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Title [sv]
Mekanismer bakom typ VI sekretion och dess användbarhet som terapeutisk måltavla
Title [en]
Mechanisms of type VI secretion and its utility as therapeutic target
Abstract [sv]
We will delineate the regulation and functions of type VI secretion systems (T6SS), essential for the virulence of many Gram-negative bacteria. We aim to identify the signals that initiate secretion, the signaling pathways controlling the secretion, and some of the eukaryotic and prokaryotic targets of the T6SS of F. tularensis. A special focus will be on the two most conserved components of T6SS, the IglA/B and VipA/B homologues with the aim to delineate their structural interaction and to also develop inhibitors thereof. As their physical interaction is essential for T6S and is highly conserved such inhibitors would potentially impair the virulence of not only F. tularensis and V. cholerae, but also of other important Gram-negative pathogens. By identifying prokaryotic targets, we will start to understand how the previously unknown inter-bacterial killing occurs and the implications of this mechanism. The understanding of the phylogenetically distinct T6SS of F. tularensis will unravel components essential for its unique intracellular life style and identify the eukaryotic targets that it utilizes to sustain to propagate its highly successful life style. We envision that this in the long-term can identify possible strategies to interfere with its virulence and create a foundation for alternative therapeutic targets.
Principal InvestigatorSjöstedt, Anders
Coordinating organisation
Umeå University
Funder
Period
2014-01-01 - 2017-12-31
National Category
ImmunologyMicrobiologyMicrobiology in the medical area
Identifiers
DiVA, id: project:1278Project, id: 2013-04581_VR

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