The role of ASNA1 in pancreatic progenitor and beta cells

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https://umu.diva-portal.org/smash/project.jsf?pid=project:1318

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Title [sv]

FUNKTIONELL ANALYS AV ASNA1 I PANKREASSTAMCELLER OCH BETACELLER

Title [en]

The role of ASNA1 in pancreatic progenitor and beta cells

Abstract [sv]

Accumulating data from experimental, clinical, and genetic studies point towards a role for sustained ER stress in both beta-cell dysfunction and beta-cell death. Increased knowledge of the role of factors regulating ER homeostasis will be instrumental for the prospect of developing mechanism based drugs and therapies that may restore beta-cell function and survival via restoration of ER homeostasis. Based on preliminary studies of mice where we have conditionally deleted the Asna1 gene in pancreatic progenitor and beta-cells, respectively, we hypothesize that Asna1 is required for maintenance of ER homeostasis. Thus, the overall aim of this proposal is to explore whether Asna1 ensures pancreatic progenitor and beta-cell integrity by regulating aspects of the Unfolded Protein Response (UPR) and ER homeostasis. To further explore the functional role for Asna1 in in the developing and adult pancreas we will pursue three main obejctives: Objective 1: To elucidate a potential role for Asna1 in regulation of ER homeostasis. Objective 2: To try to identify ASNA1 target protein(s) in pancreatic progenitor and beta-cells. Objective 3: To investigate how physiological conditions such as obesity and aging affects ASNA1 levels, as well as key components of the unfolded protein response, in beta-cells.

Principal InvestigatorEdlund, Helena Umeå University

Coordinating organisation

Umeå University

Funder

Vetenskapsrådet

Period

2014-01-01 － 2016-12-31

National Category

PhysiologyCell and Molecular BiologyMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)