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Title [sv]
Odlade senceller som en experimentell modell för tendinopati/tendinos - prövande av biokemiska och mekaniska hypoteser för patofysiologin
Title [en]
Tenocyte cell cultures as an experimental model for tendinopathy/tendinosis - testing biochemical and mechanical hypotheses of pathophysiology
Abstract [sv]
The aims of the present research project are to establish an experimental model for the painful and degenerative tendon condition called tendinopathy or tendinosis, by setting up tendon cell cultures, and then to use this model to investigate mechanistic aspects of the disease through various analytic methods on protein and gene level. The pathophysiology of tendinosis is largely unknown, and new treatment regimens are greatly needed since the present therapies are only successful in some cases of this chronically painful condition. There is therefore a great demand for experimental models in the research field. Many of the present models involve animal experiments that in varying degrees inflict trauma to the animal. A parallel aim of this project is to find ways to reduce the need of animal experiments, by using primary human cell cultures and an already established mouse cell line from the 1970s. Our previous research has provided some new hypotheses for the pathophysiology of tendinosis. We have found novel evidence of a local production of signal substances in the cells of tendinosis tissue; substances that might be involved in the pathology of the disease (tissue degeneration, angiogenesis, and pain). The role of these substances in the development of tendinosis is not yet clarified, and the role of physical strain on the tendon for this production, and for the disease, is also uncertain. We aim to test our hypotheses for the pathophysiology in this project.
Principal InvestigatorDanielson, Patrik
Coordinating organisation
Umeå University
Funder
Period
2010-01-01 - 2012-12-31
Identifiers
DiVA, id: project:1009Project, id: 2009-02921_VR

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