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Title [sv]
Roll och mekanismer för bakteriella nukleoidproteiner i kontroll av genexpression
Title [en]
Role and mechanisms of bacterial nucleoid proteins in control of gene expression
Abstract [sv]
The purpose of this project is to increase our understanding of how the nucleoid proteins in the H-NS protein family are influencing gene regulation in bacteria. In particular we aim to identify and characterize the mechanisms leading to differentiated sub-populations of bacteria. Specific goals: * To clarify the interplay between homologs/paralogues of the H-NS protein family involved in transcriptional silencing in extraintestinal E. coli isolates. * To clarify the molecular mode of action of regulatory proteins acting as anti-silencing factors alleviating H-NS activity in bacterial gene clusters encoding fimbrial adhesion organelles. * To identify and characterize the postulated regulasome complexes at the sub-cellular level in bacterial cells * To clarify the role and mode of action of bacterial nucleoid proteins in control of gene expression at post-transcriptional levels.We now find it feasible to study the actual mechanisms operating at the level of the particular sub-populations and the individual cells. Recent developments with fluorescence tagging approaches and super-resolution microscopy will allow us to identify and characterize both the spatial localization and composition of regulatory complexes in the individual bacterial cells.
Principal InvestigatorUhlin, Bernt Eric
Coordinating organisation
Umeå University
Funder
Period
2013-01-01 － 2015-12-31
National Category
Structural BiologyBiochemistry and Molecular BiologyMicrobiology
Identifiers
DiVA, id: project:1248Project, id: 2012-04638_VR
v. 2.46.0
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