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Björsell, Tove
Publications (2 of 2) Show all publications
Björsell, T., Sundh, J., Lange, A., Ahlm, C., Forsell, M. N. E., Tevell, S., . . . Cajander, S. (2023). Risk factors for impaired respiratory function post COVID-19: a prospective cohort study of nonhospitalized and hospitalized patients. Journal of Internal Medicine, 293(5), 600-614
Open this publication in new window or tab >>Risk factors for impaired respiratory function post COVID-19: a prospective cohort study of nonhospitalized and hospitalized patients
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2023 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 293, no 5, p. 600-614Article in journal (Refereed) Published
Abstract [en]

Background: Severe COVID-19 increases the risk for long-term respiratory impairment, but data after mild COVID-19 are scarce. Our aims were to determine risk factors for reduced respiratory function 3–6 months after COVID-19 infection and to investigate if reduced respiratory function would relate to impairment of exercise performance and breathlessness. Methods: Patients with COVID-19 were enrolled at the University Hospitals of Umeå and Örebro, and Karlstad Central Hospital, Sweden. Disease severity was defined as mild (nonhospitalized), moderate (hospitalized with or without oxygen treatment), and severe (intensive care). Spirometry, including diffusion capacity (DLCO), was performed 3–6 months after hospital discharge or study enrollment (for nonhospitalized patients). Breathlessness (defined as ≥1 according to the modified Medical Research Council scale) and functional exercise capacity (1-min sit-to-stand test; 1-MSTST) were assessed. Results: Between April 2020 and May 2021, 337 patients were enrolled in the study. Forced vital capacity and DLCO were significantly lower in patients with severe COVID-19. Among hospitalized patients, 20% had reduced DLCO, versus 4% in nonhospitalized. Breathlessness was found in 40.6% of the participants and was associated with impaired DLCO. A pathological desaturation or heart rate response was observed in 17% of participants during the 1-MSTST. However, this response was not associated with reduced DLCO. Conclusion: Reduced DLCO was the major respiratory impairment 3–6 months following COVID-19, with hospitalization as the most important risk factor. The lack of association between impaired DLCO and pathological physiological responses to exertion suggests that these physiological responses are not primarily related to decreased lung function.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023
Keywords
breathlessness, COVID-19, diffusion capacity, post-acute COVID-19 syndrome, spirometry
National Category
Respiratory Medicine and Allergy General Practice
Identifiers
urn:nbn:se:umu:diva-205377 (URN)10.1111/joim.13614 (DOI)000936826900001 ()36815689 (PubMedID)2-s2.0-85148632325 (Scopus ID)
Funder
Nyckelfonden, OLL-938628Nyckelfonden, OLL-961416Swedish Research Council, 2020-06235Swedish Research Council, 2016-06514Swedish Heart Lung Foundation, 20200325Swedish Heart Lung Foundation, 20210078Knut and Alice Wallenberg Foundation, VC-2020-0015Umeå University, RV‐938855Region Västerbotten, RV-938855Region Värmland, LIVFOU-939646
Available from: 2023-03-24 Created: 2023-03-24 Last updated: 2023-07-14Bibliographically approved
Normark, J., Vikström, L., Yong-Dae, G., Persson, I.-L., Edin, A., Björsell, T., . . . Forsell, M. N. E. (2021). Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination [Letter to the editor]. New England Journal of Medicine, 385(11), 1049-1051
Open this publication in new window or tab >>Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination
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2021 (English)In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 385, no 11, p. 1049-1051Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Massachusetts Medical Society, 2021
National Category
Immunology in the medical area
Identifiers
urn:nbn:se:umu:diva-187330 (URN)10.1056/NEJMc2110716 (DOI)000674415300001 ()34260850 (PubMedID)2-s2.0-85111281855 (Scopus ID)
Available from: 2021-09-08 Created: 2021-09-08 Last updated: 2022-04-27Bibliographically approved
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