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Title [sv]
Longitudinell och translationell studie av svårighetsgrad och samsjuklighet vid ankyloserande spondylit
Title [en]
Longitudinal and translational study on disease severity and comorbidities in ankylosing spondylitis
Abstract [en]
This proposal aims to identify underlying mechanisms and predictors for severe disease course and comorbidities in patients with ankylosing spondylitis (AS), also known as Bechterew?s disease, the most severe subgroup of spondyloarthritis. AS is one of the most common chronic inflammatory rheumatic diseases, however less studied than many other inflammatory rheumatic diseases. We recently showed an increased mortality ratio for both men and women with AS and the major cause of death was cardiovascular disease (CVD). Though, reasons for increased burden of CVD and other comorbidities such as osteoporosis and fractures, anterior uveitis and gastrointestinal inflammation as well as the process of osteoproliferation in the spine connected with the severe disease course are largely unknown. The basis of this comprehensive proposal consists of a unique, in detail phenotyped large cohort of AS patients followed longitudinally, results from modern imaging and an extensive biomarker program and matched controls from the same geographic area. We will also conduct a national registry investigation aiming to estimate the risk for fractures in AS compared to population comparators and a study on immunogenicity induced by infliximab. The goal is that our results gained in this proposal will improve care and treatment thereby ameliorate the prognosis of the disease and also discover new possible therapeutic targets.
Principal InvestigatorForsblad dElia, Helena
Coordinating organisation
Umeå University
Funder
Period
2017-01-01 － 2019-12-31
National Category
Endocrinology and DiabetesCardiac and Cardiovascular SystemsRheumatology and Autoimmunity
Identifiers
DiVA, id: project:1405Project, id: 2016-02035_VR
v. 2.47.0
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