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Title [sv]
Molekylära mekanismer för bildandet av stabila membranvesiklar i celler
Title [en]
Driving forces of the formation and regulation of stable membrane vesicles in cells
Abstract [en]
Forming vesicles from cellular membranes is fundamental to a living cell. Vesicles generated by specialised protein machineries are involved in molecule trafficking to maintain cellular homeostasis. In contrast to the well-known clathrin-coated vesicles responsib­le for intracellular cargo transport, the less familiar atypical vesicles are characteristically more stably attached to membranes. Atypical vesicles include caveolae, which are signalling platforms and regulators of lipid metabolism, as well as vesicles induced by viral proteins to optimise replication in cells. The overall goal of this project is to provide detailed structural and mechanistic insight to the formation and regulation of stable membrane vesicles in cells. We are applying a range of front-line technologies including innovative biochemical tools, advanced live cell microscopy and cryo-electron tomography. Specifically, we challenge our hypothesis that that specific coat proteins and lipids regu­la­te the formation and dynamics of caveolae. Furthermore, by comparative studies of stable vesicles induced by flaviviruses, we will identify common features in the structural requirements for atypical vesicle formation. As such, this project aims to unravel the elementary principles that drive formation of stable membrane vesicles and provide novel insights into this fundamental process used by both cells and a group of pathogenic viruses.
Principal InvestigatorLundmark, Richard
Coordinating organisation
Umeå University
Funder
Period
2018-01-01 － 2021-12-31
National Category
Structural BiologyBiochemistry and Molecular BiologyCell Biology
Identifiers
DiVA, id: project:1645Project, id: 2017-04028_VR
v. 2.47.0
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