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Title [sv]
Identifiering av Francisella tularensis immunsuppressiva egenskaper och utnyttjande av dessa som terapeutiska mål
Title [en]
Delineating immune-subversive mechanisms of Francisella tularensis and utilizing them as therapeutic targets
Abstract [sv]
Francisella tularensis (Ft) is one of the most infectious and pathogenic bacteria known. The remarkable virulence of Ft is believed to be due to its capacity to subvert host immune responses. The aim of the present project is to bring together three research groups with extensive and complimentary expertise from two different European countries to identify and characterize the mechanisms of Ft effectors critical for its high virulence and immune subversion. Furthermore, we will explore the potential of the novel information derived thereof to generate new therapeutics. Finally, the identification of immunomodulatory effectors of Ft and their mechanisms is expected to contribute significantly to the fundamental understanding of numerous cell biology and innate immunity processes. The major benefit of the collaboration is that it will allow the implementation of an ambitious research program of multidisciplinary nature on host-pathogen interactions that would otherwise not be feasible. Only the bundling of know-how within our consortium with complementary multidisciplinary skills and expertise will enable fulfillment of the aims. Mutual exchanges of students and postdocs will facilitate the cross-transfer of the complementary know-how between the laboratories and this will lead to the development of a strong international network and lay a solid foundation for long-term collaborative studies.
Principal InvestigatorSjöstedt, Anders
Coordinating organisation
Umeå University
Funder
Period
2013-01-01 - 2016-12-31
National Category
ImmunologyMicrobiologyMicrobiology in the medical area
Identifiers
DiVA, id: project:1320Project, id: 2013-08621_VR

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