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2022 (English)In: Journal of international medical research, ISSN 0300-0605, E-ISSN 1473-2300, Vol. 50, no 9, p. 1-12Article in journal (Refereed) Published
Abstract [en]
Objectives: Early mobilisation and effective pain management after open nephrectomy for renal cell carcinoma often include epidural analgesia (EDA), requiring an infusion pump and a urinary catheter, thus impeding mobilisation. Spinal anaesthesia (SpA) may be an alternative. This randomised clinical trial evaluated whether SpA improves analgesia and facilitates mobilisation over EDA and which factors influence mobilisation and length of stay (LOS).
Methods: Between 2012 and 2015, 135 patients were randomised and stratified by surgical method to either SpA with clonidine or EDA. Mobility index score (MobIs), pain scale, patient satisfaction questionnaire, and LOS were the main outcome measures.
Results: SpA patients exhibited an increase in MobIs significantly earlier than EDA patients. Among SpA patients >50% reached MobIs ≥13 by postoperative day 3, while 29% of EDA patients never reached MobIs ≥13 before discharge. SpA patients had higher maximum pain scores on postoperative days 1 and 2, but both groups had similar patient satisfaction. One day before discharge, 36/64 SpA versus 22/67 EDA patients (56% and 33%, respectively) were opioid-free. SpA patients were discharged significantly earlier than EDA patients.
Conclusions: SpA facilitates postoperative pain management and is associated with faster mobilisation and shorter LOS.
The trial was registered at ClinicalTrials.org (ID-NCT02030717).
Place, publisher, year, edition, pages
Sage Publications, 2022
National Category
Geriatrics Occupational Health and Environmental Health Surgery
Research subject
Anaesthesiology
Identifiers
urn:nbn:se:umu:diva-199864 (URN)10.1177/03000605221126883 (DOI)000864163600001 ()36177827 (PubMedID)2-s2.0-85138955478 (Scopus ID)
Funder
Region Västerbotten
2022-09-302022-09-302023-09-05Bibliographically approved