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Publications (5 of 5) Show all publications
Isaksson, H., Brännström, Å. & Libby, E. (2023). Minor variations in multicellular life cycles have major effects on adaptation. PloS Computational Biology, 19(4), Article ID e1010698.
Open this publication in new window or tab >>Minor variations in multicellular life cycles have major effects on adaptation
2023 (English)In: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 19, no 4, article id e1010698Article in journal (Refereed) Published
Abstract [en]

Multicellularity has evolved several independent times over the past hundreds of millions of years and given rise to a wide diversity of complex life. Recent studies have found that large differences in the fundamental structure of early multicellular life cycles can affect fitness and influence multicellular adaptation. Yet, there is an underlying assumption that at some scale or categorization multicellular life cycles are similar in terms of their adaptive potential. Here, we consider this possibility by exploring adaptation in a class of simple multicellular life cycles of filamentous organisms that only differ in one respect, how many daughter filaments are produced. We use mathematical models and evolutionary simulations to show that despite the similarities, qualitatively different mutations fix. In particular, we find that mutations with a tradeoff between cell growth and group survival, i.e. "selfish" or "altruistic" traits, spread differently. Specifically, altruistic mutations more readily spread in life cycles that produce few daughters while in life cycles producing many daughters either type of mutation can spread depending on the environment. Our results show that subtle changes in multicellular life cycles can fundamentally alter adaptation.

National Category
Evolutionary Biology
Identifiers
urn:nbn:se:umu:diva-209284 (URN)10.1371/journal.pcbi.1010698 (DOI)000974421200004 ()37083675 (PubMedID)2-s2.0-85159546634 (Scopus ID)
Funder
Swedish Research Council, 2018-0363
Available from: 2023-06-08 Created: 2023-06-08 Last updated: 2024-05-20Bibliographically approved
Andersson, R., Isaksson, H. & Libby, E. (2022). Multi-species multicellular life cycles. In: The evolution of multicellularity: (pp. 343-356). CRC Press
Open this publication in new window or tab >>Multi-species multicellular life cycles
2022 (English)In: The evolution of multicellularity, CRC Press, 2022, p. 343-356Chapter in book (Refereed)
Abstract [en]

Textbook examples of multicellular organisms vary in their scale and complexity but are typically composed of a single species. The prevalence of entities such as lichens, however, suggest that two different species may be capable of forming a type of multi-species multicellularity-though it may not resemble its clonal counterparts. In this chapter, we consider the possibility of multi-species multicellularity and in particular its origins. Drawing upon previous studies of the evolutionary origins of clonal multicellularity, we focus on the emergence of simple reproducing groups that have the capacity to gain adaptations. We present a framework for organizing these initial multi-species group life cycles based on whether the constituent species are unicellular or multicellular and whether the groups reproduce via fragmentation or cycles of dissociation and re-association. We discuss characteristics of each type of multi-species multicellularity and representative examples to assess their likely evolutionary trajectories. Ultimately, we conclude that the multi-species groups that most resemble textbook multicellular organisms are composed of unicellular and multicellular species and reproduce via cycles of dissociation and re-association.

Place, publisher, year, edition, pages
CRC Press, 2022
National Category
Evolutionary Biology
Identifiers
urn:nbn:se:umu:diva-200677 (URN)10.1201/9780429351907-21 (DOI)2-s2.0-85140170685 (Scopus ID)9781000542554 (ISBN)9780367356965 (ISBN)
Available from: 2022-11-01 Created: 2022-11-01 Last updated: 2024-05-20Bibliographically approved
Isaksson, H., Conlin, P. L., Kerr, B., Ratcliff, W. C. & Libby, E. (2021). The consequences of budding versus binary fission on adaptation and aging in primitive multicellularity. Genes, 12(5), Article ID 661.
Open this publication in new window or tab >>The consequences of budding versus binary fission on adaptation and aging in primitive multicellularity
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2021 (English)In: Genes, ISSN 2073-4425, E-ISSN 2073-4425, Vol. 12, no 5, article id 661Article in journal (Refereed) Published
Abstract [en]

Early multicellular organisms must gain adaptations to outcompete their unicellular ancestors, as well as other multicellular lineages. The tempo and mode of multicellular adaptation is influenced by many factors including the traits of individual cells. We consider how a fundamental aspect of cells, whether they reproduce via binary fission or budding, can affect the rate of adaptation in primitive multicellularity. We use mathematical models to study the spread of beneficial, growth rate mutations in unicellular populations and populations of multicellular filaments reproducing via binary fission or budding. Comparing populations once they reach carrying capacity, we find that the spread of mutations in multicellular budding populations is qualitatively distinct from the other populations and in general slower. Since budding and binary fission distribute age-accumulated damage differently, we consider the effects of cellular senescence. When growth rate decreases with cell age, we find that beneficial mutations can spread significantly faster in a multicellular budding population than its corresponding unicellular population or a population reproducing via binary fission. Our results demonstrate that basic aspects of the cell cycle can give rise to different rates of adaptation in multicellular organisms.

Place, publisher, year, edition, pages
MDPI, 2021
Keywords
Adaptation, Aging, Binary fission, Budding, Filaments, Multicellularity
National Category
Evolutionary Biology
Identifiers
urn:nbn:se:umu:diva-183525 (URN)10.3390/genes12050661 (DOI)000653921500001 ()2-s2.0-85105195781 (Scopus ID)
Available from: 2021-05-25 Created: 2021-05-25 Last updated: 2024-05-20Bibliographically approved
Isaksson, H., Lind, P. A. & Libby, E.Adaptive evolutionary trajectories in complexity: repeated transitions between unicellularity and differentiated multicellularity.
Open this publication in new window or tab >>Adaptive evolutionary trajectories in complexity: repeated transitions between unicellularity and differentiated multicellularity
(English)Manuscript (preprint) (Other academic)
National Category
Evolutionary Biology
Identifiers
urn:nbn:se:umu:diva-224560 (URN)
Available from: 2024-05-20 Created: 2024-05-20 Last updated: 2024-05-20
Isaksson, H., Ratcliff, W. & Libby, E.Cell-level information and the evolution of regulated multicellular life cycles.
Open this publication in new window or tab >>Cell-level information and the evolution of regulated multicellular life cycles
(English)Manuscript (preprint) (Other academic)
National Category
Evolutionary Biology
Identifiers
urn:nbn:se:umu:diva-224559 (URN)
Available from: 2024-05-20 Created: 2024-05-20 Last updated: 2024-05-20
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-4918-1140

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