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Title [sv]
Naturlig immunitet i Drosophila
Title [en]
The immune response in Drosophila
Abstract [sv]
BACKGROUND, SIGNIFICANCE. Our innate immune defenses are still incompletely understood. To address this problem, we have developed Drosophila as an experimental model. The usefulness of this model was demonstrated for instance by our early discovery that the receptor Toll can activate an antibacterial response in Drosophila. Toll-like receptors were later found to play an important role in human immunity. In fact, the entire signaling pathway is conserved between insect and man.AIMS. To explore the basic molecular mechanisms of innate immunity, taking advantage of the possibilities offered by Drosophila as a model system. Specifically, we will focus on cellular immunity, and also on how activated blood cells can become cancerous.WORKING PLAN. We have developed novel tools to study the activation of Drosophila blood cells in response to infection. Using genetic screens we are identifying genes that are involved in this response. In a gain-of-function screen we previously identified several signaling pathways that are involved. In this project, we are searching for relevant genes in modifier screens, using deletions that cover at least 85% of the genome. The biological role of specific genes will be studied in the immune response against the parasitoid, Leptopilina boulardi. We are also investigating the signaling interactions between blood cells and other tissues that control the immune response.
Principal InvestigatorHultmark, Dan
Coordinating organisation
Umeå University
Funder
Period
2012-01-01 － 2014-12-31
National Category
Biochemistry and Molecular BiologyCell BiologyImmunology
Identifiers
DiVA, id: project:1183Project, id: 2011-05088_VR

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