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Title [sv]
Fysiska, psykologiska och socioekonomiska effekter av barn- och ungdomsdiabetes i Sverige ? longitudinella registerstudier
Title [en]
Physical, psychological and socioeconomic effects of childhood onset diabetes in Sweden ? longitudinal register-based studies
Abstract [en]
We study time trends of childhood-onset type 1 diabetes and its most serious complication, end-stage renal disease. We will further analyse physical, psychological and socio-economic long-term effects on patients and families to identify potentially preventive factors in a population perspective. We analyse determinants of survival and diabetes- and non-diabetes-related causes of death. We investigate the economic burden of disease. We study and improve statistical methods for case-control data. The projects use a longitudinal nationwide database involving about 20 000 childhood-onset diabetes cases with maximum follow-up of 40 years and for each case 4 matched controls. The Swedish Childhood Diabetes Register is linked to a number of official registers: the Renal register, the Cause of Death register, the National Patient register, the Pharmaceuticals register, the Cancer register and the Integrated Database for Labour Market Research. We use GAM-modelling for time trend analyses, standard case-control/cohort analyses, Cox regression for life table analyses, linear fixed effect probability for career development and propensity score models for confounding. The project group is multidisciplinary and involves experts in paediatrics, nephrology, epidemiology, health economics and statistics. This unique database and team will continue to yield population-based new knowledge on the consequences of this increasingly common chronic childhood-onset disease.
Principal InvestigatorLind, Torbjörn
Coordinating organisation
Umeå University
Funder
Period
2019-01-01 － 2022-12-31
National Category
Endocrinology and DiabetesPediatrics
Identifiers
DiVA, id: project:1558Project, id: 2018-02565_VR

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