Umeå universitets logga

umu.sePublikationer
Driftstörningar
Det förekommer återkommande driftstörningar på några av sök-portalerna på grund av hög belastning. Vi arbetar på att lösa problemet, ni kan tillfälligt mötas av ett felmeddelande.
EnglishSvenskaNorsk
Ändra sökning
ExporteraLänk till posten
Permanent länk

Direktlänk
BETA

Projekt

Projekttyp/Bidragsform
Projektbidrag
Titel [sv]
Basen för stress och könshormon orsakade mentala symtom och sjukdomar.
Titel [en]
Basis for sex and stress hormone induced mood symptoms and diseases
Abstract [sv]
Metabolites of stress and sex hormones (GABA-steroids) agonistically modulate the GABA-A receptor and cause mental symptoms and disorders but the mechanisms are poorly known. Only a few individuals react negatively on GABA-steroids but all individuals have variations in GABA-steroids especially women during the menstrual cycle. The reason for individual responses to GABA-steroids is unknown. Previous research indicates that tolerance development with decreased function in the GABA-A system may be one reason. Another is that GABA-steroids have a biphasic action with low levels provoking symptoms while absence or higher levels give less severe symptoms. Personality factors and chronic stress seem to be of importance. Aims are: In humans investigate if tolerance against GABA-steroids occurs in conditions with increased endogenous or exogenous GABA-steroid exposure by using sensitivity tests of the GABA-A system? With brain imaging studies, in humans, investigate if activity in neural structures responsible for emotions, change in response to stimuli under GABA-steroid influence? In animals studies investigate if psychological trait factors, or chronic social stress, are important for the sensitivity towards GABA-steroids? In HEK-cells, expressing single recombinant human GABA-A receptor, with patch-clamp methods, investigate if 3alpha-hydroxy metabolites of endogenous or therapeutic progestagens, androgens and glucocorticoids are active on the GABA-A receptor?
ProjektledareBäckström, Torbjörn
Koordinerande organisation
Umeå universitet
Forskningsfinansiär
Tidsperiod
2010-01-01 － 2012-12-31
Identifikatorer
DiVA, id: project:949Projekt id: 2009-02637_VR

Sök vidare i DiVA

Sök vidare utanför DiVA

GoogleGoogle Scholar
v. 2.49.0
|
WCAG
|
Logga in
|
Manualer
|
Kontakta biblioteket