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Project grant
Title [sv]
Virusreceptorer: betydelse för tropism, behandling och targeting
Title [en]
Virus receptors: implications for tropism, treatment and targeting
Abstract [sv]
The overall aim of this project is to identify and characterize components and mechanisms that regulate the early steps of viral (adenovirus, picornavirus, norovirus, influenza A virus) infections of human target cells.Methods: A) virus binding assays and B) virus infection assays. These are combined with tools such as: i) cells transfected with cDNA:s encoding receptor candidates, ii) receptor candidate-binding antibodies/lectins, iii) soluble, competing receptor candidates, iv) receptor destroying enzymes, v) siRNA mediated downregulation of receptor expression etc; C) Flow cytometry, and D) Proteomics: 2D-gel electrophoresis and MALDI. In collaboration with others we also use E) X-ray crystallography, F) glycan array, G) in situ histochemistry and H) chemical synthesis of antiviral drug candidates.We have previously identified four components that different adenoviruses use for binding to target cells: sialic acid (ocular adenoviruses and picornaviruses), lactoferrin (respiratory/lymphoid adenoviruses), coagulation factor IX (systemic adenoviruses) and CD46 (renal adenoviruses).This project increases our basic understanding of virus biology, tropism and pathogenicity. It also includes development of a novel class of antiviral drugs, binding inhibitors, to be used primarily against viruses with ocular tropism. Finally, the project also contributes to development of de- (and re-) targeted adenovirus-based vectors for gene and/or cancer therapy.
Principal InvestigatorArnberg, Niklas
Coordinating organisation
Umeå University
2011-01-01 - 2013-12-31
DiVA, id: project:1044Project, id: 2010-03078_VR

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