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Title [sv]
Mekanismer för sårläkning och ärrbildning i ögats hornhinna
Title [en]
Mechanisms of wound-healing and scar-formation in the human cornea
Abstract [en]
Infection or trauma to the eye can induce excessive scarring of the cornea, which often leads to impaired vision or even blindness. Scar-formation after malfunctioning corneal wound-healing is characterized by collagen fiber malalignment, as well as excessive cell proliferation, but the underlying mechanisms are poorly understood. The purpose of this project is to unravel such pathophysiological mechanisms. The specific aim is to define intra- and intercellular signaling pathways that regulate the functional state of the collagen-synthesizing corneal cells (keratocytes), using both in vitro and in vivo model systems. Under the hypothesis that locally produced neuropeptides/neuromodulators are involved in the scar-forming processes, we will test predicted modulatory effects of such substances on the corneal cells and extracellular matrix. We will then study signaling pathways that mechanistically bring about observed effects. Furthermore, in our newly developed 3D in vitro corneal stroma model, we will test our hypothesis that locally produced neuromodulators contribute to excessive scarring by inhibiting keratocyte apoptosis. We will also test the entirely novel hypothesis that induction of keratocyte senescence, possibly by blocking of neuromodulators, can counteract scarring. The goal is to identify key processes that can be targeted in future intervention techniques preventing or reversing scar-formation of the cornea, the 4th leading cause of blindness in the world.
Principal InvestigatorDanielson, Patrik
Coordinating organisation
Umeå University
2018-01-01 - 2021-12-31
National Category
Cell and Molecular BiologyOphthalmology
DiVA, id: project:1553Project, id: 2017-01138_VR

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