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Title [sv]
Systemisk organsamverkan i immunförsvaret ? Drosophila som modellsystem
Title [en]
Tissue interactions in Drosophila immunity ? a model for a systemic immune response
Abstract [en]
BACKGROUND, SIGNIFICANCE. We developed tools to study blood cells in Drosophila and used them to identify genes that control blood cell activation and proliferation in infected or tumorous animals. Besides known oncogenes, we identified genes involved in nutrient control, such as genes for insulin and Tor signaling, as well as those involved in the control of appetite. Unexpectedly, we found that muscles respond to infection or cancer, by induced JAK/STAT signaling. This response modulates blood cell activity, apparently by controlling the availability of nutrients.I hypothesize that muscles may also act as master regulators of nutrient availability. This would be relevant for the phenomenon of cachexia.AIMS. Using Drosophila genetics we will study tissue interactions during inflammatory responses, and how they mediate activation of blood cells in immunity or malignant transformation. Specifically, we will explore the cellular mechanisms that control nutrient storage and distribution during infection and cancer.WORKING PLAN. Using the genetic tools we have developed, we will study the cross-talk between the blood cells and surrounding tissues in the context of parasite infection and tumor mutants. We will use available mutants to study in vivo the relative importance for the malignant phenotype of factors we have identified, focusing on the insulin, PI3K/Act and Tor signaling pathways and the particular role of nutrition and appetite.
Principal InvestigatorHultmark, Dan
Coordinating organisation
Umeå University
Funder
Period
2019-01-01 － 2022-12-31
National Category
Biochemistry and Molecular BiologyImmunologyGenetics
Identifiers
DiVA, id: project:1578Project, id: 2018-05114_VR

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