extremity, physical therapy, strength training, stroke rehabilitation
National Category
Physiotherapy
Research subject
physiotherapy
Identifiers
urn:nbn:se:umu:diva-230509 (URN)10.2340/jrm.v56.24168 (DOI)001329749100001 ()39360525 (PubMedID)2-s2.0-85206910647 (Scopus ID)
Funder
Region VästerbottenThe Swedish Stroke Association
Available from: 2024-10-04 Created: 2024-10-04 Last updated: 2025-11-04Bibliographically approved
Eriksson, J., Nyberg, L., Elgh, E. & Hu, X.-L. (2023). Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks. NeuroImage: Clinical, 37, Article ID 103356.
Open this publication in new window or tab >>Improvement of cognition across a decade after stroke correlates with the integrity of functional brain networks
2023 (English)In: NeuroImage: Clinical, E-ISSN 2213-1582, Vol. 37, article id 103356Article in journal (Refereed) Published
Abstract [en]

Background and objective: We recently reported improvements of working memory across 10 years post stroke among middle-aged individuals. However, the mechanisms underlying working-memory recovery are largely unknown. This study investigated the associations between long-term improvement of working memory and resting-state functional connectivity in two frontoparietal networks: the frontoparietal network and the dorsal attention network.

Methods: Working memory was repeatedly assessed by the Digit Span Backwards task in 21 persons, within 1 year after stroke onset and again 10 years post stroke onset. Brain functional connectivity was examined by resting state functional magnetic resonance imaging at the 10-year follow-up.

Results: A significant improvement of working memory was found among 21 persons after stroke (median age = 64) at the 10-year follow-up compared to the within-one-year assessment. The magnitude of performance improvement on the Digit Span Backwards task was significantly positively correlated with stronger brain connectivity in the frontoparietal network (r = 0.51, p = 0.018) measured at the 10-year follow-up only. A similar association was observed in the dorsal attention network (r = 0.43, p = 0.052) but not in a visual network (r = -0.17, p = 0.46) that served as a control network. The association between functional connectivity within the above-mentioned networks and Digit Span Backwards scores at 10-year after stroke was in the same direction but did not reach significance.

Conclusions: The present work relate stronger long-term performance improvement on the Digit Span Backwards task with higher integrity of frontoparietal network connectivity.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Cognitive improvement, Functional connectivity, Long-term, Stroke, Working memory
National Category
Neurosciences Neurology
Identifiers
urn:nbn:se:umu:diva-205503 (URN)10.1016/j.nicl.2023.103356 (DOI)000975416600001 ()36842348 (PubMedID)2-s2.0-85148731680 (Scopus ID)
Funder
The Swedish Stroke AssociationRegion VästerbottenUmeå UniversityKnut and Alice Wallenberg Foundation
Available from: 2023-03-14 Created: 2023-03-14 Last updated: 2024-01-17Bibliographically approved
Marklund, I., Sefastsson, A., Fure, B., Klässbo, M., Liv, P., Stålnacke, B.-M. & Hu, X.-L. (2023). Lower-extremity constraint-induced movement therapy improved motor function, mobility, and walking after stroke. European Journal of Physical and Rehabilitation Medicine, 59(2), 136-144
Open this publication in new window or tab >>Lower-extremity constraint-induced movement therapy improved motor function, mobility, and walking after stroke
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2023 (English)In: European Journal of Physical and Rehabilitation Medicine, ISSN 1973-9087, E-ISSN 1973-9095, Vol. 59, no 2, p. 136-144Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: To regain the ability to walk is one of the most commonly stated goals for people who have had a stroke due to its importance in everyday life. Walking ability affects patients’ mobility, self-care, and social lives. Constraint-induced movement therapy (CIMT) is known to be effective in improving upper extremity outcomes post-stroke. However, there is insufficient evidence regarding its efficacy in improving lower extremity outcomes.AIM: To investigate whether a highly intensive CIMT for lower extremity (LE-CIMT) function post-stroke can improve motor function, functional mobility, and walking ability. Furthermore, it also aimed to investigate whether age, gender, stroke type, more-affected side, or time after stroke onset affect the efficacy of LE-CIMT on walking ability outcomes.

DESIGN: Longitudinal cohort study.

SETTING: Outpatient clinic in Stockholm, Sweden.

