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Title [sv]
Tumör- och stromacellsinteraktioner vid invasionsfronten i human tjocktarmscancer
Title [en]
Tumor and stromal cell interactions at the invasive front in human colorectal cancer
Abstract [sv]
The invasion of cancer cells into the surrounding tissue is a prerequisite and intital step in metastasis, which is the leading cause of cancer death. We want to understand the underlying processes that takes place at the invasive margin in colorectal cancer (CRC), the second most common cancer in both men and women. CRC can be divided into three CIMP (CpG Island Methylator Phenotype) groups. We have tissue samples and clinical data from about 900 CRC patients. Besides these clinical materials we have during the last years developed several interesting and somewhat novel in vitro models including an explant model, to experimentally study the interactions between CRC cells and the surrounding stromal cells in local invasion. With these research tools we want to: 1) investigate differencies in the invasion machinery in different CIMP groups but also elucidate the importance of CIMP in chemotherapy and relate the findings to morphological and molecular aspects. 2) The role of inflammatory cells will be studied with focus on macrophages and their subdifferentiation into M1 and M2. 3) Gene expression array will be used to elucidate why some tumors give rise to a strong immune response and some tumors not. 4) The mechanism by which fibroblast activation is a prerequisite in local invasion will be further investigated. In conclusion, better understanding of the molecular events at the invasive front in CIMP subgroups will be crucial for improved future management for CRC patients.
Principal InvestigatorPalmqvist, Richard
Coordinating organisation
Umeå University
Funder
Period
2012-01-01 － 2014-12-31
National Category
Cancer and OncologyGastroenterology and HepatologyClinical Laboratory Medicine
Identifiers
DiVA, id: project:1104Project, id: 2011-03489_VR
v. 2.46.0
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