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Tittel [sv]
Dynamisk modellering i Poppel träd med hjälp av systembiologi och kemometri
Tittel [en]
Dynamic modeling in Poplar using a Systems Biology approach
Abstract [sv]
To further develop the area of tree biotechnology there is a need to study model organisms such as Populus with a systems biology approach. The aim of this project is to develop and apply chemometrical approaches within a systems biology study of the temporal dynamics of diurnal and circadian rhythms in wild type and mutant poplar trees; all this in collaboration with Umeå Plant Science Center. More specifically, we will use microarray and metabolite profiling technologies to detect and characterize differences between long-day (LD) and short-day (SD) grown trees. We will use advanced multivariate statistical methods, e.g. hierarchical-PCA, OPLS and O2PLS, to understand the individual dynamics and biological variation caused by genetic and environmental differences. These modeling techniques have proven to be novel key technologies in combined profiling. Their most unique feature compared to existing methods is that they contain the proper model structure to describe not only the correlation patterns among multiple data sources, but also the unique, noncorrelated patterns which, from an information aspect, provide complementary, and sometimes critical information.Statistical modeling and data integration across platforms of each individual plant trajectory can then be used to summarize the global dynamic behaviour over all plants. This will provide new insight in gene-metabolite regulation related to the diurnal and circadian rhythm in Poplar trees.
Principal InvestigatorTrygg, Johan
Koordinerande organisasjon
Umeå universitet
Forskningsfinansiär
Tidsperiod
2009-01-01 － 2011-12-31
Identifikatorer
DiVA, id: project:853Prosjekt id: 2008-03588_VR

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