POPULATION: A total of 147 patients mean age 51 years (68% males; 57% right-sided hemiparesis), at the sub-acute or chronic phases post-stroke who had not previously undergone LE-CIMT.

METHODS: All patients received LE-CIMT for 6 hours per day over 2 weeks. The Fugl-Meyer Assessment (FMA) of the lower extremity, Timed Up and Go (TUG) test, Ten-Meter Walk Test (10MWT), and six-Minute Walk Test (6MWT) were used to assess functional outcomes before and directly after the 2-week treatment was complete as well at 3-month post-intervention.

RESULTS: Compared to baseline values, FMA (P<0.001), TUG (P<0.001), 10MWT (P<0.001) and 6MWT (P<0.001) scores were statistically significantly improved directly after the LE-CIMT intervention. These improvements persisted at the 3-month post-intervention follow-up. Those who completed the intervention 1-6 months after stroke onset had statistically significant larger improvements in 10MWT compared to those who received the intervention later than 6 months after stroke onset. Age, gender, stroke type, and more-affected side did not impact 10MWT results.

CONCLUSIONS: In an outpatient clinic setting, high-intensity LE-CIMT statistically significant improved motor function, functional mobility, and walking ability in middle-aged patients in the sub-acute and chronic post-stroke phases. However, studies with more robust designs need to be conducted to deepen the understanding of the efficacy of LE-CIMT.

CLINICAL REHABILITATION IMPACT: High-intensity LE-CIMT may be a feasible and useful treatment option in outpatient clinics to improve post-stroke walking ability.

Place, publisher, year, edition, pages
Edizioni Minerva Medica, 2023
Keywords
Stroke rehabilitation, Exercise, Lower extremity, Physical therapy modalities
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-207044 (URN)10.23736/S1973-9087.23.07683-9 (DOI)000983180600002 ()36892520 (PubMedID)2-s2.0-85153120897 (Scopus ID)
Funder
Region VärmlandRegion VästerbottenUmeå UniversityThe Swedish Stroke Association
Available from: 2023-04-25 Created: 2023-04-25 Last updated: 2023-10-30Bibliographically approved
Elgh, E. & Hu, X.-L. (2023). Premorbid employment and education predicts improvement in general cognition ten years after stroke onset: a longitudinal cohort study. Journal of Neuroscience and Neurological Surgery, 13(1), Article ID 260.
Open this publication in new window or tab >>Premorbid employment and education predicts improvement in general cognition ten years after stroke onset: a longitudinal cohort study
2023 (English)In: Journal of Neuroscience and Neurological Surgery, ISSN 2578-8868, Vol. 13, no 1, article id 260Article in journal (Refereed) Published
Abstract [en]

Background: We have recently demonstrated significant general cognitive recovery with delayed improvement of working memory 10 years after stroke in a unique longitudinal cohort.Aim: This study investigated demographic and clinical characteristics relevant to improved cognitive functions 10-year after a first-ever stroke.   

Materials and Methods: A prospective longitudinal cohort study was carried out in 38 middle-aged (mean age =54 at stroke onset) stroke survivors. Cognition was assessed thrice at one week, seven months, and ten years after the stroke. Working memory and visuospatial function were assessed with the Digit Span and Block Design subtests, respectively. General cognition was evaluated with the Mini-Mental State Examination at the two later time points. Multivariate linear regression was used to identify the variables that may significantly predict improved cognitive functions at 10-year follow-up.

Results: We found that having a full-time job prior to the stroke, suffering an ischemic (as opposed to a hemorrhagic) stroke, and having a university education predicted significantly superior general cognitive function 10 years after stroke (R2 of 0.77, p <0.001), while working memory and visuospatial function at 1 week after stroke significantly predicted their respective functions at 10-year follow-up (R2 of 0.41, p = 0.003). 

Conclusions: Our results indicate that premorbid employment status and higher education as well as having suffered from an ischemic rather than a hemorrhagic stroke might predict superior cognitive recovery among middle-aged individuals 10 years after stroke. 

Place, publisher, year, edition, pages
Auctores Publishing, 2023
Keywords
cognitive improvement, cognitive reserve, education, employment, longitudinal study, stroke
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-207045 (URN)10.31579/2578-8868/260 (DOI)
Funder
The Swedish Stroke AssociationUmeå UniversityRegion Västerbotten
Available from: 2023-04-25 Created: 2023-04-25 Last updated: 2023-04-26Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-9864-7432

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