A National FESEM Resource for training and research using high resolution Field Emission Scanning-EM and Cryo-technology

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https://umu.diva-portal.org/smash/project.jsf?pid=project:1103

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Title [sv]

Nationell FESEM resurs för utbildning och forskning med högupplösande fältemission svepelektronmikroskopi och kryoteknologiInom Swedish BioImaging.

Title [en]

A National FESEM Resource for training and research using high resolution Field Emission Scanning-EM and Cryo-technology

Abstract [sv]

The proposed National FESEM Resource will provide a high resolution Field Emission Scanning Electron Microscope with a cryo-SEM system for life science and materials research. In particular, scientists within the Swedish National Network for Infection Biology from all major universities; Umeå University, Uppsala University, Stockholm University, Karolinska Institute, Linköping University, Göteborg University, Lund University, are aiming to strengthen the infection biology research in the country by this joint infrastructure. The Field Emission Scanning-EM instrument equipped with a cryo-SEM system will be integrated in the Electron Microscopy Platform and the adjacent high resolution light microscopy infrastructure at the newly established open access Visualization Center at KBC, Umeå University. It will add completely new possibilities for ultra-high resolution analysis of the three dimensional overview of surface properties and in combination with immuno-gold labeling the precise localization of surface proteins. Correlated light and electron microscopic imaging will be possible by combining structural information obtained at the EM level with functional and dynamic information obtained from 4D imaging of live cells at the light microscopy level. The National FESEM Resource will provide an infrastructure open to all researchers within the infection biology field and will facilitate research collaborations and advanced training within high resolution cryo-Scanning-EM.

Principal InvestigatorUhlin, Bernt Eric Umeå University

Coordinating organisation

Umeå University

Funder

Vetenskapsrådet

Period

2012-03-01 － 2016-03-31

National Category

Cell BiologyMicrobiology in the medical areaMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)