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Title [sv]
Tarmslemhinnans immunologi
Title [en]
Immune defense of the intestinal mucosa
Abstract [sv]
T cells execute key regulatory and effector functions in adaptive immunity while epithelial cells constitute an important part of the innate immunity as the first-line of defense of the intestinal mucosa. Objective: To elucidate the functional properties of the immune system of the gut in mammals, especially T cell-epithelial cell interactions in relation to microbial insult. Study areas: (I) Immunological consequences of bacteria - epithelial cell interactions; (II) Crosstalk between intraepithelial T cells and epithelial cells in immune protection and its consequences for innate and adaptive immunity; (III) Gut T cell function and the role of gut extrathymic T cell development in prevention of immune overreaction. Hypothesis: Epithelial cells shed vesicles both at the apical and basolateral side. We hypothesize that antigen-loaded vesicles, exosomes, released at the basolateral side induce generation of regulatory T cells, Tregs, and that glycocalyx-derived microvesicles shed apically provide a versatile innate immune protection to bacteria. Methods: The response of epithelial cells to commensals, enteropatogenic- and celiac disease-related bacteria and their released vesicles is studied in an in vitro model for gut epithelium. T cell function analysis in vivo and in vitro, measurements of antimicrobial peptide responses and screening for new effector molecules by microarrays at mRNA and protein levels will be performed.
Principal InvestigatorHammarström, Marie-Louise
Coordinating organisation
Umeå University
Funder
Period
2011-01-01 － 2013-12-31
Identifiers
DiVA, id: project:1040Project, id: 2010-05669_VR

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