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Martinez Gamero, CarlosORCID iD iconorcid.org/0000-0001-7652-1695
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Publications (4 of 4) Show all publications
Malla, S., Bhattarai, D. P., Groza, P., Melguizo-Sanchis, D., Atanasoai, I., Martinez Gamero, C., . . . Aguilo, F. (2022). ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. EMBO Reports, 23(3), Article ID e53191.
Open this publication in new window or tab >>ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
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2022 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 23, no 3, article id e53191Article in journal (Refereed) Published
Abstract [en]

The pluripotent state is not solely governed by the action of the core transcription factors OCT4, SOX2, and NANOG, but also by a series of co-transcriptional and post-transcriptional events, including alternative splicing (AS) and the interaction of RNA-binding proteins (RBPs) with defined subpopulations of RNAs. Zinc Finger Protein 207 (ZFP207) is an essential transcription factor for mammalian embryonic development. Here, we employ multiple functional analyses to characterize its role in mouse embryonic stem cells (ESCs). We find that ZFP207 plays a pivotal role in ESC maintenance, and silencing of Zfp207 leads to severe neuroectodermal differentiation defects. In striking contrast to human ESCs, mouse ZFP207 does not transcriptionally regulate neuronal and stem cell-related genes but exerts its effects by controlling AS networks and by acting as an RBP. Our study expands the role of ZFP207 in maintaining ESC identity, and underscores the functional versatility of ZFP207 in regulating neural fate commitment.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-191672 (URN)10.15252/embr.202153191 (DOI)000743102200001 ()35037361 (PubMedID)2-s2.0-85122763926 (Scopus ID)
Available from: 2022-01-21 Created: 2022-01-21 Last updated: 2024-04-08Bibliographically approved
Martinez-Gamero, C., Malla, S. & Aguilo, F. (2021). LSD1: Expanding functions in stem cells and differentiation. Cells, 10(11), Article ID 3252.
Open this publication in new window or tab >>LSD1: Expanding functions in stem cells and differentiation
2021 (English)In: Cells, E-ISSN 2073-4409, Vol. 10, no 11, article id 3252Article, review/survey (Refereed) Published
Abstract [en]

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific deme-thylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethyl-ates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of nu-merous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory cir-cuitry underlying self-renewal and pluripotency.

Place, publisher, year, edition, pages
MDPI, 2021
Keywords
Differentiation, Embryonic stem cells, Epigenetics, Histone methylation, Induced pluripotent stem cells, KDM1A, LSD1, Lysine-specific demethylase, Non-his-tone substrate, Pluripotency, Self-renewal
National Category
Cell and Molecular Biology
Research subject
Molecular Biology
Identifiers
urn:nbn:se:umu:diva-189925 (URN)10.3390/cells10113252 (DOI)000724414100001 ()34831474 (PubMedID)2-s2.0-85119274398 (Scopus ID)
Available from: 2021-11-29 Created: 2021-11-29 Last updated: 2023-09-05Bibliographically approved
Malla, S., Kumari, K., Martinez Gamero, C., Achour, C., Mermelekas, G., Coege, A., . . . Aguilo, F.LSD1 interacts with CHD7 to regulate the chromatin landscape in mouse embryonic stem cells.
Open this publication in new window or tab >>LSD1 interacts with CHD7 to regulate the chromatin landscape in mouse embryonic stem cells
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(English)Manuscript (preprint) (Other academic)
Abstract [en]

 

 

 

National Category
Cell and Molecular Biology
Research subject
Molecular Biology
Identifiers
urn:nbn:se:umu:diva-206717 (URN)
Available from: 2023-04-14 Created: 2023-04-14 Last updated: 2023-04-14
Malla, S., Kumari, K., Martinez Gamero, C., García-Prieto, c. A., Álvarez-Errico3, D., Stransky, S., . . . Aguilo, F.The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells.
Open this publication in new window or tab >>The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells
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(English)Manuscript (preprint) (Other academic)
Keywords
LSD1, DNA methylation, DNMT1, UHRF1 and USP7
National Category
Cell and Molecular Biology
Research subject
Molecular Biology
Identifiers
urn:nbn:se:umu:diva-206715 (URN)
Available from: 2023-04-14 Created: 2023-04-14 Last updated: 2023-04-14
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ORCID iD: ORCID iD iconorcid.org/0000-0001-7652-1695

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