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Title [sv]
Bukväggsdefekter - kirurgiska innovationer baserade på förståelse av biologiska interaktioner
Title [en]
Abdominal Wall Defects ? surgical innovations based on understanding of biological interactions
Abstract [en]
Abdominal wall defect repair is one of the most common surgical procedures, unfortunately the occurrence of adverse complications due to interaction between prosthetic material and human tissue is a major problem. This research focuses on a paradigm change with the development of the use of autogenous full-thickness skin graft as reinforcing material, developed by HERMUS (Hernia Multi-University Study group). A requisite for the development of such an innovative repair method is the increase in our knowledge about the biological mechanisms involved in tissue integration.A completely translational chain of research has been initiated, beginning with a unique ex vivo model developed by HERMUS, used for longitudinal studies on the interaction between human peritoneal tissue and skin grafts. Analyses include morphology with vital staining using fluorochromes and ultraviolet emission, IHC and scanning electron microscopy. To study the remodelling process, expression of MMPs and their inhibitors will be performed using ELISAs.A mouse model studying the expression of luciferase enzyme is used to study integration and to determine the optimal positioning of implanted full-thickness skin grafts for hernia repair in humans. We aim to extend the use of skin transplants to parastomal hernia repair, a field where no other successful method exists today.Results from these studies can immediately be transferred to clinical practice, including the refinement of novel surgical techniques.
Principal InvestigatorGunnarsson, Ulf
Coordinating organisation
Umeå University
Funder
Period
2018-01-01 － 2020-12-31
National Category
Cell and Molecular BiologySurgeryMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
DiVA, id: project:1613Project, id: 2017-00824_VR
v. 2.47.0
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